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Bone Marrow Transplant ; : 1-9, 2020.
Article | WHO COVID | ID: covidwho-939434


The COVID-19 pandemic has serious implications also for patients with other diseases Here, we describe the effects of the pandemic on unrelated hematopoietic stem cell donation and transplantation from the perspective of DKMS, a large international donor registry Especially, we cover the development of PBSC and bone marrow collection figures, donor management including Health and Availability Check (HAC), transport and cryopreservation of stem cell products, donor recruitment and business continuity measures The total number of stem cell products provided declined by around 15% during the crisis with a particularly strong decrease in bone marrow products We modified donor management processes to ensure donor and product safety HAC instead of confirmatory typing was helpful especially in countries with strict lockdowns New transport modes were developed so that stem cell products could be safely delivered despite COVID-19-related travel restrictions Cryopreservation of stem cell products became the new temporary standard during the pandemic to minimize risks related to transport logistics and donor availability However, many products from unrelated donors will never be transfused DKMS discontinued public offline donor recruitment, leading to a 40% decline in new donors during the crisis Most DKMS employees worked from home to ensure business continuity during the crisis

Clin Res Cardiol ; 2020.
Article | WHO COVID | ID: covidwho-938559


AIMS: During the COVID-19 pandemic, hospital admissions for cardiac care have declined However, effects on mortality are unclear Thus, we sought to evaluate the impact of the lockdown period in central Germany on overall and cardiovascular deaths Simultaneously we looked at catheterization activities in the same region METHODS AND RESULTS: Data from 22 of 24 public health-authorities in central Germany were aggregated during the pandemic related lockdown period and compared to the same time period in 2019 Information on the total number of deaths and causes of death, including cardiovascular mortality, were collected Additionally, we compared rates of hospitalization (n = 5178) for chronic coronary syndrome (CCS), acute coronary syndrome (ACS), and out of hospital cardiac arrest (OHCA) in 26 hospitals in this area Data on 5,984 deaths occurring between March 23, 2020 and April 26, 2020 were evaluated In comparison to the reference non-pandemic period in 2019 (deaths: n = 5832), there was a non-significant increase in all-cause mortality of 2 6% [incidence rate ratio (IRR) 1 03, 95% confidence interval (CI) 0 99-1 06;p = 0 16] Cardiovascular and cardiac mortality increased significantly by 7 6% (IRR 1 08, 95%-CI 1 01-1 14;p = 0 02) and by 11 8% (IRR 1 12, 95%-CI 1 05-1 19;p < 0 001), respectively During the same period, our data revealed a drop in cardiac catherization procedures CONCLUSION: During the COVID-19-related lockdown a significant increase in cardiovascular mortality was observed in central Germany, whereas catherization activities were reduced The mechanisms underlying both of these observations should be investigated further in order to better understand the effects of a pandemic-related lockdown and social-distancing restrictions on cardiovascular care and mortality

ERJ Open Research ; 6(4):1-9, 2020.
Article | WHO COVID | ID: covidwho-917913


Objectives: The aim of this study was to validate a composed coronavirus disease 2019 (COVID-19) chest radiography score (CARE) based on the extension of ground-glass opacity (GG) and consolidations (Co), separately assessed, and to investigate its prognostic performance Methods: COVID-19-positive patients referring to our tertiary centre during the first month of the outbreak in our area and with a known outcome were retrospectively evaluated Each lung was subdivided into three areas and a three-grade score assessing the extension of GG and Co was used The CARE was derived from the sum of the subscores A mixed-model ANOVA with post hoc Bonferroni correction was used to evaluate whether differences related to the referring unit (emergency room, COVID-19 wards and intensive care unit (ICU)) occurred Logistic regression analyses were used to investigate the impact of CARE, patients’ age and sex on the outcome To evaluate the prognostic performance of CARE, receiver operating characteristic curves were computed for the entire stay and at admission only Results: A total of 1203 chest radiographs of 175 patients (120 males;mean age 67 81±15 5 years old) were examined On average, each patient underwent 6 8±10 3 radiographs Patients in ICU as well as deceased patients showed higher CARE scores (p<0 05, each) Age, Co and CARE significantly influenced the outcome (p<0 05 each) The CARE demonstrated good accuracy (area under the curve (AUC)=0 736) using longitudinal data as well as at admission only (AUC=0 740) A CARE score of 17 5 during hospitalisation showed 75% sensitivity and 69 9% specificity Conclusions: The CARE was demonstrated to be a reliable tool to assess the severity of pulmonary involvement at chest radiography with a good prognostic performance

Radiologe ; 60(10):891-892, 2020.
Article | WHO COVID | ID: covidwho-807578