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J Neurovirol ; 27(5): 802-805, 2021 10.
Article in English | MEDLINE | ID: covidwho-1245766


Acute respiratory distress syndrome (ARDS) caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) is spreading around the world. Patients with coronavirus disease 2019 (COVID-19) typically present fever, cough, and respiratory illnesses. It has been revealed that the comorbidities can turn it into severe types, and the managements meet unpredicted complications. Here, we report a case of coronavirus disease 2019 (COVID-19) coincidence with confirmed acute Guillain-Barré syndrome (GBS). Ten days after admission and therapeutic process, the patient developed autonomic dysfunction. Despite respiratory support and receiving intravenous immunoglobulin, the patient died due to cardiac arrest. Albeit it is yet scientifically doubtful, there are raising concerns toward a possible association between GBS and SARS-CoV-2 infection, demonstrating potential neurological symptoms of COVID-19.

COVID-19/complications , Guillain-Barre Syndrome/virology , Aged , Fatal Outcome , Humans , Male , SARS-CoV-2
Mol Cell Probes ; 53: 101636, 2020 10.
Article in English | MEDLINE | ID: covidwho-621879


The recently known coronavirus, SARS-CoV-2, has turn into the greatest global health challenge, affecting a large number of societies. The lack of specific treatment and gold-standard diagnostic system has made the situation more complicated. Efforts have led to production of several diagnostic kits that are associated with limitations such as inadequate sensitivity and accuracy. Aptamers as multipotent biological probes could be promising candidates to design sensitive and specific biosensors. Although few studies have introduced specific aptamer types of coronavirus, they may help us select the best approach to obtain specific aptamers for this virus. On the other hand, some of already-introduced aptamers have shown the inhibitory effects on coronavirus that could be applied as therapeutics. The present study has provided a systematic overview on use of aptamer-based biosensors and drugs to diagnose and treat coronavirus.

Antiviral Agents/therapeutic use , Aptamers, Nucleotide/therapeutic use , Biosensing Techniques , Coronavirus Infections/diagnosis , Coronavirus Infections/drug therapy , Antiviral Agents/metabolism , Aptamers, Nucleotide/metabolism , COVID-19 , Humans , Pandemics , Pneumonia, Viral/diagnosis , Pneumonia, Viral/drug therapy