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J Antimicrob Chemother ; 76(2): 283-285, 2021 01 19.
Article in English | MEDLINE | ID: covidwho-889571

ABSTRACT

Severe COVID-19 is a biphasic illness, with an initial viral replication phase, followed by a cascade of inflammatory events. Progression to severe disease is predominantly a function of the inflammatory cascade, rather than viral replication per se. This understanding can be effectively translated to changing our approach in managing the disease. The natural course of disease offers us separate windows of specific time intervals to administer either antiviral or immunomodulatory therapy. Instituting the right attack at the right time would maximize the benefit of treatment. This concept must also be factored into studies that assess the efficacy of antivirals and immunomodulatory agents against COVID-19.


Subject(s)
Antiviral Agents/administration & dosage , COVID-19/drug therapy , Immunomodulation/drug effects , Immunosuppressive Agents/administration & dosage , Time-to-Treatment , Antiviral Agents/therapeutic use , COVID-19/immunology , COVID-19/virology , Cytokines/blood , Disease Progression , Humans , Immunomodulation/immunology , Immunosuppressive Agents/therapeutic use , SARS-CoV-2/drug effects , Virus Replication/drug effects
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