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1.
Value in Health ; 26(6 Supplement):S182, 2023.
Article in English | EMBASE | ID: covidwho-20243591

ABSTRACT

Objectives: Potential cutaneous adverse drug reactions (cADRs) associated with COVID-19 vaccinations are well-known. However, comprehensive evaluation including detailed patient characteristics, vaccine types, signs and symptoms, treatments and outcomes from such cADRs are still lacking in Taiwan. Method(s): A cross-sectional study was conducted from December 2019 to October 2022 to analyze spontaneous ADR reporting data from Taiwan's largest multi-institutional healthcare system. Physicians and pharmacists initially ensured the data quality and completeness of the reported ADR records. Subsequently, we applied descriptive statistics to analyze the patient cohort based on demographic characteristics, administered COVID-19 vaccines, clinical manifestations, and patient management. Result(s): We identified 242 cADRs from 759 reported COVID-19 vaccine-related ADRs, 88.3% of which were judged as "possible" using the Naranjo Scale. The mean age of patients with cADRs was 48.1+/-17.5 years, with the majority (44.2%) of cADRs reported in the 40-64yr old age group. cADRs were more common in women (68.2%) and most of the patients had no history of allergy to vaccines (99.6%). Oxford/AstraZeneca (58.6%) accounted for the most reported brand of COVID-19 vaccines. Patients developed cADRs within 1 to 198 days (median = 5.5 days), and mostly after first-dose vaccination (77.8%). The most frequently reported cADR was rash/eruption (18.7%), followed by itchiness/pruritus (11.7%) and urticaria (9.2%), mainly affecting the lower limbs (23.8%) and upper limbs (22.6%). Medications were prescribed for 65.1% of the cADRs, and signs and symptoms were resolved within 1 to 167 days (median = 7 days) after treatment with oral antihistamines (23.0%), topical corticosteroids (14.6%) or oral corticosteroids (14.4%). Conclusion(s): Our findings provide comprehensive details regarding COVID-19 vaccine-related cADRs in Taiwan. Certain groups, especially women and the middle-aged, who reported a relatively higher rate of cADRs, may benefit from pre-vaccination counseling about the risks of cADRs and the use of appropriate medications.Copyright © 2023

2.
British Journal of Haematology ; 201(Supplement 1):167, 2023.
Article in English | EMBASE | ID: covidwho-20238486

ABSTRACT

Background: COVID-19 pandemic still pose a substantial threat worldwide despite increasing vaccine availability. Patients with haematological malignancies have been shown to have increased risk of contracting COVID-19 and are more susceptible to develop severe illness from SARS-CoV- 2 infection. The immune response to vaccines is impaired in patients with haematological malignancy due to underlying disease or antineoplastic therapies. The monoclonal-antibody combination, Evusheld is composed of tixagevimab and cilgavimab, two neutralising antibodies against SARS-CoV- 2. It has been shown to be safe and have efficacy for the prevention of COVID-19. Our aim of study is to describe the incidence and outcome of breakthrough COVID-19 infection among patients who received Evusheld in our centre and analyse the factors that possibly increase the risk of breakthrough infection. Material(s) and Method(s): A retrospective review of all adult patients with haematological malignancy who received tixagevimab/ cilgavimab 150/150 mg injection in Hospital Pulau Pinang from 1 July 2022 to 31 August 2022 with a follow-up period to 30 November 2022 was conducted. Demographic data, clinical characteristics and outcome will be retrieved from patient's medical records. Data were analysed using Statistical Package for Social Sciences software (version 21.0). Result(s): A total of 96 patients (50 males and 46 females) received tixagevimab/cilgavimab injection during the study period with a median age of 61 years (range 19-82). Majority of them were diagnosed with multiple myeloma (42.7%), followed by lymphoma (33.3%) and leukaemia (24%). One third of them had history of therapy with monoclonal antibody and 20% had haematopoietic stem cell transplantation. No major adverse effects of tixagevimab/cilgavimab injection were noted among the study population. Of the 12 patients (12.5%) who had COVID-19 infection, all of them had mild infection;three were asymptomatic and six patients received Paxlovid antiviral therapy. The median time from tixagevimab/cilgavimab to the onset of COVID-19 infection was 35 days (range 5-97 days). The mean age of patients with breakthrough COVID-19 infection were older compared to those without breakthrough infection but was not statistically significant. The incidence of breakthrough COVID-19 infection was not affected by type of haematological malignancy, history of monoclonal antibody therapy or COVID-19 vaccination. Discussion and Conclusion(s): Our findings showed that tixagevimab/cilgavimab was safe and effective in preventing COVID-19- related morbidity and mortality among patients with haematological malignancy during the study period. However, the limitation is the lack of access to whole genome sequencing for detection of resistant variants for breakthrough infections.

3.
Respirology ; 28(Supplement 2):152, 2023.
Article in English | EMBASE | ID: covidwho-2317332

ABSTRACT

Introduction/Aim: Early pulmonary rehabilitation (PR) is guideline-recommended for all chronic obstructive pulmonary disease (COPD) patients post-hospitalization for COPD exacerbation but many patients cannot participate in early PR due to significant breathlessness. High flow nasal oxygen (HFO) has been shown to improve ventilatory efficiency in stable COPD patients, but there is little data on HFO use during exercise training in PR of COPD patients post-exacerbation. Method(s): We conducted a pilot randomized controlled trial (RCT) to explore the feasibility of a prospective large-scale RCT to evaluate the impact of HFO in improving PR outcomes of COPD patients post-exacerbation. Patients recently hospitalized for acute COPD exacerbation were enrolled and randomized to either HFO application or usual standard care during an early 6-week outpatient, twice-weekly pulmonary rehabilitation program. Result(s): 22 patients were randomized between May 2019 and December 2019 and 18 patients completed the study. 2 patients in the HFO arm and 1 patient in the usual care arm withdrew for reasons unrelated to the study. The 22 nd patient (HFO arm) ceased participation due to research restrictions at the COVID pandemic onset. The HFO arm achieved a greater improvement in exercise capacity than the usual care arm, with the mean difference in the 6-min walk distance (6MWD) between the two arms being 30 m (95% CI: -23 to 84 m). All 18 patients in both arms were compliant to the pulmonary rehabilitation program (defined by attending >=75% of exercise sessions). HFO was well tolerated with no adverse events associated with its implementation. Conclusion(s): This RCT has shown preliminary evidence of the feasibility and high patient acceptability of HFO during early pulmonary rehabilitation on improving exercise capacity in COPD patients post-exacerbation These promising results would justify a larger RCT to confirm HFO's benefits and has the potential to change PR practice.

4.
International Conference on Transportation and Development 2022: Other Modes-Rail, Transit, and Aviation ; : 122-133, 2022.
Article in English | Web of Science | ID: covidwho-2307858

ABSTRACT

A prime component of any effective public transportation system is equitable access for all riders within the community. Building transportation networks with equity in mind can boost ridership and transit network coverage. The problem of social equity in transportation is further exacerbated by historically auto-dependent cities and the pandemic restrictions from COVID-19. This paper aims to quantify transit equity using a disadvantage index. These results are then applied to different periods of a transit system throughout the COVID-19 pandemic to see how it affected social equity in public transportation as part of a case study in Riverside, California. Heat maps are overlaid on the transit network's lines and stops using geographic information systems (GIS) software to visualize the variables associated with transit equity calculations. Publicly released General Transit Feed Specification (GTFS) data is used to plot the state of the transit network at different points in time. The results show that route changes during the COVID-19 pandemic had a noticeable but minimal effect on social equity in transportation.

5.
Journal of Global Antimicrobial Resistance ; 31(Supplement 1):S46-S47, 2022.
Article in English | EMBASE | ID: covidwho-2305780

ABSTRACT

Aim: To evaluate the effect of decontamination and reuse on N95 masks. Background(s): The coronavirus disease (COVID-19) pandemic has strained the global availability of masks. Such shortage represents a threat to healthcare workers (HCWs). Mask reprocessing and reuse may alleviate the shortage. Many laboratory studies have proven the effectiveness and feasibility of decontaminating N95 masks. However, very few had HCWs wearing them between cycles of decontamination. Our study evaluated mask integrity (assessed by qualitative mask fitting [QMF], as well as technical measures like bacterial filtration efficacy [BFE]) through five cycles of decontamination using four different modalities - steam, moist heat (MH), UV-C irradiation (UVCI), and hydrogen peroxide vaporization (HPV). Method(s): Each study cycle involved a HCW wearing a N95 mask for two hours, followed by the assigned decontamination process, and then a QMF. This was repeated for a maximum of 5 cycles, as long as the wearer passed QMF. 40 HCWs were recruited for each of the four decontamination modalities. The technical measures of mask integrity assessed were: BFE, Particulate Filtration Efficiency (PFE), Pressure Drop and Splash Resistance. Result(s): 60.6% (HPV) to 77.5% (MH) of the masks passed five cycles of wear and decontamination, as assessed by the wearers passing QMF all five times. MH-decontaminated masks retained all technical measures of integrity through all 5 cycles. HPV reduced masks' BFE after the fourth cycle while UVCI tended to increase the Pressure Drop. Conclusion(s): The results suggest that MH is a promising method for decontaminating N95 masks without compromising fit and integrity. [Figure presented] [Table presented]Copyright © 2023 Southern Society for Clinical Investigation.

6.
Sustainability (Switzerland) ; 15(7), 2023.
Article in English | Scopus | ID: covidwho-2304559

ABSTRACT

Mastery of the English language has always been major impediment to many educators and learners around the world. In this rapidly globalising world, social networking sites (SNSs) have risen to the top, especially during the unprecedented advent of the COVID-19 pandemic. Nevertheless, the review of SNSs regarding the English education field is scant, in spite of its significance for sustainability education. On that account, this systematic literature review highlights the potential benefits of using SNSs for educational practices. Using the preferred reporting items for systematic reviews and meta-analyses (PRISMA) statement, 23 articles from 2018 to 2022 were accessed from three databases, particularly Scopus, Web of Science (WoS), and Educational Resources Information Centre (ERIC). First, the reviewed articles manifest that Facebook is the most frequently used SNSs for English educational purposes. Second, the findings indicated that SNSs have shown a positive impact in enhancing English language competency and improving learning attributes. Third, this review addressed the challenges of using SNSs in the English education field. These findings inferred that there are still research gaps related to the use of SNSs in sustaining English language education. Substantially, this review is advantageous for prospective researchers in identifying the research gaps regarding the use of SNSs for English teaching and learning. © 2023 by the authors.

7.
Letters in Applied NanoBioScience ; 12(4), 2023.
Article in English | Scopus | ID: covidwho-2299315

ABSTRACT

An individual's response to a threatening alteration is called stress, whereas a stressor is defined as a personal reaction to an external event. Since the COVID-19 disease pandemic was first announced, vaccination has become one of the government's controls and prevention measures to overcome the pandemic. Prolonged stress can lead to the inefficacy of the vaccine, thus promoting more immediate and transient vaccine adverse events. This study aimed to seek the relationship between stress and adverse event incidence after COVID-19 vaccination. The cross-sectional study was conducted on 244 respondents (18 – 40 years old) in Depok City, Indonesia. Stress levels were assessed by the Perceived Stress Scale, while Side Effects of COVID-19 vaccination and Opinion Survey were collected immediately after the vaccination. The data were analyzed using the Chi-Square test regarding stress on the adverse events after COVID-19 vaccination with a significance level of p <0.05, p-value = 0.000. The relationship between sex and age with the incidence of the adverse event after COVID-19 vaccination obtained p-values of 0.951 and 0.490, respectively. This study showed that the incidence of the adverse event after COVID-19 vaccination was statistically related to stress but not sex and age. © 2022 by the authors.

8.
Allergy: European Journal of Allergy and Clinical Immunology ; 78(Supplement 111):74, 2023.
Article in English | EMBASE | ID: covidwho-2298865

ABSTRACT

Background: During the initial rollout of COVID-19 vaccination in Singapore, the Ministry of Health (MOH) issued recommendations that patients with a history of any previous vaccine allergy be referred to an allergist for further review on suitability to proceed with mRNA-based COVID-19 vaccines. We review the evaluation of these patients with suspected vaccine allergies prior to receiving mRNA-based COVID-19 vaccines. Method(s): Between 8 April and 22 September 2021, 304 patients were evaluated prior to receiving the COVID-19 vaccinations. Of these, 63 (20.7%) patients with suspected immediate hypersensitivity reactions to non-COVID polysorbate-containing vaccines proceeded to have skin prick test (SPT) and Intradermal test (IDT) to polyethylene glycol (PEG)-3350, polysorbate 80 and polysorbate 20 containing products. Another 62 (20.4%) who reported delayed hypersensitivity reactions to polysorbate-containing vaccines proceeded to have direct inoculation (DI) of the Pfizer BNT162b2 vaccine under the supervision of an allergist. The remaining 242 (76.6%) finally assessed not allergic polysorbate-or tolerated previous non-polysorbate- containing vaccines were recommended to proceed with COVID-19 vaccinations at the community vaccination sites. 99 patients in the SPT/IDT and DI group completed a questionnaire-based survey to report any post vaccination reactions. (Figure 1) Results: Of 63 patients who underwent SPT/IDT, 2 (3.2%) with equivocal IDT tolerated both doses of the BNT162b2 vaccine without major allergic reactions. 61 (6.8%) patients with negative SPT/IDT and 62 (100%) in the DI group completed both doses of BNT162b2 vaccination without major reactions. Among those who completed the questionnaire survey, 13 (13%) reported reactions including non-specific rashes and mild urticaria/angioedema post first dose vaccine. All subsequently completed the second dose of the BNT162b2 vaccine following allergist review;with 8 (61.5%) reporting similar mild skin reactions. Conclusion(s): Majority of those with suspected reactions to polysorbate containing vaccines are able to tolerate the BNT162n2 vaccine which contains PEG-2000. Skin tests prior to mRNA COVID-19 vaccination is unnecessary. Those who report mild potentially allergic reactions after the first dose are able to tolerate the second dose of the BNT162b2 vaccine.

9.
European Respiratory Journal ; 60(Supplement 66):2695, 2022.
Article in English | EMBASE | ID: covidwho-2294419

ABSTRACT

Background: Kidney dysfunction is a prevalent disease that leads to many complications over time, such as hypertension, heart disease, and death. ACEI/ARBs are known to be renoprotective. However, few studies describe the association between ACEI/ARB use and kidney dysfunction in patients with SARS-CoV-2 infection. Purpose(s): To explore the association between patients with SARS-CoV- 2 and kidney dysfunction in patients taking an ACEI/ARB. We hypothesize a negative association between patients with SARS-CoV-2 taking an ACEI/ARB and kidney dysfunction. Method(s): A retrospective query between March 2020 and April 2021 was performed in patients 18 years and older who tested positive for SARSCoV- 2 using a polymerase chain reaction test. Patients were divided into two groups: Kidney dysfunction and no kidney dysfunction. Kidney dysfunction was defined as any diagnosis of chronic kidney disease or acute kidney injury. Primary outcomes were all-cause mortality and hospitalization rate. Secondary outcomes included myocardial infarction (MI), hypotension, intubation, vasopressor use, ventricular tachycardia, and ventricular fibrillation. We used multivariate logistic regression to adjust for baseline characteristics. Result(s): We identified 996 patients with kidney dysfunction and 22,106 without kidney dysfunction who tested positive for SARS-CoV-2. The incidence was 258 (25.9%) for ACEI/ARB use in patients with kidney dysfunction. Adjusted odds ratio (OR) for patients with kidney dysfunction was 5.705 (95% Confidence Interval [CI]: 4.554-7.146;p<0.001) for hospitalization, 0.895 (95% CI: 0.707-1.135;p<0.361) for patients taking ACEI/ARB, and 0.529 (95% CI: 0.333-0.838;<0.007) for mortality in patients with kidney dysfunction who took ACEI/ARB. All secondary outcomes had significantly greater adjusted OR (p<0.001), except for MI (p<0.339), ventricular tachycardia (p<0.697), and ventricular fibrillation (p<0.060). Conclusion(s): To date, the benefits of ACEI/ARB in SARS-CoV-2 patients have been controversial. While ACEI/ARB is known to have renoprotective properties, we did not find a significant association between ACEI/ARB and kidney dysfunction in patients with SARS-CoV-2. However, we found the use of ACEI/ARB in patients with kidney dysfunction to be associated with lower mortality. Therefore, clinicians should continue using this medication for its mortality benefits in patients with kidney dysfunction and its cardioprotective effects.

10.
European Respiratory Journal Conference: European Respiratory Society International Congress, ERS ; 60(Supplement 66), 2022.
Article in English | EMBASE | ID: covidwho-2274155

ABSTRACT

Lung cancer services have been reportedly affected in several ways by C19 across the UK. The early diagnosis oflung cancer is pivotal for better prognostic outcomes. EBUS-TBNA is a vital step in diagnosis and staging of lungcancer in patients with mediastinal disease. The aim of this single centre retrospective review was to determine theimpact of C19 on the number of EBUS cases and the sampling to histology turn-around time (HTT). Weretrospectively collected data of 682 patients whom underwent EBUS between 2015 and 2021 and did a detailedanalysis of the years 2016, 2018, 2020 and 2021 for comparison of HTT.The number of EBUS cases declined steeply in 2020 and 2021 to 42 and 69 respectively whilst median proceduresdone in preceding years were 118 (IQR 114-119). The HTT was interestingly less severely affected in 2020 whenmedian time was 7 (IQR 6-12) days (compared to median time of 6 (IQR 5-8) and 7 (IQR 6-9) days in 2016 and 2018respectively). The median time for HTT increased to 10 days (IQR 7.75 - 20.25) in 2021. These results could be dueto less procedures and lower C19 related sickness absences in 2020. The longest HTT in the years 2016, 2018,2020 and 2021 were 23, 28, 22, 34 days respectively.Our review confirms the detrimental effects of C19 on EBUS services in our centre, where the procedure numbersplummeted in 2020 and 2021 and HTT increased significantly. More importantly, it shows the longer term effects of C19 on the services, given the HTT is worst in 2021 despite the resumption of regular EBUS services.

11.
Transportation Research Interdisciplinary Perspectives ; 19, 2023.
Article in English | Scopus | ID: covidwho-2283463

ABSTRACT

Almost half of all jobs in the San Francisco Bay Area are "remote-eligible” – more than any other metropolitan area in the United States, due to the high concentration of employees in the technology sector who were early to embrace teleworking at the start of the COVID-19 pandemic in early 2020. Any significant share of these tech workers staying remote may have profound long-term impacts on aggregate travel patterns in the region. This research seeks to predict the magnitude of these impacts and derive insights about the newly learned behaviors of tech workers, as indicative of remote-eligible workers in general. A survey of over 660 tech workers ran from November 2021 to March 2022, asking about participants' employers and remote work policies, commute details and mode preferences, non-work trips, and interest in relocation. Respondents expected employer-driven hybrid arrangements of 2–3 days per week in the office after the pandemic, which in turn dictated the number of predicted future commuting trips and suppressed interest in relocation. Though almost half of respondents expressed interest in moving, they only planned to move a median of 20.93 miles – staying within the region but shifting away from their offices and towards less dense and more automobile-oriented suburban neighborhoods. Additionally, those moving more than ten miles from their office are likely to switch to less sustainable travel modes. On the other hand, robust observed retention of online shopping habits for groceries and food delivery may mitigate the added vehicle trips caused by rebound effects. © 2023 The Author(s)

12.
2022 Winter Simulation Conference, WSC 2022 ; 2022-December:605-616, 2022.
Article in English | Scopus | ID: covidwho-2280546

ABSTRACT

Global travel and trade have been hit hard by the COVID-19 pandemic. Border closures have impacted both leisure and business travel. The socioeconomic costs of border closure are particularly severe for individuals living and working across state lines, for which previously unhindered passage has been curtailed, and daily commute across borders is now virtually impossible. Here, we examine how the periodic screening of daily cross-border commuters across territories with relatively low COVID-19 incidence will impact the transmission of SARS-CoV-2 across borders using agent-based simulation. We find that periodic testing at practical frequencies of once every 7, 14 or 21 days would reduce the number of infected individuals crossing the border. The unique transmission characteristics of SARS-CoV-2 suggest that periodic testing of populations with low incidence is of limited use in reducing cross-border transmission and is not as cost-effective as other mitigation measures for preventing transmission. © 2022 IEEE.

16.
European Respiratory Journal Conference: European Respiratory Society International Congress, ERS ; 60(Supplement 66), 2022.
Article in English | EMBASE | ID: covidwho-2278005

ABSTRACT

Hospitals throughout the country have utilised different strategies in the management of COVID pneumonitis. Our hospital established a Respiratory High Care Unit (RHCU) to provide CPAP to patients deteriorating despite Standard Oxygen Therapy (SOT). Patients were considered to be either for full escalation (intubation and mechanical ventilation) or to have CPAP as a ceiling of care. Our aim was to assess CPAP success in those not eligible for mechanical ventilation. We retrospectively analysed patients admitted to RHCU who had a CPAP ceiling of care. Between 1st June 2020 and 31st March 2021, 156 patients were admitted, with 144 notes available for analysis. Patients were transferred to RHCU following review by respiratory consultant and met Trust criteria for CPAP. 75 patients (52%) had a ceiling of care of CPAP. 8 patients were excluded. Average age was 75.1 years. Mean Clinical Frailty Score (CFS) was 3.6. 70% were male. 97% were admitted with FiO2 >=40%. Mortality in patients with CPAP as ceiling of care was 79%. Patients that survived had a mean age was 74.6 years, a mean CFS of 3.1 and a pO2 on admission of 7.8kPa, as compared to a mean age of 75.2 years, a mean CFS of 3.7 and pO2 on admission of 7.7kPa in those that died. Demographics between the two cohorts of patients were similar, making it difficult to predict who would survive with CPAP therapy. 21% of patients not suitable for mechanical ventilation survived with CPAP. In other centres, these patients may have only been eligible for SOT alone. The data suggests that offering CPAP may increase survival in patients that would not be suitable for mechanical ventilation.

17.
Educational Research for Policy and Practice ; 22(1):171-191, 2023.
Article in English | Scopus | ID: covidwho-2244732

ABSTRACT

The COVID-19 pandemic has significantly affected the higher education sector in Singapore. Existing tertiary studies seeking to understand the intraperiod response to COVID-19 often focus on single institutions, jurisdictions or stakeholder groups. This study is the first in-depth qualitative multi-stakeholder examination of the higher education environment in Singapore during the COVID-19 pandemic. It explored the perceptions of the quality of digital pedagogy during COVID-19, how universities have adapted because of the pandemic, and how leaders, teaching staff and students have been affected by the management and educational changes via 13 semi-structured interviews across six Singapore higher education institutions. Through purposive sampling, we explore current stakeholder perceptions, structural education changes, and personal learning and teaching impacts of COVID-19. Applying Braun and Clarke's approach to thematic analysis, we inductively uncovered four major themes: the Singapore government's approach to COVID-19 and its effects on delivery;academic leadership approaches;education technology;and well-being. This article is critical as a key foundation to understand how Singapore is responding with unique geopolitical differences. We discuss the practical implications of our research for current university faculty and students during and beyond the pandemic, and outline opportunities for future research. © 2022, The Author(s), under exclusive licence to Springer Nature Singapore Pte Ltd.

18.
Pathology ; 55:S33, 2023.
Article in English | EMBASE | ID: covidwho-2242569

ABSTRACT

Background: Cancer patients are at high risk of severe COVID infection and recommended at least three doses of SARS-CoV2 mRNA vaccines. Various anti-neoplastic treatments may affect long-term vaccine immunogenicity. Methods: Patients with solid or haematological cancer were recruited from two Singapore hospitals between July 2021 and March 2022. GenScript cPASS surrogate virus neutralisation assays measured antibody responses, which were correlated with clinical outcomes obtained from medical records and national mandatory-reporting databases. Results: In total, 273 patients were recruited (40 with haematological malignancies and the rest solid tumours). Two-hundred and four patients (74.7%) were receiving active cancer therapy: 98 (35.9%) receiving systemic chemotherapy and the rest targeted or immunotherapy. All patients were seronegative at baseline. After receiving one, two and three doses of SARS-CoV-2-mRNA vaccination, seroconversion rate was 35.2%, 79.4% and 92.4% respectively. After three doses, patients on active treatment for haematological malignancies had lower antibodies (57.3%±46.2) as compared to patients on immunotherapy (94.1%±9.56, p<0.05) and chemotherapy (92.8%±18.1, p<0.05). SARS-CoV-2 infection was reported in 77 (28.2%) patients of which 18 were severe. Conclusion: This study demonstrates high immunogenicity of three doses of vaccines and protection against severe infection in cancer patients.

19.
Malaysian Journal of Medicine and Health Sciences ; 19(1):80-88, 2023.
Article in English | Scopus | ID: covidwho-2238955

ABSTRACT

Introduction: The Lost Food Project (TLFP) is a non-profit organization who continuously working on their strategic plan in combating the food insecurity problem by distributing food surplus to low income households within Klang Valley. This cross-sectional study aims to determine the socioeconomic status, food security status and its coping strategies among TLFP recipients in Klang Valley during COVID-19 pandemic. Methods: This study was conducted from April to June 2021. There were 88 respondents recruited through convenience sampling. A set of questionnaires regarding food assistance, nutrition knowledge, food security and its coping strategies was prepared, and the respondents were interviewed either by phone, face-to-face or self-administered questionnaire. Results: The prevalence of food insecurity among households in this study was 59.1%. Most of them have moderate (37.5%) to good (27.5%) nutrition knowledge. The coping strategy that most of the respondents applied was 'using less expensive food' (58.3%) with at least once per week within the past one month. Food insecure households tend to adopt more coping strategies compared to those food secure households (p<0.001). Moreover, households who rent their house (p<0.01), low household income (p<0.05) and high monthly food and drinks expenditure (p<0.01) were associated with the food insecurity among TLFP recipients. Conclusion: The study concluded that lower household income, higher food and drinks expenditure and those who rent the house have negative impacts on household's food security status. Thus, the situation forced them to apply more food-related coping strategies in their daily life. Further research should be conducted on the effectiveness of TLFP in helping them to improve Malaysian's food security status. © 2023 Authors. All rights reserved.

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