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1.
2022 International Workshop on Advanced Imaging Technology, IWAIT 2022 ; 12177, 2022.
Article in English | Scopus | ID: covidwho-1901892

ABSTRACT

In recent years, due to the COVID-19 pandemic and the widespread use of technology, the Internet and food and beverage websites are often used for take-out and food and beverage reservations, and information such as reviews and photos on these platforms has a significant impact on revenue. In this study, to develop an appetite-enhancing application, we focus on food images that strongly influences appetite and analyze what image features stimulate appetite. Then, based on the results of the analysis, we generate appetizing images using GAN (Generative Adversarial Network). © 2022 SPIE.

2.
PubMed; 2021.
Preprint in English | PubMed | ID: ppcovidwho-333792

ABSTRACT

Patients with COVID-19 present with a wide variety of clinical manifestations. Thromboembolic events constitute a significant cause of morbidity and mortality in patients infected with SARS-CoV-2. Severe COVID-19 has been associated with hyperinflammation and pre-existing cardiovascular disease. Platelets are important mediators and sensors of inflammation and are directly affected by cardiovascular stressors. In this report, we found that platelets from severely ill, hospitalized COVID-19 patients exhibit higher basal levels of activation measured by P-selectin surface expression, and have a poor functional reserve upon in vitro stimulation. Correlating clinical features to the ability of plasma from COVID-19 patients to stimulate control platelets identified ferritin as a pivotal clinical marker associated with platelet hyperactivation. The COVID-19 plasma-mediated effect on control platelets was highest for patients that subsequently developed inpatient thrombotic events. Proteomic analysis of plasma from COVID-19 patients identified key mediators of inflammation and cardiovascular disease that positively correlated with in vitro platelet activation. Mechanistically, blocking the signaling of the FcgammaRIIa-Syk and C5a-C5aR pathways on platelets, using antibody-mediated neutralization, IgG depletion or the Syk inhibitor fostamatinib, reversed this hyperactivity driven by COVID-19 plasma and prevented platelet aggregation in endothelial microfluidic chamber conditions, thus identifying these potentially actionable pathways as central for platelet activation and/or vascular complications in COVID-19 patients. In conclusion, we reveal a key role of platelet-mediated immunothrombosis in COVID-19 and identify distinct, clinically relevant, targetable signaling pathways that mediate this effect. These studies have implications for the role of platelet hyperactivation in complications associated with SARS-CoV-2 infection. Cover illustration: ONE-SENTENCE SUMMARY: The FcgammaRIIA and C5a-C5aR pathways mediate platelet hyperactivation in COVID-19.

3.
Embase;
Preprint in English | EMBASE | ID: ppcovidwho-326997

ABSTRACT

The SARS-CoV-2 Omicron variant has multiple Spike (S) protein mutations that contribute to escape from the neutralizing antibody responses, and reducing vaccine protection from infection. The extent to which other components of the adaptive response such as T cells may still target Omicron and contribute to protection from severe outcomes is unknown. We assessed the ability of T cells to react with Omicron spike in participants who were vaccinated with Ad26.CoV2.S or BNT162b2, and in unvaccinated convalescent COVID-19 patients (n = 70). We found that 70-80% of the CD4 and CD8 T cell response to spike was maintained across study groups. Moreover, the magnitude of Omicron cross-reactive T cells was similar to that of the Beta and Delta variants, despite Omicron harbouring considerably more mutations. Additionally, in Omicron-infected hospitalized patients (n = 19), there were comparable T cell responses to ancestral spike, nucleocapsid and membrane proteins to those found in patients hospitalized in previous waves dominated by the ancestral, Beta or Delta variants (n = 49). These results demonstrate that despite Omicron’s extensive mutations and reduced susceptibility to neutralizing antibodies, the majority of T cell response, induced by vaccination or natural infection, crossrecognises the variant. Well-preserved T cell immunity to Omicron is likely to contribute to protection from severe COVID-19, supporting early clinical observations from South Africa.

5.
Japanese Journal of Applied Physics ; 60(9):7, 2021.
Article in English | Web of Science | ID: covidwho-1372220

ABSTRACT

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in late 2019 and spread globally to cause severe damage to public health and economics worldwide as coronavirus disease 2019 (COVID-19). A deep ultraviolet light-emitting diode (DUV-LED) would be a promising candidate for the inactivation technology of SARS-CoV-2 to mitigate the spread of COVID-19. The DUV-LED has the potential to provide energy-efficient and contact-less virus inactivation technology with no residual substances after treatment, little effect on targets and the applicability of various viruses, including virus variants. This paper introduces an overview of the virus inactivation technology using DUV-LED and discusses the effect of the DUV-LED irradiation on the SARS-CoV-2.

6.
21st Congress of the International Ergonomics Association, IEA 2021 ; 222 LNNS:648-651, 2021.
Article in English | Scopus | ID: covidwho-1340374

ABSTRACT

It is important for drivers who are responsible for the lives of passengers to remain in a calm state of mind and body suitable for driving. The objective of this study is to grasp the driver’s state by using physiological data that can be continuously and relatively easily measured. To provide support in a timely manner, changes in the driver’s state must be detected with high time resolution and reliability. The spread of Covid-19 across the world has emphasized the importance of technology to remotely monitor physiological conditions in real time and provide support. This study attempted to improve the accuracy of estimation by using the appropriate indices for individuals. Specifically, we tried to estimate the tension state of drivers using both respiration-wave and ECG data. The results demonstrated that different individuals have different valid indicators and it is possible to improve the accuracy of estimation by using the appropriate indices for each individual. © 2021, The Author(s), under exclusive license to Springer Nature Switzerland AG.

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