Your browser doesn't support javascript.
Show: 20 | 50 | 100
Results 1 - 20 de 238
Filter
1.
European journal of public health ; JOUR(Suppl 3), 32.
Article in English | EuropePMC | ID: covidwho-2102189

ABSTRACT

Background There have been several case reports of herpes zoster (HZ) following COVID-19 disease and vaccination. We conducted a non-systematic literature search to elucidate the global effects of the COVID-19 pandemic on the incidence of HZ. Methods The literature search was performed in October 2021 using PubMed and Embase. The search string was herpes zoster AND COVID-19. Publications were manually reviewed;case reports were removed. Results Three retrospective studies reported the risk of HZ following COVID-19 disease. One study (Bhavsar, 2021) used two US databases and found higher risk of HZ following COVID-19 disease (relative risk [RR]=1.15) and COVID-19 hospitalisation (RR = 1.21), respectively. A strong association between HZ and COVID-19 disease (RR = 5.27) was also reported in a study of the University of Florida patient registry (Katz, 2021). The third study (Barda, 2021) reported no association between COVID-19 disease and risk of HZ (RR = 0.82). In two of the three observational studies in Israel (Furer, 2021 and Barda, 2021), the incidence of HZ was increased following COVID-19 vaccination. The third study (Shasha, 2021) found no association (RR = 1.07). Other studies included a report in Brazil (Maia, 2021) that demonstrated a 35% increase in HZ diagnoses during the pandemic versus pre-pandemic and a published model (La, 2021) that estimated the declining uptake of recombinant zoster vaccine in the US may result in 63,117 avoidable HZ cases in those who remain unvaccinated in 2021. Conclusions Emerging data suggest that the COVID-19 pandemic may have increased the risk of HZ and negatively impacted HZ vaccine uptake. Therefore, there is an important need to increase awareness of HZ and HZ vaccination during the pandemic. Key messages • There is a need to increase awareness of HZ and HZ vaccination during the COVID-19 era. • Further studies are needed to fully understand the impact of COVID-19 on the risk of HZ.

2.
Journal of Geo-Information Science ; JOUR(10):1941-1956, 24.
Article in Chinese | Scopus | ID: covidwho-2100408

ABSTRACT

Since the outbreak of the COVID-19 epidemic in 2020, the intercity travel in China has been significantly affected. With the popularity of big data, spatiotemporal modeling and analysis are widely used in epidemic and transportation research. In the post epidemic era, residents' intercity travel shows a certain recovery mode under the influence of local epidemic. The recovery mode and resilience of intercity travel reflects the resilience of cities and can provide information for cities' epidemic prevention and control. Exploring different urban modes and factors affecting the resilience of intercity travel under the influence of epidemic situation has practical significance for normalized epidemic prevention and control management. Based on the migration big data, this paper describes the differentiation pattern of intercity travel resilience under the COVID-19 epidemic from different perspectives, summarizes the time series model, and explores the factors affecting intercity travel resilience. Four indicators, namely fluctuation ratio, recovery ratio, resilience, and recovery index, are constructed to measure the resilience of intercity travel. The results show that: (1) During the epidemic period, residents' resilience to travel shows certain spatial variation. On the whole, the eastern region is the best, followed by the western region and the central region, and the northeast region is the worst;(2) The temporal patterns of intercity travel in epidemic cities are consistent with "resilience triangle" of the typical model. According to the propagation mode and correlation of the epidemic, the specific temporal patterns can be classified into five types: Relative independence mode, intermediate fluctuation mode, starting-point correlation mode, end-point correlation mode, and bidirectional restraint mode, showing different curve forms and characteristics;(3) The resilience of intercity travel is affected by complex factors. When the epidemic wave and regional variables are controlled, economic and transportation factors have a significant impact on the recovery of intercity travel. There may be a U-shaped relationship between per capita GDP and industrial structure and the resilience of intercity travel. When the economic development reaches a certain level, the supporting effect of economy on the resilience of intercity travel becomes increasingly prominent. There is a positive correlation between high-speed rail and airport and the resilience of intercity travel, which plays an important role in increasing the resilience of intercity travel. The results of this study indicate that the application of spatiotemporal big data to analyze the mode and mechanism of urban recovery in the post epidemic era is a novel research method. Subsequent research can further explore the spatiotemporal pattern and mode mechanism of epidemic recovery, in order to provide scientific basis and guidance for epidemic prevention and control of cities. © 2022, Science Press. All right reserved.

3.
Zhonghua Er Ke Za Zhi ; 60(11): 1168-1171, 2022 Nov 02.
Article in Chinese | MEDLINE | ID: covidwho-2099942

ABSTRACT

Objective: To summarize the application experience and the therapeutic effect of Nirmatrelvir-Ritonavir (trade name: Paxlovid) for COVID-19 in children. Methods: A retrospective analysis was performed on the clinical data, including collecting the clinical manifestations and clinical outcomes, dynamically monitoring the blood routine, hepatic and renal function and SARS-CoV-2 nucleic acid results, and observing the related side effects during the treatment, etc, of 3 cases with COVID-19 treated with Paxlovid admitted to Shanghai Children's Hospital (designated referral hospital for SARS-CoV-2 infection in Shanghai) from May 1st to June 1st, 2022. Results: The 3 cases were 12, 14, 17 years of age, among which 2 cases were males, 1 case was female. All 3 cases were mild cases with underlying diseases and risk of developing into severe COVID-19, with symptoms of high fever, sore throat and dry cough. The treatment of Paxlovid at 3rd day of symptom onset contributed to the symptom-free after 1-2 days and negative results of SARS-CoV-2 nucleic acid after 2-4 days. All patients had no adverse manifestations of gastrointestinal tract and nervous system but a case had little skin rashes, which recovered after the withdrawal of Paxlovid. Three cases had normal hepatic and renal function during the Paxlovid treatment. At 3 months after discharge, no clinical manifestations of post-COVID syndrome were found in all 3 cases. Conclusion: Paxlovid was effective and relatively safe in the treatment of 3 children with COVID-19.


Subject(s)
COVID-19 , Nucleic Acids , Child , Male , Humans , Female , SARS-CoV-2 , Ritonavir/therapeutic use , Retrospective Studies , China
4.
Zhonghua Er Ke Za Zhi ; 60(11): 1163-1167, 2022 Nov 02.
Article in Chinese | MEDLINE | ID: covidwho-2099938

ABSTRACT

Objective: To summarize the management and short-term outcomes of neonates delivered by mothers infected with SARS-CoV-2 Omicron variant. Methods: A retrospective study was performed on 158 neonates born to mothers infected with SARS-CoV-2 Omicron variant admitted to the isolation ward of Children's Hospital of Fudan University from March 15th, 2022 to May 30th, 2022. The postnatal infection control measures for these neonates, and their clinical characteristics and short-term outcomes were analyzed. They were divided into maternal symptomatic group and maternal asymptomatic group according to whether their mothers had SARS-CoV-2 symptoms. The clinical outcomes were compared between the 2 groups using Rank sum test and Chi-square test. Results: All neonates were under strict infection control measures at birth and after birth. Of the 158 neonates, 75 (47.5%) were male. The gestational age was (38+3±1+3) weeks and the birth weight was (3 201±463)g. Of the neonates included, ten were preterm (6.3%) and the minimum gestational age was 30+1 weeks. Six neonates (3.8%) had respiratory difficulty and 4 of them were premature and required mechanical ventilation. All 158 neonates were tested negative for SARS-COV-2 nucleic acid by daily nasal swabs for the first 7 days. A total of 156 mothers (2 cases of twin pregnancy) infected with SARS-CoV-2 Omicron variant, the time from confirmed SARS-CoV-2 infection to delivery was 7 (3, 12) days. Among them, 88 cases (56.4%) showed clinical symptoms, but none needed intensive care treatment. The peripheral white blood cell count of the neonates in maternal symptomatic group was significantly higher than that in maternal symptomatic group (23.0 (18.7, 28.0) × 109 vs. 19.6 (15.4, 36.6) × 109/L, Z=2.44, P<0.05). Conclusions: Neonates of mothers infected with SARS-CoV-2 Omicron variant during third trimester have benign short-term outcomes, without intrauterine infection through vertical transmission. Strict infection control measures at birth and after birth can effectively protect these neonates from SARS-CoV-2 infection.


Subject(s)
COVID-19 , Pregnancy Complications, Infectious , Female , Humans , Infant , Infant, Newborn , Male , Pregnancy , Mothers , Pregnancy Complications, Infectious/diagnosis , Pregnancy Complications, Infectious/prevention & control , Retrospective Studies , SARS-CoV-2
6.
Life Sci Alliance ; 6(1), 2023.
Article in English | PubMed | ID: covidwho-2081440

ABSTRACT

Coronavirus disease 2019 (COVID-19) patients with liver dysfunction (LD) have a higher chance of developing severe and critical disease. The routine hepatic biochemical parameters ALT, AST, GGT, and TBIL have limitations in reflecting COVID-19-related LD. In this study, we performed proteomic analysis on 397 serum samples from 98 COVID-19 patients to identify new biomarkers for LD. We then established 19 simple machine learning models using proteomic measurements and clinical variables to predict LD in a development cohort of 74 COVID-19 patients with normal hepatic biochemical parameters. The model based on the biomarker ANGL3 and sex (AS) exhibited the best discrimination (time-dependent AUCs: 0.60-0.80), calibration, and net benefit in the development cohort, and the accuracy of this model was 69.0-73.8% in an independent cohort. The AS model exhibits great potential in supporting optimization of therapeutic strategies for COVID-19 patients with a high risk of LD. This model is publicly available at https://xixihospital-liufang.shinyapps.io/DynNomapp/.

7.
European psychiatry : the journal of the Association of European Psychiatrists ; 65(Suppl 1):S209-S210, 2022.
Article in English | EuropePMC | ID: covidwho-2072819

ABSTRACT

Introduction Mental health regional differences during pregnancy through the COVID-19 pandemic is understudied. Objectives We aimed to quantify the impact of the COVID-19 pandemic on maternal mental health during pregnancy. Methods A cohort study with a web-based recruitment strategy and electronic data collection was initiated in 06/2020. Although Canadian women, >18 years were primarily targeted, pregnant women worldwide were eligible. The current analysis includes data on women enrolled 06/2020-11/2020. Self-reported data included mental health measures (Edinburgh Perinatal Depression Scale (EPDS), Generalized Anxiety Disorders (GAD-7)), stress. We compared maternal mental health stratifying on country/continents of residence, and identified determinants of mental health using multivariable regression models. Results Of 2,109 pregnant women recruited, 1,932 were from Canada, 48 the United States (US), 73 Europe, 35 Africa, and 21 Asia/Oceania. Mean depressive symptom scores were lower in Canada (EPDS 8.2, SD 5.2) compared to the US (EPDS 10.5, SD 4.8) and Europe (EPDS 10.4, SD 6.5) (p<0.05), regardless of being infected or not. Maternal anxiety, stress, decreased income and access to health care due to the pandemic were increasing maternal depression. The prevalence of severe anxiety was similar across country/continents. Maternal depression, stress, and earlier recruitment during the pandemic (June/July) were associated with increased maternal anxiety. Conclusions In this first international study on the impact of the COVID-19 pandemic, CONCEPTION has shown significant country/continent-specific variations in depressive symptoms during pregnancy, whereas severe anxiety was similar regardless of place of residence. Strategies are needed to reduce COVID-19’s mental health burden in pregnancy. Disclosure No significant relationships.

8.
Open Access Macedonian Journal of Medical Sciences ; 10:1452-1457, 2022.
Article in English | EMBASE | ID: covidwho-2066679

ABSTRACT

BACKGROUND: Many countries have issued “stay at home” orders to combat the spread of coronavirus disease 2019 (COVID-19), which may have hampered movement in people of all ages. This may impact adolescent physical activity, sedentary behavior, screen time, etc. AIM: The purpose of this study was to assess changes in physical activity and screen time before and during the first and second COVID-19 lockdown among adolescents in Indonesia. METHODS: This study was a national web-based survey distributed through social media platforms in Indonesia. A snowball sampling method was used to recruit participants. The final sample included 5650 participants who had provided complete information for the research topic. RESULTS: Physical activity patterns of adolescents had dramatically shifted during COVID-19 lockdown, with disparities between genders and educational levels. The majority of adolescents had maintained their physical activity levels, with 34.4% of those who engaged in active transportation and 67.3% of those who walked;while, the remaining adolescents had experienced a decrease in physical activity (30.1%–63.1%). Adolescents had maintained their sleeping (about 50%) and screen time (31.4%), but almost 40% had decreased their sleeping time and 60.5% had significantly increased their screen time. Furthermore, when compared to their peers who had maintained their sedentary time before to COVID-19, more adolescents had increased their sedentary time throughout both schooldays and weekends (about 54%). CONCLUSION: This large-scale nationwide survey could be valuable for stakeholders, when deciding when and how to relax restrictions in the future. In addition, school administrators should be aware of these changes so that in-class and/or extracurricular physical programs can be developed to offset the effects of these changes.

9.
Zhonghua Er Ke Za Zhi ; 60(10): 1054-1058, 2022 Oct 02.
Article in Chinese | MEDLINE | ID: covidwho-2066644

ABSTRACT

Objective: To analyze the clinical characteristics of SARS-CoV-2 Omicron variant infected children in convalescence in Tianjin. Methods: A total of 104 pediatric patients infected by SARS-CoV-2 Omicron variant Tianjin First Central Hospital (designated hospital for SARS-CoV-2 infection in Tianjin) for convalescent treatment from January 22nd, 2022 to February 24th were included for a retrospective study.Clinical data including clinical typing, SARS-CoV-2 IgG and IgM test and 2019-nCoV nucleic acid test were collected.The cases were divided into 2-dose group and zero-dose group based on the doses of inactivated SARS-CoV-2 vaccine. The children were divided into repositive group and negative group, according to the nucleic acid test during hospitalization. Chi-square test was used for the comparison between the groups. Results: The age of these 104 children was 10.0 (0.3, 14.0) years on admission, 53 children were males and 51 were females, 92 cases (88.5%) had mild symptoms, 12 cases (11.5%) had common symptoms.The age and SARS-CoV-2 IgG level of zero-dose group was lower (2.0 (0.3, 10.2) vs. 10.0 (3.2, 14.0) years, 10 (2, 17) vs. 193 (157, 215), χ²=-5.57, Z=-48.76,both P<0.001) than that of 2-dose group. The zero-dose group had a high rate of transmission among family members and a high level of SARS-CoV-2 IgM level (13/14 vs. 62.2% (56/90), 0.4 (0.2, 0.8) vs. 0.4 (0.2, 1.1),χ²=5.09, Z=-48.95, both P<0.05) than the 2-dose group. Repositive group had a high rate of underlying diseases and SARS-CoV-2 IgM level was higher (2/13) vs. 1.1% (1/91), (0.6 (0.2, 1.0) vs. 0.3 (0.2, 0.7), χ²=8.29, Z=2.70, both P<0.05) than negative group. The SARS-CoV-2 IgG level of repositive group was lower than that of negative group (160 (78, 197) vs. 213 (186, 231), χ²=-3.20, P<0.05). Conclusions: Children infected with SARS-CoV-2 Omicron variant in Tianjin were mainly transmitted by family members, and most of them had mild symptoms. Two-dose group had higher IgG levels and lower IgM levels than zero-dose group.The probability of SARS-CoV-2 nucleic acid test repositivity increased in children with underlying diseases and lower IgG levels.


Subject(s)
COVID-19 , Nucleic Acids , Antibodies, Viral , COVID-19/therapy , COVID-19 Vaccines , Child , Female , Humans , Immunoglobulin G , Immunoglobulin M , Male , Retrospective Studies , SARS-CoV-2
10.
American Journal of Transplantation ; 22(Supplement 3):868-869, 2022.
Article in English | EMBASE | ID: covidwho-2063539

ABSTRACT

Purpose: Telemedicine is an essential part of healthcare delivery and has grown exponentially during the COVID-19 pandemic. Data on optimal utilization and implementation of telemedicine in SOT care remain limited. We aimed to evaluate patient, provider and clinic staff perspectives on telemedicine use and potential barriers in SOT clinics. Method(s): We prospectively enrolled adults seen via telemedicine (video or telephone) in SOT clinics at a single academic transplant center between 9-10/2021. Patients completed a survey administered either online or phone following their visit. Providers and clinic staff involved in telemedicine completed online surveys. Surveys were tailored to patient, provider and clinic staff to assess specific concerns, barriers and satisfaction with telemedicine. Result(s): Survey response rate was 21% (175/853) for patients, 57% (70/122) for providers and 31% (20/64) for clinic staff. 95% of visits were video and seen in liver (39%), kidney (40%), lung (16%) and heart transplant (5%) clinics. Patients were male (51%) with a median age of 62, English-speaking (95%) and had some college experience (84%). Patient and provider descriptions of telemedicine use are shown in Figure 1. Patients were not concerned with privacy (86%), lack of physical exam (76%), audio/video difficulties (89% and 93%) or help with setup (82%). Most were satisfied with the ease of video visit (85%) and quality of care (80%). Compared to in-person visits, patients felt their telemedicine visit was similar (66%) if not better (16%). Among providers, most were satisfied with ease of video visits (74%) and quality of care (60%), but 48% were dissatisfied with telephone visits. Providers spent time assisting patients (72%) or required help from staff to aid patients (7%) with visits;90% noted functioning of software/hardware before visits as crucial to improving telemedicine use. Among clinic staff, 50% reported additional time spent aiding patients with initial visit setup due to needing to instruct how to use telemedicine software (60%) and providing additional instructions to caregiver(s) (20%). Conclusion(s): Telemedicine via video is an effective and convenient method of healthcare delivery across the continuum of SOT care according to patients, providers and clinic staff. However, concerns about time assisting with setup were noted by providers and staff. Additional resources and support are needed to improve navigation of telemedicine for patients and to improve efficiency with telemedicine for providers and staff. (Figure Presented).

11.
American Journal of Clinical Oncology: Cancer Clinical Trials ; 45(9):S46, 2022.
Article in English | EMBASE | ID: covidwho-2063019

ABSTRACT

Background: The use of telemedicine in radiation oncology increased dramatically during the COVID-19 pandemic. While prior surveys suggest high levels of satisfaction with telemedicine among radiation oncologists, the published literature is limited regarding provider-specific factors impacting satisfaction and provider preferences regarding how telemedicine is implemented. Objective(s): To assess provider characteristics associated with satisfaction and perceived adoption of telemedicine in radiation oncology, and to characterize implementation preferences of providers at our institution. Method(s): We distributed a survey to all attending radiation oncologists at our large academic institution in October 2021 to assess several measures of satisfaction with telemedicine. We also asked providers to estimate metrics suggestive of successful telemedicine use. Univariate logistic regressions were performed to assess the role of physician characteristics (including age, gender, years in practice, main vs satellite location, disease site treated, annual new patient volume, and selfreported comfort with technology) on satisfaction and on whether physicians reported telemedicine was easy to use. We also performed descriptive statistics to characterize provider-estimated time-savings and training preferences. Kruskal-Wallis tests were used to assess whether provider characteristics or scheduling strategy (telemedicine scheduled separately from in-person visits) were associated with the rate of missed video visits. Result(s): A total of 60 of 82 eligible radiation oncologists (73%) responded to the survey. 78% of respondents were satisfied with telemedicine in the radiation oncology department and 78% felt telemedicine was easy to use. None of the tested factors on univariate analysis were statistically significant predictors for these outcomes. 38% of providers believed telemedicine encounters resulted in time savings of at least 10% compared to in-person visits, while 20% of providers reported virtual encounters took at least 10% more time. A median (IQR) of 10% (5%-20%) of video visits were estimated to be missed, and none of the tested provider characteristics or scheduling preferences were associated with a significantly greater proportion of missed visits. 78% of respondents reported having adequate training and support to perform telemedicine. Text, video, and private instruction were nearly equally preferred training modalities (31%, 31%, 34% respectively). Conclusion(s): Nearly 80% of surveyed radiation oncologists were satisfied with telemedicine, felt it was easy to use, and reported adequate training and support to perform telemedicine. In this highly technologically advanced field, age and years in practice were not significantly associated with satisfaction or self-reported success rates with telemedicine. Future directions include addressing actionable concerns and correlating these findings with patient impressions.

12.
22nd COTA International Conference of Transportation Professionals, CICTP 2022 ; : 919-927, 2022.
Article in English | Scopus | ID: covidwho-2062369

ABSTRACT

With the effective control of Novel coronavirus pneumonia, the priority problem which all cities have to face is how to provide convenient transportation services for the resumption of production. Take Qingdao for example, It is proposed that the transformation of public transportation users to private transportation is the key to effectively control the spread of the epidemic before the NCP is completely resolved at the urban traffic level. On this basis, we put forward some suggestions on how to provide urban transportation services for commuting during the special period of the epidemic. Such as, we need to focus on the low-income groups who commute over long distances, the traffic environment of slow traffic commuter groups and traffic accessibility within the influential scope of core area. © ASCE.

13.
25th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2022 ; 13438 LNCS:3-12, 2022.
Article in English | Scopus | ID: covidwho-2059730

ABSTRACT

The destitution of image data and corresponding expert annotations limit the training capacities of AI diagnostic models and potentially inhibit their performance. To address such a problem of data and label scarcity, generative models have been developed to augment the training datasets. Previously proposed generative models usually require manually adjusted annotations (e.g., segmentation masks) or need pre-labeling. However, studies have found that these pre-labeling based methods can induce hallucinating artifacts, which might mislead the downstream clinical tasks, while manual adjustment could be onerous and subjective. To avoid manual adjustment and pre-labeling, we propose a novel controllable and simultaneous synthesizer (dubbed CS$$

14.
Jisuanji Fuzhu Sheji Yu Tuxingxue Xuebao/Journal of Computer-Aided Design and Computer Graphics ; 34(8):1302-1312, 2022.
Article in Chinese | Scopus | ID: covidwho-2055455

ABSTRACT

It is important for social public security and urban management to explore the spread of infectious diseases. A city-level structured prediction and simulation model for COVID-19 is proposed. This model is consisted of SEIR and social network model on the basis of latest infectious disease dynamics theory and real geographic networks. The prediction region is divided into multiple levels. Specifically, a bipartite network is applied to simulate the relationship between public facilities and community nodes at the macro level, and a modified SEIR is applied to simulate the infection within nodes at the micro level. Besides, intelligent agent is applied to track the individual transmission process. The contrast experimental results based on the confirmed and cursed cases of Wuhan and Beijing in 2020 published by National Health Commission, show that the proposed model has better flexibility and higher accuracy, and reflects the distribution and movement of people more directly. © 2022 Institute of Computing Technology. All rights reserved.

15.
Transplantation ; 106(8):143-144, 2022.
Article in English | EMBASE | ID: covidwho-2040900

ABSTRACT

Background: With the highly effective direct-acting antiviral (DAA) therapy, the number of liver transplants for hepatitis C virus (HCV) has decreased worldwide. However, similar to the phenomenon occurring in COVID-19 infection, the residual virus reservoirs in target organ is warranted to be explored due to the potential replication and disease recurrence. Hence, we aim to investigate the significance of hepatic HCV RNA identification as well as the discrepancy between HCV RNA and HCV core antigen (HCV Ag) in native liver of chronic hepatitis C recipients undergoing living donor liver transplantation (LDLT). Methods: Between Feb 2016 to Aug 2019, we prospectively enrolled 80 serum anti-HCV positive recipients who underwent LDLT. HCV RNA extracted from the native liver tissues was subjected to one-step reverse transcribed qPCR, using the TopScript One Step qRT PCR Probe Kit with HCV qPCR probe assay and human GAPDH qPCR probe assay on ViiA 7 Real Time PCR System. Hepatic HCV Ag was identified from the native liver tissues by employing the qualitative enzyme immunoassay technique. All experimental steps were based on the protocol provided by Human HCV Ag ELISA Kit (Cat. No. MBS167758). Results: Among 80 recipients, 85% (68/80) positive HCV-RNA was significantly higher in the native liver tissues than in the serum before (29/80, 36.3%;p = 0.000) and after LDLT (3/80, 4.4%;p = 0.000). In contrast, hepatic HCV Ag was 100% negative identified in all 80 explanted native liver. Conclusions: Significant positive HCV-RNA identification in the native liver suggested that pre-LDLT serum HCV RNA should be underestimated in the real status of HCV activity. HCV Ag assay may have lack of sensitivity and negative predictive value in liver tissues. In contrast to serum HCV RNA and HCV Ag, a great discrepancy might be described between hepatic HCV RNA and HCV Ag in the liver tissue. (Figure Presented).

16.
Journal of Information Science and Engineering ; 38(4):749-759, 2022.
Article in English | Scopus | ID: covidwho-2040343

ABSTRACT

Due to the highly infectious and long incubation period of COVID-19, detecting COVID-19 efficiently and accurately is crucial since the epidemic outbreak. We proposed a new detection model based on U-Net++ and adopted dense blocks as the encoder. The model not only detects and classifies COVID-19 but also segment the lesion area precisely. We also designed a two-phase training strategy along with self-defined groups, especially the retrocardiac lesion to make model robust. We achieved 0.868 precision, 0.920 recall, and 0.893 F1-score on the COVID-19 open dataset. To contribute to this pandemic, we have set up a website with our model (https://medchex.tech/). © 2022 Institute of Information Science. All rights reserved.

17.
Zhonghua Liu Xing Bing Xue Za Zhi ; 43(9): 1401-1407, 2022 Sep 10.
Article in Chinese | MEDLINE | ID: covidwho-2040005

ABSTRACT

Objective: To understand the epidemiological characteristics of notifiable infectious diseases reported in Beijing in 2021 under the influence of the novel coronavirus pneumonia epidemic prevention and control policy, and provide reference evidence for the prevention and control of notifiable infectious diseases. Methods: Descriptive epidemiological methods were used to analyze the morbidity of notifiable infectious diseases reported in Beijing in 2021, with software R 4.1.2 for data process and ArcGIS 10.8 for visualization. Results: The morbidity of notifiable infectious diseases in Beijing in 2021 was 290.51/100 000, a decrease of 43.29% compared with 2020 and a decrease of 71.45% compared with the average during 2017-2019. The top 5 reported diseases with high morbidity were other infectious diarrhea, influenza, hand foot and mouth disease, pulmonary tuberculosis and syphilis. From the perspective of transmission route, intestinal infectious diseases were the main diseases, accounting for 50.15% (31 898/63 601) of the total cases. From the perspective of pathogens, viral infectious diseases were the main diseases, accounting for 59.63% (25 259/42 356) of the total cases. The laboratory diagnosis rate of notifiable infectious diseases reported in Beijing increased from the average of 16.47% (36 289/220 371) during 2017-2019 to 35.36% (22 490/63 601) in 2021. The laboratory diagnosis rate of parasitic infectious diseases was 83.33%. The districts with high incidence of intestinal infectious diseases were Pinggu, Miyun and Fengtai; Natural foci and insect borne infectious diseases were mainly reported in Yanqing, Mentougou, Fangshan and Daxing. Conclusion: The morbidity of notifiable infectious diseases in Beijing in 2021 showed a decrease trend. The laboratory confirmation rate of reported notifiable infectious disease cases increased, and there were great differences in the laboratory confirmation rate among different diseases. It is very necessary to improve the laboratory confirmation rate of the cases. The diseases with different transmission routes showed different geographical distributions. It is necessary to conduct the targeted prevention and control of infectious diseases in different areas.


Subject(s)
COVID-19 , Communicable Diseases , Dysentery , Beijing , Communicable Diseases/epidemiology , Humans , Incidence
18.
International Journal of Radiation Oncology, Biology, Physics ; 114(3):e344-e344, 2022.
Article in English | Academic Search Complete | ID: covidwho-2036105

ABSTRACT

Telemedicine enthusiasm and uptake in radiation oncology rapidly increased during the COVID-19 pandemic, but it is unclear if and how telemedicine should be utilized after the COVID-19 public health emergency (PHE) ends. Despite ongoing COVID-19 risks and public payer support for telemedicine, several private payers have stopped reimbursing telemedicine weekly see video visits. We performed a large single-institution assessment of provider perspectives on telemedicine after we had achieved a more mature level of adoption to better understand factors considered when determining to use telemedicine and to estimate the percent of visits that could be safely performed with telemedicine. We distributed a survey to all radiation oncology attendings at our large academic institution in October 2021 to assess satisfaction, facilitators, and barriers to telemedicine implementation. We performed quantitative and qualitative analyses to characterize satisfaction and to identify factors influencing whether telemedicine is employed. For the qualitative analysis, two authors independently coded open-ended survey responses and identified categories and themes following established content analysis methodology. We calculated the average proportion of visits that providers expected could be appropriately performed with telemedicine without a clinically significant decline in the quality of care for each disease site and visit type. 60 of 82 eligible radiation oncologists (73%) responded to the survey. 78% of respondents were satisfied with telemedicine in the radiation oncology department, and 83% wished to continue offering video visits after the COVID-19 PHE ends. Common reasons providers endorsed for wanting to integrate telemedicine into practice included: patient and provider preference, increased access to care and clinical trials, allowing for greater relationship with the care team, and improved clinical safety, efficiency, and quality. Patient factors influencing whether physicians offer telemedicine included the patient's travel burden, patient preferences, and whether a physical exam is required. About 20% of new consultations and 50% of weekly management visits were estimated to be clinically appropriate for telemedicine. Central Nervous System/Pediatrics and Thoracic faculty considered telemedicine appropriate for the greatest proportion (50%) of new consultations. 93% of respondents felt comfortable determining whether telemedicine was appropriate. Surveyed radiation oncologists were satisfied with telemedicine in their practice and wished to continue offering video visits in the future. Although provider perceptions of clinical appropriateness of telemedicine varied widely based on disease site and visit type, providers felt comfortable determining when telemedicine would be appropriate for patients. Our data suggest payers should continue to support this patient-centered technology. [ FROM AUTHOR] Copyright of International Journal of Radiation Oncology, Biology, Physics is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)

19.
Prog Urol ; 2022 Sep 13.
Article in English | MEDLINE | ID: covidwho-2031645

ABSTRACT

BACKGROUND: Impaired semen quality and reproductive hormone levels were observed in patients during and after recovery from coronavirus disease 2019 (COVID-19), which raised concerns about negative effects on male fertility. Therefore, this study systematically reviews available data on semen parameters and sex hormones in patients with COVID-19. METHODS: Systematic search was performed on PubMed and Google Scholar until July 18th, 2022. We identified relevant articles that discussed the effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on male fertility. RESULTS: A total number of 1,684 articles were identified by using a suitable keyword search strategy. After screening, 26 articles were considered eligible for inclusion in this study. These articles included a total of 1,960 controls and 2,106 patients. When all studies were considered, the results showed that the semen parameters and sex hormone levels of patients infected with SARS-CoV-2 exhibited some significant differences compared with controls. Fortunately, these differences gradually disappear as patients recover from COVID-19. CONCLUSION: While present data show the negative effects of SARS-CoV-2 infection on male fertility, this does not appear to be long-term. Semen quality and hormone levels will gradually increase to normal as patients recover.

20.
Chinese Journal of Organic Chemistry ; 42(7):1974-1999, 2022.
Article in Chinese | Scopus | ID: covidwho-2025268

ABSTRACT

The COVID-19 pandemic caused by the novel coronavirus SARS-CoV-2 in late 2019 posed a serious threat to the world population. Some effective vaccines are currently approved and widely used, but the long-term efficacy and safety of this intervention is controversial given the highly mutagenic nature of the coronavirus. In addition, some antiviral drugs show better effects, but their safety and universality have not been supported by more data. Coronavirus main protease (3CLpro) is a special cysteine protease in the coronavirus family, responsible for processing viral polyproteins to produce yield mature non-structural proteins, which play an important role in the life cycle of coronaviruses and are highly conserved, and therefor is considered as a prominent target for antiviral drug. Strucure studies provide valuable insight into the function of this protease and structural basis of rational inhibitor design. This paper reviews the structure of SARS-CoV-2 3CLpro and the research progress of bright spot inhibitors targeting 3CLpro so far, and introduces binding mode and the structure-activity relationships of inhibitors and 3CLpro in detail. Additionally, we broadly examine available antiviral activity, ADMET and animal tests of these inhibitors. © 2022 Chinese Chemical Society & SIOC, CAS.

SELECTION OF CITATIONS
SEARCH DETAIL