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1.
Non-conventional in English | National Technical Information Service, Grey literature | ID: grc-753661

ABSTRACT

Year 2 focused on completing pre-trial activities, including finalizing the clinical and control PTSD interventions, corresponding counselor manuals, research protocols, recruitment advertisements, and recruitment plan. Year 2-4 have primarily focused on randomized controlled trial (RCT) activities (Phase 2), including recruitment, enrollment and data collection that began in January 2018. We obtained necessary approvals for Phase 2 from University of Washington IRB, Madigan IRB, and HRPO.

2.
Non-conventional in English | National Technical Information Service, Grey literature | ID: grc-753660
3.
Non-conventional in English | National Technical Information Service, Grey literature | ID: grc-753659

ABSTRACT

We and others previously described an enrichment for somatic and germline alterations in DNA damage repair (DDR) genes among men with metastatic prostate cancer. Several recent clinical studies have indicated many of these patients could benefit from precision medicine strategies with PARP inhibitors and DNA damaging agents. In this project, our teams would investigate genomic, transcriptomic and protein related functional signatures for a more accurate sub-classification of prostate cancers associated to DDR defects, aiming for a more precise patient care. The project is divided in 3 main aims: 1) testing the prognostic value of somatic DDR defects in a retrospective cohort of tumor biopsies, 2) developing multi-omics signatures based on prospective analyses of metastatic biopsies and 3) clinical validation of these biomarkers in a clinical trial using carboplatin as DNA damaging chemotherapy.

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