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1.
Energies ; 16(10), 2023.
Article in English | Web of Science | ID: covidwho-20243338

ABSTRACT

The use of machine learning and data-driven methods for predictive analysis of power systems offers the potential to accurately predict and manage the behavior of these systems by utilizing large volumes of data generated from various sources. These methods have gained significant attention in recent years due to their ability to handle large amounts of data and to make accurate predictions. The importance of these methods gained particular momentum with the recent transformation that the traditional power system underwent as they are morphing into the smart power grids of the future. The transition towards the smart grids that embed the high-renewables electricity systems is challenging, as the generation of electricity from renewable sources is intermittent and fluctuates with weather conditions. This transition is facilitated by the Internet of Energy (IoE) that refers to the integration of advanced digital technologies such as the Internet of Things (IoT), blockchain, and artificial intelligence (AI) into the electricity systems. It has been further enhanced by the digitalization caused by the COVID-19 pandemic that also affected the energy and power sector. Our review paper explores the prospects and challenges of using machine learning and data-driven methods in power systems and provides an overview of the ways in which the predictive analysis for constructing these systems can be applied in order to make them more efficient. The paper begins with the description of the power system and the role of the predictive analysis in power system operations. Next, the paper discusses the use of machine learning and data-driven methods for predictive analysis in power systems, including their benefits and limitations. In addition, the paper reviews the existing literature on this topic and highlights the various methods that have been used for predictive analysis of power systems. Furthermore, it identifies the challenges and opportunities associated with using these methods in power systems. The challenges of using these methods, such as data quality and availability, are also discussed. Finally, the review concludes with a discussion of recommendations for further research on the application of machine learning and data-driven methods for the predictive analysis in the future smart grid-driven power systems powered by the IoE.

2.
Grekov's Bulletin of Surgery ; 181(4):36-42, 2022.
Article in Russian | Scopus | ID: covidwho-2326910

ABSTRACT

The OBJECTIVE was to study the process of wound healing after surgical interventions in patients with urgent surgical diseases in combination with a new coronavirus infection. METHODS AND MATERIALS. We observed for 80 patients with urgent abdominal diseases. Group I – 48 patients with various urgent diseases of the abdominal organs, group II – 32 patients with similar diseases occurring against the background of coronavirus infection. Stages of postoperative examination: 2, 4 and 7 days after surgery. The nature and rate of wound regeneration was assessed by cytological examination of wound exudate. In the tissues along the suture line, trophic indicators and microcirculation were recorded. RESULTS. The number of neutrophilic leukocytes in the wound exudate in group II exceeded the values of group I by 38.7–116.8 % with a slowed down dynamics of recovery. In the II group of patients, the number of tissue polyblasts was reduced at all stages of observation in comparison with the control group by 34.2–41.9 %. The number of lymphoid polyblasts in the main group was increased in comparison with the control group on days 2, 4, 7 of observation by 33.1 %, 63.2 %, 354.9 %, respectively. The indices of microcirculation in the tissues of the laparotomic wound in the group II of patients changed to a greater extent. The redox potential and oxygen diffusion coefficient in the group II were lower than the control figures by 9.8 – 37.2 % and 35.3 – 38.1 %, respectively. The number of complications according to the Clavien – Dindo classification in the group II of patients compared to the group I was more than 6 times higher. CONCLUSION. In patients with urgent diseases of the abdominal organs with concomitant coronavirus infection, the process of incomplete reparative tissue regeneration of the wound area slows down, which increases the risk of complications. The main factors that reduce the rate of tissue healing are disorders of microcirculation and bioenergetics. © 2022 Authors. All rights reserved.

3.
Vestnik Rossiyskoy voyenno meditsinskoy akademii ; 4:105-112, 2021.
Article in Russian | GIM | ID: covidwho-2040520

ABSTRACT

Features of variation of peripheral blood leukocyte formula parameters in 86 patients with coronavirus pneumonia with leukocytosis with a background of glucocorticoid treatment were investigated. All patients were divided into 2 groups. Group 1 was 22 individuals who showed clinical signs of the bacterial infection (purulent sputum cough in combination with neutrophilic leukocytosis at hospital the admission). The 2nd group was made up of 64 patients with the glucocorticoids developed against the background of treatment with glucocorticoids (dexamethasone 20 mg/day or prednisolone 150 mg/day, intravenously for 3 days) leukocytosis >10 x109/l without signs of a bacterial infection. It was found that in patients of the 1st group compared to the 2nd group, levels of the white blood cells and neutrophils were significantly (p < 0.001) exceeded the reference values in the absence of a significant change in the number of monocytes. In patients of the 2nd group after a three-day intravenous application of the glucocorticoids on the 4th day of hospitalization, a statistically significant (p < 0.001) increase in the number of neutrophils and monocytes was established. When comparing the quantitative parameters of the leukocyte formula between the 2nd group on the 4th day of the hospitalization and the 1st group at admission, there were no differences in the level of leukocytes and neutrophils. Number of monocytes in group 2 (1.11 (0.90;1.34) x 109/l), on the contrary, statistically significantly (p < 0.001) exceeded their level in the 1st group (0.59 (0.50;0.77) x 109/l). Thus, an indicator of the number of monocytes in the peripheral blood could be a promising differential diagnostic criterion for the genesis of the leukocytosis in patients with the COVID-19. This parameter may be one of the factors influencing the decision to prescribe the antibacterial therapy.

4.
Clinical and Experimental Surgery ; 10(2):19-25, 2022.
Article in Russian | EMBASE | ID: covidwho-1939718

ABSTRACT

The course of the reparative process in surgical pathology directly depends on hemomicrocirculation, nutrition and oxygen supply in tissues, as well as the activity of lipid peroxidation processes. A novel coronavirus infection can slow down the reparative process and potentiate the development of wound complications. Aim - to study the features of the tissue healing process in patients with deep vein thrombosis of the lower extremities against the background of a new coronavirus infection. Material and methods. 130 patients were monitored: group 1 - 48 patients with acute thrombosis of the veins of the lower extremities, group 2 - 82 patients with acute deep vein thrombosis of the lower extremities, combined with coronavirus infection. Patients underwent thrombectomy followed by plication. On the 2nd, 4th and 7th days, a comprehensive study of the state of the tissues of the area of surgical intervention was carried out to determine the nature and rate of healing, the development of wound complications. Results. In a quantitative analysis of the developed complications on the side of the wound after surgery, it turned out that their number in patients with coronavirus infection was more than 7 times higher (p<0.001). A feature of the wound process as a whole was prolonged lymphorrhea. Cytological signs of impaired tissue healing in the wound area were established. So, in group 2 two days after the operation the number of neutrophilic leukocytes in the wound exudate was 48.2% more than in the group 1, by day 7th - 69.5% more. Weak dynamics of the regenerative-degenerative index was noted. The number of tissue polyblasts in patients of group 2, was 4.2-100.2% lower than those of group 1 at all stages of observation, and lymphoid polyblasts - 47.0-159.1% higher. Patients with coronavirus infection have more significant microcirculatory disorders. According to thromboelastography data, in patients of group 2, an imbalance in the blood coagulation system was registered with a predominance of thrombosis. Conclusion. In patients with acute deep vein thrombosis of the lower limb against the background of coronavirus infection, the wound healing process, which underlies the development of wound complications, slows down. One of the factors that reduce the rate of tissue healing are microcirculation disorders against the background of pronounced disorders in the hemostasis system. The most significant changes in the microenvironment of regenerating structures occur in the first 2-4 days after surgery.

5.
Russian Journal of Infection and Immunity ; 12(1):120-126, 2022.
Article in Russian | EMBASE | ID: covidwho-1856425

ABSTRACT

Despite the relatively rare comorbidity with bacterial infections, in most cases treatment of COVID-19-associated pneumonia is accompanied by empirical antibiotic therapy. In addition, the occurrence of leukocytosis in response to glucocorticosteroid (GCS) therapy is often perceived as comorbid bacterial flora and is a reason for initiating antibiotic therapy. Therefore, an urgent task is to properly interpret leukocytosis in response to GCS therapy in COVID-19. The aim of the study was to examine dynamic changes in count of venous blood leukocytes, neutrophils and monocytes in patients with moderate COVID-19 after systemic GCS. We analyzed parameters of complete blood count in 154 patients with verified moderate COVID-19, at the Temporary Infectious Diseases Hospital, the “Patriot” Park of the Moscow Region. The comparison group (I) consisted of 128 patients without clinical signs of bacterial infection and leukocytosis observed on admission, who were prescribed GCS therapy. The control group (II) consisted of 26 subjects showing on admission signs of bacterial infection — a cough with purulent sputum combined with neutrophilic leukocytosis. The dynamics in venous blood cell count was assessed in group I of patients before the onset, 3 and 6 days after beginning GCS therapy. We also compared count of leukocytes, neutrophils and monocytes between patients with developed leukocytosis in group I vs. group II. As a result, an increased count of leukocytes, neutrophils and monocytes was revealed according to assessing complete blood count test in patients from group I on days 3 and 6 of ongoing GCS therapy. All patients with developed leukocytosis after GCS admission (103 subjects) had no clinical signs of bacterial infection. Patients with developed leukocytosis from group I had increased count of monocytes (0.90 (0.84;1.02) on day 3 after GCS onset and 0.94 (0.87;1.26) on day 6 of GCS) compared with group II (0.61 [0.50;0.71]), p < 0.001. The inter-group count of leukocytes and neutrophils did not differ. Monocytosis after GCS therapy may serve as a differential diagnostic criterion to distinguish between glucocorticoid-induced leukocytosis and comorbid bacterial infection. This may be one of the factors influencing a decision to prescribe antibiotic therapy.

6.
Infektsiya Immun. ; 12(1):120-126, 2022.
Article in Russian | Web of Science | ID: covidwho-1791636

ABSTRACT

Despite the relatively rare comorbidity with bacterial infections, in most cases treatment of COVID-19-associated pneumonia is accompanied by empirical antibiotic therapy. In addition, the occurrence of leukocytosis in response to glucocorticosteroid (GCS) therapy is often perceived as comorbid bacterial flora and is a reason for initiating antibiotic therapy. Therefore, an urgent task is to properly interpret leukocytosis in response to GCS therapy in COVID-19. The aim of the study was to examine dynamic changes in count of venous blood leukocytes, neutrophils and monocytes in patients with moderate COVID-19 after systemic GCS. We analyzed parameters of complete blood count in 154 patients with verified moderate COVID-19, at the Temporary Infectious Diseases Hospital, the "Patriot" Park of the Moscow Region. The comparison group (I) consisted of 128 patients without clinical signs of bacterial infection and leukocytosis observed on admission, who were prescribed GCS therapy. The control group (II) consisted of 26 subjects showing on admission signs of bacterial infection - a cough with purulent sputum combined with neutrophilic leukocytosis. The dynamics in venous blood cell count was assessed in group I of patients before the onset, 3 and 6 days after beginning GCS therapy. We also compared count of leukocytes, neutrophils and monocytes between patients with developed leukocytosis in group I vs. group II. As a result, an increased count of leukocytes, neutrophils and monocytes was revealed according to assessing complete blood count test in patients from group I on days 3 and 6 of ongoing GCS therapy. All patients with developed leukocytosis after GCS admission (103 subjects) had no clinical signs of bacterial infection. Patients with developed leukocytosis from group I had increased count of monocytes (0.90 (0.84;1.02) on day 3 after GCS onset and 0.94 (0.87;1.26) on day 6 of GCS) compared with group II (0.61 [0.50;0.71]), p < 0.001. The inter-group count of leukocytes and neutrophils did not differ. Monocytosis after GCS therapy may serve as a differential diagnostic criterion to distinguish between glucocorticoid-induced leukocytosis and comorbid bacterial infection. This may be one of the factors influencing a decision to prescribe antibiotic therapy.

7.
Archiv Euromedica ; 11(6):55-61, 2021.
Article in English | Web of Science | ID: covidwho-1687894

ABSTRACT

Acute viral respiratory infections add to the progression risk of the already existing pathologies, including those of cardiovascular origin. Life-threatening complications emerging against SARS-CoV-2 (severe acute respiratory syndrome), which causes COVID-19 (Coronavirus disease 2019), explain the need to study the cardiovascular effects of COVID-19 in order to offer rational medical care to patients belonging to various age categories. This article presents a comprehensive assessment of changes affecting the main hemostasis parameters in patients with acute cerebral circulatory disorders against the SARS-CoV-2 virus infection. There is special attention paid to the pathophysiological features occurring against the infectious process involving the hemostasis system. Our data shows that the differences in the main hemostatic parameters in patients with acute cerebral circulatory disorders occurring against the SARS-CoV-2 virus infection are due to the degree of the body responsiveness and the severity of the comorbid pathology. Reducing the risk of adverse conditions developing in this category of patients is possible in case of responsible monitoring focusing on the main indicators of the cardiovascular system status, as well as provided there are advanced approaches introduced in order to prevent and treat thrombotic/thromboembolic complications.

8.
Health Risk Analysis ; - (4):152-161, 2021.
Article in Russian | Scopus | ID: covidwho-1680161

ABSTRACT

Personal protective equipment has become the last line of protection for medical personnel during the pandemic of thenew coronavirus infection since it allows minimizing risks of biological contagion. Given the existing staffing shortage,medical wo rkers have to spend from 4 to 12 hours a day in the “red zone” where they necessarily wear personal protectiveequipment. Protective clothing is known to produce negative effects on functional state of the body and personnel’s workingcapacities. Assessment of up-to-date protective suits will allow developing recommendations on their suitable applicationbearing in mind a balance between necessary protection, providing favorable ergonomics, and reducing risks of adverseeffects on functional state and working capacities.Our research aim was to hygienically assess health risks for medical workers who had to wear reusable protective suits.Our research object was a reusable suit made from polyether fabric with polyurethane membrane coating and antistaticthreads. We performed an experiment aimed at evaluating thermal state of the body, psychophysiological state, and responsesby the volunteers’ cardiorespiratory system in laboratory conditions during an 8 hour working shift under controlledmicroclimate. Participants in the experiment were questioned in order to assess suits’ ergonomics.Heat exchange dynamics and amount of changes in thermal physiological parameters caused by wearing a protectivesuit determined heat contents of volunteers’ bodies that conformed to optimal standard values. Data on psychophysiologicaland mental state taken in research dynamics didn’t have any statistically significant changes. Gas exchange indicators naturallygrew during the “load” phase;however, there were no significant changes detected in any phase in the research.Hygienic assessment of the thermal state, functional state of the cardiovascular and respiratory systems, and psychophysiologicalindicators confirmed that wearing a protective suit was quite safe and didn’t involve any health risks for volunteers. © 2021,Health Risk Analysis. All Rights Reserved.

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