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Quantitative Imaging in Medicine and Surgery ; 10(11):2208-2211, 2020.
Article | WHO COVID | ID: covidwho-854851
Patterns (N Y) ; : 100092, 2020 Aug 03.
Article in English | MEDLINE | ID: covidwho-692873


The emergence of novel coronavirus disease 2019 (COVID-19) is placing an increasing burden on the healthcare systems. Although the majority of infected patients have non-severe symptoms and can be managed at home, some individuals may develop severe disease and are demanding the hospital admission. Therefore, it becomes paramount to efficiently assess the severity of COVID-19 and identify hospitalization priority with precision. In this respect, a 4-variable assessment model, including lymphocyte, lactate dehydrogenase (LDH), C-reactive protein (CRP) and neutrophil, is established and validated using the XGBoost algorithm. This model is found effective to identify severe COVID-19 cases on admission, with a sensitivity of 84.6%, a specificity of 84.6%, and an accuracy of 100% to predict the disease progression toward rapid deterioration. It also suggests that a computation-derived formula of clinical measures is practically applicable for the healthcare administrators to distribute hospitalization resources to the most needed in epidemics and pandemics.

J Infect Dis ; 221(11): 1775-1781, 2020 05 11.
Article in English | MEDLINE | ID: covidwho-381706


BACKGROUND: Previous studies on the pneumonia outbreak caused by the 2019 novel coronavirus disease (COVID-19) were mainly based on information from adult populations. Limited data are available for children with COVID-19, especially for infected infants. METHODS: We report a 55-day-old case with COVID-19 confirmed in China and describe the identification, diagnosis, clinical course, and treatment of the patient, including the disease progression from day 7 to day 11 of illness. RESULTS: This case highlights that children with COVID-19 can also present with multiple organ damage and rapid disease changes. CONCLUSIONS: When managing such infant patients with COVID-19, frequent and careful clinical monitoring is essential.

Coronavirus Infections/complications , Coronavirus Infections/diagnosis , Heart Injuries/etiology , Liver/injuries , Pneumonia, Viral/complications , Pneumonia, Viral/diagnosis , Pneumonia/etiology , Betacoronavirus , China , Coronavirus Infections/pathology , Coronavirus Infections/therapy , Disease Progression , Female , Humans , Infant , Pandemics , Pneumonia, Viral/pathology , Pneumonia, Viral/therapy , Treatment Outcome
Chin. J. Med. Imaging Technol. ; 3(36): 381-20200320.
Article in Chinese | ELSEVIER | ID: covidwho-143593
Ann Palliat Med ; 2020 Apr 20.
Article in English | MEDLINE | ID: covidwho-101323


The coronavirus disease 2019 (COVID-19) is a new infectious disease, firstly appeared in Wuhan city and has rapidly spread to 114 countries outside China, which is receiving worldwide attention. As two important means of examination, computed tomography (CT) and real-time reverse transcription polymerase chain reaction (RT-PCR) have always been controversial in the clinical diagnosis of COVID-19 pneumonia. Here, we report a family cluster case of a father and a son diagnosed as COVID-19 at our hospital, and described the clinical manifestations, laboratory results, CT changes, diagnosis and treatment strategy of these two patients. Focus on the value of these two methods in the diagnosis and treatment of diseases, as well as their respective deficiencies. For patient 1 (father), the efficacy of RT-PCR is not satisfactory either in terms of diagnosis or follow-up, which may cause misdiagnosis and delay treatment. For patient 2 (son), the clinical symptoms were not obvious, but CT imaging clearly displayed dynamic changes of the lung lesions. Meanwhile, the two patients respectively underwent five chest CT examinations during their hospitalization and discharge follow-up, showing the potential harm of radiation. Therefore, in clinical work, doctors should make full use of the advantages of CT and RT-PCR, and take other measures to make up for their disadvantages.