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1.
4th International Conference on Information Systems and Computer Aided Education, ICISCAE 2021 ; : 2694-2698, 2021.
Article in English | Scopus | ID: covidwho-1566402

ABSTRACT

The COVID-19 that has continued since the end of 2019 has made the use of online teaching an important and feasible way to relieve the pressure of offline school hours during the epidemic, avoid the large-scale spread of the epidemic, and ensure that the annual teaching plan is completed on time. The online teaching caused by the epidemic is different from the normal online teaching application in terms of reasons, expected purpose, and organization methods. Based on the comparative analysis of the existing main online teaching organization forms, the online teaching organization forms in special periods are discussed from the aspects of curriculum content design and teaching methods. We have proposed an all-on-line hybrid teaching model of online self-study and online live broadcast interaction. Teaching practice shows that it has promotion value for teaching organization and implementation under special circumstances of teacher-student space isolation, and has reference significance for the application of online teaching in daily teaching reform. © 2021 ACM.

2.
Chinese Journal of Psychiatry ; 54(2):81-86, 2021.
Article in Chinese | Scopus | ID: covidwho-1403897

ABSTRACT

【Abstract】 After the epidemic of COVID‑19 has been basically under control interiorly, China is under the situation of regular epidemic prevention and control. Hence a reflection on the problems about the risk of gaming disorder in the epidemic period can be helpful to mental health professionals who prevent and control gaming disorder. The authors clarified the improper publicity of the gaming industry and false media report, and also reviewed the trend of game using was rapidly rising and game market was rapidly expanding. Consequently, as the author addressed, the health risks due to excessive gaming patterns were increasing. This review also pointed out and analyzed some new trend of the expansion of female game users during the epidemic, and the further in-depth integration of games and gambling. Finally, some advice was provided to the mental health workers to cope with the increasing risk of gaming disorder during a post-epidemic era. © Chinese Journal of Psychiatry 2021.

3.
Ieee Access ; 8:164705-164716, 2020.
Article in English | Web of Science | ID: covidwho-1396622

ABSTRACT

In this paper, considering the difference in social distancing among individuals, according to the extent of social distancing, a group composed of N mobile agents is divided into multiple different subgroups. Especially, from the perspective of differential game theory, the flocking problem of different subgroups can be regarded as collision avoidance between neighboring agents, or obstacle avoidance between agents and virtual static/dynamic obstacles. To explore the internal mechanism of this interesting problem, a novel flocking algorithm with multiple virtual leaders is designed. The proposed algorithm is a modified version of the traditional flocking and semi-flocking algorithms. Based on the Lyapunov stability theorem and LaSalle's invariance principle, the stability analysis of the proposed algorithm is then proven. Furthermore, considering the complex environment that swarm robots or unmanned aerial vehicles (UAVs) may face when performing military missions such as surveillance, reconnaissance, and rescue, etc., we also investigate the flocking problem of multi-agents in both virtual static and dynamic obstacles environment. Finally, three kinds of simulation results are provided to demonstrate the effectiveness of the proposed results.

4.
Eur Rev Med Pharmacol Sci ; 25(7): 3136-3144, 2021 04.
Article in English | MEDLINE | ID: covidwho-1194855

ABSTRACT

OBJECTIVE: Disruption of intracellular Ca2+ homeostasis via excessive and pathological Ca2+ release from the endoplasmic reticulum (ER) and/or sarcoplasmic reticulum (SR) through ryanodine receptor (RyRs) Ca2+ channels play a critical role in the pathology of systemic inflammatory response syndrome (SIRS) and associated multiple organ dysfunction syndrome (MODS) in sepsis or septic shock. Dantrolene, a potent inhibitor of RyRs, is expected to ameliorate SIRS and MODS and decrease mortality in sepsis or septic shock patients. This review summarized the potential mechanisms of therapeutic effects of dantrolene in sepsis or septic shock at molecular, cell, and organ levels and provided suggestions and strategies for future clinical studies.


Subject(s)
COVID-19/drug therapy , Calcium Channel Blockers/therapeutic use , Dantrolene/therapeutic use , Sepsis/drug therapy , COVID-19/metabolism , Calcium/metabolism , Drug Repositioning , Endoplasmic Reticulum/metabolism , Humans , Mortality , Multiple Organ Failure , Ryanodine Receptor Calcium Release Channel/metabolism , SARS-CoV-2 , Sarcoplasmic Reticulum/metabolism , Sepsis/metabolism , Shock, Septic/drug therapy , Shock, Septic/metabolism
5.
Journal of Xi'an Jiaotong University (Medical Sciences) ; 42(2):197-200, 2021.
Article in Chinese | Scopus | ID: covidwho-1190620

ABSTRACT

Objective: To investigate the clinical characteristics of COVID-19 induced deaths and analyze the causes of death. Methods: This was a hospital-based, retrospective, observational cohort study involving hospitalized patients diagnosed with COVID-19 in People's Hospital of Wuhan University during January 27 and February 25, 2020. The clinical data of identified patients who had died of COVID-19 were retrieved and reviewed. We analyzed the death causes and compared the changes in laboratory findings between patients before death and early onset to summarize the inherent clinical characteristics. Results: We recorded a total of 21 deaths, 61.9% of which had occurred due to simple respiratory failure, followed by respiratory failure with myocardial injury (19%), respiratory failure with renal failure (9.5%), and respiratory failure with shock (9.5%). At the late time, lab test data indicated that white blood cells, D-dimer, amino-terminal brain natriuretic peptide precursors, and hypersensitive C-reactive protein significantly increased while counts of lymphosyte significantly decreased (P<0.05). Conclusion: Continuous monitoring of cardiac function, renal function, and infection severity can assess the disease progression accurately. Moreover, timely intervention has a positive effect in reducing COVID-19 mortality. © 2021, Editorial Board of Journal of Xi'an Jiaotong University (Medical Sciences). All right reserved.

6.
The Medical journal / US Army Medical Center of Excellence ; - (PB 8-21-01/02/03):83-89, 2021.
Article in English | MEDLINE | ID: covidwho-1117857

ABSTRACT

With limited clinical resources, burgeoning testing requests from Army and other Service units to clinical laboratories, and the continued spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) throughout the military population, the Army Public Health Laboratory (APHL) Enterprise was tasked to establish surveillance testing capabilities for active duty military populations in an expedient manner. Following a proof-of-concept study conducted by Public Health Command-Pacific, Public Health Command-Europe was the first public health laboratory to offer the capability to assess for SARS-CoV-2 in pooled samples, followed closely by the Army Public Health Center (APHC) at Aberdeen Proving Grounds, MD, paralleling the spread of the SARS-CoV-2 virus from China to Europe to the continental US. The APHLs have selected pool sizes of up to 10 samples per pool based on the best evidence available at the time of method development and validation. Real-Time quantitative Reverse Transcriptase-Polymerase Chain Reaction (qRT-PCR) assays using RNA extracts from pooled nasopharyngeal swabs preserved in viral transport media were selected to assess the presence of SARS-CoV-2. The rapid development of initial surveillance testing capabilities depended on existing equipment in each laboratory, with a plan to implement full operational capability using additional staff and common high-throughput platforms. APHL Enterprise has successfully used existing resources to begin to address the changing and complex needs for COVID-19 testing within the Army population. Successful implementation of pooled surveillance testing at the APHC Laboratory has enabled more than 8,600 Soldiers to avoid clinical testing to date. The APHC Laboratory alone has tested over 10,000 samples and prevented approximately 8,600 soldiers from seeking testing with clinical diagnostic assays.

7.
J. Phys. Conf. Ser. ; 1693, 2020.
Article in English | Scopus | ID: covidwho-1026902

ABSTRACT

Under the background of the global COVID-19 pandemic, the global COVID-19 epidemic spread was modeled and analyzed, and its future trend was predicted. The dataset covers 163 countries and almost 2 full months from 2020, which is enough data to get some clues about the pandemic. The epidemic situation was predicted by the fusion of SIR model and ML regression, and the results showed that the model analysis was basically consistent with the real performance of the epidemic development. Finally, the development stage and trend of the epidemic situation are evaluated to provide a basis for the government to formulate relevant epidemic prevention policies. © Published under licence by IOP Publishing Ltd.

9.
Medical Journal of Chinese People's Liberation Army ; 45(11):1156-1160, 2020.
Article in Chinese | EMBASE | ID: covidwho-994247

ABSTRACT

Objective: To get the message of kidney injury and its causes in patients with COVID-19, and analyze the correlation of kidney injury to COVID-19 typing and prognosis, so provide a reference for the treatment and prognosis evaluation of COVID-19. Methods: According to the retrospective cohort study protocol, the clinical data and prognosis of 319 confirmed patients with COVID-19, admitted in the General Hospital of Central Theater Command (Wuhan) from Jan. 1st to Mar. 14th, 2020, were collected. The correlation of COVID-19 patients' renal function changes to the classification and prognosis of diseases were analyzed using univariate and multivariate logistic regression analysis. Results: The mean age of the 319 confirmed patients with COVID-19 was (55.2±17.0) years. The proportion of non-critical group (mild+moderate type) and critical group (severe+critical type) were 62.1% (198/319) and 37.9% (121/319), respectively. The fatality rate of present study cohort was 5.6% (18/319). About 3.8% cases (12/319) were with elevated blood urea nitrogen (BUN) and serum creatinine (SCr) at admission, and about 5.6% cases (18/319) were with elevated BUN only at admission. Univariate logistic regression analysis revealed that the age, the levels of SCr and BUN at admission and one week after admission, the combination of diabetes mellitus, and chronic kidney disease were the risk factors associated with the death in critical group patients (P<0.05). Multivariate logistic regression analysis revealed that the elevated levels of BUN at admission and one week after admission were the independent risk factors of death in the critical group patients. Conclusions: The elevated levels of BUN at admission and one week after admission were the important clinical features and independent risk factors associated with the death of critical COVID-19 patients. More attention should be paid to all kinds of clinical factors that may lead to increase the level of BUN.

10.
Proc. ACM SIGSPATIAL Int. Workshop Model. Underst. Spread COVID, COVID ; : 53-62, 2020.
Article in English | Scopus | ID: covidwho-991925

ABSTRACT

CoronaViz (http://coronaviz.umiacs.io) is a research prototype developed by us to enable the dynamic map visualization of COVID-19 related variables including the number of confirmed cases, active cases, recoveries, and deaths all on a daily basis from the Johns Hopkins University web site at ter.ps/coronajhu, by allowing the underlying spatial region and the spanned time interval to vary. Any combination of the variables can be viewed. subject to a possibility of clutter which is avoided by the use of concentric circles (termed geo-circles) whose radius values correspond to the variable values. The variable values are provided both on cumulative and day-by-day bases. The visualization enables spatial and temporal variation. © 2020 ACM.

11.
Journal of Xi'an Jiaotong University (Medical Sciences) ; 41(6):945-949, 2020.
Article in Chinese | Scopus | ID: covidwho-961827

ABSTRACT

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is highly infectious and causes severe harm to human health. Almost everyone is susceptible to coronavirus disease 2019 (COVID-19). It is thought that COVID-19 is transmitted via droplets and close contact without protection. Aerosol propagation is possible in confined space. Preclinical patients and recessive infected people have certain infectivity, which increases the difficulty of prevention and control. Treatment for cancer patients needs to be continuous. Cancer patients on radiotherapy once a day need continuous treatment. Since a large number of patients come to the hospital for radiotherapy, medical staff need to contact them frequently. It is particularly important to absolutely avoid cross infection between tumor patients and medical staff. To this end, we have developed detailed management strategies, including establishing a core group, standardizing inpatient diagnosis and treatment processes, standardizing outpatient radiotherapy patient process, strengthening the ward and room disinfection, strengthening personnel management and other measures. We hope this paper provides reference for the department of tumor radiotherapy. © 2020, Editorial Board of Journal of Xi'an Jiaotong University (Medical Sciences). All right reserved.

12.
Eur Rev Med Pharmacol Sci ; 24(19): 10239-10246, 2020 Oct.
Article in English | MEDLINE | ID: covidwho-890959

ABSTRACT

OBJECTIVE: Hypoxia is one of the primary causes that leads to multiple organ injuries and death in COVID-19 patients. Aggressive oxygen therapy for the treatment of hypoxia is important in saving these patients. We have summarized the mechanisms, efficacy, and side effects of various oxygen therapy techniques and their status or the potential to treat hypoxia in COVID-19 patients. The benefit to risk ratio of each oxygen therapy technique and strategy to use them in COVID-19 patients are discussed. High flow nasal cannula oxygen (HFNO) should be considered a better choice as an early stage oxygen therapy. Supraglottic jet oxygenation and ventilation (SJOV) is a promising alternative for HFNO with potential benefits.


Subject(s)
COVID-19/complications , COVID-19/therapy , Hypoxia/complications , Hypoxia/therapy , Oxygen Inhalation Therapy/methods , COVID-19/metabolism , Humans , Oxygen Inhalation Therapy/adverse effects , Pandemics , SARS-CoV-2
13.
Eur Rev Med Pharmacol Sci ; 24(19): 10228-10238, 2020 10.
Article in English | MEDLINE | ID: covidwho-890958

ABSTRACT

Dantrolene, an FDA approved drug to treat malignant hyperthermia and muscle spasm, has been demonstrated to inhibit severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mediated toxicity of host cells. Ryanodine receptor overactivation and associated disruption of intracellular Ca2+ homeostasis play important roles in SARS-CoV-2 infection and replication of host cells. Dantrolene, as an inhibitor of RyRs, is expected to ameliorate these detrimental effects of SARS-CoV-2 in host cells. Additionally, dantrolene has also been shown to inhibit multiple cell or organ damage induced by hypoxia/ischemia, mitochondria damage, oxidative stresses, inflammation, impairment of autophagy and apoptosis, etc., which are often the causes of severity and mortality of COVID-19 patients. We have repurposed that dantrolene has a high potential at treating COVID-19 patients and reducing its morbidity and mortality.


Subject(s)
COVID-19/drug therapy , COVID-19/metabolism , Calcium/metabolism , Dantrolene/therapeutic use , Drug Repositioning , Homeostasis/drug effects , Humans , Muscle Relaxants, Central/therapeutic use , Pandemics
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