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2.
Frontiers in Cell and Developmental Biology ; 8, 2020.
Article | WHO COVID | ID: covidwho-723529

ABSTRACT

The recent outbreak of the coronavirus disease-2019 (COVID-19) caused serious challenges to the human society in China and across the world COVID-19 induced pneumonia in human hosts and carried a highly inter-person contagiousness The COVID-19 patients may carry severe symptoms, and some of them may even die of major organ failures This study utilized the machine learning algorithms to build the COVID-19 severeness detection model Support vector machine (SVM) demonstrated a promising detection accuracy after 32 features were detected to be significantly associated with the COVID-19 severeness These 32 features were further screened for inter-feature redundancies The final SVM model was trained using 28 features and achieved the overall accuracy 0 8148 This work may facilitate the risk estimation of whether the COVID-19 patients would develop the severe symptoms The 28 COVID-19 severeness associated biomarkers may also be investigated for their underlining mechanisms how they were involved in the COVID-19 infections

5.
Zhonghua Xin Xue Guan Bing Za Zhi ; 48(7): 580-586, 2020 Jul 24.
Article in Chinese | MEDLINE | ID: covidwho-381905

ABSTRACT

Objective: To analyse the clinical history, laboratory tests and pathological data of a patient who suffered from novel coronavirus pneumonia(COVID-19) and provide reference for the clinical treatment of similar cases. Methods: Data of clinical manifestation, laboratory examination, bronchoscopy, echocardiography and cardiopulmonary pathological results were retrospectively reviewed in a case of COVID-19 with rapid exacerbation from mild to critical condition. Results: This patient hospitalized at day 9 post 2019 novel coronavirus(2019-nCoV) infection, experienced progressive deterioration from mild to severe at day 12, severe to critical at day 18 and underwent extracorporeal membrane oxygenation(ECMO) and continuous renal replacement therapy(CRRT) as well as heart lung transplantation during day 28-45 post infection, and died at the second day post heart and lung transplantation. The patient had suffered from hypertension for 8 years. At the early stage of the disease, his symptoms were mild and the inflammatory indices increased and the lymphocyte count decreased continuously. The patient's condition exacerbated rapidly with multi-organ infections, and eventually developed pulmonary hemorrhage and consolidation, pulmonary hypertension, right heart failure, malignant ventricular arrhythmias, liver dysfunction, etc. His clinical manifestations could not be improved despite viral RNAs test results became negative. The patient underwent lung and heart transplantation and finally died of multi organ failure at the second day post lung and heart transplantation. Pathological examination indicated massive mucus, dark red secretions and blood clots in bronchus. The pathological changes were mainly diffused pulmonary hemorrhagic injuries and necrosis, fibrosis, small vessel disease with cardiac edema and lymphocyte infiltration. Conclusions: The clinical course of severe COVID-19 can exacerbate rapidly from mild to critical with lung, liver and heart injuries.


Subject(s)
Coronavirus Infections/pathology , Lung/pathology , Myocardium/pathology , Pneumonia, Viral/pathology , Betacoronavirus , Fatal Outcome , Hemorrhage/virology , Humans , Pandemics , Retrospective Studies
6.
Pharmazie ; 75(5): 161-163, 2020 05 01.
Article in English | MEDLINE | ID: covidwho-251922

ABSTRACT

Since December 2019, numerous cases of coronavirus disease 2019 (COVID-19) caused by the infection of the novel coronavirus (2019-nCoV) have been confirmed in Wuhan, China. The outbreak of 2019-nCoV in China embodied a significant and urgent threat to global health. 2019-nCoV was a new, highly contagious coronavirus discovered following the outbreak of SARS coronavirus (SARS-CoV) and MERS coronavirus (MERS-CoV). The novel coronavirus can cause severe respiratory disease and even death. However, no specific therapeutic drugs have been developed clinically thus far. This article examines the potential of therapeutic drugs by assessing the structure of 2019-nCoV, its mechanism in invading host cells, and the anti-viral mechanism of the human autoimmune system. We also review the latest research regarding the progress of potential therapeutic drugs and provide references for new drug developments of COVID-19.


Subject(s)
Coronavirus Infections/drug therapy , Pneumonia, Viral/drug therapy , Angiotensin-Converting Enzyme Inhibitors/pharmacology , Antibodies, Neutralizing/pharmacology , Antibodies, Viral/immunology , Antiviral Agents/pharmacology , Betacoronavirus , Humans , Medicine, Chinese Traditional , Pandemics , Peptidyl-Dipeptidase A , Spike Glycoprotein, Coronavirus/antagonists & inhibitors , Viral Proteins/antagonists & inhibitors
7.
Clin Microbiol Infect ; 26(6): 767-772, 2020 Jun.
Article in English | MEDLINE | ID: covidwho-143671

ABSTRACT

OBJECTIVE: In December 2019, coronavirus disease (COVID-19) emerged in Wuhan. However, the characteristics and risk factors associated with disease severity, unimprovement and mortality are unclear and our objective is to throw some light on these. METHODS: All consecutive patients diagnosed with COVID-19 admitted to the Renmin Hospital of Wuhan University from January 11 to February 6, 2020, were enrolled in this retrospective cohort study. RESULTS: A total of 663 COVID-19 patients were included in this study. Among these, 247 (37.3%) had at least one kind of chronic disease; 0.5% of the patients (n = 3) were diagnosed with mild COVID-19, while 37.8% (251/663), 47.5% (315/663), and 14.2% (94/663) were in moderate, severe, and critical conditions, respectively. In our hospital, during follow-up 251 of 663 patients (37.9%) improved and 25 patients died, a mortality rate of 3.77%. Older patients (>60 years old) and those with chronic diseases were prone to have a severe to critical COVID-19 condition, to show unimprovement, and to die (p <0.001, <0.001). Multivariate logistic regression analysis identified being male (OR = 0.486, 95%CI 0.311-0.758; p 0.001), having a severe COVID-19 condition (OR = 0.129, 95%CI 0.082-0.201; p <0.001), expectoration (OR = 1.796, 95%CI 1.062-3.036; p 0.029), muscle ache (OR = 0.309, 95%CI 0.153-0.626; p 0.001), and decreased albumin (OR = 1.929, 95%CI 1.199-3.104; p 0.007) as being associated with unimprovement in COVID-19 patients. CONCLUSION: Male sex, a severe COVID-19 condition, expectoration, muscle ache, and decreased albumin were independent risk factors which influence the improvement of COVID-19 patients.


Subject(s)
Coronavirus Infections/mortality , Coronavirus Infections/therapy , Disease Progression , Patient Acuity , Pneumonia, Viral/mortality , Pneumonia, Viral/therapy , Adolescent , Adult , Age Factors , Aged , Aged, 80 and over , Betacoronavirus , China/epidemiology , Chronic Disease , Coronavirus Infections/blood , Coronavirus Infections/complications , Female , Humans , Male , Middle Aged , Myalgia/virology , Pandemics , Pneumonia, Viral/blood , Pneumonia, Viral/complications , Retrospective Studies , Risk Factors , Serum Albumin/metabolism , Sex Factors , Symptom Assessment , Treatment Failure , Young Adult
9.
Clin Microbiol Infect ; 26(6): 767-772, 2020 Jun.
Article in English | MEDLINE | ID: covidwho-76811

ABSTRACT

OBJECTIVE: In December 2019, coronavirus disease (COVID-19) emerged in Wuhan. However, the characteristics and risk factors associated with disease severity, unimprovement and mortality are unclear and our objective is to throw some light on these. METHODS: All consecutive patients diagnosed with COVID-19 admitted to the Renmin Hospital of Wuhan University from January 11 to February 6, 2020, were enrolled in this retrospective cohort study. RESULTS: A total of 663 COVID-19 patients were included in this study. Among these, 247 (37.3%) had at least one kind of chronic disease; 0.5% of the patients (n = 3) were diagnosed with mild COVID-19, while 37.8% (251/663), 47.5% (315/663), and 14.2% (94/663) were in moderate, severe, and critical conditions, respectively. In our hospital, during follow-up 251 of 663 patients (37.9%) improved and 25 patients died, a mortality rate of 3.77%. Older patients (>60 years old) and those with chronic diseases were prone to have a severe to critical COVID-19 condition, to show unimprovement, and to die (p <0.001, <0.001). Multivariate logistic regression analysis identified being male (OR = 0.486, 95%CI 0.311-0.758; p 0.001), having a severe COVID-19 condition (OR = 0.129, 95%CI 0.082-0.201; p <0.001), expectoration (OR = 1.796, 95%CI 1.062-3.036; p 0.029), muscle ache (OR = 0.309, 95%CI 0.153-0.626; p 0.001), and decreased albumin (OR = 1.929, 95%CI 1.199-3.104; p 0.007) as being associated with unimprovement in COVID-19 patients. CONCLUSION: Male sex, a severe COVID-19 condition, expectoration, muscle ache, and decreased albumin were independent risk factors which influence the improvement of COVID-19 patients.


Subject(s)
Coronavirus Infections/mortality , Coronavirus Infections/therapy , Disease Progression , Patient Acuity , Pneumonia, Viral/mortality , Pneumonia, Viral/therapy , Adolescent , Adult , Age Factors , Aged , Aged, 80 and over , Betacoronavirus , China/epidemiology , Chronic Disease , Coronavirus Infections/blood , Coronavirus Infections/complications , Female , Humans , Male , Middle Aged , Myalgia/virology , Pandemics , Pneumonia, Viral/blood , Pneumonia, Viral/complications , Retrospective Studies , Risk Factors , Serum Albumin/metabolism , Sex Factors , Symptom Assessment , Treatment Failure , Young Adult
11.
Zhonghua Wai Ke Za Zhi ; 58(6): 404-407, 2020 Jun 01.
Article in Chinese | MEDLINE | ID: covidwho-38530

ABSTRACT

As a newly epidemic, 2019 coronavirus disease (COVID-19) with a concentrated outbreak poses a great challenge to medical treatment. The severe and critical patients are complex complicatied with the psychological problems, and the medical staff are overworked and under tremendous psychological pressure. The surgeon participated in emergency medical rescue could provide professional treatment for the patients combined with surgical diseases, as well as specialized training for the non-surgeon crew, to reduce surgical-related mortality. With the advantages of good team consciousness, strong aseptic concept and good psychological quality, the surgeons can quickly adapt to and carry out rescue work under the premise of good self-protection. Surgeons need to develop critical care management concepts and focus on the critical care support equipment. Some suggestions are put forward for the standardized training of resident surgeons to cultivate compound talents. It is hoped that this article can lead to the thinking of how to participate in the emergency medical rescue of infectious diseases among surgeons and provide some enlightenment for future surgical education.


Subject(s)
Coronavirus Infections/therapy , Critical Care/standards , Delivery of Health Care/standards , Patient Care Management/standards , Pneumonia, Viral/therapy , Professional Practice/standards , Surgeons/standards , Betacoronavirus , Clinical Competence , Critical Care/psychology , Emergencies , Humans , Internship and Residency/standards , Occupational Stress/prevention & control , Pandemics , Surgeons/education , Surgeons/psychology
12.
Zhonghua Wei Chang Wai Ke Za Zhi ; 23(3): 201-208, 2020 Mar 25.
Article in Chinese | MEDLINE | ID: covidwho-12779

ABSTRACT

In December 2019, a new outbreak of corona virus disease 2019 began to occur. Its pathogen is 2019-nCoV, which has the characteristics of strong infectivity and general susceptibility. The current situation of prevention and control of new coronavirus pneumonia is severe. In this context, as front-line medical workers bearing important responsibilities and pressure, while through strict management strategy, we can minimize the risk of infection exposure. By summarizing the research progress and guidelines in recent years in the fields of colorectal cancer disease screening, treatment strategies (including early colorectal cancer, locally advanced colorectal cancer, obstructive colorectal cancer, metastatic colorectal cancer and the treatment of patients after neoadjuvant therapy), the choice of medication and time limit for adjuvant therapy, the protective measures for patients undergoing emergency surgery, the re-examination of postoperative patients and the protection of medical staff, etc., authors improve treatment strategies in order to provide more choices for patients to obtain the best treatment under the severe epidemic situation of new coronavirus pneumonia. Meanwhile we hope that it can also provide more timely treatment modeling schemes for colleagues.


Subject(s)
Colorectal Neoplasms , Coronavirus Infections/therapy , Pneumonia, Viral/therapy , Colorectal Neoplasms/complications , Colorectal Neoplasms/therapy , Coronavirus Infections/complications , Disease Outbreaks , Early Detection of Cancer , Humans , Pneumonia, Viral/complications
13.
Zhonghua Wai Ke Za Zhi ; 58(3): 170-177, 2020 Mar 01.
Article in Chinese | MEDLINE | ID: covidwho-9956

ABSTRACT

The 2019 coronavirus disease(COVID-19) is a highly infectious disease, has a long incubation period and a variety of clinical manifestations, which has a significant impact on public health and life. Afterwards, scientific and standardized work processing during the epidemic is of great significance for prevention and control. In order to implement the central government's decision-making deployment and defeat the COVID-19 as soon as possible, we had focused on the key points in the clinical work of general surgery according to latest relevant guidelines, literature and experience in epidemic prevention. Finally, we drafted the prevention and control strategies and recommendations to make a reference for medical staff of general surgery to fight against COVID-19.


Subject(s)
Betacoronavirus , Coronavirus Infections , General Surgery/standards , Pneumonia, Viral , China , Humans , Practice Guidelines as Topic
16.
Zhonghua Wai Ke Za Zhi ; 58(0): E001, 2020 Feb 14.
Article in Chinese | MEDLINE | ID: covidwho-911

ABSTRACT

Novel coronavirus pneumonia (NCP) is a highly infectious disease, has a long incubation period and a variety of clinical manifestations, which has a significant impact on public health and life. Afterwards, scientific and standardized work processing during the epidemic is of great significance for prevention and control. In order to implement the central government's decision-making deployment and defeat the NCP as soon as possible, we had focused on the key points in the clinical work of general surgery according to latest relevant guidelines, literature and experience in epidemic prevention. Finally, we drafted the prevention and control strategies and recommendations to make a reference for medical staff of general surgery to fight NCP.

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