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J Infect Dis ; 225(2): 214-218, 2022 01 18.
Article in English | MEDLINE | ID: covidwho-1638018

ABSTRACT

Air pollution particulate matter (PM) is associated with SARS-CoV-2 infection and severity, although mechanistic studies are lacking. We tested whether airway surface liquid (ASL) from primary human airway epithelial cells is antiviral against SARS-CoV-2 and human alphacoronavirus 229E (CoV-229E) (responsible for common colds), and whether PM (urban, indoor air pollution [IAP], volcanic ash) affected ASL antiviral activity. ASL inactivated SARS-CoV-2 and CoV-229E. Independently, urban PM also decreased SARS-CoV-2 and CoV-229E infection, and IAP PM decreased CoV-229E infection. However, in combination, urban PM impaired ASL's antiviral activity against both viruses, and the same effect occurred for IAP PM and ash against SARS-CoV-2, suggesting that PM may enhance SARS-CoV-2 infection.


Subject(s)
COVID-19 , Coronavirus 229E, Human , Immunity, Innate , Particulate Matter/adverse effects , Urban Population , Antiviral Agents/pharmacology , COVID-19/prevention & control , COVID-19/transmission , Humans , Polymerase Chain Reaction , SARS-CoV-2 , Urban Health
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