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Malaysian Journal of Medicine and Health Sciences ; 18:1-6, 2022.
Article in English | Scopus | ID: covidwho-2126227

ABSTRACT

Introduction: Assessing patient history is solely insufficient to identify the asymptomatic Covid-19 cases in pregnancy. Therefore, regular laboratory examinations should be deemed to find the actual case. However, this strategy might be more challenging for a limited-resource area. Hence, finding the most effective laboratory screening is beneficial. This study aimed to collate the effectiveness of rapid antibody and universal reverse transcriptase-polymerase chain reaction (RT-PCR) for asymptomatic Covid-19 testing among pregnant women in low-resource settings. Methods: We performed a study using one-year retrospective data of asymptomatic Covid-19 cases among pregnant women admitted in Dr. Soetomo General Academic Hospital Surabaya, conducted with the paired rapid antibody test and RT-PCR SARS-CoV-2 result. Results: Of 265 cases included, 217 samples had a reactive rapid antibody test (81.89%). There was a significant association between rapid antibody test and RT-PCR (p=0.026) with sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were 89%, 22%, 38%, and 79%, respectively. Thus, it can identify more asymptomatic cases compared to identification by history and symptoms only. This study also revealed a higher significant efficiency cost (p<0.001) by reducing the overall expense up to IDR 36, 180, 000 (USD 2, 514) or 15% lower than the universal RT-PCR SARS-CoV-2 testing strategy. Conclusion: This study suggests that implementing a rapid antibody test has favour in identifying more asymptomatic Covid-19 cases in pregnancy and evince more cost-effective than universal PCR testing. © 2022 UPM Press. All rights reserved.

2.
New Armenian Medical Journal ; 16(2):25-32, 2022.
Article in English | EMBASE | ID: covidwho-2067787

ABSTRACT

Objectives: to assess the effect-related inflammatory and coagulation biomarkers in pregnancy and their connection with the coronavirus disease of 2019 (COVID-19). Method(s): A prospective case-control study was carried out among normal third-trimester pregnant women admitted to the labor room of Dr. Soetomo General Academic Hospital between January until June 2021. Two classified groups of patients were established in accordance with the result of the RT-PCR test. Demographic, clinical and laboratory results data of the two groups were collected and compared. Result(s): Platelet-to-lymphocyte ratio (PLR) was shown to be the only significant biomarkers found in the expectant with COVID-19, which was 35.8% higher compared to the ones free of COVID-19 [212.25 (157.57-269.37) vs 156.29 (128.55-195.3), p=0.048]. Logistic regression analysis of PLR between groups showed that the level of PLR was an independent factor in pregnant women with COVID-19 (OR 4.483, 95%CI 1.262-15.926). The ROC analysis showed that the PLR cut-off among the expectant was 171.335, with both sensitivity and specificity were 66.7% (p=0.021). The result shows no significant differences in leukocyte count, absolute neutrophils - lymphocyte count and percentage, neutrophil-to-lymphocyte ratio (NLR) and D-Dimer level between pregnant women infected with COVID-19 and free of the virus (p>0.05). Conclusion(s): Intriguingly, physiological adaptation during the course of the third trimester of pregnancy found no difference in most inflammation and coagulation markers, both in the condition of infected COVID-19 or not. The evidence from this single-centre study supports the viewpoint that elevated PLR was associated with independent biomarkers and thereby might be helpful to detect expectant with COVID-19. Copyright © 2022, Yerevan State Medical University. All rights reserved.

3.
Open Access Macedonian Journal of Medical Sciences ; 10:1914-1921, 2022.
Article in English | EMBASE | ID: covidwho-2066688

ABSTRACT

BACKGROUND: The fluctuating COVID-19 cases among the pregnant women’s population encountered increased of cases and maternal mortality. AIM: This research aimed to describe the case of maternal deaths caused by COVID-19. CASE REPORT: We present nine serial cases of maternal death caused by COVID-19 who were admitted to Dr. Soetomo General Academic Hospital for 14 days in June. We found 32 positive COVID-19 obstetric cases and reported nine maternal deaths with a fatality rate of up to 28%. Seven of nine patients had reverse transcription-polymerase chain reaction–confirmed SARS-CoV-2 infection, while two had a positive antigen swab. Half of the patients ≥35 years old, and five of nine patients had Class I obesity as preexisting comorbidity. This study reported the death of pregnant woman at their 2nd trimester and 3rd trimester presenting infected by severe COVID-19. The usual symptoms are dyspnea, cough, fever, and decreased consciousness. The result of chest X-ray examination among eight patients showed bilateral pneumonia. Most of cases were referrals from a secondary hospital due to overload hospital capacity. Three patients were directly transferred to the tertiary hospital without receiving initial treatment. Eight of 9 patients (88.9%) were transferred to intensive care unit and intubated due to low oxygen saturation. CONCLUSION: In conclusion, the limited hospital facility and lack of intensive care capacity for obstetric cases during the second wave of the COVID-19 pandemic may enhance the probability of mortality and morbidity in pregnant women infected by COVID-19.

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