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1.
Complexity ; 2022, 2022.
Article in English | ProQuest Central | ID: covidwho-1877481

ABSTRACT

This article effectively identifies the high and low volatility state of asset prices in China by constructing the MS-AR model, and further investigates the relationship between different dimensions of liquidity and asset price volatility. Moreover, we try to incorporate liquidity into the analytical framework and adopt the TVP-SV-VAR model to study the time-varying characteristics between monetary policy, liquidity, asset price volatility and macroeconomy. The results are as follows: firstly, it shows that the high or low volatility state of China’s stock market and real estate market can be clearly divided, and display the consistency with the trend of asset price volatility. Secondly, liquidity has a strong ability to explain the high and low volatility state of asset prices, but it shows some hysteresis effects. Thirdly, the time-varying results reveal that monetary policy has a regulating effect on liquidity, and the response cycle of quantitative monetary policy is relatively short, which reflects the effects of macroeconomy precisely. However, price-based monetary policy has a longer response cycle and plays a vital role in the anticipatory adjustment and fine-tuning of asset price volatility. These conclusions can provide an explanation for the attention to asset price bubbles and potential financial risks, and offer decision-making references for the central bank to implement differentiated and dynamic monetary policy choices.

3.
Psychol Res Behav Manag ; 15: 823-837, 2022.
Article in English | MEDLINE | ID: covidwho-1855210

ABSTRACT

Background: The COVID-19 pandemic motivated people to stay at home to reduce the risk of COVID-19 infection and community transmission, but limited research has investigated the behavioral mechanisms underlying home quarantine. Methods: Based on the theory of planned behavior (TPB), this study explored the mediating role of intention toward home quarantine and the moderating role of nationality among attitude, subjective norms, and perceived behavioral control. A total of 827 college students from the United States and China were recruited to complete an online survey. Results: The results of structural equation modeling showed that antecedents (ie, attitude, subjective norms, and perceived behavioral control) could predict actual home-quarantine behavior through the role of intention. Notably, the relation between both attitude and intention and perceived behavioral control and intention were moderated by nationality. Specifically, attitude was a stronger predictor of intention for American participants than for Chinese participants; however, perceived behavioral control was a stronger predictor of intention for Chinese participants. Conclusion: These findings reveal the internal mechanism of home-quarantine behavior and the heterogeneous explanations attributed to cultural diversity during the pandemic, which not only expands the application of TPB but also provides a reference for infectious disease mitigation in the field of public health policy.

4.
Front Psychol ; 13: 860289, 2022.
Article in English | MEDLINE | ID: covidwho-1834545

ABSTRACT

Objective: We conducted the following cross-sectional study to comprehensively assess the anxiety among Chinese international students who studied online during the COVID-19 pandemic and its influencing factors. Methods: Questionnaires were distributed through "Sojump," and a total of 1,090 valid questionnaires were collected. The questionnaire was divided into two parts: general situation and anxiety assessment of students. The former used a self-made questionnaire, and the international general GAD-7 scale was used to measure anxiety. Chi-square test was used to analyze the differences between groups, and logistic regression analysis was performed for the factors with differences. Results: Anxiety was found in 707 (64.9%) of 1,090 international students. Chi-square test and multivariate Logistic regression analysis showed that the incidence of anxiety was higher in the group under 22 years of age than in the group over 22 years of age (68% vs. 61%, p = 0.015; OR = 1.186, 95% CI 1.045-1.347, p = 0.008); International students living in big cities had a higher incidence of anxiety than those living in rural areas (67% vs. 60%, p = 0.022; OR = 1.419, 95%CI 1.038-1.859, p = 0.011); international students who socialized 3 times or less monthly had a higher incidence of anxiety than those who socialized more than 3 times per month (68% vs. 58%, p = 0.003; OR = 1.52, 95%CI 1.160-1.992, p = 0.002); international students who expected purely online teaching had a higher incidence of anxiety than those who expected purely offline teaching or dual-track teaching (72% vs. 64%, p = 0.037; OR = 1.525, 95%CI 1.069-2.177, p = 0.02); international students with a subjective score of online learning experience of 6 or less had a higher incidence of anxiety than those with subjective scores of more than 6 (70% vs. 60%, p = 0.001, OR = 1.25, 95%CI 1.099-1.422, p = 0.001). However, gender, emotional status, BMI, major of study, vaccination status, and degree type had no significant difference in the incidence of anxiety among international students who studied online during the COVID-19 pandemic. Conclusion: During COVID-19, international students who were younger, came from big cities, had low social frequency, expected purely online teaching, and had poor experience of online classes were risk factors for anxiety during online classes.

5.
Demography ; 59(3): 921-947, 2022 Jun 01.
Article in English | MEDLINE | ID: covidwho-1833449

ABSTRACT

We provide an empirical foundation for research on the demography of loneliness at older ages. First, we use published life tables and data from the U.S.-based Health and Retirement Study for the period 2008-2016 to calculate lonely life expectancy for Americans aged 55 or older. Using Sullivan's method, we demonstrate pronounced differences in lonely life expectancy by sex, race/ethnicity, and educational attainment that correspond to well-established patterns of stratification in other dimensions of well-being. Next, we estimate models that decompose observed sex, racial/ethnic, and educational differences in three key health outcomes into the part explained (in a statistical accounting sense) by loneliness and the part accounted for by other factors. We find little evidence of an important role for loneliness in understanding disparities in mortality and the onset of physical disability and cognitive impairment among Americans aged 55 or older, net of several established correlates of health disparities. These descriptive findings provide an empirical foundation for continued development of a demography of loneliness at older ages in response to the anticipated growth in scientific and policy emphasis on loneliness and the fundamental life changes that have accompanied the COVID-19 pandemic.


Subject(s)
COVID-19 , Loneliness , Aged , Humans , Life Expectancy , Life Tables , Loneliness/psychology , Middle Aged , Pandemics , United States/epidemiology
6.
J Am Heart Assoc ; 11(9): e023516, 2022 May 03.
Article in English | MEDLINE | ID: covidwho-1807753

ABSTRACT

Background This study sought to better understand the experiences of adults with congenital heart disease throughout the pandemic. Objectives were to determine (1) psychological distress before and throughout the pandemic; (2) changes in day-to-day functioning; and (3) the percentage of adults with congenital heart disease who experienced COVID-19 related symptoms, underwent testing, and tested positive. Methods and Results This was a cross-sectional study paired with retrospective chart review. A web-based survey was distributed to patients between December 2020 and January 2021. Patients reported on psychological distress across 5 categories (Screening Tool for Psychological Distress; depression, anxiety, stress, anger, and lack of social support), whether they experienced symptoms of COVID-19 and/or sought testing, and changes to their work and social behavior. Five hundred seventy-nine survey responses were received, of which 555 were linked to clinical data. Patients were aged 45±15 years. The proportion of patients reporting above-threshold values for all Screening Tool for Psychological Distress items significantly increased during the early pandemic compared with before the pandemic. Stress returned to baseline in December 2020/January 2021, whereas all others remained elevated. Psychological distress decreased with age, and women reported persistently elevated stress and anxiety compared with men during the pandemic. A consistent trend was not observed with regard to American College of Cardiology/American Heart Association anatomic and physiologic classification. Fifty (9%) patients lost employment because of a COVID-19-related reason. COVID-19 symptoms were reported by 145 (25%) patients, 182 (31%) sought testing, and 10 (2%) tested positive. Conclusions A substantial proportion of adults with congenital heart disease reported clinically significant psychological distress during the pandemic.


Subject(s)
COVID-19 , Heart Defects, Congenital , Psychological Distress , Adult , COVID-19/epidemiology , Cross-Sectional Studies , Depression/psychology , Female , Heart Defects, Congenital/diagnosis , Heart Defects, Congenital/epidemiology , Humans , Male , Pandemics , Retrospective Studies , Stress, Psychological/diagnosis , Stress, Psychological/epidemiology , United States
7.
EuropePMC; 2022.
Preprint in English | EuropePMC | ID: ppcovidwho-332764

ABSTRACT

Objective: The aim of this study was to investigate the mental health status and sleep quality of university students after local outbreak of COVID-19, and to help them understand the psychological stress reaction and provide base for their mental health education. Methods: A cross-sectional survey was conducted on the mental health status of university students in a Wuhan-based university. Results: A total of 897 university students were enrolled in the study. Compared with the epidemic period, university students' mental health status and sleep quality has a great deal of difference in the aspects of gender, grade, discipline and specialty, physical exercise, as well as with their family relationships and so on. 64.26% students would like to talk to their peers or close friends, while only 2.71% would like to call a caring hotline or seek help from a psychologist. Conclusion: After the local outbreak of COVID-19 in Wuhan was contained, the mental health status and sleep quality of more than half of the students improved. However, priority attention and care should be given to female students, senior students, those undertaking literature and history majors and those dissatisfied with family relationships.

8.
iScience ; 25(5): 104188, 2022 May 20.
Article in English | MEDLINE | ID: covidwho-1768219

ABSTRACT

Mesenchymal stem cells (MSCs) are being studied for the treatment of COVID-19-associated critical illness, due to their immunomodulatory properties. Here, we hypothesized that viral mimic-priming improves MSCs' abilities to rebalance the dysregulated immune responses in COVID-19. Transcriptome analysis of poly(I:C)-primed MSCs (pIC-MSCs) showed upregulation of pathways in antiviral and immunomodulatory responses. Together with increased expression of antiviral proteins such as MX1, IFITM3, and OAS1, these changes translated to greater effector functions in regulating monocytes and granulocytes while further enhancing MSCs' ability to block SARS-CoV-2 pseudovirus entry into epithelial cells. Most importantly, the addition of pIC-MSCs to COVID-19 patient whole blood significantly reduced inflammatory neutrophils and increased M2 monocytes while enhancing their phagocytic effector function. We reveal for the first time that MSCs can be primed by Toll-like receptor 3 agonist to improve their ability to rebalance the dysregulated immune responses seen in severe SARS-CoV-2 infection.

9.
Structural heart : the journal of the Heart Team ; 5(6):596-604, 2021.
Article in English | EuropePMC | ID: covidwho-1755993

ABSTRACT

Background Transcatheter aortic valve replacement (TAVR) with a standardized clinical pathway allows most patients to achieve safe next-day discharge. This approach has been successfully implemented across global centers as part of the Benchmark Program. Considering restricted hospital resources resulting from the COVID-19 pandemic, a modified same day discharge (SDD) clinical pathway was implemented for selected TAVR patients at a single Benchmark site. Methods All patients accepted for TAVR were assessed for the SDD clinical pathway. Eligibility criteria included adequate social support and accessibility to the TAVR program post-discharge. Patients with preexisting conduction disease were excluded. The clinical pathway comprised of mobilization, bloodwork and electrocardiogram 4 hours post-TAVR and discharge ≥8 hours following groin hemostasis. Results From June to December 2020, 142 patients underwent TAVR at a single community Benchmark site. Of those, 29 highly selected patients were successfully discharged the same day using the SDD clinical pathway. There were no vascular access complications, permanent pacemaker (PPM) implantation, or mortality in the SDD group during index admission or at 30-day follow-up. When compared to a standard therapy group, there was no statistically significant difference in 30-day cardiovascular readmission. Conclusions This study demonstrates the safety and feasibility of same day discharge post-TAVR in a highly selected cohort of patients, with no observable difference in safety outcomes when compared to patients who were discharged according to standard institutional practice.Abbreviations: AS: aortic stenosis;ACT: Activated clotting time;AV: atrioventricular;AVB: atrioventricular block;BBB: bundle branch block;CAIC: Canadian Society for Cardiovascular Angiography;CCL: cardiac catheterization laboratory;CT: Computed topography;CV: cardiovascular;IQR: Interquartile Range;IVCD: intraventricular conduction delay;LBBB: left bundle branch block;LOS: length of stay;NDD: next day discharge;PPM: permanent pacemaker;RBBB: right bundle branch block;SCAI: Society for Cardiovascular Angiography and Intervention;SD: standard deviation;SDD: same day discharge;ST: standard therapy;STS PROM: society of thoracic surgeons predicted risk of mortality;TAVR: transcatheter aortic valve replacement;TF: transfemoral;THV: transcatheter heart valve;TTE: transthoracic echocardiogram;VARC: Valve Academic Research Consortium

10.
Sustainability ; 14(6):3530, 2022.
Article in English | MDPI | ID: covidwho-1753680

ABSTRACT

In the dynamic environment where 'Black Swan';events occur frequently, the dual business model innovation (DBMI) which has both proactive and reactive characteristics is the core force for the enterprises to turn crises into opportunities and achieve their survival and sustainability. However, prevailing views do not clearly explain how to drive dual business model innovation. Based on the upper echelon theory, this study developed a multiple mediation model, which links entrepreneurial cognition of the top management team (TMT), knowledge search with dual business model innovation. By taking the data of 217 TMTs, the hypotheses are verified. The results show that TMT's configuration cognition, willing cognition, and ability cognition all have a positive effect on both proactive and reactive business model innovation. Knowledge search acts as a 'bridge';between TMT's entrepreneurial cognition and DBMI. Greater entrepreneurial cognition can guide exploratory and exploitative knowledge searches and promote the DBMI. The results also show the mediating effect between different entrepreneurial cognition and DBMI is not completely consistent, and a partial mediation effect exists associating configuration cognition with DBMI, but a full mediation effect is present between other cognitions and DBMI. These results provide more understanding to the formation of dual business model innovation under the impact of COVID-19.

11.
BMC Med Educ ; 22(1): 154, 2022 Mar 08.
Article in English | MEDLINE | ID: covidwho-1731527

ABSTRACT

BACKGROUND: Undergraduate medical (UM) students faced the difficulties inherent in medical careers due to the coronavirus (COVID-19) outbreak. Thus, imperative containment measures might affect UM students' career intentions. Information on the factors that may be associated with these students' career change intentions is limited. METHODS: We conducted a cross-sectional survey in August 2020 to investigate the impact of the COVID-19 pandemic on career intention and the associated factors in UM students. Univariate analyses and logistic regression analysis were performed to identify said factors. RESULTS: A total of 2040 medical students from the Hubei University of Medicine were surveyed. Univariate analyses showed that grade, attitude towards healthcare, and the degree of the COVID-19 pandemic's impact on the students' lives were associated with changes in career choice (P<0.05). Logistic regression analysis showed that Grade 2, Grade 5, attitude towards a medical career, and having relatives with a medical background were associated with changes in career choice. The degree of the COVID-19 pandemic's impact was a common and significant factor associated with career preference, career perspective, and ideal workplace. CONCLUSIONS: Changes in career intentions were particularly influenced by grade, attitude towards being a health worker, and the degree of COVID-19's impact on the participants' lives. Treating large-scale public health emergencies rationally, setting up correct views of occupation choice, and building reasonable career planning may reduce the loss of medical talent.


Subject(s)
COVID-19 , Students, Medical , COVID-19/epidemiology , Career Choice , Cross-Sectional Studies , Humans , Intention , Occupations , Pandemics , SARS-CoV-2 , Surveys and Questionnaires
12.
EuropePMC; 2021.
Preprint in English | EuropePMC | ID: ppcovidwho-313410

ABSTRACT

The transmission dynamics of COVID-19 is investigated in this study. A SINDy-LM modeling method that can effectively balance model complexity and prediction accuracy is proposed based on data-driven technique. First, the Sparse Identification of Nonlinear Dynamical systems (SINDy) method is used to discover and describe the nonlinear functional relationship between the dynamic terms in the model in accordance with the observation data of the COVID-19 epidemic. Moreover, the Levenberg–Marquardt (LM) algorithm is utilized to optimize the obtained model for improving the accuracy of the SINDy algorithm. Second, the obtained model, which is consistent with the logistic model in mathematical form with small errors and high robustness, is leveraged to review the epidemic situation in China. Otherwise, the evolution of the epidemic in Australia and Egypt is predicted, which demonstrates that this method has universality for constructing the global COVID-19 model. The proposed model is also compared with the extreme learning machine (ELM), which shows that the prediction accuracy of the SINDy-LM method outperforms that of the ELM method and the generated model has higher sparsity.

13.
EuropePMC; 2021.
Preprint in English | EuropePMC | ID: ppcovidwho-311593

ABSTRACT

Hopes for a COVID-19 vaccine are now a reality. The spike protein of SARS-CoV-2, which majorly binds to the host receptor ACE2 for cell entry, is used by most of the COVID-19 vaccine candidates as a choice of antigen. ACE2 is highly expressed in the heart and is known to be protective in multiple organs. Interaction of spike with ACE2 has been reported to reduce ACE2 expression and affect ACE2-mediated signal transduction in the heart. However, whether a spike-encoding vaccine will aggravate myocardial damage after a heart attack via affecting ACE2 remains unclear. Therefore, for patients with or at risk of heart diseases, questions arise around the safety of the spike-based vaccines. Here, we demonstrate that ACE2 is up-regulated and protective in the injured mouse heart after myocardial ischemia/reperfusion (I/R). Infecting human cardiomyocyte, smooth muscle cells, endothelial cells, and cardiac fibroblasts with a recombinant adenovirus type-5 vectored COVID-19 vaccine expressing the spike protein (AdSpike) does not affect cell survival and cardiomyocyte function, whether the cells are subjected to hypoxia-reoxygenation injury or not. This observation is further confirmed in human engineered heart tissues. Furthermore, AdSpike vaccination does not aggravate heart damage in wild-type or humanized ACE2 mice after I/R injury, even at a dose that is ten-fold higher as used in human. This study represents the first systematic evaluation of the safety of a leading COVID-19 vaccine under a disease context and may provide important information to ensure maximal protection from COVID-19 in patients with or at risk of heart diseases.

14.
EuropePMC; 2020.
Preprint in English | EuropePMC | ID: ppcovidwho-308532

ABSTRACT

Background: Complete absorption of coronavirus disease 2019 (COVID-19) pneumonia in a short term was not detailedly reported. We aimed to investigate the clinical and imaging characteristics of COVID-19 patients with complete absorption of pulmonary lesions. Methods: Retrospectively collected the clinical and chest CT data of 224 patients with COVID-19 in one regional medical center. Currently, pulmonary lesions in 37 patients were completely absorbed. The clinical manifestations, laboratory examinations, and CT findings of lesions for these patients were summarized. Results: Among the 37 patients (age, 39.0 ± 12.4 [14 - 63] years, 20 males), disease in 36 (97.3%) was mild and in 1 (3.7%) was from severe to mild. The most common symptoms were cough (24/37, 64.9%) and fever (23/37, 62.2%). Their laboratory indicators at admission were usually normal, while the white blood cell and neutrophil count significantly increased at discharge (p = 0.004, p = 0.006). On initial CT images, all patients had various pulmonary lesions (mean involved lobes:2.8 ± 1.5, range:1-5;mean involved segments: 6.6 ± 4.3, range: 1-16), which mainly manifested as multiple patchy and or spherical ground glass opacities (GGOs) (30/37, 81.1%) with fibrous strips (19/30, 63.3%) or consolidation (11/30, 36.7%). After treatment, lesions in most (33/37, 89.2%) patients were continuously absorbed. At discharge, previous lesions were mostly absorbed in 11 patients (11/37, 29.7%), the main residues were GGOs (24/37, 64.9%), followed by fibrous strips (13/37, 35.1%). On the latest CT, all the pulmonary lesions were completely absorbed, the duration of lesions was 31.6 ± 11.4 days (range: 5 - 50 days). Conclusion: The pulmonary lesions in some mild COVID-19 patients (generally with normal laboratory indicators at admission, GGOs as the main manifestation on initial CT, and representation of continuous absorption after treatment) could be completely absorbed with a mean duration of 31.6 days.

15.
EuropePMC; 2020.
Preprint in English | EuropePMC | ID: ppcovidwho-325204

ABSTRACT

Objective: Our objective is to investigate and analyze the psychological status of medical staff in a designated community hospital for COVID-19. Methods. We conducted a survey on medical staff in a designated community hospital for COVID-19 among the during-pandemic group (n = 120) and the after-pandemic group (n = 34). The symptom checklist 90 (SCL-90) questionnaire was used as a self-report instrument for the measurement of psychopathological complaints. Results. The during-pandemic group consisted of 120 individuals, including doctors (n = 36), nurses (n = 69) and technicians (n = 15). The SCL-90 sum scores showed no difference among doctors, nurses, and technicians (P > 0.05), but the somatization (SOM) item-scores of nurses were significantly higher than those of doctors and technicians (all P < 0.05). Meanwhile, the paranoid ideation (PAR) item-scores of nurses were significantly higher than those of doctors (P < 0.05). The after-pandemic group consisted only of nurses (n = 34). The score of each dimension of SCL-90 in nurses after the pandemic were relatively lower than that in nurses during the pandemic. Conclusions. Our study showed that nurses suffered with more psychological symptoms when fighting against COVID-19. The emergence of COVID-19 was the main factor leading to psychological problems of nurses.

16.
EuropePMC; 2021.
Preprint in English | EuropePMC | ID: ppcovidwho-324456

ABSTRACT

Background: The COVID-19 epidemic affected the career choice of healthcare professionals and students. To explore career choice regret of healthcare professionals and students during COVID-19 outbreak and its affected factors. Methods: Convenience sample of nurses, doctors, and medical students were recruited from hospitals and universities nationwide. The data collected including demographic information, professional value before and after the COVID-19 outbreak, the Connor-Davidson Resilience Scale, and career choice regret level by an online questionnaire. Multinominal logistic regression was employed to explore the factors associated with career choice regret. Results: In total, 9322 participants of convenience sampling were enrolled in, including 5786 nurses, 1664 doctors, and 1872 medical students. 6.7% participants had career choice regret. Multinominal logistic regression analysis showed, compared to participants with no regret, that as levels of resilience increased, the odds of experiencing career choice regret decreased (OR=0.951,P<0.001), while participants with lower professional value evaluation after the COVID-19 outbreak had higher probability to experience career choice regret(OR=1.552,P<0.001). Medical students were more likely to regret than nurses (OR=1.654,P=0.002), participants whose career/major choice was according to their personal ideal had higher risk of experience career choice regret (OR=1.592,P<0.001), while participants who were very afraid of the coronavirus had higher risk to experience career choice regret then participants with no fear at all(OR=1.997,P=0.004).As for the medical students, results indicated that medical students major in nursing and undergraduates had higher risk to experience career choice regret compared to medical students major in clinical medicine and postgraduate (Master or PhD), with an odds ratios of 2.645 and 6.851 respectively. Conclusions: A minority of healthcare professionals and medical students regretted their career choices during the COVID-19 outbreak. Enhance personal psychological resilience and professional value would helpful to reduce career choice regret among healthcare professionals and students during pandemic.

17.
EuropePMC; 2020.
Preprint in English | EuropePMC | ID: ppcovidwho-323777

ABSTRACT

Background: Taiwan medical centers mainly use "Central Pharmacy" to carry out pharmaceutical operations and human resources management. The pharmacy is a 24-hour medication supply center for all units in the Hospital. Therefore, how to make the pharmacy run continuously in the potential impact of COVID-19 pandemic is an important issue in the epidemic prevention of the medical center. The purpose of this study is to design to reduce the incidence of cross or cluster infection in the event of nosocomial infection and to maintain the continuous operation of pharmaceutical service. Methods: : The planning of "isolation and triage" of pharmaceutical operations is based on the epidemic level of COVID-19, the closing situation of outpatient service, the number of outpatients receiving medicine service and the number of inpatient beds. Results: : After the overall planning, in the case of the low epidemic level (level A1), the emergency pharmacy took advance deployment, and fixed personnel was assigned to work in fixed location in the isolation, while other units started the isolation mode in the case of the moderate epidemic level (level B). Grouping mode was added for the severe epidemic level (level C). Different management measures should be planned according to the different level of risk area evaluated by the infection control center. Conclusions: : In this study, the risk reduction management mechanism of "isolation and triage" was effectively used to make proper manpower allocation and work planning for all pharmaceutical service in Hospital.

18.
EuropePMC; 2021.
Preprint in English | EuropePMC | ID: ppcovidwho-323734

ABSTRACT

Background: :Undergraduate medical (UM) students faced the realities of the difficulties inherent in medical careers due to the coronavirus 2019 (COVID-19) outbreak. Thus imperative containment measures could affect UM students’ career intentions. There is limited information regarding the factors potentially associated with these students’ career change intentions.Methods:we conducted a cross-sectional survey to investigate the impact of the COVID-19 pandemic on career intention and the associated factors in UM students in August 2020. Univariate analyses and logistic regression analysis were used to identify the factors that contributed to any change of career intention. Results: A total of 2,040 medical students were contained from Hubei University of Medicine. The change of career intention was related to grade, attitude towards being a health worker and the impact of the COVID-19 pandemic. Conclusions: Changes in career intentions were particularly influenced by grade, attitude towards being a health worker, and the degree of COVID-19’s impact on the participants’ lives. Treating large-scale public health emergencies in rational way, setting up correct views of occupation choice and building reasonable career planning may reduce the loss of medical talents.

19.
EuropePMC; 2021.
Preprint in English | EuropePMC | ID: ppcovidwho-323612

ABSTRACT

The analysis of the coronavirus disease 2019 (COVID-19) is of great importance to deeply understand the dynamics of this coronavirus spread. Based on the complexity of it, a modified susceptible-infected-removed (SIR) model is applied to analyze the time dependence of active and hospitalized cases in China. The time evolution of the virus spread in different provinces was adequately modeled. Changeable parameters among them have been obtained and turned to be not naively independent with each other. The non-extensive parameter was found to be strongly connected with the freedom of systems. Taken into the prevention and treatment of disease, more measures by the government lead to higher values of it.

20.
J Environ Manage ; 309: 114728, 2022 May 01.
Article in English | MEDLINE | ID: covidwho-1683294

ABSTRACT

Real-time evaluation of the fighting activities during a sudden unknown disaster like the COVID-19 pandemic is a critical challenge for control. This study demonstrates that the temporal variations of effluents from hospital sewage treatment facilities can be used as an effective indicator for such evaluation. Taking a typical infection-suffering city in China as an example, we found that there was an obvious decrease in effluent ammonia and COD concentrations in line with the start of city lockdown, and its temporal variations well indicated the major events happened during the pandemic control. Notably, the lagging period between the change point of effluent residual chlorine and the change points of COD and ammonia concentration coincided with a period in which there was a deficiency in local medical resources. In addition, the diurnal behavior of effluents from designated hospitals has varied significantly at different stages of the pandemic development. The effluent ammonia peaks shifted from daytime to nighttime after the outbreak of the COVID-19 pandemic, suggesting a high workload of the designated hospitals in fighting the rapidly emerging pandemic. This work well demonstrates the necessary for data integration at the wastewater-medical service nexus and highlights an unusual role of the effluents from hospital sewage treatment facilities in revealing the status of fighting the pandemic, which helps to control the pandemic.


Subject(s)
COVID-19 , Pandemics , COVID-19/epidemiology , COVID-19/prevention & control , Communicable Disease Control , Hospitals , Humans , Pandemics/prevention & control , SARS-CoV-2 , Sewage
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