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1.
Nutritional Sciences Journal ; 46(1):30-43, 2022.
Article in Chinese | EMBASE | ID: covidwho-20238643

ABSTRACT

This purpose of this study is to help students developing problem-solving skills by using Problem-based Learning (PBL) as a teaching model, combining with the Objective Structured Clinical Examination (OSCE) as a training tool to evaluate students' clinical competencies. Sixty-five college junior students from a therapeutic nutrition course were participated. The topics of PBL included diabetes, kidney disease, cancer, and cardiovascular disease. For each disease, pre- and post-test quiz and after class exam were assessed to evaluate the students' learning effectiveness. Due to the impact of the COVID-19 epidemic, OSCE was performed online. The focus group interview and learning effectiveness questionnaire were conducted by the end of this course for all participants. Moreover, 37 students who attended the dietitian internship filled in the learning effectiveness questionnaire again after the internship. The results indicated that after the PBL, the post quiz score for each disease was increased, and through the online OSCE training, students' abilities to master nutrition education and counseling had been upgraded. Students indicated that both PBL and OSCE training could contributed to the learning effectiveness. The better academic performance students were, the more willing they are to work in nutrition-related fields in the future. For those who finished the dietitian internship agreed that they could understand the work content better in general regional and regional hospitals than in teaching ones. In conclusion, PBL teaching model combined with OSCE training could effectively improve students' learning motivation, learning effectiveness and practical application in a therapeutic nutrition course.Copyright © 2022 Nutrition Society in Taipei. All rights reserved.

3.
2022 19th China International Forum on Solid State Lighting & 2022 8th International Forum on Wide Bandgap Semiconductors, Sslchina: Ifws ; : 74-77, 2022.
Article in English | Web of Science | ID: covidwho-2327661

ABSTRACT

As the global spread of COVID-19becomesarapidly19 becomes a rapidly evolvingcrisis,thedevelopmentofcontactlesssharedevolving crisis, the development of contactless shared interactivedisplaysisanurgentiinteractive displays is an urgent issuetoreducetheriskofssue to reduce the risk of viralandbacterialcrosscontaminationduetotheuseofviral and bacterial cross contamination due to the use of touchtouch -operatedshareduserterminals.Here,weoperated shared user terminals. Here, we experimentallydemonstrateacontactlessuserterminalexperimentally demonstrate a contactless user terminal fabricatedwithamonolithicGaNOptoelectronicsystemfabricated with a monolithic GaN Optoelectronic system (MGOS),which(MGOS), which integratesthetransmitterandreceiverintointegrates the transmitter and receiver into asinglechip.a single chip. TheinherentspectralemissionThe inherent spectral emission-responsivenessresponsiveness overlapofGaNQWdiodesgivesthedeviceauniqueabilityoverlap of GaN QW diodes gives the device a unique ability todetectlighttransmittedbydiodesthatsharethesameQWto detect light transmitted by diodes that share the same QW structure.WhentheGaNtransmstructure. When the GaN transm itteremitslighttoitter emits light to illuminateanexternalobject,theintegratedGaNreceiverilluminate an external object, the integrated GaN receiver candetectthereflectedlightencodingtheinformationandcan detect the reflected light encoding the information and converttheopticalsignalintoanelectricalsignal,sothatconvert the optical signal into an electrical signal, so that thenonthe non--contactuserterminalhastheabilitytouselcontact user terminal has the ability to use lightforight for bidirectionaldatacommunication.Comparedtotraditionalbidirectional data communication. Compared to traditional handwritingsystems,theseterminalsoperateascontactlesshandwriting systems, these terminals operate as contactless informationentrydevicesthatcanhelpreducepotentialinformation entry devices that can help reduce potential crosscross--contaminationduetocontactwithhandwritingcontamination due to contact with handwriting terminals,providepterminals, provide precautionstokeeptheenvironmentrecautions to keep the environment clean,andhelppreventvirustransmission.clean, and help prevent virus transmission.

4.
Chinese Traditional and Herbal Drugs ; 54(4):1201-1207, 2023.
Article in Chinese | EMBASE | ID: covidwho-2324524

ABSTRACT

Objective To explore the clinical effect and safety of Suhexiang Pills () in the treatment of patients infected with SARS-CoV-2. Methods A total of 192 patients infected with SARS-CoV-2 admitted to 17 hospitals including Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University from December 2022 to January 2023 were randomly divided into control group and treatment group, with 89 patients in the treatment group and 103 in the control group. The patients in control group received basic treatment according to the Diagnosis and Treatment Protocol for COVID-19 (Trial Version 10). The patients in treatment group were oral administered with Suhexiang Pills on the basis of the control group, one pill each time, twice day. The patients in two groups were treated for 5 d. The clinical efficacy of the two groups after treatment was compared. The differences in scores of headache, chest pain, limb pain and inflammatory indexes before and after treatment were compared. Results After treatment, the total clinical effective rate of the treatment group was 95.51%, which was significantly higher than that of the control group (81.55%, P < 0.05). After treatment, headache, chest pain and limb pain scores were significantly decreased in both groups (P < 0.05), the headache score of the treatment group was significantly lower than that of the control group from the first day of treatment (P < 0.05), the chest pain score of the treatment group was significantly lower than that of the control group on the fifth day of treatment (P < 0.05), the limb pain score of the treatment group was significantly lower than that of the control group from the third day of treatment (P < 0.05). After treatment, the levels of C-reactive protein (CRP), procalcitonin (PCT), interleukin-6 (IL-6) in the two groups were decreased significantly (P < 0.05) and the levels of CRP and IL-6 in the treatment group were significantly lower than those of the control group (P < 0.05). There was no significant difference in the incidence of adverse events between the two groups. Conclusion Suhexiang Pills have a certain effect on headache, chest pain and limb pain, inhibiting the inflammatory response in patients infected with SARS-CoV-2, with good safety.Copyright © 2023 Editorial Office of Chinese Traditional and Herbal Drugs. All rights reserved.

5.
Chinese Traditional and Herbal Drugs ; 54(4):1201-1207, 2023.
Article in Chinese | EMBASE | ID: covidwho-2298983

ABSTRACT

Objective To explore the clinical effect and safety of Suhexiang Pills () in the treatment of patients infected with SARS-CoV-2. Methods A total of 192 patients infected with SARS-CoV-2 admitted to 17 hospitals including Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University from December 2022 to January 2023 were randomly divided into control group and treatment group, with 89 patients in the treatment group and 103 in the control group. The patients in control group received basic treatment according to the Diagnosis and Treatment Protocol for COVID-19 (Trial Version 10). The patients in treatment group were oral administered with Suhexiang Pills on the basis of the control group, one pill each time, twice day. The patients in two groups were treated for 5 d. The clinical efficacy of the two groups after treatment was compared. The differences in scores of headache, chest pain, limb pain and inflammatory indexes before and after treatment were compared. Results After treatment, the total clinical effective rate of the treatment group was 95.51%, which was significantly higher than that of the control group (81.55%, P < 0.05). After treatment, headache, chest pain and limb pain scores were significantly decreased in both groups (P < 0.05), the headache score of the treatment group was significantly lower than that of the control group from the first day of treatment (P < 0.05), the chest pain score of the treatment group was significantly lower than that of the control group on the fifth day of treatment (P < 0.05), the limb pain score of the treatment group was significantly lower than that of the control group from the third day of treatment (P < 0.05). After treatment, the levels of C-reactive protein (CRP), procalcitonin (PCT), interleukin-6 (IL-6) in the two groups were decreased significantly (P < 0.05) and the levels of CRP and IL-6 in the treatment group were significantly lower than those of the control group (P < 0.05). There was no significant difference in the incidence of adverse events between the two groups. Conclusion Suhexiang Pills have a certain effect on headache, chest pain and limb pain, inhibiting the inflammatory response in patients infected with SARS-CoV-2, with good safety.Copyright © 2023 Editorial Office of Chinese Traditional and Herbal Drugs. All rights reserved.

6.
Journal of Product and Brand Management ; 2022.
Article in English | Scopus | ID: covidwho-1752301

ABSTRACT

Purpose: The novel coronavirus 2019 (COVID-19) pandemic provided new and various opportunities for corporate social responsibility (CSR) activities. This study intended to compare three types of CSR activities – product development, in-kind donation and CSR commercial – undertaken by two companies – Nike, Inc. and The Coca-Cola Company in response to the pandemic. The purpose of this study was to investigate how CSR activity type and their attributes affected effectiveness. Design/methodology/approach: This study used an experiment using a 3 (CSR activity type) × 2 (company) mixed factorial design. CSR activity type was a between-subjects factor, and company was a within-subjects factor. The attributes of dynamism and innovativeness, corporate image, brand equity and social media sharing likelihood were dependent variables. Findings: The findings underscored the importance of CSR activity type and their attributes of dynamism and innovativeness in the effects on corporate image and brand equity. Product development and in-kind donation, which were perceived as more dynamic than CSR commercial, resulted in more desirable corporate images. Product development, which was perceived as more innovative than in-kind donation and CSR commercial, did not result in greater brand equity than in-kind donation, but resulted in greater brand equity than CSR commercial. The CSR activity type and their attributes did not affect social media sharing likelihood. Differences in content modes could be considered. Originality/value: This study advanced the knowledge on the effectiveness of CSR activities by comparing CSR activity types varying in dynamism and innovativeness in the context of a public health crisis that caused unprecedented societal changes and challenges. © 2022, Emerald Publishing Limited.

7.
European Journal of Public Health ; 31:2, 2021.
Article in English | Web of Science | ID: covidwho-1609849
8.
European Journal of Public Health ; 31, 2021.
Article in English | ProQuest Central | ID: covidwho-1514934

ABSTRACT

Background COVID-19 has shown varying impacts on different populations. In the Western Pacific (WP) Region with a relatively low COVID-19 burden, the variabilities of its impact on mental health, wellbeing and preventive behaviors across countries are unclear. Methods We analyzed repeated national-representative, cross-sectional data of 87,787 adults collected via the Imperial College London YouGov COVID-19 behavior tracker in ten WP countries-Australia, China, Singapore, Japan, South Korea, Vietnam, Taiwan, the Philippines, Malaysia and Hong Kong during the pandemic (April-September 2020). Main outcomes were severe depression/anxiety (Patient Health Questionnaire-4 score≥9), wellbeing (Cantril Ladder Scale 0-10), worries of contracting COVID-19 and prevalence of preventive behaviors. Monthly temporal trends were examined. Results Percentages of severe depression/anxiety were higher in Australia (12.9%), Hong Kong (11.8%) and lowest in Vietnam (6.8%);increasing trends were noted in the Philippines (5.9% to 12.3%, p < 0.0001) and Malaysia (8.2% to 10.7%, p = 0.019). South Korea, China and Taiwan had the lowest levels of wellbeing (5.0-5.5) compared with their highest counterparts in the Philippines, Australia and Vietnam (6.2-6.5). Worries of COVID-19 remained high in Asia countries (Japan, South Korea, Malaysia, Vietnam and the Philippines: 79.2%-81.6%), compared to that in Australia (41%). 83.5%-97.2% of the Asian respondents persistently wore face masks outside home, while the mean percentages were low in Australia (32.2%) despite the increasing trend observed (24.1% to 48.6%, p < 0.000). Over half of the WP countries have significant decreasing trends (p < 0.000) for avoid going out;Taiwan showed the lowest prevalence (45.7%). Conclusions Psychological and behavioral responses to COVID-19 in the WP region varied widely. COVID-19-related negative impact on mental health and wellbeing was universal. A Global effort to tackle the aftermath of the pandemic is crucial. Key messages The psychological and behavioral responses to COVID-19 in Western Pacific countries varied widely. Severe depression/anxiety and low levels of wellbeing were prevalent in Western Pacific Region.

9.
Molecular Systems Design & Engineering ; : 11, 2021.
Article in English | Web of Science | ID: covidwho-1434160

ABSTRACT

Multiple SARS-CoV-2 variants have widely spread around the globe since the end of 2020, all carrying the common N501Y mutation at the receptor binding motif of the viral-surface spike protein. Experimental studies show that N501Y enhances viral binding to human angiotensin converting enzyme 2 (ACE2) and confers moderate resistance to certain monoclonal antibodies (mAbs). A mechanistic understanding of this mutation remains elusive. In this study, we used molecular dynamics simulation and alchemical free energy calculations, to systematically evaluate the effects of this prominent substitution on recognizing the host receptor ACE2 and different types of neutralizing mAbs. Our results suggest that this mutation alters the delicate local interaction with its binding partners: Y501 enhances local hydrophobicity, strengthens interaction with neighbouring K353 and Y41, and yields a Delta Delta G(binding) value of about -0.9 kcal mol(-1) to human ACE2, in quantitative agreement with the experimental measurement. Yet, N501Y diminishes the binding to cat ACE2 due to steric clash, indicating distinct transmissibility in different species. Meanwhile, the bulky Y501 reduces the binding to the antibody CB6 by about 4 folds, confirming recent experimental results. Intriguingly, the N501Y substitution fuses a larger hydrophobic core and sensitizes the binding to H014, which makes the viral strain more vulnerable to this typical antibody. The present study portraits the chemical nature of protein-protein interaction due to the SARS-CoV-2 spike protein mutation at atomic resolution and enlightens future investigations of other variants and vaccine design.

10.
Stroke ; 52(SUPPL 1), 2021.
Article in English | EMBASE | ID: covidwho-1234401

ABSTRACT

Background: It is unclear the impact of the COVID-19 pandemic on the health care and outcomes for in-hospital patients with acute ischemic stroke (AIS). We aimed to evaluate the influence of COVID-19 on the quality of care for in-hospital patients with AIS. Methods: This is an observational registry study between November 23rd, 2019 and March 22nd, 2020. 408 hospital from 29 provinces in China were enrolled from Chinese Stroke Center Alliance (CSCA). Patients with AIS were extracted with demographic, clinical and previous history information. We focus on the time period before and after January 23rd, 2020, when the public health interventions were carried out in China. The primary outcome was adherence to 11 performance measures, with co-primary outcomes of a composite of percentage of performance measures adhered to. Secondary outcomes included were time measures and in-hospital outcomes. Results: 42056 patients with AIS was enrolled (mean age 66.5±12.1, male 61.3%). The overall inhospital patients decreased slightly from 14323 to 14204 before the COVID-19 outbreak and went down sharply by 31.4% and 61.1% after the outbreak and the public conducted interventions in China. A remarkable reduction was shown in patients with NIHSS score ≤ 3 from 57.7% to 55.7% after the outbreak (p<.001). Adherence to performance kept steady and grew slightly overall, for the composite measure (0.78±0.19 vs. 0.79±0.18, p<.001) increased after the COVID-19 outbreak. Discharged against medical advice increased from 5.9% to 7.3% after the outbreak (p<.001). The length of stay fell as expected after the public health interventions (10.0 (7.0-13.0) vs. 9.0 (7.0-13.0), p<.001). Conclusions: The admission number of patients with AIS declined significantly after the COVID-19outbreak, but the quality of care and outcomes kept stable. Hospitals should admit AIS patients tothe fullest extent of ability and provide tailored treatment strategies under the premise of no thecross-infection of COVID-19.

11.
Zhonghua Yan Ke Za Zhi ; 57(4): 305-310, 2021 Apr 11.
Article in Chinese | MEDLINE | ID: covidwho-1173000

ABSTRACT

Coronaviruses are a common class of respiratory viruses that can cause human infections. 2019 novel coronavirus(2019-nCoV), a new coronavirus that has recently caused a pandemic, has affected millions of people and put tremendous pressure on the health systems of almost every country in the world. Coronaviruses are known to spread from person to person through droplets or contact. The 2019-nCoV has also been found in the conjunctival secretions and tears of some clinically diagnosed patients. To assess whether the eye is one of the transmission routes of the virus, we review literature, and summarize the anatomy of the eye-nose pathway, the expression of the virus receptor in the eye, the preclinical animal studies, and the clinical data. We analyze the possibility of eyes as a means of transmission and propose some suggestions of ocular protection. (Chin J Ophthalmol, 2021, 57: 305-310).


Subject(s)
COVID-19 , Coronavirus Infections , Coronavirus , Animals , Humans , Pandemics , SARS-CoV-2
12.
Malaysian Journal of Library & Information Science ; 25(3):91-101, 2020.
Article in English | Web of Science | ID: covidwho-1022339

ABSTRACT

The emergence of the novel coronavirus disease 2019 (COVID-19) is a serious global public health problem. The mystery around the causative agent was revealed on 7 January 2020 when the pathogen was isolated by Chinese scientists and named as novel coronavirus-2019 (2019-nCoV). With quicker reaction to the contagion, the number of scholarly research publications have increased exponentially, which calls for bibliometric analysis and review of the incipient studies. Therefore on 7 Feb 2020, the English language and Chinese publications on COVID-19 were retrieved from PubMed and CNKI (China National Knowledge Infrastructure). A retrospective bibliometric analysis was performed to gauge the output, language, document type, journal, authorship, geographical distribution, research focus, resulting in a total of 154 papers comprising 100 papers in English and another 54 in Chinese. There were 30 journals published at least 2 papers, and the Journal of Medical Virology published the most papers (11). China and USA were the most productive countries, and there were 24 international collaborative papers. Fudan University contributed the most papers. Isaac I. Bogoch, Kunling Shen, Xingguang LI, Hongzhou Lu were the most active authors as first authors, with 2 papers respectively. Among the 154 publications, 35 were opinions papers, and 30 were research articles. Papers were categorized by research areas, and five research foci were identified. Our study offers an overview of the incipient publications and quantitative information for future research on coronavirus. Besides, Chinese publications were also retrieved for an integrated data analysis and diversity comparison.

13.
Zhonghua Wai Ke Za Zhi ; 58(4): 273-277, 2020 Apr 01.
Article in Chinese | MEDLINE | ID: covidwho-824073

ABSTRACT

In this paper, the mechanism of destroying human alveolar epithelial cells and pulmonary tissue by 2019 novel coronavirus (2019-nCoV) was discussed firstly. There may be multiple mechanisms including killing directly the target cells and hyperinflammatory responses. Secondly, the clinical features, CT imaging, short-term and long-term pulmonary function damage of the 2019 coronavirus disease (COVID-19) was analyzed. Finally, some suggestions for thoracic surgery clinical practice in non-epidemic area during and after the epidemic of COVID-19 were provided, to help all the thoracic surgery patients receive active and effective treatment.


Subject(s)
Alveolar Epithelial Cells/virology , Betacoronavirus/pathogenicity , Coronavirus Infections/pathology , Pneumonia, Viral/pathology , Thoracic Surgery , Alveolar Epithelial Cells/pathology , COVID-19 , Humans , Lung/pathology , Lung/virology , Pandemics , SARS-CoV-2
14.
Zhonghua Er Ke Za Zhi ; 58(4): 269-274, 2020 Apr 02.
Article in Chinese | MEDLINE | ID: covidwho-3049

ABSTRACT

Objective: To analyze the epidemiological history, clinical manifestations, treatment and the short-term prognosis of 31 cases of 2019 novel coronavirus (2019-nCoV) infection in children from six provinces (autonomous region) in northern China. Methods: A retrospective analysis of the epidemiological history, clinical symptoms, signs, laboratory examinations, chest imaging, treatment and the short-term prognosis of 31 cases of 2019-nCoV was conducted. The patients were diagnosed between January 25th, 2020 and February 21st, 2020 in 21 hospitals in 17 cities of six provinces (autonomous region) of Shaanxi, Gansu, Ningxia, Hebei, Henan and Shandong. Results: The age of the 31 children with 2019-nCoV infection was 7 years and 1 month (6 months-17 years). Nine cases (29%) were imported cases. Other 21 cases (68%) had contact with confirmed infected adults. One case (3%) had contact with asymptomatic returnees from Wuhan. Among the 31 children, 28 patients (90%) were family cluster cases. The clinical types were asymptomatic type in 4 cases (13%), mild type in 13 cases (42%), and common type in 14 cases (45%). No severe or critical type existed. The most common symptom was fever (n=20, 65%), including 1 case of high fever, 9 cases of moderate fever, 10 cases of low fever. Fever lasted from 1 day to 9 days. The fever of fifteen cases lasted for ≤3 d, while in other 5 cases lasted >3 d. Other symptoms included cough (n=14, 45%), fatigue (n=3, 10%) and diarrhea (n=3, 10%). Pharyngalgia, runny nose, dizziness, headache and vomiting were rare. In the early stage, the total leukocytes count in peripheral blood decreased in 2 cases (6%), the lymphocytes count decreased in 2 cases (6%), and the platelet count increased in 2 cases (6%).Elevation of C-reactive protein (10%, 3/30), erythrocyte sedimentation rate (19%, 4/21), procalcitonin (4%,1/28), liver enzyme (22%, 6/27) and muscle enzyme (15%, 4/27) occurred in different proportions. Renal function and blood glucose were normal. There were abnormal chest CT changes in 14 cases, including 9 cases with patchy ground glass opacities and nodules, mostly located in the lower lobe of both lungs near the pleural area. After receiving supportive treatment, the viral nucleic acid turned negative in 25 cases within 7-23 days. Among them, 24 children (77%) recovered and were discharged from hospital. No death occurred. Conclusions: In this case series, 2019-nCoV infection in children from six provinces (autonomous region) in northern China are mainly caused by close family contact. Clinical types are asymptomatic, mild and common types. Clinical manifestations and laboratory examination results are nonspecific. Close contact history of epidemiology, nucleic acid detection and chest imaging are important bases for diagnosis of 2019-nCoV infection. After general treatment, the short-term prognosis is good.


Subject(s)
Coronavirus Infections/diagnosis , Coronavirus Infections/physiopathology , Pneumonia, Viral/diagnosis , Pneumonia, Viral/physiopathology , Adolescent , Asymptomatic Infections , Betacoronavirus , COVID-19 , Child , Child, Preschool , China , Fever/virology , Humans , Infant , Pandemics , Prognosis , Retrospective Studies , SARS-CoV-2
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