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2.
Allergy: European Journal of Allergy and Clinical Immunology ; 78(Supplement 111):302, 2023.
Article in English | EMBASE | ID: covidwho-2298036

ABSTRACT

Background: Chronic urticaria (CU) is a common chronic inflammatory disease. Vaccination against viral infections including COVID-19 can induce increased CU disease activity. As of now, it is unclear how often CU exacerbations occur after COVID-19 vaccination. Method(s): COVAC-CU is an international, multicenter, observational, cross-sectional study of the global network of urticaria centers of reference and excellence (UCAREs). COVAC-CU evaluates the effects of COVID-19 vaccination in patients with CU including rates and risk factors of CU exacerbation. Here, we analyzed 1857 patients with CU who had received at least one COVID-19 vaccination. Data were collected via a questionnaire and retrieved from patient charts. Result(s): Of 1857 patients with CU (median age: 42 years;range: 18-91 years), 72.1% were female and 71.2%, 14.4% and 14.4% had chronic spontaneous urticaria, chronic inducible urticaria, or both, respectively. Most patients had received two doses of COVID-19 vaccine (79.1%), compared to one (9.7%), three (11%), or four (0.3%). Vaccine type included: BTN162b2 (58.4%;BioNTech/Pfizer), ChAdOx1 nCOV-19 (13.8%;AstraZeneca), BBIBP-CorV (8.2%;Sinopharm), Gam-COVID- Vac (8%;Sputnik), mRNA-1273 (5.3%;Moderna), and Ad26.COV 2.5 (4.7%;Janssen/J&J). Less than 10% of patients used premedication, and less than half of patients (44.4%) reported one or more adverse reactions after vaccination. The most common adverse reactions were local injection site reactions (29.6%), fatigue (19.7%), fever (19%), muscle pain (17.9%), headache (14%), and exacerbation of CU (15%). Severe allergic reactions/anaphylaxis were reported by 0.4% of CU patients. In almost all patients who experienced exacerbation of their CU, this occurred within one week after receiving the vaccine, i.e. after 1 to 12 hours (25.8 %), after 12 hours to 48 hours (31.1%) or after 2-7 days (37.9%). Conclusion(s): Most CU patients tolerate COVID-19 vaccination well;severe allergic reaction (anaphylaxis) rates were similar or lower than the self-reported rates reported in the general population. Exacerbation of urticaria was reported in one in five patients, mostly in a week after receiving the vaccine.

3.
Danish Medical Journal ; 67(9), 2020.
Article in English | GIM | ID: covidwho-1431526

ABSTRACT

The prevalence of people infected with COVID-19 in Aarhus on 7 August can be calculated using the dark figure of seroprevalence studies and a conservative estimate of the 12-day contagiousness. This conservative estimate is based on the fact that the transmission of the disease may already begin in the Pressentomatic period, 23 days before symptoms, and even in asymptomatic patients, and is at maximum during symptomatic disease, but is unlikely after 710 days of symptoms. These numbers correspond to a prevalence ratio of 2.8%. A recent study has estimated that most individuals are infectious for about five weeks only, which is the number of infected individuals can be 4,080, producing a prevalence ratio of 1, 2%. Therefore, the risk of satisfying an individual who can transmit Sars Cov2 is in the range of one in 3686 people. These numbers and risks can be more relevant to consider when choosing to visit a disco, a football celebration or even a supermarket. This can be extended to the micro leadership, as well as macroLevel. The previous considerations are based on the presumption that the cases of accidents represent the background population and not a border subgroup. The current outbreak in the municipality of Aarhus, in Denmark, is considered limited to the access points that surround the Omnibus operations of the municipalities in an introductory course for economic students, a group of minorities and Somali participants at a football festival. However, a case was also reported in an elderly asylum and can reflect a more casual and widespread infection in the municipality. An improvement in the estimate of the prevalence calculated by the space autocortion control of the cases could be carried out. The prevalence is such a measure;And despite the uncertainties in the esteem, it can generate relevance for adherence to the recommendations of the health authorities.

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