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1.
Annals of Medicine and Surgery ; 82:104767, 2022.
Article in English | ScienceDirect | ID: covidwho-2041503

ABSTRACT

Background During the COVID-19 pandemic, the number of bariatric surgeries was decreased to ensure patient safety. This study aimed to evaluate the effect of such delays on the psychological status and weight management behaviors of waitlisted pre-bariatric surgery patients in Jeddah, Saudi Arabia. Materials and methods A web-based cross-sectional survey was conducted. Results were then evaluated with simple descriptive statistics and inferential analyses through the Chi-square test, one-way ANOVA, and the general linear regression model. Results Of 437 patients, 208 successfully completed the survey. Approximately half of the participants reported weight change (46.6%, n = 97), while other weight management behaviors remained unchanged. The mean Patient Health Questionnaire-9 (PHQ-9) total score of the respondents was 8.29 ± 6.3, indicating mild depression. Higher PHQ-9 scores were associated with being a student, unhealthy dietary habits, physical inactivity, worsened psychological status, and weight gain. Among these factors, being a student was the strongest predictor of the total PHQ-9 score. Conclusion The COVID-19 pandemic significantly affected the psychological status of patients with obesity on the bariatric surgery waitlist. Since delays in bariatric surgeries could worsen patients’ psychological status, as substantiated in this study, the provision of virtual care through telemedicine and the development of policies for reintroducing bariatric surgeries for future lockdowns are highly recommended.

2.
Cureus ; 14(7):e27441, 2022.
Article in English | MEDLINE | ID: covidwho-2025390

ABSTRACT

As the globe continues to grapple and scuffle with new emerging strains of COVID every day, a set of recovered patients continue to show persistent enervating symptoms. Many patients never fully recovered after COVID and had neurological and psychiatric symptoms for weeks or months. The emphasis of our study is on these long haulers, particularly on the two critical organ systems of the body, i.e., the central nervous system and the muscular system. Depending upon the severity of the disease, many signs and symptoms continue to linger, ranging from weeks to months. A total of 29 studies are included in our review after thorough screening, application of inclusion and exclusion criteria, and quality appraisals. The total number of patients included is 6012. We found many long-term effects, but the emphasis of our study continued to remain on the two main organ systems that resulted in prolonged COVID with debilitating symptoms and thus affected the quality of life of these patients. Various factors and underlying pathophysiologic manifestations result in the predominance of these signs and symptoms. Furthermore, the patient's underlying medical conditions and other environmental factors may add to it. More focus is required on the quality of life post-COVID, and this requires a team of specialists. There are still many unanswered questions like which ethnicity is affected more, why females are more prone to the long symptoms, and the effects of various treatments on the long-term signs and symptoms.

3.
2nd International Conference on Emerging Frontiers in Electrical and Electronic Technologies, ICEFEET 2022 ; 2022.
Article in English | Scopus | ID: covidwho-2018821

ABSTRACT

The COVID-19 pandemic has expanded all over the globe in a short span of time. It has created a colossal impact on the environment leading to severe consequences. Since March 2020, India has witnessed untold misery and suffering when millions of people have been hit by virus. The pandemic poses both enormous problems as well as several opportunities for the countries to achieve the Sustainable Development Goals (SDGs) set out according to the agenda by the year 2030. The SDGs consist pragmatically of different aspects of humans and their environmental well-being, and achieving it will provide ecology with a stable and sustainable life by maintaining the health of our green planet also. It has been damaged by a devastating blow due to Covid-19. The pandemic is bound to have consequences that will have an impact for years to come. The continuous decline in the economy of India with inclination in COVID-19 cases has resulted in an uneven track to fulfilling, meeting, and delivering the SDGs by 2030. The devastating impact on all 17 goals has already endangered the achievements made earlier. COVID-19's effects have highlighted the fundamental need for human well-being. This paper exclusively highlights the SDGs in India which have faced or likely to face an impact due to pandemic and the roadmap for future action to achieve Agenda 2030. This research will also help in understanding the effect of the pandemic on SDGs at state level as in countries around the globe. The paper would open a wide area of research for policymakers to strengthen the SDGs in line with the current pandemic situation. © 2022 IEEE.

4.
JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION ; 72(7):1467-1467, 2022.
Article in English | Web of Science | ID: covidwho-1912784
5.
Clin Infect Dis ; 2022 Jun 20.
Article in English | MEDLINE | ID: covidwho-1901151

ABSTRACT

We isolated a SARS-CoV-2 BA.2 variant from a person with COVID-19 recrudescence after nirmatrelvir/ritonavir treatment. Antiviral sensitivity and neutralizing antibody testing were performed with both parental SARS-CoV-2 and multiple variants of concern. We found that neither NM resistance nor absence of neutralizing immunity were likely causes of the recrudescence.

6.
IEEE Sensors Journal ; 2022.
Article in English | Scopus | ID: covidwho-1846128

ABSTRACT

Coronavirus (COVID-19) pandemic has incurred huge loss to human lives throughout the world. Scientists, researchers, and doctors are trying their best to develop and distribute the COVID-19 vaccine throughout the world at the earliest. In current circumstances, different tracking systems are utilized to control or stop the spread of the virus till the whole population of the world gets vaccinated. To track and trace patients in COVID-19 like pandemics, various tracking systems based on different technologies are discussed and compared in this paper. These technologies include, cellular, cyber, satellite-based radio navigation and low range wireless technologies. The main aim of this paper is to conduct a comprehensive survey that can overview all such tracking systems, which are used in minimizing the spread of COVID-19 like pandemics. This paper also highlights the shortcoming of each tracking systems and suggests new mechanisms to overcome such limitations. In addition, the authors propose some futuristic approaches to track patients in prospective pandemics, based on artificial intelligence and big data analysis. Potential research directions, challenges, and the introduction of next-generation tracking systems for minimizing the spread of prospective pandemics, are also discussed at the end. IEEE

8.
Ophthalmol Ther ; 11(3): 1017-1030, 2022 Jun.
Article in English | MEDLINE | ID: covidwho-1821036

ABSTRACT

PURPOSE: To evaluate the effect of COVID-19 on retinal tissues by conducting a systematic review and meta-analysis of the current literature. BACKGROUND: The novel coronavirus disease is not yet well understood. The orbit provides a window into the body's microvasculature, and as such, it is a non-invasive opportunity to analyse the systemic circulation in vivo. By analysing the current literature, we test the hypothesis that non-invasive imaging of the retina could provide insight into the effect of COVID-19 on the retinal microvasculature. METHODS: For this systematic review and meta-analysis, we screened PubMed databases and LitCOVID19 using the search criteria: (OCTA or Optical Coherence Tomography Angiography) AND (COVID-19 or corona or SARS-CoV-2) AND (retina or fundus). Databases were searched on 11 January 2022. The primary study outcomes were studies that utilised OCTA to analyse the retina; secondary outcomes involved studies that involved other imaging modalities such as OCT, fundus photography, and fundus autofluorescence. FINDINGS: The total number of studies included in this review was 32. Optical coherence tomography angiography scans show reduced central retinal vascular density, a thinner ganglion cell layer, a thicker retinal nerve fibre layer, and an enlarged foveal avascular zone. Optical coherence tomography scans demonstrate a thicker central macular thickness and other changes to the macula, ganglion cell, and inner nuclear layers. Many fundus photographs depicted cotton wool spots, microhaemorrhages, and vascular occlusions. Non-invasive imaging technology has demonstrated that COVID-19 can profoundly affect the retina. Therefore, there is a requirement for long-term follow-up of COVID-19 patients to assess whether the retinal damage caused by COVID-19 is reversible.

9.
Preprint in English | bioRxiv | ID: ppbiorxiv-489834

ABSTRACT

To address the need for multivalent vaccines against Coronaviridae that can be rapidly developed and manufactured, we compared antibody responses against SARS-CoV, SARS-CoV-2, and several variants of concern in mice immunized with mRNA-lipid nanoparticle vaccines encoding homodimers or heterodimers of SARS-CoV/SARS-CoV-2 receptor-binding domains. All vaccine constructs induced robust anti-viral antibody responses, and the heterodimeric vaccine elicited an IgG response capable of cross-neutralizing SARS-CoV, SARS-CoV-2 Wuhan-Hu-1, B.1.351 (beta), and B.1.617.2 (delta) variants.

10.
Pakistan Journal of Commerce and Social Science ; 15(4):684-710, 2021.
Article in English | Scopus | ID: covidwho-1695264

ABSTRACT

The current study aims to investigate the influence of budget-hotels' environmental orientation (EO) on their eco-innovation (EI) and environmental performance (EP). Besides empirically testing the said direct relationship, mediating role of EI in the relationship between EO and EP has also been investigated. Moderating effect of competitive intensity (CI) of the firm has also been examined on the link between EI and EP. The requisite data for this study was collected from 422 individuals, working on various managerial positions in the budget-hotels in Pakistan. Correlation, path analysis, structural equation modelling and hierarchical regression were used for the purpose of data analysis. Data analysis using SPSS and AMOS reveals a direct effect of EO on EI and EP. Moreover, the results substantiated that EI mediates between EO and EP. Moderating effect of CI on the link between EI and EP has also been confirmed. The study advocates new mechanisms which would be helpful in protecting natural environment. In the context of budget hotel segment of hospitality industry of Pakistan, the present study makes significant contribution to the literature through knowledge addition regarding the positive association of EO and EI © 2021,Pakistan Journal of Commerce and Social Sciences.All Rights Reserved

11.
Khyber Medical University Journal-Kmuj ; 13(3):136-141, 2021.
Article in English | Web of Science | ID: covidwho-1614617

ABSTRACT

OBJECTIVE: To analyze SARS-CoV-2 whole genome reported of Pakistan and compare them with other viral strains collected from other world region to better understand the origin and genetic characterization of the virus. METHODS: All the available genomic information of SARS-CoV-2 including Pakistani strains were collected from various online sources. Phylogenetic analysis of 131 sequences from 11 countries (Brazil, China, India, Italy, Nepal, Pakistan, Spain, Sweden, Taiwan, USA and Viet-Nam) were performed and compared with other related coronaviruses to find the evolution of virus and its origin. Individual SARS-CoV-2 gene, spike (S) glycoprotein and the receptor binding domain (RBD) with closely related coronaviruses were compared to further explore genetic variations and the likely RBD properties of the virus. RESULTS: The analysis shows that genome of all analyzed 131 SARS-CoV-2 strains collected from different geographical area were extremely similar, exhibiting >99% sequence identity. Notably, genome of the SARS-CoV-2 has high similarity (89.1% sequence identity) with the two bat-derived severe acute respiratory syndrome (SARS) like betacoronaviruses, bat-SL-CoVZC45 and bat-SL-CoVZXC21 but was sufficiently divergent from SARS-CoV (82.3% similarity) and MERS-CoV (50% similarity). Phylogenetic analysis shows that the SARS-CoV-2 has relatively similar spike glycoprotein with bat-SL-CoVZC45, however, the RBD was more like that of SARS-CoVGZ02. CONCLUSION: Using different bioinformatics tools, we determined that SARS-CoV-2 has high similarities to bat-derived SARS like betacoronaviruses than SARS-CoV at the whole genome level, however, the RBD was more like that of SARS-CoVGZ02, which shows that they use similar ACE2 as a cell receptor.

12.
STAR Protoc ; 3(1): 101067, 2022 03 18.
Article in English | MEDLINE | ID: covidwho-1595326

ABSTRACT

N 6 -methylation of adenosine (m6A) is the most abundant internal mRNA modification and is an important post-transcriptional regulator of gene expression. Here, we describe a protocol for methylated RNA immunoprecipitation sequencing (MeRIP-Seq) to detect and quantify m6A modifications in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA. The protocol is optimized for low viral RNA levels and is readily adaptable for other applications. For complete details on the use and execution of this protocol, please refer to Li et al. (2021).


Subject(s)
Adenosine/analogs & derivatives , Immunoprecipitation/methods , Sequence Analysis, RNA/methods , Adenosine/analysis , Adenosine/genetics , Animals , COVID-19/genetics , Caco-2 Cells , Chlorocebus aethiops , Gene Expression/genetics , Gene Expression Regulation/genetics , Genetic Techniques , HEK293 Cells , Humans , Methylation , RNA/chemistry , RNA/genetics , RNA Processing, Post-Transcriptional , RNA, Viral/metabolism , SARS-CoV-2/genetics , SARS-CoV-2/pathogenicity , Vero Cells
13.
Allergy: European Journal of Allergy and Clinical Immunology ; 76(SUPPL 110):570-571, 2021.
Article in English | EMBASE | ID: covidwho-1570363

ABSTRACT

Background: Internationally, the COVID-19 pandemic severely curtailed access to hospital facilities for those awaiting elective/semi elective procedures. For allergic children in Ireland, already waiting to 4yr for an elective oral food challenge (OFC), the restrictions signified indefinite delay. At the time of the initiative there were approx 900 children on the Chidren's Health Ireland (CHI) waiting list. In July 2020, a project was facilitated by short term (6wk) access to an empty COVID stepdown facility built, in a hotel conference centre, commandeered by the Health Service Executive Ireland (HSE). The aim was to the achieve rapid rollout of an off-site OFC service, delivering high throughput of long waiting patients, while aligning with hospital existing policies and quality standards, international allergy guidelines and national social distancing standards. Method: The working group engaged key stakeholders to rapidly develop an offsite OFC facility. Consultant Paediatric Allergists, Consultant Paediatricians, trainees and Allergy Clinical Nurse Specialists were seconded from other duties. The facility was already equipped with hospital beds, bedside monitors (BP, Pulse, Oxygen saturation) bedside oxygen. All medication and supplies had to be brought from the base hospital. Daily onsite consultant anaesthetic cover was resourced and a resuscitation room equipped. Standardised food challenge protocols were created. Access to onsite hotel chef facilitated food preparation. A risk register was established. Results: After 6wks planning, the remote centre became operational on 7/9/20, with the capacity of 27 OFC/day. 474 challenges were commenced, 465 (98%) were completed, 9(2%) were inconclusive. 135(29.03%) OFC were positive, 25(5%) causing anaphylaxis. No child required advanced airway intervention. 8 children were transferred to the base hospital. The CHI allergy waiting list was reduced by almost 60% in only 24 days. Conclusion: OFCs remain a vital tool in the care of allergic children, with their cost saving and quality of life benefits negatively affected by delay in their delivery. This project has shown it is possible to have huge impacts on a waiting list efficiently, effectively and safely with good planning and staff buy in -even in a pandemic. Adoption of new, flexible and efficient models of service delivery will be important for healthcare delivery in the post-COVID- 19 era.

14.
Research and Practice in Thrombosis and Haemostasis ; 5(SUPPL 2), 2021.
Article in English | EMBASE | ID: covidwho-1508996

ABSTRACT

Background : Thromboprophylaxis is currently recommended for all COVID-19 patients requiring hospitalization. Whether therapeutic anticoagulation should be considered is highly debated. Aims : Compare mortality, thromboembolism, and bleeding rates between prophylactic and therapeutic anticoagulation. Methods : We performed a systematic search on PubMed and the Cochrane COVID-19 Study Register for studies comparing prophylactic and therapeutic anticoagulation, up to January 31, 2021. Search terms were: ('anticoagulant' OR 'anticoagulation' OR 'heparin' OR 'thromboprophylaxis') AND ('COVID-19' OR 'SARSCoV-2'). No language restriction was applied. Filters were applied to display comparative studies, clinical trials, and observational cohort studies. The Newcastle-Ottawa scale was used to assess the quality of included studies. Results : We identified 472 records and screened 412 for eligibility. Thirty-eight studies were found to be eligible, including thirty-four retrospective cohorts and four prospective studies. Twenty-three, twenty-two, and twenty-three studies were included in the metaanalysis of mortality, thromboembolism, and bleeding outcomes respectively. Patients receiving prophylactic anticoagulation had better survival compared to those treated with therapeutic anticoagulation (OR, 0.65, 95% CI, 0.46-0.91). Therapeutic anticoagulation did not decrease risk of thromboembolism and was associated with significantly higher risk of bleeding (Figures 1 and 2). Severe COVID-19 patients admitted to intensive care unit (ICU) showed a non-significant trend towards improved mortality (OR, 1.85, 95% CI 0.90-3.81), and lower rates of thromboembolism (OR, 1.46, 95% CI, 0.83-2.57) with therapeutic anticoagulation. Conclusions : To our knowledge, this is the first in-depth review of the outcomes of prophylactic versus therapeutic anticoagulation in COVID-19. Our findings argue against the empiric use of therapeutic anticoagulation in COVID-19 patients. Compared to prophylactic anticoagulation, therapeutic anticoagulation did not improve survival or reduce risk of thromboembolism, and was associated with significantly higher risk of bleeding. Prospective trials are encouraged to explore the benefit of therapeutic anticoagulation in critically ill COVID-19 patients admitted to ICU.

15.
Journal of Clinical Oncology ; 39(28):2, 2021.
Article in English | Web of Science | ID: covidwho-1486612
16.
European Journal of Psychology Open ; : 8, 2021.
Article in English | Web of Science | ID: covidwho-1483097

ABSTRACT

This study investigates the role of emotional intelligence (EI) in consumers' satisfaction with life (SWL), particularly during the COVID-19 crisis. It looks into the relationship between consumer EI, impulsive buying (IB), and SWL, particularly during the dreadful COVID-19 pandemic. It also reflects on the mediating role of IB in the indirect association between consumer EI and SWL. The data were collected from 483 public-sector university graduates in Islamabad, Pakistan. Findings reveal a significant association between consumer EI and IB as well as between consumer EI and SWL. In addition, consumer IB behavior played a significant mediating role in the indirect relationship between consumer EI and SWL: When consumers have a high level of EI, their involvement in IB is low, and they are more satisfied with their lives. This study helps consumers to understand how to effectively manage emotions ensuing during shopping experiences to control their buying behavior. The study also broadens our understanding of how EI can help consumers to remain satisfied during the COVID-19 crisis.

17.
J Med Chem ; 65(4): 2866-2879, 2022 02 24.
Article in English | MEDLINE | ID: covidwho-1440451

ABSTRACT

The emergence of a new coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), presents an urgent public health crisis. Without available targeted therapies, treatment options remain limited for COVID-19 patients. Using medicinal chemistry and rational drug design strategies, we identify a 2-phenyl-1,2-benzoselenazol-3-one class of compounds targeting the SARS-CoV-2 main protease (Mpro). FRET-based screening against recombinant SARS-CoV-2 Mpro identified six compounds that inhibit proteolysis with nanomolar IC50 values. Preincubation dilution experiments and molecular docking determined that the inhibition of SARS-CoV-2 Mpro can occur by either covalent or noncovalent mechanisms, and lead E04 was determined to inhibit Mpro competitively. Lead E24 inhibited viral replication with a nanomolar EC50 value (844 nM) in SARS-CoV-2-infected Vero E6 cells and was further confirmed to impair SARS-CoV-2 replication in human lung epithelial cells and human-induced pluripotent stem cell-derived 3D lung organoids. Altogether, these studies provide a structural framework and mechanism of Mpro inhibition that should facilitate the design of future COVID-19 treatments.


Subject(s)
Antiviral Agents/pharmacology , Benzothiazoles/pharmacology , Coronavirus 3C Proteases/antagonists & inhibitors , Cysteine Proteinase Inhibitors/pharmacology , Drug Discovery , SARS-CoV-2/drug effects , Animals , Antiviral Agents/chemical synthesis , Antiviral Agents/chemistry , Benzothiazoles/chemistry , COVID-19/drug therapy , COVID-19/metabolism , Chlorocebus aethiops , Coronavirus 3C Proteases/isolation & purification , Coronavirus 3C Proteases/metabolism , Crystallography, X-Ray , Cysteine Proteinase Inhibitors/chemical synthesis , Cysteine Proteinase Inhibitors/chemistry , Dose-Response Relationship, Drug , Fluorescence Resonance Energy Transfer , Humans , Microbial Sensitivity Tests , Molecular Docking Simulation , Molecular Structure , SARS-CoV-2/enzymology , Vero Cells , Virus Replication/drug effects
19.
Journal of General Internal Medicine ; 36(SUPPL 1):S163-S163, 2021.
Article in English | Web of Science | ID: covidwho-1349107
20.
Risk Manag Healthc Policy ; 14: 3079-3090, 2021.
Article in English | MEDLINE | ID: covidwho-1334847

ABSTRACT

PURPOSE: The COVID-19 outbreak has caused governments to put pandemic-related guidelines requiring compliance and understanding by healthcare professionals to mitigate its spread uncontrollably. We studied pharmacists' knowledge, attitude, and practice towards the COVD-19 outbreak compared with other healthcare workers during the pandemic in Saudi Arabia. METHODS: We surveyed pharmacists' socio-demographics (n=50) compared with other healthcare professionals (n=378) during lockdown starting in June 2020. We measured respondents' level of knowledge (n=10 questions, maximum score of 10), attitude (n=17 questions, maximum score of 80), and their practices (n=16 questions, maximum score of 80) towards COVID-19 infection. RESULTS: Median knowledge score was 8 (25th-75th percentiles: 7-9), attitude score 76 (70-80) and practice score 74 (68-78). Good knowledge predictors were >20 years working experience [OR: 2.05 (95% CI: 1.03-4.06); P=0.04] and >50% working in clinical practice [OR: 1.72 (95% CI: 1.12-2.66); P=0.01], in inverse relationship with paramedical professions [OR: 0.45 (95% CI: 0.45 (0.28-0.72)); P=0.001] and working in a university hospital [OR: 0.51 (95% CI: 0.33. 0.81); P=0.004]. Availability of pharmaceutical information and treatment options was associated with good attitude [OR: 2.19 (95% CI: 1.04-4.59); P=0.039] and acquaintance as primary information sources negatively associated with good attitude [OR: 0.34 (95% CI: 0.15-0.8); P=0.013]. Good practice predictors were female gender [OR: 3.84 (95% CI: 2.37-6.24); P<0.001], military hospital employment [OR: 2.32 (95% CI: 1.25-4.31); P=0.008], USA [OR: 3.41 (95% CI: 1.03-11.22); P=0.044] or UK [OR: 8.86 (95% CI: 1.91-41.07); P=0.005] qualifications, and information on supportive measures [OR: 2.2 (95% CI: 1.36-3.56); P=0.001]. CONCLUSION: Health workers displayed good knowledge about COVID-19, while profession and working experience predicted adequate knowledge, positive attitude, or practice towards disease management.

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