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1.
Neurologia Argentina. ; 2022.
Article in English, Spanish | EMBASE | ID: covidwho-2061706

ABSTRACT

Introduction: The SARS-CoV-2 coronavirus has been a challenge for public health, establishing the vaccine as the best tool for its prevention. Clinical case: We present the case of a patient in whom Miller Fisher syndrome was documented after receiving her booster dose with the Oxford-AstraZeneca vaccine. Conclusion(s): At the moment, a causal relationship between vaccination against COVID-19 and the development of Miller Fisher syndrome cannot be established, but knowledge of this potential adverse effect is relevant for early diagnosis and timely treatment. Copyright © 2022 Sociedad Neurologica Argentina

3.
Atencion Familiar ; 29(3):180-185, 2022.
Article in Spanish | EMBASE | ID: covidwho-1998141

ABSTRACT

Objective: to identify depressive symptomatology and job satisfaction in family physicians at the Family Medicine Unit No. 49 in Celaya, Guanajuato, Mexico.Methods: cross-sectional analytical study conducted from December 2020 to February 2021, 51 family physicians participated, the Beck-ii inventory was used to measure depression and the general scale of Warr, Cook and Wall to determine job satisfaction. Results: the age of the participants was 38.5 } 5.9 years, with a predominance of 54.9% women. Minimal depression was identified in 92.2% of participants and mild depression in 7.8%;in relation to job satisfaction, intrinsic factors were presented in a range of 27 to 47 points and extrinsic factors in a range of 34 to 54 points;depression and job satisfaction had a correlation of r=-0.40, p<0.01, indicating that as physicians experienced more job satisfaction they presented relatively less depression;there were no statistically significant differences with respect to gender and age group with depression and job satisfaction. Conclusions: no moderate or severe depressive symptomatology was reported, participants showed high job satisfaction. Age and gender did not correlate with the two variables of interest during one of the most important peaks of the covid-19 pandemic in Mexico.

4.
Movement Disorders Clinical Practice ; 9(SUPPL 1):S39, 2022.
Article in English | EMBASE | ID: covidwho-1925961

ABSTRACT

Objective: We aimed to assess whether SARS-CoV2 vaccines have any positive or negative impact on motor symptoms in PD patients. Background: Studies focusing on the relationship between SARSCoV- 2, COVID-19 and PD have provided conflicting results (1). Recently, few cases of severe dyskinesia after receiving BNT162b2 mRNA vaccine have been reported but there is no data about impact of vaccines on motor symptoms in larger series of PD patients (2). Methods: We reviewed the charts of the last two months of consecutive PD patients who were attended monthly by telemedicine during the pandemic and who had received one or two doses of any of the SARSCoV- 2 vaccines available in Peru (BNT162b2, Pfizer/BioNTech and BBIBP-CorV, Sinopharm). We specifically searched for any reported variation on motor symptoms including dyskinesia during a period of at least three days after any of each dose. Results: One hundred eighty-one PD patients met inclusion criteria. 107 males and 74 females were included. Mean age was 65 years old (range 31-99). 178 patients received two doses of SARSCoV2 vaccine (177 Pfizer/BioNTech and 1 Sinopharm respectively) and three patients received only one dose of Pfizer/BioNTech vaccine. Eleven patients (6%) had COVID19 infection during the pandemic. The effect of the infection on parkinsonian symptoms was not evaluated in this report. Only two patients (1.1%) reported some degree of exacerbation following one of the dose of the vaccine. First one presented with increased rigidity and gait impairment soon after the first dose and the second case presented with increased resting tremor that lasted for two weeks also after the first dose. In both cases exacerbation improved spontaneously. Conclusion: The approved mRNA-based vaccines and viral vector vaccines are not expected to interact with the neurodegenerative process nor modify motor symptoms in PD. SARS-CoV-2 vaccines are not known neither to interfere with the current therapies for PD. Some patients have developed exacerbation of motor symptoms or severe dyskinesia after vaccination and the reasons remain unclear but they might be explained by triggering a systemic inflammatory response, by stress or excessive anxiety or due to modification of habitual medication response. These very low incidence should not discourage patients to receive vaccines and we recommend COVID-19 vaccination with approved vaccines for persons with PD, unless there is a specific contraindication.

5.
Revista Universidad Y Sociedad ; 14:19-26, 2022.
Article in Spanish | Web of Science | ID: covidwho-1913272

ABSTRACT

This study aims to determine the prevalence of taste disorders in patients diagnosed positive for COVID 19 infection in the San Luis Grande urban center. For this purpose, a descriptive and cross-sectional study was designed, with a sample of 292 patients through the use of surveys. Through the analysis of the data collected, the presence of several types of taste disorders was observed in the sample analyzed, with a prevalence of ageusia in the study sample. The results suggest that hypogeusia occurred suddenly in 53.3% of the cases reported, while ageusia and dysgeusia appear as symptoms mostly between the first and third day (56.7% and 43.3% respectively). It was also observed that the disorders analyzed had a predominant duration of 8 to 15 days. On the other hand, there was a predominance of reported cases of ageusia (48.03%) in the age groups 18 to 35, a prevalence of cases of hypogeusia in the age groups 36 to 55, while in the age range 56 to 70 there was a predominance of dysgeusia (31.67%).

6.
Revista Cubana de Salud y Trabajo ; 23(2):3-14, 2022.
Article in Spanish | CAB Abstracts | ID: covidwho-1864149

ABSTRACT

Introduction: COVID-19 has posed a challenge to labor activities in the world favoring the modality of online work, as an alternative to avoid being present and thus increasing the transmission of SARS-CoV-2. The social behaviors of workers and administrations are associated with the risk perception regarding COVID-19.

7.
PubMed; 2020.
Preprint in English | PubMed | ID: ppcovidwho-333553

ABSTRACT

BACKGROUND: The absence of systematic surveillance for SARS-CoV-2 has curtailed accurate appraisal of transmission intensity. Our objective was to perform case detection of an entire rural community to quantify SARS-CoV-2 transmission using PCR and antibody testing. METHODS: We conducted a cross-sectional survey of the prevalence and cumulative incidence of SARS-CoV-2 infection in the rural town of Bolinas, California (population 1,620), four weeks following shelter-in-place orders. Residents and county essential workers were tested between April 20th-24th, 2020. Prevalence by PCR and seroprevalence combining data from two forms of antibody testing were performed in parallel (Abbott ARCHITECT IgG to nucleocapsid protein and in-house IgG ELISA to the receptor binding domain). RESULTS: Of 1,891 participants, 1,312 were confirmed Bolinas residents (>80% community ascertainment). Zero participants were PCR positive. Assuming 80% sensitivity, it would have been unlikely to observe these results (p<0.05) if there were >3 active infections in the community. Based on antibody results, estimated prevalence of prior infection was 0.16% (95% CrI: 0.02%, 0.46%). Seroprevalence estimates using only one of the two tests would have been higher, with greater uncertainty. The positive predictive value (PPV) of a positive result on both tests was 99.11% (95% CrI: 95.75%, 99.94%), compared to PPV 44.19%-63.32% (95% CrI range 3.25%-98.64%) if only one test was utilized. CONCLUSIONS: Four weeks following shelter-in-place, active and prior SARS-CoV-2 infection in a rural Northern California community was extremely rare. In this low prevalence setting, use of two antibody tests increased the PPV and precision of seroprevalence estimates.

8.
PubMed; 2020.
Preprint in English | PubMed | ID: ppcovidwho-333508

ABSTRACT

BACKGROUND: Serological tests are crucial tools for assessments of SARS-CoV-2 exposure, infection and potential immunity. Their appropriate use and interpretation require accurate assay performance data. METHOD: We conducted an evaluation of 10 lateral flow assays (LFAs) and two ELISAs to detect anti-SARS-CoV-2 antibodies. The specimen set comprised 128 plasma or serum samples from 79 symptomatic SARS-CoV-2 RT-PCR-positive individuals;108 pre-COVID-19 negative controls;and 52 recent samples from individuals who underwent respiratory viral testing but were not diagnosed with Coronavirus Disease 2019 (COVID-19). Samples were blinded and LFA results were interpreted by two independent readers, using a standardized intensity scoring system. RESULTS: Among specimens from SARS-CoV-2 RT-PCR-positive individuals, the percent seropositive increased with time interval, peaking at 81.8-100.0% in samples taken >20 days after symptom onset. Test specificity ranged from 84.3-100.0% in pre-COVID-19 specimens. Specificity was higher when weak LFA bands were considered negative, but this decreased sensitivity. IgM detection was more variable than IgG, and detection was highest when IgM and IgG results were combined. Agreement between ELISAs and LFAs ranged from 75.7-94.8%. No consistent cross-reactivity was observed. CONCLUSION: Our evaluation showed heterogeneous assay performance. Reader training is key to reliable LFA performance, and can be tailored for survey goals. Informed use of serology will require evaluations covering the full spectrum of SARS-CoV-2 infections, from asymptomatic and mild infection to severe disease, and later convalescence. Well-designed studies to elucidate the mechanisms and serological correlates of protective immunity will be crucial to guide rational clinical and public health policies.

9.
J. Psychopathol. ; 28(1):27-29, 2022.
Article in English | Web of Science | ID: covidwho-1791267

ABSTRACT

Objective To evaluate the feasibility of remotely providing a diagnosis of autism during the Coronavirus Disease pandemic of 2019. Methods A child psychiatrist guided the parents' Autism Diagnostic Observation Schedule (ADOS-2) administration to assess their child's developmental delay through a video conference. Trained clinicians (n = 10) rated the recorded procedure. Interrater reliability for each item was evaluated using the kappa statistic and percent agreement. Results The mean percent agreement across all items was 96%, range = 85.96-100%, and mean weighted kappa = .81, range = .44-1. Conclusions This study highlights the feasibility of providing early identification and continuous psychiatric care during a pandemic lockdown.

10.
Rev Med Inst Mex Seguro Soc ; 60(1):59-66, 2022.
Article in Spanish | PubMed | ID: covidwho-1733081

ABSTRACT

BACKGROUND: Patients with SARS-CoV-2 present signs and symptoms that primarily involve the respiratory system. The sequelae result in impaired quality of life, pneumonia, dyspnea, fatigue, and joint pain. OBJECTIVE: To sustain with scientific evidence the importance of respiratory physiotherapy and its effects on post-acute COVID-19 adult patients. MATERIAL AND METHODS: A systematic review was conducted in four databases (Scopus, Web of Science, PubMed, and ScienceDirect). The searching period was carried out in February 2021 with a total of one 1229 potential studies. Finally, 5 studies that met the eligibility criteria were included: two clinical trials, two case reports and one cross-sectional study. The methodological quality of the articles was evaluated. RESULTS: Respiratory muscle training, targeted breathing, and strength training provide significant data of improvement of functional performance. Evidence shows positive effects of respiratory physiotherapy in post-acute COVID-19 adult patients, since it increases resistance to exercise, it decreases fatigue, reduces dyspnea, improves functionality and quality of life. CONCLUSIONS: More future studies, such as randomized controlled trials, studies including lower age range groups, and individualized approaches, need to be developed.

11.
PubMed; 2022.
Preprint in English | PubMed | ID: ppcovidwho-329057

ABSTRACT

Background: The COVID-19 pandemic is dominated by variant viruses;the resulting impact on disease severity remains unclear. Using a retrospective cohort study, we assessed the hospitalization risk following infection with seven SARS-CoV-2 variants. Methods: Our study includes individuals with positive SARS-CoV-2 RT-PCR in the Washington Disease Reporting System with available viral genome data, from December 1, 2020 to January 14, 2022. The analysis was restricted to cases with specimens collected through sentinel surveillance. Using a Cox proportional hazards model with mixed effects, we estimated hazard ratios (HR) for hospitalization risk following infection with a variant, adjusting for age, sex, calendar week, and vaccination. Findings: 58,848 cases were sequenced through sentinel surveillance, of which 1705 (2.9%) were hospitalized due to COVID-19. Higher hospitalization risk was found for infections with Gamma (HR 3.20, 95%CI 2.40-4.26), Beta (HR 2.85, 95%CI 1.56-5.23), Delta (HR 2.28 95%CI 1.56-3.34) or Alpha (HR 1.64, 95%CI 1.29-2.07) compared to infections with ancestral lineages;Omicron (HR 0.92, 95%CI 0.56-1.52) showed no significant difference in risk. Following Alpha, Gamma, or Delta infection, unvaccinated patients show higher hospitalization risk, while vaccinated patients show no significant difference in risk, both compared to unvaccinated, ancestral lineage cases. Hospitalization risk following Omicron infection is lower with vaccination. Conclusion: Infection with Alpha, Gamma, or Delta results in a higher hospitalization risk, with vaccination attenuating that risk. Our findings support hospital preparedness, vaccination, and genomic surveillance. Summary: Hospitalization risk following infection with SARS-CoV-2 variant remains unclear. We find a higher hospitalization risk in cases infected with Alpha, Beta, Gamma, and Delta, but not Omicron, with vaccination lowering risk. Our findings support hospital preparedness, vaccination, and genomic surveillance.

12.
European Journal of General Practice ; 27(1):358, 2021.
Article in English | EMBASE | ID: covidwho-1612364

ABSTRACT

Background: Olfactory and taste dysfunction (OD and TD) have been considered symptoms of SARS-CoV-2 infection. Although these clinical features may occur prior to the general symptoms of such infection, their presence in specific populations, especially those with mild symptoms, has not been clarified. This study aimed to estimate the frequency of OD and TD, and its predictive validity in patients with SARS-CoV-2 infection detected in primary care. Research question: What is the frequency of OD and TD, and its predictive validity in patients with SARS-CoV-2 infection detected in primary care? Methods: A cross-sectional study was carried out in the Spanish National Health System through an epidemiological survey administered to patients who required an RT-PCR test (real-time polymerase chain reaction in a nasal/pharyngeal swab) to detect SARS-CoV-2. Odds Ratio(OR)(s) were estimated to measure the magnitude of the association between OD or TD, and the presence of SARS-CoV-2 infection. The study sample also calculated the sensitivity, specificity, and positive and negative predictive values (PPV, NPV) of these symptoms. Results: Of 1038 patients screened, 209 (20.1%) had SARS-CoV-2 infection. OD and DG were detected in 64.4% (95% CI: 56.0-72.1) and 56.2% (95% CI: 47.9-64.2) of subjects with infection, respectively. The OR for OD and TD was 12.2 (95% CI: 8.26-18.06) and 7.95 (95% CI: 5.48-11.53), respectively. OD showed a sensitivity of 45.0% (95% CI: 37.6-51.5), a specificity of 93.7% (95% CI: 91.8-95.0), a PPV of 64.4% (95% CI: 56.0-72.1), and a NPV of 87.1% (95% CI: 84.7-89.2) while the TD presented a sensitivity of 41.1% (95% CI: 34.4-46.1), a specificity of 91.9% (95% CI: 89.8-93.7), a PPV of 56.2% (95% CI: 48.0-64.2) and a NPV of 86.1% (95% CI: 83.6-88.3). Conclusion: More than half of the subjects with SARS-CoV-2 infection have olfactory or taste dysfunction. These clinical features could be considered of diagnostic utility due to their ability to predict infection in more than half of the cases.

13.
Revista Medica del Instituto Mexicano del Seguro Social ; 59(5):412-416, 2021.
Article in Spanish | MEDLINE | ID: covidwho-1589945

ABSTRACT

Background: Mental health problems derived from the COVID-19 pandemic, including depression, anxiety, and stress, need to be identified. Objective: To validate and adapt the COVID-19 Anxiety Scale (CAS) into Spanish. Material and methods: A cross-sectional study was carried out in a total of 303 individuals who answered the Covid-19 Anxiety Scale. Antibody tests for SARS-CoV-2 were identified as a secondary comparison. Results: It was carried out the cross-cultural validation process recommended by the American Academy of Orthopeadic Surgeon (AAOS). It was obtained a Cronbach's alpha of 0.8493 (with an average interitem covariance of 0.2620). Conclusions: It was achieved a valid Spanish version of CAS to be used in routine clinical practice.

14.
International Journal of Data and Network Science ; 6(1):59-66, 2022.
Article in English | Scopus | ID: covidwho-1598982

ABSTRACT

The present study's main objective was to analyze and determine the impact of digital marketing on the management of relationships with university students in times of Covid-19. The study was conducted from a quantitative approach, with a non-experimental transactional correlational transactional research design. A questionnaire was applied to 400 students aged 18 to 37 years belonging to the Continental University of the city of Huancayo in Peru. The analysis of the results was developed through a data structure and tabulation model with the SmartPLS3 program and it was obtained that Content Marketing has a significant influence on the operational management of customer relationships (p<0.05), as well as on the analytical and collaborative management of customer relationships. As for Social Media Marketing, it was identified that it has a significant influence on operational customer relationship management (p<0.05), as well as on analytical and collaborative customer relationship management, due to the fact that the digital media used by Continental University are attractive to parents and families. It is concluded that Digital Marketing has a great impact on the management of relationships with students of the Continental University in the city of Huancayo in Peru. © 2022 by the authors;licensee Growing Science, Canada.

15.
Revista Cubana de Pediatria ; 93(3), 2021.
Article in Spanish | Scopus | ID: covidwho-1573342

ABSTRACT

Introduction: COVID-19 is a disease that has shown low morbidity and mortality in pediatrics. Febrile crises are one of the most common causes of admission to emergency services and consultations with the neuropediatrician. Objective: Interpret the presence of simple febrile crisis in patients admitted to pediatric emergency services as an initial manifestation of COVID-19. Case presentation: One-year-old female patient, with a previous health history, who is attended in the emergency service with a fever of 38 ℃ and motor crisis, of widespread onset, with tonic-clonic seizures, which yielded with antypiretic measures. By protocol, lumbar puncture is performed which is negative. She was admitted, and 24 hours later there is an onset of catarrhal manifestations;an otoscopy is performed and acute otitis media is diagnosed, so antibiotic treatment is initiated. The polymerase chain reaction test for COVID-19 (PCR) is performed with a positive result, so, the patient is referred to the "San Miguel del Padrón" Pediatric Hospital. Conclusions: COVID-19 should be suspected in patients who attend to the emergency services due to a febrile crisis as the only health problem. COVID-19 is a disease that has been shown to occur in a variety of ways. © 2021, Editorial Ciencias Medicas. All rights reserved.

16.
Psychology Public Policy and Law ; 27(4):522-536, 2021.
Article in English | Web of Science | ID: covidwho-1557680

ABSTRACT

In this article, we briefly discuss how competency to proceed evaluations are conducted within the state of Colorado, the impact that COVID-19 had on forensic evaluations within the Colorado forensic services system, and the acquisition and adoption of videoconferencing (VC) capabilities. We then shift to an in-depth consideration of how VC forensic evaluations are facilitated in four different contexts: for adult defendants in custody, on bond, and in hospitals, and for juvenile defendants. Challenges and limitations are also addressed.

17.
EuropePMC; 2021.
Preprint in English | EuropePMC | ID: ppcovidwho-296167

ABSTRACT

ABSTRACT Background SOBERANA 02 is a COVID-19 conjugate vaccine (recombinant RBD conjugated to tetanus toxoid). Phase 1 and 2 clinical trials demonstrated its high immunogenicity, promoting neutralizing IgG and specific T-cell response. A third dose, of SOBERANA Plus (RBD-dimer), further increased the specific anti-RBD neutralizing antibodies. Methods In a randomized, double-blind, placebo-controlled, phase-3 trial ( https://rpcec.sld.cu/trials/RPCEC00000354-En ) we randomly assigned 44 031 participants, aged 19–80 years to three groups to receive a) two doses, SOBERANA 02, or b) two doses, SOBERANA 02 and a third dose, SOBERANA Plus, or c) placebo. Study endpoints are vaccine efficacy (VE) evaluated through confirmed symptomatic COVID-19 and safety. During the trial, the SARS CoV-2 isolates in Havana were 74.0 % β, shifting gradually to 100% δ. Results Two doses of SOBERANA 02 protected against symptomatic COVID-19: 43 cases in the two-dose group (14 371) vs. 155 in the placebo group (14 403), VE 71.0%, adjusted (CI 95%, 58.9–79.1). The heterologous three-dose combination increased the protection: 15 cases in the vaccine groups (13 833) vs. 155 in the placebo group (14 303), VE 92.4%, adjusted (CI 95%, 86.9–95.6%). For the two-dose schedule, VE against severe COVID-19 was 63.0% and for death, 59.0%;for the heterologous three-dose schedule, VE was 100% in both cases. Conclusions This is the first phase-3 study of a three-dose, heterologous COVID-19 vaccine. Two doses of SOBERANA 02 were safe and attained efficacy of 71.0% in the adult population 19-80 y/o;incorporating SOBERANA Plus increased efficacy from 71.0 % to 92.4%.

18.
PUBMED; 2021.
Preprint in English | PUBMED | ID: ppcovidwho-293066

ABSTRACT

Background: The COVID-19 pandemic is now dominated by variant lineages;the resulting impact on disease severity remains unclear. Using a retrospective cohort study, we assessed the risk of hospitalization following infection with nine variants of concern or interest (VOC/VOI). Methods: Our study includes individuals with positive SARS-CoV-2 RT-PCR in the Washington Disease Reporting System and with available viral genome data, from December 1, 2020 to July 30, 2021. The main analysis was restricted to cases with specimens collected through sentinel surveillance. Using a Cox proportional hazards model with mixed effects, we estimated hazard ratios (HR) for the risk of hospitalization following infection with a VOC/VOI, adjusting for age, sex, and vaccination status. Findings: Of the 23,563 cases, 22,068 (93.7%) were sequenced through sentinel surveillance, of which 582 (2.6%) were hospitalized due to COVID-19. Higher hospitalization risk was found for infections with Gamma (HR 3.23, 95% CI 2.19-4.76), Beta (HR 3.03, 95% CI 1.68-5.47), Delta (HR 2.35, 95% CI 1.72-3.22), and Alpha (HR 1.61, 95% CI 1.28-2.03) compared to infections with an ancestral lineage. Following VOC infection, unvaccinated patients show a similar higher hospitalization risk, while vaccinated patients show no significant difference in risk, both when compared to unvaccinated, ancestral lineage cases. Interpretation: Infection with a VOC results in a higher hospitalization risk, with an active vaccination attenuating that risk. Our findings support promoting hospital preparedness, vaccination, and robust genomic surveillance.

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