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1.
The British Journal of Social Work ; 2022.
Article in English | Web of Science | ID: covidwho-2032020

ABSTRACT

The COVID-19 pandemic may have resulted in front line social workers experiencing job stress, burnout and other psychological distress. Little is known about the work-related stress experienced by Chinese social workers during the pandemic. This study focused on the job stress of social workers from Mainland and Macao. The research aims of this study included: (1) testing whether there is a difference in job stress between social workers from Mainland and Macao during the pandemic and (2) identifying mediating factors that helped explain such regional differences. An online survey collected data from 292 social workers in Mainland China and 108 from Macao in 2020. Mainland participants reported significantly higher job stress than Macao participants. Regional differences in job stress amongst Mainland and Macao social workers were partially attributed to their age and professional role identity. More attention needs to be paid to social workers in Mainland China as they experience higher job stress than their counterparts from Macao. Future research is needed to examine other factors (e.g. job demand and financial compensation) that may contribute to such regional differences. This article studied the job stress of social workers, during COVID-19, in two different Chinese regions. A survey collected data from 292 social workers in Mainland China and 108 social workers in Macao in 2020. The findings showed that the Mainland social workers reported higher job stress than their Macao counterparts. Regional differences in job stress were partially attributed to their age and professional role identity. Future research is needed to examine other factors (e.g. job demand and financial compensation) that may contribute to such regional differences.

2.
J Thromb Haemost ; 18(7): 1798, 2020 07.
Article in English | MEDLINE | ID: covidwho-1383426
3.
Int J Environ Res Public Health ; 19(5)2022 03 01.
Article in English | MEDLINE | ID: covidwho-1771188

ABSTRACT

Total suspended particles (TSP) were collected in Vladivostok, Russia, which is a typical port city. This study investigated the concentration, potential sources, and long-term variation in particle PAHs and NPAHs in the atmosphere of Vladivostok. The PAH and NPAH concentrations were higher in winter than in summer (PAHs: winter: 18.6 ± 9.80 ng/m3 summer: 0.54 ± 0.21 ng/m3; NPAHs: winter: 143 ± 81.5 pg/m3 summer: 143 ± 81.5 pg/m3). The diagnostic ratios showed that PAHs and NPAHs mainly came from vehicle emissions in both seasons, while heating systems were the main source of air pollution in winter. The TEQ assessment values were 2.90 ng/m3 and 0.06 ng/m3 in winter and summer, respectively, suggesting a significant excess cancer risk in the general population in winter. The ILCR values conveyed a potential carcinogenic risk because the value was between 1 × 10-5 and 1 × 10-7 and ingestion was a main contributor in Vladivostok. However, it is worth noting that the concentrations of PAHs and NPAHs showed an overall downward trend from 1999 to 2020. An important reason for this is the cogenerations project implemented by the Far Eastern Center for Strategic Research on Fuel and Energy Complex Development in 2010. This research clarified the latest variations in PAHs and NPAHs to provide continuous observation data for future chemical reaction or model prediction research.


Subject(s)
Air Pollutants , Polycyclic Aromatic Hydrocarbons , Air Pollutants/analysis , China , Environmental Monitoring , Humans , Particulate Matter/analysis , Polycyclic Aromatic Hydrocarbons/analysis , Risk Assessment , Seasons
4.
Alzheimers Dement (N Y) ; 7(1): e12141, 2021.
Article in English | MEDLINE | ID: covidwho-1669647

ABSTRACT

INTRODUCTION: The SINGER pilot randomized controlled trial aims to examine the feasibility and acceptability of the Finnish Geriatric Intervention Study (FINGER) multi-domain lifestyle interventions compared to Singaporean adaptations. METHODS: Seventy elderly participants were recruited and randomized into FINGER (n = 36) or SINGER (n = 34) interventions; involving physical exercise, cognitive training, diet, and vascular risk factors management, for 6 months. RESULTS: Both intervention groups were equally feasible and acceptable with participants completing at least 80% of the interventions. Body strength improved in both groups (Pupper body = .04, P lower body = .06, P core = .05). More participants in the SINGER group attained good blood pressure control at month-6 compared to FINGER (41% vs 19%; P = .06). DISCUSSION: This study is the first to compare the feasibility of multi-domain interventions adapted to local culture with the FINGER interventions. The findings will be utilized for a larger study to provide evidence for the efficacy of multi-domain lifestyle interventions in preventing cognitive decline.

5.
Environ Pollut ; 287: 117360, 2021 Oct 15.
Article in English | MEDLINE | ID: covidwho-1433202

ABSTRACT

Total suspended particulate matter and fine particulate matter were collected in five East Asian cities (Sapporo, Sagamihara, Kirishima, Shenyang, and Vladivostok) during warm and cold periods from 2017 to 2018. Nine polycyclic aromatic hydrocarbons (PAHs) and three nitro-polycyclic aromatic hydrocarbons (NPAHs) were detected by high-performance liquid chromatography with a fluorescence detector. The average concentrations of ∑PAHs and ∑NPAHs differed significantly both temporally and spatially and were the lowest in Kirishima during the warm period (∑PAHs: 0.11 ± 0.06 ng m-3; ∑NPAHs: 1.23 ± 0.96 pg m-3) and the highest in Shenyang during the cold period (∑PAHs: 49.7 ± 21.8 ng m-3; ∑NPAHs: 357 ± 180 pg m-3). The average total benzo[a]pyrene-equivalent concentrations were also higher in Shenyang and Vladivostok than in Japanese cities. According to the results of source apportionment, traffic emissions impacted these cities in both the warm and cold periods, whereas coal combustion-generated effects were obvious in Shenyang and Vladivostok during the cold period. Furthermore, PAHs and NPAHs originating from the Asian continent, including Shenyang and Vladivostok, exerted some influence on Japanese cities, especially in the cold period. Compared to Japanese cities and Vladivostok, yearly variations in ∑PAHs and 1-nitropyrene in Shenyang showed that their concentrations were considerably lower than those reported in past studies, indicating the positive effects of air pollutant control policies in China. These results not only describe the current characteristics and yearly variations of PAHs and NPAHs in typical urban cities in East Asia but also, more importantly, reveal that the effects of the East Asian monsoon play an important role in the analysis of atmospheric behaviours of PAHs and NPAHs. Furthermore, this study supports the role of multinational cooperation to promote air pollution control in East Asia.


Subject(s)
Air Pollutants , Polycyclic Aromatic Hydrocarbons , Air Pollutants/analysis , China , Cities , Environmental Monitoring , Particulate Matter/analysis , Polycyclic Aromatic Hydrocarbons/analysis , Seasons
6.
Chemical & Pharmaceutical Bulletin ; 69(3):237-245, 2021.
Article in English | CAB Abstracts | ID: covidwho-1408633

ABSTRACT

As a background sampling site in western Japan, the Kanazawa University Wajima Air Monitoring Station (KUWAMS) continuously observes the air pollutants, including PM1, PM2.5, organic carbon (OC) and element carbon (EC). Data for September 2019 to April 2020 were compared with data for September 2018 to April 2019. The mean concentrations of both PM1 and PM2.5 were 4.10 micro g/m3 (47%) and 5.82 micro g/m3 (33%) lower, respectively in the Coronavirus Disease 2019 (COVID-19) period (January to April) than in the same period in 2019. Notably, the average concentrations of both classes of particulate matter (PM) in the COVID-19 period were the lowest for that period in all years since 2016. OC and EC also considerably lower (by 69 and 63%, respectively) during the COVID-19 period than during the same period in 2019. All pollutants were then started to increase after the resumption of the work in 2020. The pollutant variations correspond to the measure implemented during the COVID-19 period, including the nationwide lockdown and work resumption. Furthermore, the reductions in the ratios PM1/PM2.5 and OC/EC during COVID-19 period indicate lighter pollution and fewer emission sources. This analysis of the changes in the pollutant concentrations during the epidemic and non-epidemic periods illustrates the significance of the dominant pollution emissions at KUWAMS and the impact of pollution from China that undergoes long-range transport to KUWAMS.

7.
Chemical Engineering Journal ; : 131902, 2021.
Article in English | ScienceDirect | ID: covidwho-1363115

ABSTRACT

Developing green and highly efficient water disinfection technique is of great importance to public health. Herein, a near-infrared (NIR) light-triggerable thermo-sensitive defective molybdenum oxide-nitrogen doped carbon (MoO3-x/NCNs) composite was fabricated and applied to water disinfection. With the synergy of photodynamic and photothermal effects, the MoO3-x/NCNs achieve a rapid and effective inactivation of Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) as compared to photocatalytic treatment or thermal catalytic alone. Particularly, MONC-3 with optimal ratio can completely inactivate 7.6 log of E. coli and S. aureus within 60 min and 100 min, respectively. The MONC-3 hybrid exhibits efficient charge separation and migration ability due to the formation of Schottky heterojunction, resulting in the highly enhanced ·O2– (11.34×10-10 M) generation activity. Meanwhile, excellent NIR light absorption and photothermal conversion efficiency (52.6%) of MONC-3 can generate local high temperature to promote photocatalytic reaction rate and destruct the bacterial integrity. The monitoring of cell damage process confirmed the irreversible death of bacteria. Based on density functional theory (DFT) calculation, the antibacterial mechanism and Schottky effect were clarified. This work provides new insights for constructing a water disinfection strategy based on plasma-induced photothermal synergy catalysis.

9.
Journal of Modern Laboratory Medicine ; 35(5):93-98, 2020.
Article in Chinese | GIM | ID: covidwho-1073554

ABSTRACT

The aim of the article was to analyze the characteristics of early peripheral blood laboratory examination results of patients with new coronavirus pneumonia (coronavirus disease 2019, COVID-19), and provide references for early clinical identification. From January 11, 2020 to February 18, 2020, all 626 patients who attended the fever clinic of Tongji Hospital affiliated to Tongji Medical College of Huazhong University of Science and Technology and tested positive for the new coronavirus (SARS-CoV-2) nucleic acid were selected as the research group In addition, 254 suspected patients who visited the fever clinic during the same period and the SARS-CoV-2 nucleic acid test was negative for two or more consecutive times were selected as the control group, and analyzed the blood cell test, biochemical routine, and inflammation markers of the two groups of patients at the fever clinic for the first time. The characteristics of 31 hematological indicators. Compared with the control group, the white blood cell (WBC), lymphocyte (LYMPH), platelet (PLT), serum calcium (serum calcium, Ca) of the study group were significantly reduced, and the hypersensitive C-reactive protein (hypersensitive C-reactive protein, hsCRP) significantly increased, the difference was statistically significant, and there was a difference in the distribution of results. In the study group, WBC was mostly normal or decreased. WBC was normal in 85.3%, decreased in 9.4%, LYMPH decreased in 43.1%, PLT decreased in 12.8%, Ca decreased in 61.8%, hsCRP was higher than 10mg/L accounted for 66.2%. The remaining 26 hematological indicators (Cl, Na, K, HCO3, Urea, UA, Cr, TBA, CHE, ALB, ALT, ALP, LDH, TP, PCT, DBIL, GLB, IBIL, TBIL, P-GGT, TCHOL, AST, Hb, RBC, NEUT, MON) There was no statistically significant difference between the two groups. WBC, LYMPH, PLT, Ca and hsCRP have significant changes in the early stage of COVID-19 patients. Joint detection and observation of the above indicators can provide important references for early clinical identification.

10.
Arch Pathol Lab Med ; 144(10): 1223-1229, 2020 10 01.
Article in English | MEDLINE | ID: covidwho-860466

ABSTRACT

CONTEXT.­: The coronavirus disease 2019 (COVID-19) is a highly contagious respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Coagulation dysfunction is a hallmark in patients with COVID-19. Fulminant thrombotic complications emerge as critical issues in patients with severe COVID-19. OBJECTIVE.­: To present a review of the literature and discuss the mechanisms of COVID-19 underlying coagulation activation and the implications for anticoagulant and thrombolytic treatment in the management of COVID-19. DATA SOURCES.­: We performed a systemic review of scientific papers on the topic of COVID-19, available online via the PubMed NCBI, medRxiv, and Preprints as of May 15, 2020. We also shared our experience on the management of thrombotic events in patients with COVID-19. CONCLUSIONS.­: COVID-19-associated coagulopathy ranges from mild laboratory alterations to disseminated intravascular coagulation (DIC) with a predominant phenotype of thrombotic/multiple organ failure. Characteristically, high D-dimer levels on admission and/or continuously increasing concentrations of D-dimer are associated with disease progression and poor overall survival. SARS-CoV-2 infection triggers the immune-hemostatic response. Drastic inflammatory responses including, but not limited to, cytokine storm, vasculopathy, and NETosis may contribute to an overwhelming activation of coagulation. Hypercoagulability and systemic thrombotic complications necessitate anticoagulant and thrombolytic interventions, which provide opportunities to prevent or reduce "excessive" thrombin generation while preserving "adaptive" hemostasis and bring additional benefit via their anti-inflammatory effect in the setting of COVID-19.


Subject(s)
Blood Coagulation Disorders/virology , Coronavirus Infections/blood , Pneumonia, Viral/blood , Thrombosis/virology , Betacoronavirus , COVID-19 , Coronavirus Infections/complications , Humans , Pandemics , Pneumonia, Viral/complications , SARS-CoV-2
11.
J Thromb Haemost ; 18(6): 1513-1514, 2020 06.
Article in English | MEDLINE | ID: covidwho-832011
12.
Clin Exp Med ; 21(1): 35-39, 2021 Feb.
Article in English | MEDLINE | ID: covidwho-777871

ABSTRACT

With the outbreak of COVID-19 ongoing, this infectious disease has been posing a significant threat to public health. However, we are still relatively inexperienced on recognizing the clinical characteristics of severe COVID-19 and death cases. Therefore, we hereby collected and analyzed a total of 232 cases to illustrate the clinical characteristics of such patients in Wuhan and to find notable marks for early clinical warning. We consider age, comorbidities, platelet count, albumin, D-dimer, LDH, CRP and IL-6 level might be more meaningful marks for COVID-19 prognostic evaluation.


Subject(s)
COVID-19/etiology , Aged , Aged, 80 and over , Blood Cell Count , Blood Chemical Analysis , COVID-19/epidemiology , COVID-19/mortality , China/epidemiology , Comorbidity , Humans , Inflammation/blood , Inflammation/virology , Intensive Care Units , Interleukin-6/blood , Middle Aged , Retrospective Studies
14.
J Thromb Thrombolysis ; 50(3): 580-586, 2020 Oct.
Article in English | MEDLINE | ID: covidwho-637607

ABSTRACT

The outbreak of novel coronavirus disease 2019 (COVID-19) has now become a global pandemic. Coagulopathy has been reported widely in critically ill COVID-19 patients and was related to high mortality. However, the comprehensive coagulation profiles have not been examined and the underlying mechanism of the coagulopathy in COVID-19 patients is unclear. To study the coagulation profiles of routine hemostasis tests, natural anticoagulants, coagulant factors and antiphospholipid antibodies in critically ill COVID-19 patients. This single-center and cross-section study included 19 patients with COVID-19, who were admitted to intensive care unit (ICU) at Tongji hospital in Wuhan, China, from Feb 23 to Mar 3, 2020. Demographic data, laboratory parameters, treatments and clinical outcomes of the patients were collected and analyzed. The final date of follow-up was Mar 31, 2020. In this study, 12 thrombotic events occurred in 9 patients, including 4 cerebral infarctions, 7 acro-ischemia and 1 internal jugular vein thrombosis. The common abnormalities of routine coagulation tests included evelated D-Dimer level (100%), prolonged prothrombin time (73.7%) and hyperfibrinogenemia (73.7%). The median activities of natural anticoagulants including protein C, protein S and antithrombin were all below the normal range. Factor VIII activities were significantly above normal range (median value 307%, IQR 198-441) in all patients. Factor V and factor VII activities were significantly lower in near-terminal stage patients. Anti-phospholipid antibodies were present in 10 patients. Strikingly, 4 cerebral infarction events were in patients had anti-phospholipid antibodies of multiple isotypes. Sustained hypercoagulable status and thrombotic events were common in critically ill patients with COVID-19. The low activities of natural anticoagulants, elevated factor VIII level and the presence of antiphospholipid antibodies, together, may contribute to the etiopathology of coagulopathy in COVID-19 patients.


Subject(s)
Antibodies, Antiphospholipid/blood , Betacoronavirus/pathogenicity , Blood Coagulation Factor Inhibitors/blood , Blood Coagulation Factors/analysis , Blood Coagulation , Coronavirus Infections/blood , Pneumonia, Viral/blood , Thrombosis/blood , Aged , Antithrombin Proteins/analysis , Biomarkers/blood , COVID-19 , China , Coronavirus Infections/diagnosis , Coronavirus Infections/virology , Critical Illness , Cross-Sectional Studies , Female , Fibrin Fibrinogen Degradation Products/analysis , Host-Pathogen Interactions , Humans , Male , Middle Aged , Pandemics , Pneumonia, Viral/diagnosis , Pneumonia, Viral/virology , Protein C/analysis , Protein S/analysis , Risk Factors , SARS-CoV-2 , Thrombosis/diagnosis , Thrombosis/virology
19.
J Thromb Haemost ; 18(4): 844-847, 2020 04.
Article in English | MEDLINE | ID: covidwho-52266

ABSTRACT

BACKGROUND: In the recent outbreak of novel coronavirus infection in Wuhan, China, significantly abnormal coagulation parameters in severe novel coronavirus pneumonia (NCP) cases were a concern. OBJECTIVES: To describe the coagulation feature of patients with NCP. METHODS: Conventional coagulation results and outcomes of 183 consecutive patients with confirmed NCP in Tongji hospital were retrospectively analyzed. RESULTS: The overall mortality was 11.5%, the non-survivors revealed significantly higher D-dimer and fibrin degradation product (FDP) levels, longer prothrombin time and activated partial thromboplastin time compared to survivors on admission (P < .05); 71.4% of non-survivors and 0.6% survivors met the criteria of disseminated intravascular coagulation during their hospital stay. CONCLUSIONS: The present study shows that abnormal coagulation results, especially markedly elevated D-dimer and FDP are common in deaths with NCP.


Subject(s)
Betacoronavirus , Blood Coagulation , Coronavirus Infections/mortality , Coronavirus Infections/physiopathology , Disseminated Intravascular Coagulation/mortality , Disseminated Intravascular Coagulation/virology , Pneumonia, Viral/mortality , Pneumonia, Viral/physiopathology , Adolescent , Adult , Aged , Aged, 80 and over , COVID-19 , China , Female , Fibrin Fibrinogen Degradation Products/analysis , Humans , Male , Middle Aged , Pandemics , Partial Thromboplastin Time , Prothrombin Time , Retrospective Studies , SARS-CoV-2 , Young Adult
20.
J Thromb Thrombolysis ; 51(4): 1107-1110, 2021 May.
Article in English | MEDLINE | ID: covidwho-31241

ABSTRACT

Severe coronavirus disease 2019 (COVID-19) is commonly complicated with coagulopathy, the difference of coagulation features between severe pneumonia induced by SARS-CoV2 and non-SARS-CoV2 has not been analyzed. Coagulation results and clinical features of consecutive patients with severe pneumonia induced by SARS-CoV2 (COVID group) and non-SARS-CoV2 (non-COVID group) in Tongji hospital were retrospectively analyzed and compared. Whether patients with elevated D-dimer could benefit from anticoagulant treatment was evaluated. There were 449 COVID patients and 104 non-COVID patients enrolled into the study. The 28-day mortality in COVID group was approximately twofold of mortality in non-COVID group (29.8% vs. 15.4%, P = 0.003), COVID group were older (65.1 ± 12.0 vs. 58.4 ± 18.0, years, P < 0.001) and with higher platelet count (215 ± 100 vs. 188 ± 98, ×109/L, P = 0.015), comparing to non-COVID group. The 28-day mortality of heparin users were lower than nonusers In COVID group with D-dimer > 3.0 µg/mL (32.8% vs. 52.4%, P = 0.017). Patients with severe pneumonia induced by SARS-CoV2 had higher platelet count than those induced by non-SARS-CoV2, and only the former with markedly elevated D-dimer may benefit from anticoagulant treatment.


Subject(s)
COVID-19 , Platelet Count/methods , Pneumonia , Sepsis , Thrombophilia , Age Factors , Aged , Blood Coagulation Tests/methods , COVID-19/blood , COVID-19/diagnosis , COVID-19/epidemiology , COVID-19/physiopathology , China/epidemiology , Diagnosis, Differential , Female , Fibrin Fibrinogen Degradation Products/analysis , Humans , Male , Middle Aged , Organ Dysfunction Scores , Pneumonia/blood , Pneumonia/diagnosis , Pneumonia/etiology , Retrospective Studies , Risk Factors , Sepsis/blood , Sepsis/diagnosis , Sepsis/etiology , Sex Factors , Thrombophilia/diagnosis , Thrombophilia/etiology
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