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1.
Eur Rev Med Pharmacol Sci ; 27(7): 3191-3200, 2023 04.
Article in English | MEDLINE | ID: covidwho-2296648

ABSTRACT

A few patients who have recovered from COVID-19 develop persistent or new symptoms that last for weeks or months; this is called "long COVID" or "post-COVID-19 syndrome." Over time, awareness of the short- and long-term consequences of COVID-19 has increased. The pulmonary consequences are now fairly well established, but little is known about the extrapulmonary system of COVID-19, particularly its effects on bones. Current evidence and reports indicate a direct relationship between SARS-CoV-2 infection and bone health, with SARS-CoV-2 having a significant negative effect on bone health. In this review, we analyzed the impact of SARS-CoV-2 infection on bone health and assessed the impact of COVID-19 on the diagnosis and treatment of osteoporosis.


Subject(s)
COVID-19 , Osteoporosis , Humans , Post-Acute COVID-19 Syndrome , SARS-CoV-2 , Bone Density
2.
Applied Thermal Engineering ; 226, 2023.
Article in English | Scopus | ID: covidwho-2269191

ABSTRACT

The nucleic acid detection is an effective way for the prevention and control of COVID-19. PCR amplification is an important process in the nucleic acid detection. At present, PCR amplification has the problem of low heating/cooling rates, and poor temperature uniformity. This paper proposes a microchannel temperature control device for the nucleic acid detection. Five groups of parallel serpentine channels are used to increase the cooling rate of the PCR amplification. A gradual thermal conductivity design is applied to the reaction module to increase the temperature uniformity. The experimental results show that the best temperature uniformity is obtained when the materials of the inner and outer layers of the reaction module are copper and aluminum alloys, respectively. The limit and average heating/cooling rate are 7.2, 6.12, 5.52 and 5.28 °C/s, respectively, when the input power of the thermoelectric cooler is 11.07 W/cm2, the temperature and flow rate of the cooling water are 15℃ and 700 ml/min, and the thermal conductivity of the thermal grease is 6 W/(m·K). Compared with the commercial fan-fin cooling method, the limit and average heating/cooling rates are increased by 38.02%, 80.82%, 86.49% and 208.77%, respectively, with the help of microchannel cooling method. © 2023 Elsevier Ltd

3.
Frontiers in Environmental Science ; 11, 2023.
Article in English | Scopus | ID: covidwho-2286479

ABSTRACT

In the published article, there was an error in Affiliation 1. Instead of "MinNan Science and Technology University, Quanzhou, China”, it should be "College of Business, MinNan Science and Technology University, Quanzhou, China.” There was also a mistake in the Funding statement. The funding statement for the Key Development Project of the Department of Science and Technology was displayed as "2015CBd051”. The correct statement is "Key Development Project of Department of Science and Technology (2015C03Bd051).'' Funding This research projectwas funded by BeijingMunicipal Philosophy and Social Science Planning Office "Research on the Coordinated Development of Beijing–Tianjin–Hebei Financial Agglomeration and Industrial Structure Upgrading” (16YJB037) and Key Development Project of Department of Science and Technology (2015C03Bd051). The authors apologize for these errors and state that they do not change the scientific conclusions of the article in any way. The original article has been updated. © 2023 Wei, Xiao, Yaqub, Irfan, Murad and Yaqub.

4.
Chemical Engineering Journal ; 452, 2023.
Article in English | Scopus | ID: covidwho-2246182

ABSTRACT

Metal-organic frameworks (MOFs) featuring composition and bandstructure diversity, are an emerging class of photoresponsive disinfectants. In this study, we demonstrated the superiority of core–shell arranged photoactive MOFs (prussian blue (PB) and zeolitic imidazolate framework (ZIF-8)) for pathogen inactivation in terms of biocidal efficiency and broad-spectrum sensitivity. Reactive oxygen species (ROS) production was significantly promoted after the integration of PB due to the photosensitization effect and initiation of in situ Fenton reaction. Favorably, another inactivation channel was also opened owing to the unique photothermal effect of PB. Attributed to the facilitated ROS intracellular penetration by heat, the composite outperforms not only individual component but anatase TiO2 in pathogen elimination. Specifically, the Staphylococcus aureus (S. aureus) inactivation efficiency of the composite (6.6 log) is 2, 1.8 and 5.1 times higher than that of PB (3.3 log), ZIF-8 (3.7 log) and TiO2 (1.3 log) over 45 min of simulated sunlight illumination. Significantly, the infectivity of Bacillus anthracis and murine coronavirus in droplets on composite-coated filter surface could be greatly reduced (approximately 3 log reduction in colony number/coronavirus titer) within few minutes of solar exposure, indicative of the great potential of MOF composites toward life-threatening microbial infection prevention. © 2022 Elsevier B.V.

5.
Frontiers in Environmental Science ; 10, 2023.
Article in English | Scopus | ID: covidwho-2236911

ABSTRACT

Online purchasing is increasing because customers are shifting to digital wallets and digital money, as these services are provided by different microfinance and other commercial banking sectors, and different online brands are working in Pakistan to support environmental sustainability. The objective of this study was to demonstrate to what extent low distribution charges and low transit time is contributing to impulsive buying when customers can use digital money in Pakistan. The study was conducted using survey research. Importantly, 650 questionnaires were distributed to the respondents with a received response rate of 40%. The study found that digital money (e-wallet) is positively associated with impulsive buying. Moreover, the moderating role of distribution charges and low transit time has been significant in impulsive buying has been significant. This study concludes that low transit time and load distribution charges must be considered by online businesses and brands working in Pakistan to ensure productivity and capture a larger market share of impulsive buying in Pakistan. Also, the current study contributes a theoretical framework to the knowledge and literature related to impulsive buying. The scope of this study is limited to the online businesses and brands that are working to provide products and services to the Pakistani people with the help of digital money and digital transactions. Significantly, this study provides significant future directions that are important to consider for upcoming studies to focus on and contribute to effectively. Copyright © 2023 Wei, Xiao, Yaqub, Irfan, Murad and Yaqub.

6.
Advanced Functional Materials ; 2023.
Article in English | Scopus | ID: covidwho-2172323

ABSTRACT

Non-contact human-machine interaction is the future trend for wearable technologies. This demand is recently highlighted by the pandemic of coronavirus disease (COVID-19). Herein, an anti-fatigue and highly conductive hydrogel thermocell with photo-thermal conversion ability for non-contact self-powering applications is designed. Double hydrogen-bonding enhanced supramolecular hydrogel is obtained with N-acryloyl glycinamide (NAGA) and diacrylate capped Pluronic F68 (F68-DA) via one-step photo-initiated polymerization. The supramolecular hydrogel can accommodate saturated electrolytes to fulfill the triple function of ionic crosslinking, heat-to-electricity conversion, and light response of thermocell. Eminently, the thermocell stands out by virtue of its high seebeck coefficient (-2.17 mV K−1) and extraordinary toughness (Fatigue threshold ≈ 3120 J m−2). The self-powering ability under the control of light heating is explored, and a model of a non-contact "light-remoted” sensor with self-powered and sensing integrated performance remote-controlled by light is constructed. It is believed that this study will pave the way for the non-contact energy supply of wearable devices. © 2023 Wiley-VCH GmbH.

7.
Annals of the Rheumatic Diseases ; 81:161-162, 2022.
Article in English | EMBASE | ID: covidwho-2008939

ABSTRACT

Background: The risk of acquiring COVID-19, and the severity of illness if acquired, in the context of immune-mediated infammatory diseases (IMIDs) and their therapy, remains incompletely understood. Reported infection rates and outcomes have varied depending on the IMIDs being studied, the nature and size of the study population, and the presence or absence of appropriate control populations. Having more reliable analysis on larger populations is essential for current and future pandemics. Objectives: Health records from one of the largest health systems in the US are analyzed to determine whether specifc IMIDs, including common rheumatologic conditions and specifc immunomodulatory drugs, are associated with certain COVID-19 outcomes, using multivariate models that include common chronic comorbidities. Methods: Patients (pts) with and without IMIDs who were tested for SARS-CoV-2 antigen (n=1,101,431) were identifed from the EHR from Providence St. Joseph Health, which serves much of the western US. Immunomodulatory drug therapy was defned as use within three months prior to the frst test. Multivariate logistic regression (LR) was applied with machine learning metrics (feature importance, p-value) reported on an 80% training set and AUROC reported on 20% test set. Results: Rates for positive COVID-19 tests, invasive mechanical ventilation (IMV) and mortality were not greater in the IMID than non-IMID population, whilst hospitalization was similar (Table 1). Importance and statistical signifcance of selected factors are shown in (Figure 1). The most important risk factors for hos-pitalization were age and heart failure. Heart failure was the most important risk factor for IMV, and age for increased mortality. Diabetes showed weak associations with these three outcomes. Spondyloarthritis was weakly associated with decreased hospitalization, IMV, and death. The use of conventional synthetic disease-modifying antirheumatic drugs (csDMARDS) and corticosteroids (CS) showed a weak association with hospitalization, and rituximab (RTX) showed a weak association with increased mortality. Limitations include lack of vaccination status and IMID disease severity/fare status. Testing was not universal. Conclusion: This analysis of COVID+ patients (n=1,101,431) from a large US health care system analyzes outcomes of patients with and without IMIDs;the majority were rheumatologic IMIDs. Patients with IMIDs had a similar rate of hospitalization, IMV, and death as those without IMIDs. The strongest associations with COVID-19 severity included heart failure and age. Spondyloarthritis was weakly associated with favorable outcomes whilst other conditions, including rheumatologic, were not worse than those of non-IMID patients. csDMARDs and corticosteroids were weakly associated with hospitalization and RTX with increased mortality. Other therapies were not associated with severe adverse outcomes.

8.
Chinese Journal of Disease Control and Prevention ; 25(4):421-426, 2021.
Article in Chinese | Scopus | ID: covidwho-1566857

ABSTRACT

Objective To explore the epidemic characteristics of COVID-19 in Lu’an city, so as to provide scientific basis for the prevention and control of COVID-19 in this area. Methods All the confirmed cases of COVID-19 were selected from the Infectious Disease Reporting System from the onset of disease to 24:00 on February 18th, 2020 in Lu’an City. The general demographic, onset and medical information, and epidemiological characteristics of confirmed cases were collected to describe the feature of patients. The spatial and temporal distribution of disease transmission was analyzed by SaTScan 9.6.0.0 software, and Excel 2010 software was used to draw the epidemic curves of all cases. Results A total of 69 confirmed cases were reported in Lu’an City by February 18th, 2020. There were more male cases (44) than female (25), and cases mainly aged 36-45 years old (37.68%). The proportion of workers was the highest (24.64%). The first symptom of conformed cases was fever (50, 72.46%), cough (25, 36.23%) and fatigue (12, 17.40%). The epidemic was more serious in Jinzhai County (23), Huoshan County (17) and Huoqiu County (13). The number of cases in Lu’an showed that the first epidemic peak occurred between January 25th and January 28th, and the largest number of cases occurred on January 27th, then showed a downward trend. A total of 45 aggregate cases were found. Conclusion The COVID-19 epidemic in Lu’an City is generally preventable and controllable. It will be alert to the risk of family clustering, spread of asymptomatic infections and imported cases. Future work should focus on the investigation of close contacts. © 2021, Publication Centre of Anhui Medical University. All rights reserved.

10.
Drugs of the Future ; 46(7):579-582, 2021.
Article in English | Web of Science | ID: covidwho-1325362

ABSTRACT

BioCon China 2021 was held in Shanghai, China, April 22-23, 2021, focusing on the discovery and design, process development and optimization of biological products, including next-generation bispecific antibodies, antibody-drug conjugates (ADCs), cell and gene therapies, oncolytic virus therapies and mRNA vaccines. This report concentrates on the R&D of antibodies and ADCs, mRNA COVID-19 vaccines and other mRNA therapies presented at the event.

11.
Drugs of the Future ; 45(12):917-921, 2021.
Article in English | EMBASE | ID: covidwho-1067380

ABSTRACT

The Chinese Society of Clinical Oncology (CSCO) 2020 annual meeting was held on September 19-26, 2020. The format was mostly online, but the virtual meeting was supplemented by on-site participation in the cities of Beijing, Shanghai, Wuhan, Harbin and Guangzhou, in order to meet the requirements of the COVID-19 epidemic prevention and control. The CSCO 2020 theme was “Precision Treatment, Win-Win Together,” promoting academic exchanges and technical cooperation on scientific research and innovation to encourage precision oncology based on multidisciplinary standardized comprehensive treatment. The annual meeting continued to have focused sessions on Frontiers of Oncology Clinical Research, Center for Drug Evaluation (CDE), which jointly build technical standards to accelerate the development and launch of new antitumor drugs, and Innovative Drug Clinical Research Data. This report focuses on discussions in the CDE session and provides highlights on the clinical data presented in the Innovative Drug session.

12.
J Cell Sci ; 134(4)2021 02 19.
Article in English | MEDLINE | ID: covidwho-1067374

ABSTRACT

In order to produce proteins essential for their propagation, many pathogenic human viruses, including SARS-CoV-2, the causative agent of COVID-19 respiratory disease, commandeer host biosynthetic machineries and mechanisms. Three major structural proteins, the spike, envelope and membrane proteins, are amongst several SARS-CoV-2 components synthesised at the endoplasmic reticulum (ER) of infected human cells prior to the assembly of new viral particles. Hence, the inhibition of membrane protein synthesis at the ER is an attractive strategy for reducing the pathogenicity of SARS-CoV-2 and other obligate viral pathogens. Using an in vitro system, we demonstrate that the small molecule inhibitor ipomoeassin F (Ipom-F) potently blocks the Sec61-mediated ER membrane translocation and/or insertion of three therapeutic protein targets for SARS-CoV-2 infection; the viral spike and ORF8 proteins together with angiotensin-converting enzyme 2, the host cell plasma membrane receptor. Our findings highlight the potential for using ER protein translocation inhibitors such as Ipom-F as host-targeting, broad-spectrum antiviral agents.This article has an associated First Person interview with the first author of the paper.


Subject(s)
COVID-19 Drug Treatment , Glycoconjugates/pharmacology , SARS-CoV-2/drug effects , Spike Glycoprotein, Coronavirus/drug effects , Antiviral Agents/pharmacology , COVID-19/virology , Humans , SARS-CoV-2/pathogenicity , Spike Glycoprotein, Coronavirus/metabolism , Virus Internalization/drug effects
13.
bioRxiv ; 2021 Jan 05.
Article in English | MEDLINE | ID: covidwho-955719

ABSTRACT

In order to produce proteins essential for their propagation, many pathogenic human viruses, including SARS-CoV-2 the causative agent of COVID-19 respiratory disease, commandeer host biosynthetic machineries and mechanisms. Three major structural proteins, the spike, envelope and membrane proteins, are amongst several SARS-CoV-2 components synthesised at the endoplasmic reticulum (ER) of infected human cells prior to the assembly of new viral particles. Hence, the inhibition of membrane protein synthesis at the ER is an attractive strategy for reducing the pathogenicity of SARS-CoV-2 and other obligate viral pathogens. Using an in vitro system, we demonstrate that the small molecule inhibitor ipomoeassin F (Ipom-F) potently blocks the Sec61-mediated ER membrane translocation/insertion of three therapeutic protein targets for SARS-CoV-2 infection; the viral spike and ORF8 proteins together with angiotensin-converting enzyme 2, the host cell plasma membrane receptor. Our findings highlight the potential for using ER protein translocation inhibitors such as Ipom-F as host-targeting, broad-spectrum, antiviral agents.

14.
biorxiv; 2020.
Preprint in English | bioRxiv | ID: ppzbmed-10.1101.2020.11.24.390039

ABSTRACT

In order to produce proteins essential for their propagation, many pathogenic human viruses, including SARS-CoV-2 the causative agent of COVID-19 respiratory disease, commandeer host biosynthetic machineries and mechanisms. Three major structural proteins, the spike, envelope and membrane proteins, are amongst several SARS-CoV-2 components synthesised at the endoplasmic reticulum (ER) of infected human cells prior to the assembly of new viral particles. Hence, the inhibition of membrane protein synthesis at the ER is an attractive strategy for reducing the pathogenicity of SARS-CoV-2 and other obligate viral pathogens. Using an in vitro system, we demonstrate that the small molecule inhibitor ipomoeassin F (Ipom-F) potently blocks the Sec61-mediated ER membrane translocation/insertion of three therapeutic protein targets for SARS-CoV-2 infection; the viral spike and ORF8 proteins together with angiotensin-converting enzyme 2, the host cell plasma membrane receptor. Our findings highlight the potential for using ER protein translocation inhibitors such as Ipom-F as host-targeting, broad-spectrum, antiviral agents.


Subject(s)
Respiratory Tract Diseases , COVID-19
15.
Chinese Journal of Laboratory Medicine ; 43(10):973-977, 2020.
Article in Chinese | EMBASE | ID: covidwho-918261

ABSTRACT

Objective: To analyze the laboratory tests in newly hospitalized patients with COVID-19 and their predictive values for the severity of the disease. Methods: 83 patients, including 54 males and 29 females, with median interquartile range of 63(53-70)years diagnosed with covid-19 who were managed by Fujian medical team from January 27, 2020 to February 20, 2020 in Wuhan JinYinTan Hospital were studied retrospectively. According to the severity of the disease, they were divided into common, severe and critical groups. White blood cell (WBC), lymphocyte (LYM), loctate dehydrogenase (LDH), interleukin-6 (IL-6), procalcitonin (PCT), serum ferritin (SF), erythrocyte sedimentation rate (ESR), hypersensitive C-reactive protein (hs-CRP) and D-Dimer (D-D) on admission were analyzed retrospectively. And the predictive value of each indicator for critical group was analyzed by Logistic regression. Results: On admission, in common, severe and critical groups, WBC (×109/L) values were 7.10±3.88, 7.73±3.77 and 9.07±5.61, respectively (F = 1.315,P=0.274);IL-6 (μg/L) values were 11.76(9.42-15.18), 11.93(10.15-15.63) and 11.24(8.06-13.75), respectively(Z=0.591,P=0.744);D-D (mg/L) values were 0.70(0.48-1.12), 1.67(1.07-7.14) and 1.96(0.71-8.18), respectively(Z=3.363,P=0.186).There were no significant differences among three groups. On admission, in common, severe and critical groups, LYM(×109/L) values were 1.10±0.33, 0.80±0.35 and 0.66±0.32, respectively(F=11.415,P<0.001);SF(μg/L) values were 470.83±283.43, 835.66±819.43, and 1341.15±949.54, respectively (F=7.98,P=0.001);ESR(mm/h) values were 30.76±15.70, 42.55±22.51 and 51.04±25.09, respectively(F=5.181,P=0.008);LDH(U/L) values were 314.71±105.46, 325.69±109.85 and 444.03±181.07, respectively(F=7.17,P=0.001);hs-CRP(μg/L)values were 16(7.20-19.90), 31.00(20.00-87.60) and 80.50(33.70-113.00), respectively(Z=12.185,P=0.002);PCT(μg/L) values were 0.025(0.02-0.05), 0.05(0.02-0.13) and 0.09(0.05-0.39), respectively(Z=9.694,P=0.008). There were significant differences among three groups. Pairwise comparison showed that the LYM value in common group was higher than those in severe and critical groups, and the hs-CRP values in severe and critical groups were higher than that in common group,while SF, ESR, LDH and PCT values in critical group were all higher than those in severe and common groups(P<0.05). Conclusions: On admission, WBC, LYM, ESR and LDH are helpful to predict the severity of COVID-19. Although the level of IL-6 is increased, it may not be meaningful to judge the severity of COVID-19.

16.
Journal of Fishery Sciences of China ; 27(8):980-1002, 2020.
Article in Chinese | Scopus | ID: covidwho-847479

ABSTRACT

The recent outbreak of the COVID-19 virus has raised concerns regarding the trade in aquatic wildlife. Species of aquatic wildlife are both valuable natural resources and important ecosystem constituents. Their value is reflected not only in maintaining an ecological balance but also in meeting the diverse needs of human cultivation, development and utilization. Aquatic wildlife plays an irreplaceable role in achieving sustainable socio-economic development, as well as improving and enriching human material and cultural life. However, from the perspective of valuing aquatic wildlife, there exists a certain conflict between protection and utilization. In this paper, we examine the seemingly disparate aims of aquatic wildlife protection and breeding and utilization, and consider future progress with respect to aquatic wildlife resource protection and regulation of the breeding and utilization of aquatic animals. Appeal society actively encourage and promote aquatic wild animal domestication and breeding and processing enterprise, guide the consumer right edible safety of domestic products, and expand and improve the aquatic wild animals living space and environment, realization of aquatic wildlife species gauge touch is growing stronger, finally realize the sustainable use of wildlife resources. © Chinese Academy of Fishery Sciences.

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