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Eur Rev Med Pharmacol Sci ; 24(15): 8187-8193, 2020 08.
Article in English | MEDLINE | ID: covidwho-696399


The ongoing worldwide pandemic of Coronavirus disease 2019 (COVID-19), raised the urgency to address knowledge gaps and to establish evidence for improving management and control of this viral infection. Throughout a keen analysis of the World Health Organization (WHO) most updated data, a gender-specific difference in the occurrence of infection was determined, which seems to correlate with patient's vitamin D status. Therefore, our purpose is to provide insights into the nutritional importance of vitamin D for its immunomodulatory effect, in order to help counteracting the COVID-19 pandemic. Novel interesting findings suggest that vitamin D, by inducing progesterone-induced blocking factor (PIBF), might regulate the immune response and also modulate cytokine IL-6, which appears to be increased in COVID-19 infections. Therefore, in addition to the standard recommendations to prevent the infection, supplementation of vitamin D might be considered an approach to help counteracting this global epidemic.

Coronavirus Infections/immunology , Interleukin-6/immunology , Pneumonia, Viral/immunology , Pregnancy Proteins/immunology , Suppressor Factors, Immunologic/immunology , Vitamin D Deficiency/drug therapy , Vitamin D/immunology , Vitamin D/therapeutic use , Vitamins/therapeutic use , Betacoronavirus , COVID-19 , Coronavirus Infections/drug therapy , Coronavirus Infections/epidemiology , Coronavirus Infections/prevention & control , Geography , Humans , Inflammation , Italy/epidemiology , Pandemics/prevention & control , Pneumonia, Viral/epidemiology , Pneumonia, Viral/prevention & control , SARS-CoV-2 , Ultraviolet Rays , Vitamin D Deficiency/immunology