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Journal of Family Medicine and Primary Care ; 11(9):5718-5719, 2022.
Article in English | GIM | ID: covidwho-2144209
Journal of Family Medicine and Primary Care ; 11(9):5706-5707, 2022.
Article in English | CAB Abstracts | ID: covidwho-2144208
Journal of Family Medicine and Primary Care ; 11(9):5708-5709, 2022.
Article in English | CAB Abstracts | ID: covidwho-2144206
Journal of Pacific Rim Psychology ; 16:18, 2022.
Article in English | Web of Science | ID: covidwho-1886894


While most studies have been reporting the psychological issues being faced by the public due to the global spread of coronavirus and sudden restrictions and changes accompanying it, the present study attempted to explore dynamic human experiences during the COVID-19 pandemic and resultant lockdown, so as to understand the psycho-social factors that acted as adaptive resources or as buffers to maintain a stable mental state amidst this crisis. In-depth telephonic interviews with 30 participants were conducted to explore their experiences in dealing with the COVID-19 pandemic and the lockdown. Thematic analysis performed to identify the positive and protective factors that helped people adapt in a healthy way revealed that although the initial response of the participants to the pandemic was "optimistic bias" followed by downplaying the seriousness of the issue, later they demonstrated increased realization and acceptance to the seriousness of the situation. Upon realizing the situation, their positive psychological resources acted as a buffer against the ill effects of the pandemic, and they used both cognitive and behavioral coping. The study clearly demonstrates that crisis in life is not just a source of stress, anxiety, and uncertainty but also an opportunity to test one's psychological resources to learn and grow.

Fabad Journal of Pharmaceutical Sciences ; 46(2):147-158, 2021.
Article in English | EMBASE | ID: covidwho-1486901


The current eruption of the novel severe acute respiratory syndrom causing coronavirus 2 (SARS-CoV-2) is an atrocious health tragedy. In this virulent disease, the computational approach appears to be the most hopeful choice to make out an efficient remedial medicinal agent for the treatment of an infected population. This current exploration inclined to analyze the similar druggable compounds as hydroxychloroquine to combat unworn coronavirus (COVID-19), using a pharmacoinformatics study. Docking-based virtual screening was carried-out using Glide, followed by Absorption Distribution Metabolism Excretion (ADME) anticipation. Hydroxychloroquine is being used as the criterion for comparison as it showed potential effect for symptomatic relief. Target-based virtual screening study divulged 28 top-ranked compounds based on their binding energy and dock score from 10695 PubChem compounds. In the additional weed-out process, 07 compounds were selected based on their similar interactions as hydroxychloroquine, comparable binding energy, and shape complementarity of the binding pocket of 6LU7. The three-dimensional binding pose of screened 07 hits and their chemo-essential features were successfully matched with reference compound. These candidates showed potential interactions with the amino acid residues of the active site of SARS-CoV-2 (PDB ID 6LU7). Therefore, they may have the capability as lead compound(s) against COVID-19.