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1.
National Journal of Physiology, Pharmacy and Pharmacology ; 13(5):1055-1059, 2023.
Article in English | EMBASE | ID: covidwho-20243402

ABSTRACT

Background: The 2019 coronavirus disease (COVID-19) outbreak, which was brought on by the SARS-CoV-2 novel coronavirus, has had a significant negative influence on our environment and exposed health-care personnel to a new level of risk. Very few studies have addressed the disturbances in the sleep quality of healthcare workers during COVID-19 pandemic. Aim and Objectives: The primary objective of the study was to examine the sleep quality of frontline healthcare workers during COVID-19 pandemic in a tertiary care center in northern Kerala. Material(s) and Method(s): Healthcare workers belonging to a tertiary care center were invited to participate in the study. An online questionnaire including sociodemographics, Pittsburgh sleep quality index, and Insomnia severity index was used to evaluate sleep disturbances in healthcare workers. Univariate and bivariate analysis of the results were done to identify the predictors of poor sleep quality. Result(s): A total of 250 frontline healthcare workers were enrolled in the study, out of which 243 participants provided usable responses. About 27.6% of health workers showed features of poor sleep quality. The prevalence rate of poor sleep quality was highest among nurses, 55.2% followed by doctors and ambulance drivers, 22.4% and 11.9%, respectively. About 17.7% of the study population had subthreshold insomnia and 1.2% had clinical insomnia of moderate intensity. Conclusion(s): The prevalence of poor sleep quality is high among healthcare workers confronting COVID pandemic. This study emphasizes the need to implement specific protective measures for maintaining the sleep quality and decreasing stress among frontline health care workers during pandemics.Copyright © 2023, Mr Bhawani Singh. All rights reserved.

2.
Educational Administration: Theory and Practice ; 29(2):271-283, 2023.
Article in English | Scopus | ID: covidwho-2326506

ABSTRACT

The economy globally has impacted livelihood and organizations because of the COVID-19 pandemic. It has also impacted the 4th Industrial Revolution Digitalization in education, carried many programs with STEM-based courses that entail hands-on methods to online manner. This study was carried out to ensure that STEM education at Malaysian higher education institutions was well-integrated through e-learning (HEIs). Data were collected via questionnaires and semi-structured interviews with a mixed-methods research design. Respondents were STEM educators in HEIs within the Klang Valley. Educators between the ages of 30-35 are found to be more adept at using various software suites, browsing websites, and handling multimedia tools for e-learning. 83 percent of the sample stated that their institution has no STEM e-learning procedure, contributing to extra challenges in STEM education. A sound e-learning integration of STEM requires educators with specialization in the courses being taught, able to process knowledge of digital applications, cultivate skills and values to problem resolve, and integrate collaboration in the technological curriculum. HEIs must involve stakeholders to develop resistance plan modification and to portion the integration of e-learning in segments pertaining to course learning outcomes for achieving strategic objectives in STEM education. © 2023, Auricle Global Society of Education and Research. All rights reserved.

3.
Journal of Investigative Medicine ; 69(1):134-135, 2021.
Article in English | EMBASE | ID: covidwho-2315025

ABSTRACT

Purpose of Study The COVID-19 pandemic changed the physician- patient interaction. Telemedicine has emerged as the universal method of communication with patients. We compared conventional clinic visit (CCV) with telemedicine (TM) in clinic administered through video conferencing. Physician patient communication is key in determining treatment outcome and patient satisfaction in complex auto immune disease process including Systemic Lupus Erythematosus (cSLE) and Juvenile Idiopathic Arthritis (JIA). Methods Used We performed a quality improvement project using a telephone questionnaire survey in rheumatology clinic at Valley Children's Healthcare. We surveyed 25 patients total. The respondents in the survey experienced both CCV before and during pandemic and TM during pandemic. Summary of Results Among the 25 patients surveyed 15 had JIA and 10 had cSLE. Among JIA patients 95% felt doctor was paying attention, able to make shared decision regarding the medications and treatment options. All the JIA and cSLE patients in the group felt that doctor listened and asked appropriate questions. Patients in both groups felt they were able to discuss all their problems and had a strong positive impact on the quality of care during the TM visit as compared with CCV. In cSLE group 70% felt shared decision making and ability to discuss their medical problem via TM was not as good as CCV. Conclusions This survey divulged patient perspective regarding clinic visit during pandemic. Telemedicine is preferred by 95% and 75% of the respondents over the conventional clinic visit during the pandemic among JIA and CSLE groups. The main concerns were breakdown of the physician-patient relationship and issues regarding the technologies with connectivity along with organizational challenges. Patients in both groups strongly agreed that TM met the need for their care compared to conventional clinic visit. Patients in the JIA group were satisfied with TM visit in handling complex medical problems and shared decision making. Patients in cSLE group preferred CCV especially in addressing complex medical issues and shared decision making.

4.
NeuroQuantology ; 20(20):2340-2355, 2022.
Article in English | EMBASE | ID: covidwho-2226826

ABSTRACT

Employment of social media is becoming all-pervasive and disease analogous communities are organizing online, together with communities of attentiveness encompassing health care domain. Despite Facebook being the most sought out social media platform, utilization of supplementary social media platform like Twitter is increasing. To be more specific, in recent days patients with COVID and diabetes commenced to gather and take active participations in online discussions about diabetes and COVID on Twitter, engross in communication and sharing virtually and perceive peer support online. In this work a method called, Mean Silhouette-based Genetic and Elman Deep Sentiment Analysis (MSG-EDSA) is proposed. Elman Deep Recurrent Network Sentiment Classification is applied to the selected features, to classify the tweets in an accurate and timely manner. The tweets are finally classified as extremely positive, positive, extremely negative, negative or neutral from the tweets obtained via different users. The proposed MSG-EDSA is experimented with using the diabetes and COVID real-time datasets from social media platforms to analyze healthcare sentimental analysis. The parameters like, precision, recall, accuracy and error rate are selected to analyze the performance against the state-of-the-art sentimental analysis methods. Copyright © 2022, Anka Publishers. All rights reserved.

5.
Polycyclic Aromatic Compounds ; 2023.
Article in English | Web of Science | ID: covidwho-2187239

ABSTRACT

Combination of FDA approved drugs may be more effective in biological activities by targeting different protein mechanism at a same time and less toxic. A combination of 5-Fluorouracil and tamoxifen may cause a synergistic effect and induce cancer cell death and more effective against corona virus. In this study, constructed 5-Fluorouracil with tamoxifen structure was optimized through DFT/B3LYP approach with the basis set 6-311 G. Theoretical, ultraviolet-visible spectrum was calculated, and electronic transitions were examined. The energy gap between HOMO and LUMO was used to study the combined structure's structural stability and reactivity and the computed energy gap (Delta E) was 4.3023825 eV. The Mulliken charge distribution was assessed and the atomic charges were calculated. The molecular docking simulation was performed with breast cancer and SARS-CoV-19 target proteins. The docking scores showed that the complex compound's binding affinity was higher, that confirms better synergistic effect of 5-Fluorouracil and tamoxifen. The complex compound's maximum binding affinity was -8.0 Kcal/mol against caspase 6 and -8.1 Kcal/mol against furin, that showed inhibitory potential against cancer and corona virus. The pharmacokinetic properties and toxicity of the complex structure was studied, and the results showed the safety profile of the complex lead compound and can be utilized as an effective anticancer and antiviral drug.

6.
CALL-EJ ; 23(4):26-45, 2022.
Article in English | Scopus | ID: covidwho-2046623

ABSTRACT

Teaching practicum in early childhood education (ECE) is usually carried out in physical classrooms, where pre-service teachers (PSTs) can plan, observe and carry out activities that promote children’s active learning, and where meaningful, developmentally appropriate practices (DAP) take place. Unfortunately, due to the COVID-19 pandemic, PSTs are forced to carry out their teaching practice in virtual classrooms. This study explored early childhood (EC) PSTs’ online practicum experiences and their implementation of DAP. In-depth semi-structured interviews were carried out with 8 PSTs. Thematic analysis was used to derive themes that answered research questions. The findings identified some major challenges faced by PSTs, which included difficulty with lesson planning, implementing fair assessments, managing online classes, limited teaching strategies, as well as limited student engagement and social interaction. The findings also showed that with extra effort and creativity, PSTs were able to implement DAP and manage their limitation. Findings confirmed that PSTs improved their digital skills, adapted well to online lessons, and were satisfied with their overall practicum experiences. Based on the findings, this study recommends higher institutions that train EC teachers incorporate courses that educate trainees on the effective implementation of DAP in virtual classrooms, and design coursework to assess PSTs’ technological, pedagogical, content knowledge and skills. Besides, PSTs also need to collaborate with parents to assist with children’s online learning. © 2022, The Pacific Association for Computer Assisted Language Learning (PacCALL). All rights reserved.

7.
Arthritis & Rheumatology ; 73:3374-3375, 2021.
Article in English | Web of Science | ID: covidwho-1728494
8.
Asian Journal of University Education ; 17(4):259-271, 2021.
Article in English | Scopus | ID: covidwho-1598438

ABSTRACT

The 4th Industrial Revolution and COVID-19 pandemic have globally impacted the economy, livelihood and organizations. With digitalization, many programs including STEM-based courses that require hands-on approach have gone online. This research was carried out to analyze the status of STEM Education in Malaysian higher education institutions and to explore challenges of e-learning integration with STEM subjects. A concurrent triangulation mixed-methods design was employed whereby quantitative and qualitative approaches took place simultaneously. The qualitative data were gathered via questionnaire while qualitative approach used semi-structured interviews. Respondents were STEM educators who teach and/or manage STEM programs in HEIs within the Klang Valley. Junior lecturers are found comparatively better using different software programs, exploring websites and handling multimedia tools for e-learning purposes. 83% survey respondents claimed their institution has no STEM e-learning policy, contributing to further challenge in STEM Education development. Respondents agreed sound e-learning implementation of STEM requires lecturers with subject specialization, able to approach application of knowledge, skills and values to problem solving, can collaborate with others and adept at integrating technology. Meanwhile, the HEIs must engage stakeholders to counter resistance plan to change, and to measure the effectiveness of integrating e-learning in meeting the strategic goals in STEM education. © 2021

9.
International Journal of Rheumatic Diseases ; 24(SUPPL 2):200, 2021.
Article in English | EMBASE | ID: covidwho-1458376

ABSTRACT

Purpose of the Study: COVID 19 pandemic changed the physicianpatient interaction. Telemedicine has emerged as the universal method of communication with patients. Physician patient communication is key in determining treatment outcome and patient satisfaction in complex auto immune disease process including Systemic Lupus Erythematosus (cSLE), systemic vasculitis and Juvenile Idiopathic Arthritis (JIA) Methods Used: We performed a quality improvement project using a telephone survey among patients seen in pediatric rheumatology clinic at Valley Children ' s Healthcare. We compared conventional clinic visit with telemedicine in the rheumatology clinic. The respondents in the survey experienced both regular clinic visit before and during pandemic and Telemedicine during pandemic. Summary of the Results: We surveyed 75 patients using telephone questionnaire. 75% of JIA patients felt doctor was attentive and able to make shared decision regarding treatment options. JIA patients felt they were able to discuss the problems and had a strong positive impact on the quality of care during the Telemedicine visit as compared with Conventional clinic visit. cSLE and vasculitis group only 45% felt that they were able to discuss their problems by telemedicine. Conclusion: This survey revealed patient perspective regarding clinic visit during pandemic. Telemedicine is preferred by 65 % of the respondents over the conventional clinic visit during the pandemic. Patients in both groups strongly agreed that Telemedicine met the need for their care compared to conventional clinic visit. Patients in the JIA group were satisfied with Telemedicine visit in handling complex medical problems and shared decision making. Patients in cSLE and vasculitis group preferred Conventional clinic visit in addressing complex medical issues and shared decision making. The main concerns with telemedicine were breakdown of the physician patient relationship and issues regarding the technologies. Patients in rural area preferred telemedicine due to limited access and distance to travel.

10.
International Journal of Applied Pharmaceutics ; 13(5):10-14, 2021.
Article in English | Scopus | ID: covidwho-1417418

ABSTRACT

Covid19 (Coronavirus) is a life-threatening virus that mainly affects our respiratory system, kidney, and GIT tract. People with a low immune system in their body fall prey to it. This virus (2019-nCoV) spreads easily from one person to another. As there is no treatment to kill the virus, the only way to stop this pandemic is through precautions and reduce the viral load in the body. This review reveals the main types of coronaviruses, history, pathophysiology, current treatment, drawbacks of current treatment, targets for drug development against Covid-19, vaccines discovered for covid-19, side effects of the currently available vaccines, and current status of this situation. The main mechanism of action of the virus easily enters to bind with the Angiotensin-Converting Enzyme 2 (ACE2) in the human body cells. Management of the virus several approaches will be taken mainly isolation of the patients and contacts the contacts, oxygen therapy for respiratory failure patients based on the severity Remdesivir, Lopinavir/ritonavir, Chloroquine, and Hydroxychloroquine, Alpha-interferon and plasma therapy can be used to control the infections. In India, AYUSH is also recommended to enhance the immune system through herbal-based products, Vaccination is also recommended by most of the countries, but many side effects and drug-drug interactions were reported for the above treatments. So that in future a new way of approach should be developed by our health organization as soon as possible. © 2021 The Authors. Published by Innovare Academic Sciences Pvt Ltd.

11.
Journal of Clinical and Diagnostic Research ; 15(6):LC05-LC08, 2021.
Article in English | EMBASE | ID: covidwho-1278706

ABSTRACT

Introduction: COVID-19 pandemic is posing a challenge not only with sheer number of people infected but also with the large number of patients with persistent symptoms of COVID-19 infection. A proper understanding of the magnitude and associated factors of persistent COVID-19 symptoms will go a long way in planning treatment and control strategies. Aim: To determine the proportion of patients who have persistent symptoms post-acute COVID-19 infection and to determine the factors associated with it, among those who have been discharged from Government Medical College, Thrissur. Materials and Methods: The current cross-sectional study was conducted among 335 patients who were admitted and discharged with COVID-19 infection in Government Medical College, Thrissur, Kerala, a tertiary care institution in southern India between December 2020 and February 2021. They were contacted through a telephonic interview 28 days from symptom onset through a semi-structured interview schedule. The questions included basic demographic details, symptomatology at admission, persistent symptoms at 28 days after onset and other clinical details including comorbidities. For defining post-COVID-19 symptom persistence National Institute for Health and Care (NICE) guidelines were used. Association between persistent symptoms and selected factors was done by Chi-square test. Results: Out of the 335 patients, the persistence of symptoms of COVID-19 infection after 28days of symptom onset was 221 (66%) C.I -60.7-70.8%). Persistence of two or more COVID-19 symptoms after 28 days of onset was seen in 120 (35.8%). The most common persistent symptoms among the patients were fatigue in 109 (32.5%) of people followed by dyspnoea in 77 (23%), cough in 45 (13.4%) and myalgia in 37 (11%) patients Highest persistence was seen in Category C patients where symptoms were persisting in 75%. Persistence was also higher in those with diabetes mellitus, those who received oxygen support and those who were in Intensive Care Unit (ICU) or ventilator and the association was statistically significant(p-value<0.05). Conclusion: The study shows that 2/3rd of patients still continues to have persistent symptoms even after 28 days of symptom onset. Health systems should be prepared to face the consequences of morbidities caused by post COVID-19 syndrome.

12.
Journal of Clinical and Diagnostic Research ; 15(3):LC34-LC37, 2021.
Article in English | EMBASE | ID: covidwho-1158998

ABSTRACT

Introduction: The knowledge of epidemiologic characteristics and transmission dynamics of a novel pathogen, such as Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) among close contacts can help in planning and development of effective control policies in different parts of the world. Aim: To assess the epidemiological and clinical outcome of close contacts of Coronavirus Disease (COVID-2019) cases admitted in a tertiary COVID hospital and to assess the role of risk factors in predicting the epidemiological outcome of these contacts. Materials and Methods: The current retrospective cohort study was conducted among 1286 close contacts of COVID-19 patients admitted to Government Medical College, Thrissur, Kerala. The data collection was done by a semi-structured telephonic interview by the contact tracing team. The questions included the type of exposure to the index case, symptoms if any, date of last exposure with COVID-19 patient, and final COVID-19 status of the contact at the end of 14 days. The association of risk factors of COVID-19 positivity was done using binary logistic regression. Results: Proportion of close contacts of COVID-19 who developed the disease was 24.2% (21.87-26.52%). The mean incubation period was found to be 4.22 days (C.I-3.71-4.65). The serial interval was found to be a mean of 5.24 days (C.I 4.764-5.716). The proportion of household contacts of COVID-19 cases who developed the disease was found to be 26% (C.I-23%-29%). The majority (52.4%) of infections among contacts were asymptomatic. Most common symptom among the COVID-19 +ve was fever (32.8%) followed by cough (16.1%). The most common risk factors of infection among primary close contacts were sharing the same room (adjusted odds ratio-2.394) and common use of fomites (adjusted odds ratio-1.953) while use of a mask was found to be protective (adjusted odds ratio-0.570). Significant factors associated with the type of contact with infection were workplace-related contact (adjusted odds ratio-6.629), household contact (adjusted odds ratio-4.856), and travel-related contact (adjusted odds ratio-2.899). Conclusion: The study concludes important risk factors of transmission among close contacts of COVID-19 as being in a household, workplace and travel related contact where the use of mask was found to be protective. The study also concludes that most of the COVID-19 infections in close contacts are asymptomatic.

13.
Journal of Investigative Medicine ; 69(1):136-136, 2021.
Article in English | Web of Science | ID: covidwho-1079098
14.
Journal of Investigative Medicine ; 69(1):135-135, 2021.
Article in English | Web of Science | ID: covidwho-1079097
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