Generation of novel SARS-CoV-2 variants on B.1.1.7 lineage in three patients with advanced HIV disease (preprint)

The emergence of new SARS-COV-2 variants is of public health concern in case of vaccine escape. Described are three patients with advanced HIV-1 and chronic SARS-CoV-2 infection in whom there is evidence of selection and persistence of novel mutations which are associated with increased transmissibility and immune escape.