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1.
Nanotechnological Applications in Virology ; : 235-252, 2022.
Article in English | Scopus | ID: covidwho-2035634

ABSTRACT

Since the outbreak of the novel SARS-CoV-2, i.e., in December 2019, in Wuhan, China, more than 110 million cases have been reported, with 2.5 million deaths worldwide. It is not the first time, earlier in 2002–2003 SARS-CoV and in 2010 MERS-CoV outbreaks were reported. However, in 2019 novel SARS-CoV-2 outbreak prevailed to a great extent worldwide. Still, we are in the middle of a pandemic and seek effective vaccines and therapeutics for prevention and complete cure, respectively. There are new strains of novel SARS-CoV2 reported in a different part of the world. Considering the research data and statistics from CDC and WHO, the novel SARS-CoV-2 is the second most deadly viral outbreak after the Spanish Flu in 1918. Compared to previous coronavirus outbreak cases, the novel SARS-CoV-2 attack was reported to be more transmissible but less fatal. Among the top five countries worst affected by novel SARS-CoV-2 infection and mortality are the United States, India, Brazil, Russia, and the United Kingdom. Similarly, many countries in Europe, including Spain and Italy have endured a similar impact with viral outbreaks. The pandemic started in China and traveled to Europe, the United States and the American continent, and many Asian countries, including Russia and India, which are “hot spots” for virus infection and disease outbreak. In the first wave of the virus outbreak, many countries including China, South Korea, Japan, New Zealand, etc., successfully controlled and contained the virus, using strict social distancing and other containment measures. The reproductive number (R 0) and fatality rate of COVID-19 disease caused by novel SARS-CoV-2 infection vary among different populations. However, infection and disease are a function of several risk factors, including age, sex, comorbidity, and strain of novel SARS-CoV-2. Simultaneously, there is a massive effort in research for diagnostic, therapeutic, and vaccine development. It was the first time in human history where a clinical diagnosis was implemented very early in the case of a pandemic. Several antiviral drugs, antiinflammatory agents, immune modulators, and vitamins were used to control the COVID-19 disease. © 2022 Elsevier Inc. All rights reserved.

2.
Library Hi Tech ; 2022.
Article in English | Scopus | ID: covidwho-1874123

ABSTRACT

Purpose: Mucormycosis has evolved as a post-COVID-19 complication globally, especially in India. The research on fungus has been very primitive, and many scientific publications have been discovered. The current COVID-19 pandemic needs further investigation into this unusual fungal infection. This review study aims to provide a pen-picture to researchers, science policymakers and scientists about different bibliometric indicators related to the research literature on mucormycosis. Design/methodology/approach: The quantitative research was conducted using the established procedure of bibliometric investigation on data collected from Scopus from 2011 to 2020 using a validated search query. The search query consisted of keywords “Mucormycosis” or “Mucormycoses” or “Mucormycose” or “Mucorales Infection” or “Mucorales Infections” or “Black Fungus Infection” or “Black Fungus Infections” or “Zygomycosis” in the “Title-Keyword-” search option for data extraction. The analysis of data is performed using MS-Excel. Mapping was done with state-of-the-art visualization tools Biblioshiny and VOSviewer, using bibliometric indicators as units of analysis. Findings: The analysis reveals that the first publication on this topic was reported from 1923 onwards. In total, 9,423 authors contributed 1,896 papers with 11,437 collaborated authors, documents per author are 0.201, authors per document are 4.97 and co-authors per document are 6.03. Total records were published in 779 journals in the English language from 75 countries globally. Mucormycosis literature is mostly open access, with 1,210 publications available via different open access routes. The highest number of articles (204) published in the journal “Mycoses” with 1,333 authors received 4,875 cited references, and the h-index has 24. The growth of publications is exponential, as depicted by the Price Law. The USA has recorded a maximum number of publications at both country and institutional levels compared to the other nations. There has been extensive research on mucormycosis before the outbreak as a post-COVID complication, as indicated by the highest number of publications in 2019. Practical implications: The research hot spots have altered from “Mucormycosis,” “fungi,” “Zygomycosis” and “Drug efficacy”, “Drug Safety” to “Microbiology,” “Pathology,” “nucleotide sequence,” “surgical debridement” which indicates that potential area of research in the near future will be concerned with more extensive research in mucormycosis to develop standard treatment procedures to fight this infection. The quantity of scientific publications has also increased over time. The research and health community are called upon to join forces to activate existing knowledge, generate new insights and develop decision-supporting tools for health authorities in different nations to leverage vaccination in its transformational role toward successfully attaining nil cases of COVID-19. Originality/value: The analysis of collaboration, findings, the research networks and visualization makes this study novel and separates from traditional metrics analysis. To the best of the authors’ knowledge, this work is original, and no similar studies have been found with the objectives included here. © 2022, Emerald Publishing Limited.

3.
Journal of Clinical and Diagnostic Research ; 15(11):OI1-OI3, 2021.
Article in English | Web of Science | ID: covidwho-1538818

ABSTRACT

Coronavirus Disease 2019 (COVID-19) is a respiratory and systemic illness that may progress to severe Acute Respiratory Distress Syndrome (ARDS). There is a pressing need to identify clinical predictors of severe COVID-19 which can help in risk stratification and prognostication. The COVID-19 pandemic tends to have more severe clinical presentation in older age group and in chronic diseases;Chronic Obstructive Pulmonary Disease (COPD) is one of them. COPD is the common cause of high mortality and morbidity worldwide. It is obvious to fear for patients with underlying COPD. Acute episode of exacerbation and COVID-19 pneumonia are the two pivotal differential diagnoses in contemporary era, in patients of COPD presenting with worsening dyspnoea. Mortality rate have been higher among COPD group of patients with the development of hypoxemia. Literature shows that pre-existing COPD worsens the risk of COVID-19 progression and leads to poorer prognosis. Even after recovery from the acute event, proper adherence to maintenance therapy for COPD (inhalational agents) continues to be of paramount importance and remains the standard of care. Because COPD remains a subset that is highly vulnerable for adverse outcomes with COVID-19 infection, preventive therapy should be directed towards-attenuation of contact with droplets, proper hand hygiene and maintenance of adequate nutritional status. The aim of this brief review is to know the burden and impact of COPD on COVID-19 pandemic and challenges in diagnosis and management of COPD patients.

4.
J. Pure Appl. Microbiol. ; 1(14): 775-788, 20200523.
Article in English | WHO COVID, ELSEVIER | ID: covidwho-1395571

ABSTRACT

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-Cov-2), a new enveloped RNA virus known as Coronavirus (COvID-19) are most prevalent in humans and wild animals. All four species that is alpha, beta, delta and theta have been identified till date and are responsible for human disease; causing influenza like illness (ILI). This virus has similar lineage of Middle East Respiratory Syndrome coronavirus (MERS-CoV) and related Coronavirus (SARS-CoV). This outbreak initially presented as pneumonia-like illness in a group of people in Wuhan, China. The infection was said to be caused by seafood and unusual animals in the wholesale markets of this city. SARS-CoV-2 is highly infectious and has resulted in a rapid pandemic. As of now it has spread to 197 countries with total no of cases in the world being 3.76 million as of early march. The mortality till now is 7.11% . The cases have been increasing since its first discovery in China. In India also the number has been increased. Till now India has total of 39,980 cases and mortality is attributed to be 3.26%. As per data from Ministry of health and family welfare (MoHFW) death is more commonly seen in males with age >60years. Among these most of the deaths were related to other co-morbid conditions. This article will help the readers with an overview of novel Coronavirus spanning around the clinical features, diagnostic modalities, treatment strategies and infection control measures. It will also help in raising awareness among healthcare workers regarding COVID-19 and aid in early recognition of these patients. Moreover, this review will also focus on the most recent information for the effective management, prevention, and treatment of patients worldwide.

5.
Int J Pept Res Ther ; 27(3): 1633-1640, 2021.
Article in English | MEDLINE | ID: covidwho-1139372

ABSTRACT

The realm Riboviria constitutes Coronaviruses, which led to the emergence of the pandemic COVID 19 in the twenty-first century affected millions of lives. At present, the management of COVID 19 largely depends on antiviral therapeutics along with the anti-inflammatory drug. The vaccine is under the final clinical phase, and emergency use is available. We aim at ACE2 and Nsp10/Nsp16 MTase as potential drug candidate in COVID 19 management in the present work. For drug designing, various computational simulation strategies have been employed like Swiss-Model, Hawk Dock, HDOCK, py Dock, and PockDrug for homology modeling, binding energies of the molecule with a target, simulate the conformation and binding poses, statistics of protein lock with target key and drug ability, respectively. The current in-silico screening depicts that the spike protein receptor is complementary to the target when bound to each other and forms a stable complex. The MMGBSA free energy binding property of receptor and ligand is critical. The intermolecular Statistics with the target Nsp10/Nsp16 MTase complex are plausible. We have also observed a high-affinity pocket binding site with the target. Therefore, the favorable intermolecular interactions and Physico-chemical properties emanate as a drug candidate treating COVID-19. This study has approached computational tools to analyze the conformation, binding affinity, and drug ability of receptor-ligand. Thus, the spike receptor with its ACE2 receptor with Nsp10/Nsp16 MTase complex would be a potent drug against SARS CoV-2 and can cure the infection as per consensus scoring.

6.
Library Philosophy and Practice ; 2020(2020):1-14, 2020.
Article in English | Scopus | ID: covidwho-1012048

ABSTRACT

COVID-19 virus originated from Wuhan city of China in December 2019. The emergence of COVID-19 the whole world and severely affected by The United States, China, Brazil, and India etc. World Health Organization (WHO) declared it as a pandemic in March 2020. Due to COVID-19, a large number of literature published in early 2020. However, very few studies address the impact of published related to literature Coronavirus. In response to the current study conducted and reviewed 20 years’ period from 2001- May 2020. A total of 14439 documents were found in the Scopus database, which was published during the study period i.e. 2001- May 2020. The study found that The United States 9973 contributed the highest number of published literature on Coronavirus followed by China. Overall, the USA, China, Germany, The UK, Canada, South Korea accounted for most of the Coronavirus research activity at the global level. Globally, the University of Hong Kong and the Chinese University of Hong Kong ranked with first and second positions in terms of the number of publications contributed to individual institutes. The large quantity of scholarly documents related to Coronavirus has considerably increased in early 2020. © 2020. All Rights Reserved.

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