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J Am Acad Dermatol ; 84(5): e229-e230, 2021 05.
Article in English | MEDLINE | ID: covidwho-1130292
J Immunother Cancer ; 8(2)2020 12.
Article in English | MEDLINE | ID: covidwho-971586


The COVID-19 outbreak caused by SARS-CoV-2 challenges the medical system by interfering with routine therapies for many patients with chronic diseases. In patients with cancer receiving immune checkpoint inhibitors (ICIs), difficulties also arise from the incomplete understanding of the intricate interplay between their routine treatment and pathogenesis of the novel virus. By referring to previous ICI-based investigations, we speculate that ICIs themselves are not linked to high-infection risks of respiratory diseases or inflammation-related adverse effects in patients with cancer. Moreover, ICI treatment may even enhance coronavirus clearance in some patients with malignant tumor by boosting antiviral T-cell responsiveness. However, the 'explosive' inflammation during COVID-19 in some ICI-treated patients with cancer was illustrated as exuberant immunopathological damage or even death. In case of the COVID-19 immunopathogenesis fueled by ICIs, we propose a regular monitor of pathogenic T-cell subsets and their exhaustion marker expression (eg, Th17 and interleukin (IL)-6-producing Th1 subsets with surface programmed death 1 expression) to guide the usage of ICI. Here we aimed to address these considerations, based on available literature and experience from our practice, that may assist with the decision-making of ICI administration during the pandemic.

Antineoplastic Agents, Immunological/pharmacology , COVID-19/immunology , Cytokine Release Syndrome/prevention & control , Neoplasms/drug therapy , SARS-CoV-2/immunology , Antineoplastic Agents, Immunological/therapeutic use , COVID-19/complications , COVID-19/diagnosis , COVID-19/epidemiology , Clinical Decision-Making , Cytokine Release Syndrome/blood , Cytokine Release Syndrome/immunology , Drug Monitoring , Humans , Lung/diagnostic imaging , Neoplasms/blood , Neoplasms/immunology , Pandemics , Patient Selection , Programmed Cell Death 1 Receptor/antagonists & inhibitors , Programmed Cell Death 1 Receptor/metabolism , SARS-CoV-2/isolation & purification , Th1 Cells/drug effects , Th1 Cells/immunology , Th1 Cells/metabolism , Th17 Cells/drug effects , Th17 Cells/immunology , Th17 Cells/metabolism , Tomography, X-Ray Computed
Chinese Journal of Dermatovenereology ; 34(4):367-370, 2020.
Article in Chinese | GIM | ID: covidwho-923248


Since December 2019, novel coronavirus-infected pneumonia emerged in Wuhan city and rapidly spread throughout China. Skin is the first line of defense to prevent infection. It is responsibility as a dermatologist to fight the novel coronavirus. In order to prevent and control the novel coronavirus, and decrease its transmission in dermatological wards, we draft the strategy for preventing and controlling the novel coronavirus infection in dermatological wards, based on our experience in the diagnosis and treatment of a suspected patient of novel coronavirus-infected pneumonia admitted to our dermatological ward and the related system of hospital infection of anti-novel coronavirus infection.

Dermatol Ther ; 33(4): e13310, 2020 Jul.
Article in English | MEDLINE | ID: covidwho-767240


Health professions preventing and controlling Coronavirus Disease 2019 are prone to skin and mucous membrane injury, which may cause acute and chronic dermatitis, secondary infection and aggravation of underlying skin diseases. This is a consensus of Chinese experts on protective measures and advice on hand-cleaning- and medical-glove-related hand protection, mask- and goggles-related face protection, UV-related protection, eye protection, nasal and oral mucosa protection, outer ear, and hair protection. It is necessary to strictly follow standards of wearing protective equipment and specification of sterilizing and cleaning. Insufficient and excessive protection will have adverse effects on the skin and mucous membrane barrier. At the same time, using moisturizing products is highly recommended to achieve better protection.

Coronavirus Infections/therapy , Health Personnel , Mucous Membrane/pathology , Occupational Diseases/prevention & control , Pneumonia, Viral/therapy , Skin/pathology , COVID-19 , China , Consensus , Emollients/administration & dosage , Gloves, Protective , Hand Disinfection/methods , Humans , Masks , Pandemics , Personal Protective Equipment