Subject(s)

Antiviral Agents/pharmacology , Betacoronavirus/drug effects , Endoribonucleases/antagonists & inhibitors , Glucocorticoids/pharmacology , Pregnenediones/pharmacology , Viral Nonstructural Proteins/antagonists & inhibitors , Virus Replication/drug effects , Antiviral Agents/chemistry , Antiviral Agents/metabolism , Betacoronavirus/enzymology , Betacoronavirus/genetics , Binding Sites , COVID-19 , Coronavirus Infections/drug therapy , Coronavirus Infections/virology , Endoribonucleases/chemistry , Endoribonucleases/genetics , Endoribonucleases/metabolism , Gene Expression , Glucocorticoids/chemistry , Glucocorticoids/metabolism , Humans , Molecular Dynamics Simulation , Pandemics , Pneumonia, Viral/drug therapy , Pneumonia, Viral/virology , Pregnenediones/chemistry , Pregnenediones/metabolism , Protein Binding , Protein Interaction Domains and Motifs , Protein Structure, Secondary , RNA-Dependent RNA Polymerase/chemistry , RNA-Dependent RNA Polymerase/genetics , RNA-Dependent RNA Polymerase/metabolism , SARS-CoV-2 , Structural Homology, Protein , Thermodynamics , Viral Nonstructural Proteins/chemistry , Viral Nonstructural Proteins/genetics , Viral Nonstructural Proteins/metabolism