Your browser doesn't support javascript.
Show: 20 | 50 | 100
Results 1 - 9 de 9
Filter
2.
Int J Environ Res Public Health ; 19(1)2021 Dec 21.
Article in English | MEDLINE | ID: covidwho-1580863

ABSTRACT

The syndemic framework proposed by the 2021-2030 World Health Organization (WHO) action plan for patient safety and the introduction of enabling technologies in health services involve a more effective interpretation of the data to understand causation. Based on the Systemic Theory, this communication proposes the "Systemic Clinical Risk Management" (SCRM) to improve the Quality of Care and Patient Safety. This is a new Clinical Risk Management model capable of developing the ability to observe and synthesize different elements in ways that lead to in-depth interventions to achieve solutions aligned with the sustainable development of health services. In order to avoid uncontrolled decision-making related to the use of enabling technologies, we devised an internal Learning Algorithm Risk Management (LARM) level based on a Bayesian approach. Moreover, according to the ethics of Job Well Done, the SCRM, instead of giving an opinion on events that have already occurred, proposes a bioethical co-working because it suggests the best way to act from a scientific point of view.


Subject(s)
COVID-19 , Bayes Theorem , Humans , Pandemics/prevention & control , Risk Management , SARS-CoV-2 , Syndemic
3.
Commun Biol ; 4(1): 489, 2021 04 21.
Article in English | MEDLINE | ID: covidwho-1387493

ABSTRACT

We investigated SARS-CoV-2 transmission dynamics in Italy, one of the countries hit hardest by the pandemic, using phylodynamic analysis of viral genetic and epidemiological data. We observed the co-circulation of multiple SARS-CoV-2 lineages over time, which were linked to multiple importations and characterized by large transmission clusters concomitant with a high number of infections. Subsequent implementation of a three-phase nationwide lockdown strategy greatly reduced infection numbers and hospitalizations. Yet we present evidence of sustained viral spread among sporadic clusters acting as "hidden reservoirs" during summer 2020. Mathematical modelling shows that increased mobility among residents eventually catalyzed the coalescence of such clusters, thus driving up the number of infections and initiating a new epidemic wave. Our results suggest that the efficacy of public health interventions is, ultimately, limited by the size and structure of epidemic reservoirs, which may warrant prioritization during vaccine deployment.


Subject(s)
COVID-19/transmission , Communicable Disease Control/methods , Genome, Viral/genetics , Mutation , Public Health/methods , SARS-CoV-2/genetics , COVID-19/epidemiology , COVID-19/virology , Geography , Humans , Italy/epidemiology , Pandemics , Phylogeny , Public Health/trends , SARS-CoV-2/classification , SARS-CoV-2/physiology
4.
Expert Rev Mol Diagn ; 21(6): 547-562, 2021 06.
Article in English | MEDLINE | ID: covidwho-1182936

ABSTRACT

Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has pushed the scientific community to undertake intense research efforts. Understanding SARS-CoV-2 biology is necessary to discover therapeutic or preventive strategies capable of containing the pandemic. Knowledge of the structural characteristics of the virus genome and proteins is essential to find targets for therapies and immunological interventions.Areas covered: This review covers different areas of expertise, genomic analysis of circulating strains, structural biology, viral mutations, molecular diagnostics, disease, and vaccines. In particular, the review is focused on the molecular approaches and modern clinical strategies used in these fields.Expert opinion: Molecular approaches to SARS-CoV-2 pandemic have been critical to shorten time for new diagnostic, therapeutic and prevention strategies. In this perspective, the entire scientific community is moving in the same direction. Vaccines, together with the development of new drugs to treat the disease, represent the most important strategy to protect human from viral disease and prevent further spread. In this regard, new molecular technologies have been successfully implemented. The use of a novel strategy of communication is suggested for a better diffusion to the broader public of new data and results.


Subject(s)
COVID-19 Nucleic Acid Testing/methods , COVID-19 Vaccines/pharmacology , COVID-19/epidemiology , SARS-CoV-2/genetics , Animals , COVID-19/etiology , Genome, Viral , Humans , Mutation , Phylogeny , SARS-CoV-2/isolation & purification , Viral Proteins/chemistry , Viral Proteins/genetics
6.
Biochem Biophys Res Commun ; 538: 88-91, 2021 01 29.
Article in English | MEDLINE | ID: covidwho-912050

ABSTRACT

An acute respiratory syndrome (COVID-19), caused by a novel coronavirus (SARS-CoV-2) with a high rate of morbidity and elevate mortality, has emerged as one of the most important threats to humankind in the last centuries. Rigorous determination of SARS-CoV-2 infectivity is very difficult owing to the continuous evolution of the virus, with its single nucleotide polymorphism (SNP) variants and many lineages. However, it is urgently necessary to study the virus in depth, to understand the mechanism of its pathogenicity and virulence, and to develop effective therapeutic strategies. The present contribution summarizes in a succinct way the current knowledge on the evolutionary and structural features of the virus, with the aim of clarifying its mutational pattern and its possible role in the ongoing pandemic.


Subject(s)
COVID-19/virology , Evolution, Molecular , Genome, Viral , SARS-CoV-2/genetics , Humans , Mutation , Phylogeny , SARS-CoV-2/classification
7.
Bioethics Update ; 2020.
Article | ScienceDirect | ID: covidwho-778477

ABSTRACT

The COVID-19 pandemic has been affecting surgical residents in many ways and to varying degrees. While the senior surgical residents have been facing a drastic decrease in the operation time, the junior surgical residents have been exposed to an increased number of beside procedures. However, both of them have been affected by an increased exposure to deaths. This sudden exposure to this amount of deaths can, and has been, greatly impressing mostly the young surgeon generation, still green and impressionable. PGY-1 residents have been balancing emotional confusion between the eagerness of learning new procedures and the anguish coming from facing the loss of patients that they have been trying so hard to save day by day. This situation is leading to an increase in burn-out cases, mostly from the general physicians and health care providers. The real effect of this emotional distress is still unknown and it will be topic of further studies once situation is resolved. This article is described using a multidisciplinary approach, giving a PGY-1 personal point of view and an inner philosophical prospective. Resumen La pandemia de COVID-19 ha estado afectando a los residentes quirúrgicos de múltiples formas y en diversos grados. Mientras que los residentes de cirugía senior se han enfrentado a una disminución drástica en el tiempo operatorio, los residentes de cirugía junior han estado expuestos a un mayor número de procedimientos adicionales: sin embargo, ambos se han visto afectados por una mayor exposición a las muertes. Esta repentina exposición a tal cantidad de muertes puede y ha impresionado mucho sobre todo a la generación de jóvenes cirujanos, todavía verdes e impresionables. Los residentes de PGY-1 han estado equilibrando la confusión emocional entre el afán de aprender nuevos procedimientos y la angustia que surge de enfrentar la pérdida de pacientes a los que están tratando de salvar día a día. Esta situación está provocando un aumento de los casos de agotamiento, principalmente de los médicos y proveedores de atención médica en general. El efecto real de esta angustia emocional aún se desconoce y será tema de más estudios una vez que se aclimatará la situación. Hemos estado escribiendo este manuscrito con un enfoque multidisciplinario, dando un punto de vista personal PGY-1 y una perspectiva filosófica interna.

SELECTION OF CITATIONS
SEARCH DETAIL