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Annals of HPB Surgery ; 25(3):72-87, 2020.
Article in Russian | EMBASE | ID: covidwho-994695

ABSTRACT

Purpose. To assess the liver density according to the data of native CT studies in patients with COVID-19, depending on the severity of the pulmonary parenchyma damage and the prescribed treatment, to compare the data with biochemical indicators, and also to demonstrate changes in density indicators over time. Material and methods. Lung CT data from 200 patients with COVID-19 were retrospectively analyzed. The density of the liver, spleen, and subcutaneous fat tissue was measured in all patients on the images of the upper abdominal cavity that entered the scan area. The ratio of the density of the liver to the spleen and to the density of the fat tissue was assesed. These indicators were compared with each other in two groups of lung tissue damage: CT 1-2 and CT 3-4. The CT 3-4 group was assessed in detail: the density indicators of the liver were studied in dynamics, and their relationship with biochemical indicators - during the initial study. A comparison was also made between two subgroups: patients taking tocilizumab and those without tocilizumab. Results. A decrease in liver density and the ratio of liver density to spleen density was observed in 35.5% and 47.5% of patients respectively. Liver density and the ratio of liver density to spleen density were lower in the CT 3-4 group than in the CT 1-2 group, and amounted to 43.9 HU versus 49.3 HU (p < 0.008) and 0.9 versus 1.0 respectively (p < 0.014). In the initial study, there were a moderate (r = −0.30;p < 0.05) and weak (r = −0.26;p < 0.05) negative correlation of liver density and the ratio of liver density to spleen density with serum albumin. When assessing the dynamics in patients in the CT 3-4 group, with each subsequent study, an increase in the density of the liver parenchyma and the ratio of liver density to spleen density was noted. The difference between the mean values of liver density at the first and at the fourth CT examinations was 11.85 HU. Liver density values were independent of treatment with tocilizumab. Conclusion. Liver density values were lower in patients with COVID-19 with the degree of lung parenchyma lesion CT 3-4, increased during treatment and did not depend on the prescription of tocilizumab. Evaluation and monitoring of the dynamics of liver density could become a useful parameter in determining the severity of the disease course. No strong relationships were found between the density parameters during primary CT and any of the biochemical parameters. A more detailed analysis of these changes in dynamics is required, which may suggest the prevailing mechanism of liver damage in COVID-19.

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