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BMJ Case Rep ; 14(4)2021 Apr 12.
Article in English | MEDLINE | ID: covidwho-1180949


Since the emergence of SARS-CoV-2, clinicians have been challenged with a wide spectrum of disease severity. One of the serious complications associated with the virus is multisystem inflammatory syndrome in children (MIS-C). It is characterised by inflammation leading to organ damage, in the setting of positive SARS-CoV-2 infection. MIS-C is thought to be a postviral reaction where most children are negative on PCR testing but are positive for SARS-CoV-2 antibodies. The Centers for Disease Control and Prevention recently defined the same phenomenon occurring in adults as multisystem inflammatory syndrome in adults (MIS-A) and emphasised on the use of antibody testing in this population. Here we describe an adult woman with an exposure to SARS-CoV-2 who presented with unexplained organ failure and shock. Positive antibody testing was the only clue to the diagnosis of MIS-A. We stress the importance of SARS-CoV-2 antibody detection in order to identify these cases.

COVID-19/complications , Systemic Inflammatory Response Syndrome/virology , Adult , Antibodies, Viral , COVID-19/diagnosis , COVID-19 Serological Testing , Diagnosis, Differential , Female , Humans , Multiple Organ Failure/diagnosis , Multiple Organ Failure/virology , Systemic Inflammatory Response Syndrome/diagnosis , Systemic Inflammatory Response Syndrome/drug therapy