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2.
European Journal of Public Health ; 31, 2021.
Article in English | ProQuest Central | ID: covidwho-1514681

ABSTRACT

Background Mobilizing real world data from multiple data hubs in multiple countries to carry out policy-oriented research, requires orchestrating the governance of workflows, being compliant with legal and ethical requirements, and semantic harmonization and technological interoperability. In the context of PHIRI, policy-oriented research has to provide insight to policy-makers to cope with pandemics. Methods PHIRI builds this concept on the deployment of four use cases throughout a federated research infrastructure. A central hub orchestrates all the elements encompassing the development of such an infrastructure;so, a common governance model, common methodology pursuing semantic interoperability, and the development and deployment of technological solution containing ETL processes, data quality assessment solutions and data analyses, all packaged to be rolled out in the different data hubs composing the federation. Results A prototype orchestrating those workflows is being followed in four use cases: indirect effects of the pandemic on vulnerable populations, delayed breast cancer treatments due to the pandemic, perinatal health affections along the COVID19 crisis, effects of the pandemic on mental health care. A prototype of the technological platform supporting interoperable federated analyses has been prepared. Conclusions It is pertinent, feasible and reliable using a federated research infrastructure leveraging real world data from many data hubs in many countries to answer research queries on the COVID19 pandemic.

3.
European Journal of Public Health ; 31, 2021.
Article in English | ProQuest Central | ID: covidwho-1514584

ABSTRACT

Background Wide variations in COVID-19 infection and outcomes exist across Europe and within countries. PHIRI will look at COVID-19 impacts in specific subgroups by conducting research through use cases of immediate relevance for public health policies focusing on indirect effects of the pandemic related to healthcare and other policies to contain the pandemic. Furthermore, the use cases represent pilot activities for the benefits and added value of a research infrastructure by bringing together data from different European countries. Methods Four research use cases will focus on selected aspects of vulnerable population groups and risk factors, delayed medical care in cancer, perinatal health outcomes, as well as mental health outcomes and are selected based on public health importance, geographic coverage, feasibility of producing actionable insights and relevance for the PHIRI infrastructure. The use cases will demonstrate how a broad variety of secondary data (e.g. administrative and survey data) can be pooled and/or reused in a distributed way across Europe. Results The outputs of the use cases will be processed by formalizing data models, data management processes and analytical pipelines in an interoperable way to feed in the federated research infrastructure. The use cases facilitate research by making scalable, reproducible methods available within PHIRI and by publishing the FAIRified use cases analysis results on the Health Information Portal. They will provide outcomes to guide policy makers in preparedness and response scenarios and will ensure the development of a format for the timely dissemination of use case results to the targeted groups. Conclusions PHIRI will provide insights in real life use cases to generate immediate results on key health impacts of COVID-19 on population health to underpin decision making and will drive the development of the federated research infrastructure that allows rapid cycle analysis.

4.
Scienze Regionali ; 20:3-24, 2021.
Article in English | Scopus | ID: covidwho-1212700

ABSTRACT

This paper argues that for regional policies to be effective for resilience and economic diversification, a larger understanding of both the complexity of inter-regional networks and the absorptive capacities of firms in regions is needed. Using Brexit and the corona pandemic as examples of shocks, the heterogeneity of regional and sectoral impacts on firms is shown. Although exposures to and potentials of shocks can be identified for regions (speculatively, as both shocks have not materialized fully yet), translation of these into policy measures that address firms’ selective competitive needs is challenging. Many impacts are generated and distributed along market and competition relations, which are not always sensitive to (the same) place-based policies. A discussion on policies that link to a broader interpretation of resilience (of both repair and renewal) is presented, and a research agenda is adhered that more extensively explores how local policies can be implemented in the multilevel network-region-firm structure of impacts. © Società editrice il Mulino.

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