Your browser doesn't support javascript.
Show: 20 | 50 | 100
Results 1 - 8 de 8
Filter
1.
Front Psychiatry ; 13: 1035075, 2022.
Article in English | MEDLINE | ID: covidwho-2236115

ABSTRACT

Background: As the COVID-19 epidemic was gradually brought under control, a new autumn semester began in 2020. How was the mental health of postgraduates as they experienced quarantine at home, only commuting between the school and hospital? Methods: The research was conducted in a cross-sectional online survey in October 2020. The data were collected from 1,645 medical postgraduates (master's and doctoral students) by using the demographic information questionnaire, the Self-rating Depression Scale (SDS), the Self-rating Anxiety Scale (SAS), the Questionnaire on Psychological Stressors of Postgraduates (QPSP), the Simplified Coping Style Questionnaire (SCSQ) and the Social Support Rate Scale (SSRS). One-way ANOVA and Pearson correlation were used to explore the relationships among anxiety, depression, psychological stressors, social support and coping style. Structural equation modeling (SEM) was conducted to assess the mediation model. Results: Among the total of 1,645 medical postgraduates, 21.6% (n = 356) had self-rated depression symptoms, and 9.4% (n = 155) had self-rated anxiety symptoms. The main disturbances they experienced were employment, academic and interpersonal pressure. The master of third grade students had the highest employment pressure, and the master of second grade students had the highest academic and interpersonal pressure. Negative coping played a negative mediating role and social support played a positive mediating role in the relationships between perceived stress and anxiety (ß = 0.027, P < 0.01; ß = 0.124, P < 0.01) and depression (ß = 0.016, P < 0.01; ß = 0.193, P < 0.01). Conclusion: Medical postgraduates in China restricted to studies on campus and in the hospital experienced psychological distress. Our results suggest that providing employment and learning guidance, while strengthening social support and guiding positive coping may be effective at improving the mental health of the medical graduate students, mediating their perceived stress and negative emotions.

2.
TESL-EJ ; 26(1), 2022.
Article in English | ProQuest Central | ID: covidwho-2101997

ABSTRACT

The COVID-19 pandemic has forced us to engage in the ubiquitous use of virtual interpreting teaching and learning. The sudden shift of teaching mode has resulted in unplanned challenges. The main concerns among teachers and students include teaching quality and learning effectiveness. To examine the effectiveness of interpreting teaching and learning online, we conducted a survey about students' perceptions of satisfaction concerning online interpreting teaching and learning via an online platform. This survey is composed of questions to measure student satisfaction from six aspects, namely, instructor, technology, setup, interaction, outcomes, and overall. Results showed that the shift to abrupt online interpreting teaching and learning did not have any significant impact on teaching quality and learning effectiveness. Findings also highlighted the need for further investigation of self-regulation and self-directiveness in online interpreting teaching and learning. Essential pedagogical tasks can be conducted online (e.g., triangulation exercises, relays, handover, and channel switching). Implications are provided based on the findings.

3.
Frontiers in psychiatry ; 13, 2022.
Article in English | EuropePMC | ID: covidwho-2208020

ABSTRACT

Background As the COVID-19 epidemic was gradually brought under control, a new autumn semester began in 2020. How was the mental health of postgraduates as they experienced quarantine at home, only commuting between the school and hospital? Methods The research was conducted in a cross-sectional online survey in October 2020. The data were collected from 1,645 medical postgraduates (master's and doctoral students) by using the demographic information questionnaire, the Self-rating Depression Scale (SDS), the Self-rating Anxiety Scale (SAS), the Questionnaire on Psychological Stressors of Postgraduates (QPSP), the Simplified Coping Style Questionnaire (SCSQ) and the Social Support Rate Scale (SSRS). One-way ANOVA and Pearson correlation were used to explore the relationships among anxiety, depression, psychological stressors, social support and coping style. Structural equation modeling (SEM) was conducted to assess the mediation model. Results Among the total of 1,645 medical postgraduates, 21.6% (n = 356) had self-rated depression symptoms, and 9.4% (n = 155) had self-rated anxiety symptoms. The main disturbances they experienced were employment, academic and interpersonal pressure. The master of third grade students had the highest employment pressure, and the master of second grade students had the highest academic and interpersonal pressure. Negative coping played a negative mediating role and social support played a positive mediating role in the relationships between perceived stress and anxiety (β = 0.027, P < 0.01;β = 0.124, P < 0.01) and depression (β = 0.016, P < 0.01;β = 0.193, P < 0.01). Conclusion Medical postgraduates in China restricted to studies on campus and in the hospital experienced psychological distress. Our results suggest that providing employment and learning guidance, while strengthening social support and guiding positive coping may be effective at improving the mental health of the medical graduate students, mediating their perceived stress and negative emotions.

4.
J Infect Public Health ; 16(1): 125-132, 2023 Jan.
Article in English | MEDLINE | ID: covidwho-2150141

ABSTRACT

BACKGROUND: Considering the adverse reactions to vaccination against coronavirus disease 2019 (COVID-19), some people, particularly the elderly and those with underlying medical conditions, are hesitant to be vaccinated. This study aimed to explore the prevalence of adverse reactions and provide direct evidence of vaccine safety, mainly for the elderly and people with underlying medical conditions, to receive COVID-19 vaccination. METHODS: From 1st March to 30th April 2022, we conducted an online survey of people who had completed three doses of COVID-19 vaccination by convenience sampling. Adverse reaction rates and 95% confidence intervals were calculated. In addition, conditional logistic regression was used to compare the differences in adverse reactions among the elderly and those with underlying medical conditions with the general population. RESULTS: A total of 3339 individuals were included in this study, of which 2335 (69.9%) were female, with an average age of 32.1 ± 11.4 years. The prevalence of adverse reactions after the first dose of inactivated vaccine was 24.6% (23.1-26.2%), 19.2% (17.8-20.7%) for the second dose, and 19.1% (17.7-20.6%) for the booster dose; among individuals using messenger RNA vaccines, the prevalence was 42.7% (32.3-53.6%) for the first dose, 47.2% (36.5-58.1%) for the second dose, and 46.1% (35.4-57.0%) for the booster dose. Compared with the general population, the prevalence of adverse events did not differ in individuals with underlying medical conditions and those aged 60 and above. CONCLUSIONS: For individuals with underlying medical conditions and those aged 60 and above, the prevalence of adverse reactions is similar to that of the general population, which provides a scientific basis regarding vaccination safety for these populations.


Subject(s)
COVID-19 Vaccines , COVID-19 , Adult , Aged , Female , Humans , Male , Young Adult , COVID-19/epidemiology , COVID-19/prevention & control , COVID-19 Vaccines/adverse effects , Prevalence , Research Design , Vaccination/adverse effects
5.
Int J Environ Res Public Health ; 19(5)2022 03 05.
Article in English | MEDLINE | ID: covidwho-1732023

ABSTRACT

(1) Background: The COVID-19 pandemic has led to significant shifts in university students' lives, which could be displayed by social mentality, a psychosocial conception at the individual and social levels. This five-wave longitudinal study aims to evaluate the changing social mentality of university students during the peak and preventive-order phases of the pandemic in China and investigate the trends and differences in social-demographic variables. (2) Methods: The Bi-Dimensional Structure Questionnaire of Social Mentality (B-DSMQ) was used to collect data from March 2020 to January 2021. Five-wave surveys were administered to 1319 students from five universities using online questionnaires. Analysis of variance (ANOVA) was used to compare the changes in social mentality over time and covariate groups. Linear mixed models were used to explore the associations of overall social mentality with time and covariates. Post hoc analysis was implemented within subgroups, including university, major, grade, parenting style, and the harmonious degree of parents. (3) Results: Students' social mentality changed significantly from Waves 1 to 5 (p < 0.001). It fell to its lowest in the third survey, increased in the fourth survey, and peaked in the fifth survey. In all of the subgroups, the changing social mentality differed significantly over time (p < 0.001). The p-values between groups suggested that changing social mentality was significantly different regarding gender, residence, university, major, grade, student cadre, graduates, nuclear family, economic status, parenting styles, and the harmonious degree of parents' relationship (p < 0.001). (4) Conclusions: Social mentality among university students decreased during the peak of the pandemic before increasing in the contained-risk period. It was the lowest in June when students began to return to the pandemic-preventive campus from quarantined homes. Students living in provinces (except for Shandong) who were from high-level universities in 2016 and 2017 and who majored in medicine displayed a more negative social mentality. Students who were female, student cadres, non-graduates, and enjoying high socioeconomic status displayed a more positive social mentality. Further research is needed on the relationship between mental health and social mentality, specifically the associates and interventions for positive social mentality.


Subject(s)
COVID-19 , Pandemics , COVID-19/epidemiology , China/epidemiology , Female , Humans , Longitudinal Studies , SARS-CoV-2 , Students/psychology , Universities
6.
Pharmacol Res ; 176: 106083, 2022 02.
Article in English | MEDLINE | ID: covidwho-1638968

ABSTRACT

The pathogenic hyper-inflammatory response has been revealed as the major cause of the severity and death of the Corona Virus Disease 2019 (COVID-19). Xuanfei Baidu Decoction (XFBD) as one of the "three medicines and three prescriptions" for the clinically effective treatment of COVID-19 in China, shows unique advantages in the control of symptomatic transition from moderate to severe disease states. However, the roles of XFBD to against hyper-inflammatory response and its mechanism remain unclear. Here, we established acute lung injury (ALI) model induced by lipopolysaccharide (LPS), presenting a hyperinflammatory process to explore the pharmacodynamic effect and molecular mechanism of XFBD on ALI. The in vitro experiments demonstrated that XFBD inhibited the secretion of IL-6 and TNF-α and iNOS activity in LPS-stimulated RAW264.7 macrophages. In vivo, we confirmed that XFBD improved pulmonary injury via down-regulating the expression of proinflammatory cytokines such as IL-6, TNF-α and IL1-ß as well as macrophages and neutrophils infiltration in LPS-induced ALI mice. Mechanically, we revealed that XFBD treated LPS-induced acute lung injury through PD-1/IL17A pathway which regulates the infiltration of neutrophils and macrophages. Additionally, one major compound from XFBD, i.e. glycyrrhizic acid, shows a high binding affinity with IL17A. In conclusion, we demonstrated the therapeutic effects of XFBD, which provides the immune foundations of XFBD and fatherly support its clinical applications.


Subject(s)
Acute Lung Injury/drug therapy , Drugs, Chinese Herbal/pharmacology , Interleukin-17/metabolism , Macrophages/drug effects , Neutrophils/drug effects , Programmed Cell Death 1 Receptor/metabolism , Signal Transduction/drug effects , Acute Lung Injury/metabolism , Animals , COVID-19/metabolism , Cell Line , China , Cytokines/metabolism , Leukocyte Count/methods , Macrophages/metabolism , Male , Mice , Mice, Inbred C57BL , Neutrophils/metabolism , RAW 264.7 Cells , COVID-19 Drug Treatment
7.
J Ethnopharmacol ; 283: 114701, 2022 Jan 30.
Article in English | MEDLINE | ID: covidwho-1446835

ABSTRACT

ETHNOPHARMACOLOGICAL RELEVANCE: Xuanfei Baidu Decoction (XFBD), one of the "three medicines and three prescriptions" for the clinically effective treatment of COVID-19 in China, plays an important role in the treatment of mild and/or common patients with dampness-toxin obstructing lung syndrome. AIM OF THE STUDY: The present work aims to elucidate the protective effects and the possible mechanism of XFBD against the acute inflammation and pulmonary fibrosis. METHODS: We use TGF-ß1 induced fibroblast activation model and LPS/IL-4 induced macrophage inflammation model as in vitro cell models. The mice model of lung fibrosis was induced by BLM via endotracheal drip, and then XFBD (4.6 g/kg, 9.2 g/kg) were administered orally respectively. The efficacy and molecular mechanisms in the presence or absence of XFBD were investigated. RESULTS: The results proved that XFBD can effectively inhibit fibroblast collagen deposition, down-regulate the level of α-SMA and inhibit the migration of fibroblasts. IL-4 induced macrophage polarization was also inhibited and the secretions of the inflammatory factors including IL6, iNOS were down-regulated. In vivo experiments, the results proved that XFBD improved the weight loss and survival rate of the mice. The XFBD high-dose administration group had a significant effect in inhibiting collagen deposition and the expression of α-SMA in the lungs of mice. XFBD can reduce bleomycin-induced pulmonary fibrosis by inhibiting IL-6/STAT3 activation and related macrophage infiltration. CONCLUSIONS: Xuanfei Baidu Decoction protects against macrophages induced inflammation and pulmonary fibrosis via inhibiting IL-6/STAT3 signaling pathway.


Subject(s)
COVID-19 Drug Treatment , Drugs, Chinese Herbal , Inflammation/drug therapy , Macrophages/drug effects , SARS-CoV-2 , Signal Transduction/drug effects , Animals , Cell Survival/drug effects , Drugs, Chinese Herbal/pharmacology , Drugs, Chinese Herbal/therapeutic use , Fibroblasts/drug effects , Gene Expression Regulation/drug effects , Gene Regulatory Networks , Humans , Interleukin-6/antagonists & inhibitors , Interleukin-6/genetics , Interleukin-6/metabolism , Male , Mice , Mice, Inbred C57BL , NIH 3T3 Cells , Phytotherapy , Pulmonary Fibrosis/pathology , Pulmonary Fibrosis/prevention & control , RAW 264.7 Cells , STAT3 Transcription Factor/antagonists & inhibitors , STAT3 Transcription Factor/genetics , STAT3 Transcription Factor/metabolism
8.
Medicine (Baltimore) ; 99(37): e22114, 2020 Sep 11.
Article in English | MEDLINE | ID: covidwho-760049

ABSTRACT

BACKGROUND: Bromhexine hydrochloride tablets may be effective in the treatment of Coronavirus disease 2019 (COVID-19) in children. This study will further evaluate the efficacy and safety of bromhexine hydrochloride tablets in the treatment of COVID-19 in children. METHODS: The following electronic databases will be searched, with all relevant randomized controlled trials (RCTs) up to August 2020 to be included: PubMed, Embase, Web of Science, the Cochrane Library, China National Knowledge Infrastructure (CNKI), the Chongqing VIP China Science and Technology Database (VIP), Wanfang, the Technology Periodical Database, and the Chinese Biomedical Literature Database (CBM). As well as the above, Baidu, the International Clinical Trials Registry Platform (ICTRP), Google Scholar, and the Chinese Clinical Trial Registry (ChiCTR) will also be searched to obtain more comprehensive data. Besides, the references of the included literature will also be traced to supplement our search results and to obtain all relevant literature. RESULTS: This systematic review will evaluate the current status of bromhexine hydrochloride in the treatment of COVID-19 in children, to evaluate its efficacy and safety. CONCLUSION: This study will provide the latest evidence for evaluating the efficacy and safety of bromhexine hydrochloride in the treatment of COVID-19 in children. PROSPERO REGISTRATION NUMBER: CRD42020199805. ETHICS AND DISSEMINATION: The private information of individuals will not be published. This systematic review will also not involve endangering participant rights. Ethical approval is not available. The results may be published in peer-reviewed journals or disseminated at relevant conferences.


Subject(s)
Bromhexine/pharmacology , Coronavirus Infections/drug therapy , Pneumonia, Viral/drug therapy , Betacoronavirus , COVID-19 , Child , Coronavirus Infections/epidemiology , Coronavirus Infections/physiopathology , Expectorants/pharmacology , Humans , Meta-Analysis as Topic , Pandemics , Pneumonia, Viral/epidemiology , Pneumonia, Viral/physiopathology , Research Design , SARS-CoV-2 , Systematic Reviews as Topic , Treatment Outcome
SELECTION OF CITATIONS
SEARCH DETAIL