ABSTRACT
At present, coronavirus disease-19 (COVID-19) caused by novel coronavirus (SARS-CoV-2) has been spreading around the world, but no specific therapeutic drug or vaccine has been developed for the virus. By collecting the latest literature and searching related database websites, the biological characteristics and main targets of SARS-CoV-2, the clinical therapeu tic drugs and the latest drug research were reviewed to provide information for clinical treatment and provide reference for the research and development of new drugs against SARS-CoV-2.Copyright © 2020 Publication Centre of Anhui Medical University. All rights reserved.
ABSTRACT
In December 2019, Wuhan, China, found SARS-CoV-2. It causes covid-19, a worldwide respiratory illness. Its global pandemic broke out unexpectedly, and the number of infections and deaths continued to rise dramatically, causing the collapse of medical systems and disease control organizations in many countries at the start of the outbreak. Vaccine research and development must be prioritized in order to control and reduce virus spread as soon as possible. The mRNA vaccine stands out among traditional vaccines due to its rapid research and development, ability to stimulate human dual immune responses and non-infectivity. Both humoral and cellular immunity can be stimulated by mRNA vaccines, which means that the produced T cells can help eliminate antigens in time, so their number does not increase in order to protect the original cells, and they can also create long-lived plasma cells and memory B cells to continue playing an immunological role for years. mRNA vaccines may not need repeated injections, unlike inactivated vaccinations, which may enhance efficiency. the first mRNA vaccinations that were made accessible to the general population when the US FDA approved its emergency use in December 2020. The generation of mRNA for the mRNA vaccination uses cell-free expression techniques and in vitro transcription-based systems. LNPs system, a nanoscale vesicle that can enclose mRNA in their cavity and imitates the lipid structure of the cell membrane, is the most often utilized delivery system in mRNA vaccines. The most common mRNA vaccine technique involves injecting a genetic component that tells the body to make a protein fragment of a specific pathogen, which the immune system recognizes and keeps mounting a robust response if it is subsequently exposed to that pathogen. © 2023 SPIE.
ABSTRACT
Objective To explore the clinical effect and safety of Suhexiang Pills () in the treatment of patients infected with SARS-CoV-2. Methods A total of 192 patients infected with SARS-CoV-2 admitted to 17 hospitals including Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University from December 2022 to January 2023 were randomly divided into control group and treatment group, with 89 patients in the treatment group and 103 in the control group. The patients in control group received basic treatment according to the Diagnosis and Treatment Protocol for COVID-19 (Trial Version 10). The patients in treatment group were oral administered with Suhexiang Pills on the basis of the control group, one pill each time, twice day. The patients in two groups were treated for 5 d. The clinical efficacy of the two groups after treatment was compared. The differences in scores of headache, chest pain, limb pain and inflammatory indexes before and after treatment were compared. Results After treatment, the total clinical effective rate of the treatment group was 95.51%, which was significantly higher than that of the control group (81.55%, P < 0.05). After treatment, headache, chest pain and limb pain scores were significantly decreased in both groups (P < 0.05), the headache score of the treatment group was significantly lower than that of the control group from the first day of treatment (P < 0.05), the chest pain score of the treatment group was significantly lower than that of the control group on the fifth day of treatment (P < 0.05), the limb pain score of the treatment group was significantly lower than that of the control group from the third day of treatment (P < 0.05). After treatment, the levels of C-reactive protein (CRP), procalcitonin (PCT), interleukin-6 (IL-6) in the two groups were decreased significantly (P < 0.05) and the levels of CRP and IL-6 in the treatment group were significantly lower than those of the control group (P < 0.05). There was no significant difference in the incidence of adverse events between the two groups. Conclusion Suhexiang Pills have a certain effect on headache, chest pain and limb pain, inhibiting the inflammatory response in patients infected with SARS-CoV-2, with good safety.Copyright © 2023 Editorial Office of Chinese Traditional and Herbal Drugs. All rights reserved.
ABSTRACT
Understanding indoor occupancy patterns is crucial for energy model calibration, efficient operations of fresh air systems, and COVID-19 exposure risk assessment. University libraries, as one of centers of campus life, due to the high mobility and "foot-voting” nature of them, i.e., occupants pick seats in the micro-environments they prefer, provide a non-intrusive opportunity to carry out post-occupancy evaluations. We conducted a long-term online monitoring of occupancy in libraries of a university in China by web-crawling the online seat reservation system, based on which, we constructed two sets of databases consisting of around 70 million records of nearly 3, 000 seats in 4 library sections, with seat-level resolution and sampling frequency up to every 10 seconds. The informative data set depicts not only the overall spatio-temporal occupancy patterns, but also nuances hidden within seats and visits. The daily flow of the main libraries exceeded two visits per seat. Half of the visitors stayed at the libraries for 3-6 hours during a single occupancy. Semester schedules and campus accessibility together influence students' decisions on when and which library to go, while even within the same zone, some seats were always more popular than their neighbours. "Semi-isolation” is one of the candidate attractive features proposed to understand the underlying patterns. © 2022 17th International Conference on Indoor Air Quality and Climate, INDOOR AIR 2022. All rights reserved.
ABSTRACT
During the novel coronavirus pneumonia (COVID-19) pandemic from 2020 to 2021, lung transplantation entered a new stage of development worldwide. Globally, more than 70 000 cases of lung transplantation have been reported to the International Society for Heart and Lung Transplantation (ISHLT). With the development of medical techniques over time, the characteristics of lung transplant donors and recipients and the indications of pediatric lung transplantation recipients have undergone significant changes. Application of lung transplantation in the treatment of COVID-19-related acute respiratory distress syndrome (ARDS) has also captivated worldwide attention. Along with persistent development of lung transplantation, it will be integrated with more novel techniques to make breakthroughs in the fields of artificial lung and xenotransplantation. In this article, research progresses on the characteristics of lung transplant donors and recipients around the world were reviewed and the development trend was predicted, enabling patients with end-stage lung disease to obtain more benefits from the development of lung transplantation technique.Copyright © 2022 Organ Transplantation. All rights reserved.
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COVID-19's impacts have spread widely in all directions such as economy, people's lifestyles and well-being. Though existing studies have highlighted such an impact, it remains unclear how the current COVID-19 situation has affected the retrenchment, vaccination and global happiness. In this paper, we present an automated tool enables the public to view various insight. In particular, we integrate and analyze the data from various data sources and show how the COVID19 has impacted Singapore and globally. We employ the regression models to identify the correlation between Human Development Index, Stringency Index, Gross Domestic Product per Capita, Total Deaths from COVID-19, and Total Cases of COVID-19;the rate of vaccination and vaccine hesitancy;and the factors to positively correlate to the global happiness. The insight provided adds values to better fight against the COVID-19 pandemic and future global crisis. © 2023 IEEE.