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1.
International Journal of Social Economics ; : 18, 2022.
Article in English | Web of Science | ID: covidwho-1895876

ABSTRACT

Purpose - This research aims to identify Brazil's socioeconomic vulnerability to wicked multi-problems arising from coronavirus disease 2019 (COVID-19) (2019-2020), from the most extensive (similar to 3,000 km) oil spill in tropical oceans (2019/2020) and from the highest rate of wildfires in the last decade. Design/methodology/approach - To this end, the authors measured the socioeconomic vulnerabilities of the 27 Brazilian states to these multi-problems (COVID-19 + Oil Spill + wildFire), considering the effects of these events individually and together. In addition, the authors calculated the vulnerability indices using two variables: production value and number of jobs created by an economic activity. Findings - Results show the states of Sao Paulo, Minas Gerais, and Rio de Janeiro as the most susceptible, with a potential loss of 74.2% in production value and 47% in active employment relationships, caused by these overlapping events in time. The results also demonstrate that the country has failed in the coordination and management of these events (separately and jointly), showing difficulties especially in the stages of immediate response and recovery. Originality/value - Regarding its contributions, this paper innovates by establishing an unprecedented overlap of wicked problems, linking this concept to the analysis of socioeconomic vulnerability of the affected communities, through a model that applies to other regions worldwide.

2.
International Journal of Social Economics ; 2022.
Article in English | Scopus | ID: covidwho-1891336

ABSTRACT

Purpose: This research aims to identify Brazil's socioeconomic vulnerability to wicked multi-problems arising from coronavirus disease 2019 (COVID-19) (2019–2020), from the most extensive (∼ 3,000 km) oil spill in tropical oceans (2019/2020) and from the highest rate of wildfires in the last decade. Design/methodology/approach: To this end, the authors measured the socioeconomic vulnerabilities of the 27 Brazilian states to these multi-problems (COVID-19 + Oil Spill + wildFire), considering the effects of these events individually and together. In addition, the authors calculated the vulnerability indices using two variables: production value and number of jobs created by an economic activity. Findings: Results show the states of São Paulo, Minas Gerais, and Rio de Janeiro as the most susceptible, with a potential loss of 74.2% in production value and 47% in active employment relationships, caused by these overlapping events in time. The results also demonstrate that the country has failed in the coordination and management of these events (separately and jointly), showing difficulties especially in the stages of immediate response and recovery. Originality/value: Regarding its contributions, this paper innovates by establishing an unprecedented overlap of wicked problems, linking this concept to the analysis of socioeconomic vulnerability of the affected communities, through a model that applies to other regions worldwide. Peer review: The peer review history for this article is available at: https://publons.com/publon/10.1108/IJSE-09-2021-0536 © 2022, Emerald Publishing Limited.

3.
Embase; 2022.
Preprint in English | EMBASE | ID: ppcovidwho-337462

ABSTRACT

Background: Since the beginning of the COVID-19 pandemic, health professionals have been working under extreme conditions, increasing the risk of physical and mental illness. We evaluated the prevalence of burnout and its associated factors among postgraduate student residents in health professions during the global health crisis. Methods: Healthcare residents were recruited from all across Brazil between July and September 2020 through digital forms containing instruments for assessing burnout (Oldenburg Burnout Inventory (OLBI)), resilience (brief resilient coping scale (BRCS)) and anxiety, stress and depression (depression, anxiety and stress scale (DASS-21) and Patient Health Questionnaire (PHQ-9)). Additionally, the relationships between burnout and chronic diseases, autonomy and educational adequacy in the residency programme, personal protective equipment (PPE), workload and care for patients with COVID-19 were evaluated. The chi-square test, Student’s t test, Pearson’s correlation test and logistic regression were performed. Results: A total of 1,313 participants were included: mean (standard deviation) age, 27.8 (4.4) years;female gender, 78.1%;white race, 59.3%;and physicians, 51.3%. The overall prevalence of burnout was 33.4%. The odds (odds ratio [95% confidence interval]) of burnout were higher in the presence of pre-existing diseases (1.76 [1.26–2.47]) and weekly work > 60 h (1.36 [1.03–1.79]) and were lower in the presence of high resilience (0.84 [0.81–0.88]), autonomy (0.87 [0.81–0.93]), and educational structure (0.77 [0.73–0.82]), adequate availability of PPE (0.72 [0.63–0.83]) and non-white race (0.63 [0.47–0.83]). Burnout was correlated with anxiety (r = 0.47;p < 0.05), stress (r: 0.58;p < 0.05) and depression (r: 0.65;p < 0.05). Conclusions: We observed a high prevalence of burnout among residents during the COVID-19 pandemic. Individual characteristics and conditions related to the work environment were associated with a higher or lower occurrence of the syndrome.

4.
PubMed; 2020.
Preprint in English | PubMed | ID: ppcovidwho-333555

ABSTRACT

Numerous factors have been identified to influence susceptibility to SARS-CoV-2 infection and disease severity. Cancer patients are more prone to clinically evolve to more severe COVID-19 conditions, but the determinants of such a more severe outcome remain largely unknown. We have determined the full-length SARS-CoV-2 genomic sequences of cancer patients and healthcare workers (HCW;non-cancer controls) by deep sequencing and investigated the within-host viral quasispecies of each infection, quantifying intrahost genetic diversity. Naso- and oropharyngeal SARS-CoV-2 + swabs from 57 cancer patients and 14 healthcare workers (HCW) from the Brazilian Cancer Institute were collected in April-May 2020. Complete genome amplification using ARTIC network V3 multiplex primers was performed followed by next-generation sequencing. Assemblies were conducted in Geneious R11, where consensus sequences were extracted and intrahost single nucleotide variants (iSNVs) were identified. Maximum likelihood phylogenetic analysis was performed using PhyMLv.3.0 and lineages were classified using Pangolin and CoV-GLUE. Phylogenetic analysis showed that all but one strain belonged to clade B1.1. Four genetically linked mutations known as the globally dominant SARS-CoV-2 haplotype (C241T, C3037T, C14408T and A23403G) were found in the majority of consensus sequences. SNV signatures of previously characterized Brazilian genomes were also observed in most samples. Another 85 SNVs were found at a lower frequency (1.4-19.7%). Cancer patients displayed a significantly higher intrahost viral genetic diversity compared to HCW (p = 0.009). Intrahost genetic diversity in cancer patients was independent of SARS-CoV-2 Ct values, and was not associated with disease severity, use of corticosteroids, or use of antivirals, characteristics that could influence viral diversity. Such a feature may explain, at least in part, the more adverse outcomes to which cancer/COVID-19 patients experience. AUTHOR SUMMARY: Cancer patients are more prone to clinically evolve to more severe COVID-19 conditions, but the determinants of such a more severe outcome remain largely unknown. In this study, phylogenetic and variation analysis of SARS-CoV-2 genomes from cancer patients and non-cancer healthcare workers at the Brazilian National Cancer Institute were characterized by deep sequencing. Viral genomes showed signatures characteristic of Brazilian viruses, consistent with the hypothesis of local, community transmission rather than virus importation from abroad. Despite most genomes in patients and healthcare workers belonging to the same lineage, intrahost variability was higher in cancer patients when compared to non-cancer counterparts. The intrahost genomic diversity analysis presented in our study highlights the relaxed evolution of SARS-CoV-2 in a vulnerable population of cancer patients. The high number of minor variations can result in the selection of immune escape variants, resistance to potential drugs, and/or increased pathogenicity. The impact of this higher intrahost variability over time warrants further investigation.

5.
Biomedical and Biopharmaceutical Research ; 17(2):134, 2020.
Article in English | EMBASE | ID: covidwho-1771988

ABSTRACT

Introduction: In Brazilian universities, with the start of the pandemic caused by the Coronavirus disease (Covid-19), traditional methods of face-to-face classes were suspended indefinitely. As an alternative to maintain the interaction of students with our university during the Covid-19 pandemic, we proposed a free online course. Objective: To describe a Human Physiology web course offered to undergraduate students and evaluate the students' perceptions about it. Methods: The course proposal included activities carried out during May 2020 and was approved by the Institutional Education Committee (IRB No. 10.069.20). We offer 50 vacancies. Students should be regularly registered in an undergraduate program of Federal University of Pampa/Brazil, and have prior approval in the Human Physiology course or equivalent. We proposed to students synchronous and asynchronous activities, using active teachig methods (flipped class) to address topics considered important for understanding and review different Human Physiology systems. For asynchronous activities, developed according to the preferred time of each student, we used different online tools and platforms, such as Lt® Plataform (ADInstruments), Socrative®, social medias, etc. To promote a real time interaction between students and teachers, synchronous activities on Zoom® and interactive questions using the Mentimeter® were proposed. Results: Considering the 50 students that started the course, 58% (n = 29) completed at least 70% of the total course, and 16% (n = 8) completed at least 60%. 40 students answered to the evaluation questionnaire. In general, the students' expectations about the course included the Human Physiology contents' review and the opportunity for new learning (about the content and the remote teaching) - in this sense, the course fully to the expectations of 85% of students (n = 34). For most students (90%;n = 36) this was the first web course with this type of method. About the different online tools and activities used during the course, the students inducated that they liked more the exercised in Lt® Platform (100%;n = 40), followed by Zoom®'s interactions (77.5%;n = 31), Mentimeter® webquizzes (60%;n = 24) and Youtube® videos (57.5%;n = 23). The dynamic used in the activities was well accepted by students and most of them considered that it contributed to their understanding of the content (85%;n = 34). Moreover, most students (80%;n = 32) considered the dynamic of the activities as important to increase their frequency of studies during the quarantine period. Considering a scale from 0 (bad) to 10 (excellent), the average grade attributed by the students to the course was 9.15 ± 1.23. Conclusions and Support: Here we report that a web course designed to review the main topics in Human Physiology during the Covid-19 quarantine was well accepted and approved by students. The methods proposed can be considered as a successful alternative to the webteach of Physiology, especially in the current moment that requires social distancing due to the Covid-19 pandemic.

6.
Embase; 2021.
Preprint in English | EMBASE | ID: ppcovidwho-291569

ABSTRACT

Background: Severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) belongs to a subgroup of coronaviruses rampant in bats for centuries. It caused the coronavirus disease 2019 (COVID-19) pandemic. Most patients recover, but a minority of severe cases experience acute respiratory distress or an inflammatory storm devastating many organs that can lead to patient death. The spread of SARS-CoV-2 was facilitated by the increasing intensity of air travel, urban congestion and human contact during the past decades. Until therapies and vaccines are available, tests for virus exposure, confinement and distancing measures have helped curb the pandemic. Vision: The COVID-19 pandemic calls for safeguards and remediation measures through a systemic response. Self-organizing initiatives by scientists and citizens are developing an advanced collective intelligence response to the coronavirus crisis. Their integration forms Olympiads of Solidarity and Health. Their ability to optimize our response to COVID-19 could serve as a model to trigger a global metamorphosis of our societies with far-reaching consequences for attacking fundamental challenges facing humanity in the 21st century. Mission: For COVID-19 and these other challenges, there is no alternative but action. Meeting in Paris in 2003, we set out to "rethink research to understand life and improve health." We have formed an international coalition of academia and industry ecosystems taking a systems medicine approach to understanding COVID-19 by thoroughly characterizing viruses, patients and populations during the pandemic, using openly shared tools. All results will be publicly available with no initial claims for intellectual property rights. This World Alliance for Health and Wellbeing will catalyze the creation of medical and health products such as diagnostic tests, drugs and vaccines that become common goods accessible to all, while seeking further alliances with civil society to bridge with socio-ecological and technological approaches that characterise urban systems, for a collective response to future health emergencies.

7.
AJNR Am J Neuroradiol ; 42(9): E66-E68, 2021 09.
Article in English | MEDLINE | ID: covidwho-1485009
8.
European Psychiatry ; 64(S1):S659, 2021.
Article in English | ProQuest Central | ID: covidwho-1357350

ABSTRACT

IntroductionIn early 2020, governments started to implement different forms of public health measures, from physical distancing recommendations, to stay-at-home orders, to limit the propagation of COVID-19. Here we report the case of a 41-year-old woman, with a diagnosis of panic disorder. During the end of the lockdown, the patient presented psychopathological worsening, from her fear of Covid-19 infection, stemming from a heart failure disease and concerns regarding the hygiene and safety measures of those around her.ObjectivesPresentation of a clinical vignette.MethodsSelection and analisis of clinical case and review of the literature using PubMed database.ResultsThe COVID-19 pandemic and the measures adopted to prevent the spread of the disease had a huge impact on a personal, social, and economic level for the world population. The rise of fear and anxiety among people due to uncertainty about the disease are coupled with essential yet disruptive measures such as lockdowns and quarantines. The chronically ill population are especially vulnerable during such circumstances and require addressing their physical health and any psychological difficulties they might experience, being at higher risk of suffering physically from the pandemic’s disease as well as psychologically from the implemented countermeasures.ConclusionsThis vignette provides a case where a person’s psychiatric conditions are worsened due to the end of a pandemic lockdown, rather than the lockdown itself. Additional work should aim at comparing the experiences of the different countries affected by the pandemic in order to understand the size of the psychological impact, the potential risk and protective factors.DisclosureNo significant relationships.

9.
European Psychiatry ; 64(S1):S285, 2021.
Article in English | ProQuest Central | ID: covidwho-1357214

ABSTRACT

IntroductionCoronavirus disease 2019 (COVID-19) pandemic has had a negative impact for mental health. ULS-Guarda in cooperation with Portugal National Health Service, provided the population of the district of Guarda with a mental health helpline (MHHL).ObjectivesProvide a descriptive data analysis of the MHHL calls received between April 1st and September 20th of 2020.MethodsThe data was obtained through the filling out of questionnaires. It included fields for gender, age, the type of service provided, relation to COVID-19, symptoms displayed and the number calls made per patient. For the statistical analysis, Microsoft Excel TM was utilized.ResultsMHHL received 191 calls. The largest volume was received during April, which saw 116 instances of patients seeking the MHHL. The number of calls then tapered progressively throughout the following months. The services provided were split between psychiatric assistance, psychologic assistance, and the renovation of medical prescriptions, in 44%, 31% and 19% of the cases, respectively. The 101 patients who resorted to the MHHL were unevenly distributed in gender, being 74 female and 27 male individuals. Their ages were mostly between 50 and 69 years old. The most common symptoms were anxiety, depressed humor and insomnia, in 35%, 16% and 11% of the cases, respectively.ConclusionsThe largest influx of calls coincides with the home confinement period, and decreased alongside the relaxation of the confinement measures held. The MHHL had enough adherence to warrant consideration of it being an alternative means of healthcare access, especially in situations where physical access to healthcare is restricted.

10.
European Psychiatry ; 64(S1):S95, 2021.
Article in English | ProQuest Central | ID: covidwho-1357103

ABSTRACT

IntroductionThe mental health impact of the COVID-19 pandemic is well documented. Portugal entered the emergency state on 19th march due to rising numbers of infected patients. The emergency state introduced regulatory measures that restricted people’s movements, applied a curfew, and closed most non-essential spaces and activities, such as shops and religious celebrations.ObjectivesTo evaluate the rates of suicides during the emergency state in Portugal.MethodsWe obtained the number of probable suicides during 19th march and 2nd may 2020, 2019 and 2018 from SICO/eVM (Real Time Mortality Electronic Surveillance). This system is used for health planning in Portugal and provides provisory data which is updated every 10 minutes. ExcelÒ was used for the statistical analysis.ResultsDuring the Emergency State in Portugal there were 57 probable suicides. Comparing to the same period in 2018 and 2019, there were 62 and 70 probable suicides, respectively. Social isolation, anxiety, fear of contagion, chronic stress, and economic difficulties may lead to the development or exacerbation of depressive, anxiety, substance use, and other psychiatric disorders. Literature on suicides due to COVID-19 mention not only fear of infection, but also social isolation and distancing and economic recession as causes for suicide attempts and completions.ConclusionsDuring the emergency state there was not an increase of probable suicides, compared to previous years. The greater vigilance of people’s movements may have deterred many attempts. However, policymakers and health care providers must be alert as the current psychosocial predispose to an increase in suicide rates.DisclosureNo significant relationships.

12.
Geography, Environment, Sustainability ; 14(1):9-16, 2021.
Article in English | Scopus | ID: covidwho-1210165

ABSTRACT

The aim of this article is to understand the relationship between two of the Sustainable Development Goals (UN Agenda 2030) – Good health and well-being (SDG 3) and Clean water and sanitation (SDG 6) – and the statistics of the COVID-19 pandemic (number of cases and deaths) in Brazilian cities. To analyze this relationship, we used secondary data from public organizations on the SDG panorama by city and conducted a moderated regression analysis. The sample was composed of 649 cities with a population exceeding 50 thousand inhabitants. The results show that the higher were the indicators used to measure SDGs, the lower was the number of cases and deaths from the disease. We have also proved that cities’ population density and their distance from the pandemic epicenter moderate this relationship, since a higher level of these moderation variables increases the impact of a lower level of SDGs 3 and 6 coverage in society on the number of cases and deaths from COVID-19. Thus, the efficient and effective investment to reach SDGs 3 and 6 is directly associated with cities’ ability to successfully deal with infectious diseases and the resulting number of deaths. As for its contribution, this research innovates by establishing a model for analyzing the impact of compliance with SDGs on cities’ performance in their fight against COVID-19, which may also suit other nations. © 2021, Russian Geographical Society. All rights reserved.

13.
Journal of Thoracic Oncology ; 16(3):S285-S286, 2021.
Article in English | EMBASE | ID: covidwho-1159457

ABSTRACT

Introduction: The first patient with COVID-19 in Portugal was diagnosed on March 2. There was a lack of knowledge concerning the risks of COVID-19 infection in lung cancer patients, prognostic factors, the influence of cancer treatments and cure criteria. Treatments and consultations were readjusted in order to maintain the ones that increase patients’ survival, while reducing the risks of SARS-CoV-2 infection. International and national “guidelines” were followed, but each hospital had its own strategies to reduce COVID-19 risk. Purpose: The Portuguese Lung Cancer Study Group launched a survey in order to study the early impact of COVID-19 in lung cancer patients, changes in treatments and the way of implementation of COVID-free circuits. Methods: A survey was sent to lung cancer doctors of all the Portuguese hospitals. Results: At the data cut-off, information from twenty one hospitals was collected, corresponding to about 66% (n=3.446) of each year new diagnoses of lung cancer in Portugal. In March and April there was a reduction in newly lung cancer diagnosed patients while comparing with 2019: in March, 86% had a reduction;in April, 90% of the hospitals reported a reduction and it was greater than 40% in eight hospitals (38%). About 62% of the doctors considered less referral from primary care as a cause, and 33% delayed biopsies or other imaging exams. The most difficult exams to obtain were CT guided biopsies and EBUS for 48%. The majority of the hospitals (57%) were also referral for COVID-19 patients’ treatment. In 48% of the lung cancer treating departments’ there were doctors reallocated to COVID-19 treatment areas. In 48% the assistance teams were divided into teams that weren’t previously working together. The majority of doctors (90%) reported having individual protection equipment available. Hospitals performed teleconsultation (100%), and, in seven hospitals (33%), more than half of the consultations were done using communication technology. All the hospitals were able to perform SARS-CoV-2 testing. It was done before every cycle of chemotherapy in 90% of the hospitals. In the majority (67%) it was only performed before day D1, in D1 and D8 chemotherapy protocols. About 19% reported changes in prescription of adjuvant chemotherapy and in maintenance chemotherapy, 33% increased the prescription of oral chemotherapy, 33% changed the periodicity, 29% reported reduction in inclusion in clinical trials. In 33% there was an earlier end of chemotherapy in ECOG2 and vulnerable patients. In 38% the prescription of G-CSF (Granulocity-colony stimulating factor) increased, being used for prophylaxis if the risk of febrile neutropenia was more than 10-15%. The periodicity of consultations was changed for patients under TKI treatment in 86%, and 67% hospitals reported changes in immune checkpoint inhibitor treatment schedule. In 29% oral drugs could be delivered at patients’ home. All the patients admitted for surgery were tested for SARS-CoV-2, and 86% performed SARS-COV-2 testing before radiotherapy. Conclusion: Portuguese hospitals responded to the sudden need of creation of COVID-free circuits, change protocols and even teleconsultation. With a larger follow up we will study the late consequences of COVID-19 pandemic in lung cancer diagnosis and treatment. Keywords: COVID-19, survey, Portuguese Lung Cancer Study Group

14.
Hematology, Transfusion and Cell Therapy ; 42:9-10, 2020.
Article in English | EMBASE | ID: covidwho-957084

ABSTRACT

Anemia Aplasica Severa (AAS) tem como principal característica a Pancitopenia (diminuição do número de elementos figurados do sangue). As infecções apresentadas decorrem de neutropenia intensa e fraqueza. A identificação da doença no seu estágio inicial, encaminhamento ágil e adequado para o atendimento especializado oportunizam um tratamento satisfatório para o prolongamento da sobrevida. J.S.S, 21 anos, sexo masculino, estudante, atleta, residente em Cupira–PE. Diagnóstico: AAS Transitória setembro de 2012. Agosto de 2013 verificou-se recidiva da doença. Tratamento CSA desde 08/06/2019 sem resposta. Suspenso no fim de 2019. Sem doador de medula óssea. Cadastrado no REREME. Procurou Hospital Hemope após aparecimento de lesões com presença de bolhas, hiperemia, dor e edema. Internado em 10/06/2020 permanecendo por mais de um mês com febre persistente, COVID NEGATIVO. Fez os seguintes antibióticos: Meronem, Teicoplamina e Amicacina por mais de 25 dias. Internado realizou sessões de laserterapia e curativo das lesões. 20/07/2020 retornou ao serviço de pronto atendimento–SPA, avaliado pelo médico assistente, apresentou pancitopenia sem sangramentos, solicitada avaliação pela enfermagem. Ao exame referiu dor local das lesões. Panturrilha direita com três lesões, categoria não classificável, com esfacelos, exsudato amarelo sanguinolento, edema, sem odor, área perilesão com tecido hiperpigmentado. Realizado desbridamento mecânico com uso da técnica de Square e Cover. Tecido desvitalizado, esfacelos de fácil remoção e sem sangramento. Curativo das lesões com cobertura de alginato de cálcio com prata e gel de limpeza PHMB. Orientado troca dos curativos primários a cada 72 h e dos secundários se necessário, repouso e elevação do membro. Programadas transfusões de concentrado de plaquetas e hemácias. Retornou dia 31 de julho para realizar as transfusões e reavaliação das lesões, melhora significativa, pouco exsudato amarelado, evidenciado tecido de granulação, sem dor, área perilesão ainda com edema e hiperpigmentação. Realizado curativo com coberturas especiais. Orientado uso de creme de barreira, manter cuidados diários com os curativos. Averiguar as comorbidades associadas que possam alterar o processo de cicatrização, hábitos de vida do paciente, alimentação e condições sócio econômicas para apresentar um plano de tratamento baseado em sua realidade. Destacado o aumento das lesões devido tratamento impróprio. Lesões são fenômenos complexos e devem ser contidas através de embasamento teórico-científico. Tratar lesões cutâneas depende da evolução da fase de cicatrização e da escolha da cobertura para o curativo fundamentado no conhecimento fisiopatológico e bioquímico da reparação tecidual. Faz-se necessário investigar os aspectos das lesões pela enfermagem, sendo o ideal que pacientes sejam acompanhados pela equipe, através de consultas frequentes e sessões de trocas de curativos. O curativo facilita a cicatrização contudo se mal indicado pode retarda-la, além de agravar sua condição. A aplicabilidade correta do curativo garante uma recuperação mais ágil das lesões com o intuito de trazer qualidade de vida ao paciente, reduzir o tempo de tratamento das lesões e seus custos.

16.
Braz. j. biol ; 81(4): 1132-1132, Oct.-Dec. 2021.
Article in English | WHO COVID, LILACS (Americas) | ID: covidwho-868728
17.
Sci Rep ; 10(1): 14733, 2020 09 07.
Article in English | MEDLINE | ID: covidwho-748189

ABSTRACT

Nitazoxanide (NTZ) is effective against helminths and numerous microorganisms, including bacteria and viruses. In vivo, NTZ is metabolized into Tizoxanide (TIZ), which is the active circulating metabolite. With the emergence of SARS-Cov-2 as a Pandemic agent, NTZ became one of the molecules already approved for human use to engage clinical trials, due to results in vitro showing that NTZ was highly effective against the SARS-Cov-2, agent of COVID-19. There are currently several ongoing clinical trials mainly in the USA and Brazil involving NTZ due not only to the in vitro results, but also for its long-known safety. Here, we study the response of Vero cells to TIZ treatment and unveil possible mechanisms for its antimicrobial effect, using a label-free proteomic approach (LC/MS/MS) analysis to compare the proteomic profile between untreated- and TIZ-treated cells. Fifteen differentially expressed proteins were observed related to various biological processes, including translation, intracellular trafficking, RNA processing and modification, and signal transduction. The broad antimicrobial range of TIZ points towards its overall effect in lowering cell metabolism and RNA processing and modification. The decreased levels of FASN, HNRNPH and HNRNPK with the treatment appear to be important for antiviral activity.


Subject(s)
Anti-Infective Agents/pharmacology , Proteome/drug effects , Thiazoles/pharmacology , Animals , Chlorocebus aethiops , Fatty Acid Synthases/genetics , Fatty Acid Synthases/metabolism , Proteome/genetics , Proteome/metabolism , Ribonucleoproteins/genetics , Ribonucleoproteins/metabolism , Vero Cells
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