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Global Congress on Manufacturing and Management, GCMM 2021 ; 335 LNNS:698-713, 2022.
Article in English | Scopus | ID: covidwho-1826173


With many unanswered questions about SARS-CoV-2, the research community needs to immediately prioritize research areas in the fight against the current COVID-19 pandemic. An accelerated and coordinated multidisciplinary research effort is needed from the wider scientific community in many sectors from vaccine and antiviral development to digital technology. This mini-review highlights key research opportunities such as vaccine development, diagnostics, antiviral masks, environmental transmission and antiviral treatments, and outlines how systematic efforts can be focused in these key areas. Some alternate strategies such as the use of novel nanostructured surfaces to slow and prevent the spread of COVID-19 are presented. © 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.

Open Bioinformatics Journal ; 14(1):13-20, 2021.
Article in English | EMBASE | ID: covidwho-1581526


Background: The ongoing COVID-19 pandemic is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). International travels to Australia during the early stages of the pandemic prior to border closure provided avenues for this virus to spread into Australia. Studies of SARS-CoV-2 biogeographical distribution can contribute to the understanding of the viral original sources to Australia. Objective: This study aimed to investigate the clonality and ancestral sources of Australian SARS-CoV-2 isolates using phylogenetic methods. Methods: We retrieved 1,346 complete genomes from Australia along with 153 genomes from other countries from the GISAID and NCBI nucleotide databases as of the 14th May 2020. A representative dataset of 270 Australian and international sequences were resulted from performance of nucleotide redundancy reduction by CD-HIT. We then constructed a median-joining network by Network, and phylogenies by IQ-Tree, BEAST and FastTree. The Bayesian statistical dispersal-vicariance analysis (S-DIVA) and Bayesian interference for discrete areas (BayArea) built in RASP were used to reconstruct ancestral ranges over the phylogenetic trees. Results: Two major clusters, from Europe and from Asia, were observed on the network of 183 haplotypes with distinct nucleotide variations. Analysis of ancestral area reconstruction over the phylogenies indicated most Australian SARS-CoV-2 sequences were disseminated from Europe and East Asia-Southeast Asia. Conclusion: The finding is genetic evidence for the geographic origins of the Australian SARS-CoV-2 sequences. Most Australian sequences were genetically similar to those from Europe and East Asia-Southeast Asia, which were also suggested as two main sources of introduction of SARS-CoV-2 to Australia.