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1.
American Journal of Transplantation ; 22(Supplement 3):638-639, 2022.
Article in English | EMBASE | ID: covidwho-2063546

ABSTRACT

Purpose: Solid organ transplant recipients (SOTR) develop weak antibody responses after SARS-CoV-2 vaccination. Published data on neutralizing activity of plasma, a better measure of protection, in SOTR following an additional dose of SARSCoV- 2 vaccine is limited. Method(s): Plasma was longitudinally collected from SOTR following initial COVID- 19 vaccination. Neutralizing activity against SARS-CoV-2 was assessed using the cPass Neutralization Antibody Detection Kit (GenScript, Biotech). ELISAs were performed against SARS-CoV-2 proteins (S1, N, RBD), CMV (glycoprotein B), Influenza A H1N1 (nucleoprotein), HSV-1, EBV glycoprotein (gp350), and tetanus toxoid for comparison. Result(s): Demographic and clinical characteristics are summarized in table 1. No participants had evidence of COVID-19 infection as IgG titers to SARS-CoV-2 N protein were low. Neutralizing activity against SARS-CoV-2 RBD was observed in 39.6% of individuals (N=21/53) ~93 days after initial vaccination. Participants with neutralizing activity were more likely to have received a liver transplant (47.6% vs 6.25%, p=0.001), and less likely to be on an anti-metabolite (52.4% vs. 87.5%, p=0.009) or triple immunosuppression (14.3% vs. 53.1%, p=0.008). After an additional vaccine dose, 78.1% (N=25/32) of participants developed neutralizing activity with significant increases in viral neutralization (figure 1, median 36.8% [95%CI 18.9-64.6] to 97.2% [95%CI 74.0-98.9], p<0.0001). Participants with low neutralizing activity demonstrated adequate antibody titers to other microbial antigens (figure 2). Conclusion(s): An additional dose of SARS-CoV-2 vaccine increased the number of SOTR with neutralizing activity and the magnitude of the seroresponse. SOTR with low neutralizing activity maintain humoral responses to other microbial antigens suggesting the diminished seroresponse might be related to inhibition of new B cell responses.

2.
China Journal of Leprosy and Skin Diseases ; 38(8):499-502, 2022.
Article in Chinese | Scopus | ID: covidwho-1954980

ABSTRACT

Background: Eight pm on April 13, 2022,a10:1 mixed test tube was found to be positive in the COVID-19 nucleic acid test site set up outside the hospital. In order to identify the infected case and control the spread of COVID-19 rapidly, we conducted this emergency investigation. Methods: According to the National COVID-19 Control and Prevention Protocol (8th edition), Guideline on Emergency Response to COVID-19 Case Found in Hospital in Shandong Province, and the Emergency Response Plan for COVID-19 in our hospital, information reporting, hospitalblockading, potential COVID- 19 cases tracing, close contact screening, environmental sampling and disinfecting, COVID-19 nucleic acid testing and risk assessment were carried out by our team. Results: A female COVID-19 case aged 50 years was identified. She is aodd-jobber who works in the labour market near the hospital. The virus strain was sequenced as Omicron BA.2. A total of 65 close contacts was controlled in a hotel. The COVID-19 nucleic acid test results for all the staff of hospital, environmental samples were negative. The risk of COVID-19 spread was controlled and the hospital restarted of clinical activities as normal at 8 am on April 14 after blockaded for 12 hours. Inthe following 7 days, the staff of the hospital were tested for COVID-19 nucleic acid twice a day, and the results were negative. Then the testing frequency changed to once a day. Conclusion: Formulating detailed and feasible COVID-19 emergency response plans based on the requirements of the public documents and the actual conditions of the hospital, is useful to improve the efficiency of emergency response to COVID-19 cases and save time for control of COVID-19 spread and restart the clinical activities of hospital. © 2022 Shandong Yinbao Technology Co. Ltd. All Rights Reserved.

3.
Lecture Notes on Data Engineering and Communications Technologies ; 135:547-554, 2022.
Article in English | Scopus | ID: covidwho-1844305

ABSTRACT

The rapid development of e-commerce industry has put forward higher requirements on the speed, safety, reliability and low price of logistics services, and China Railway Highspeed Express (CRHE) has ushered in a broad market prospect because it meets these requirements very well. Firstly, according to the SWOT analysis of CRHE in Guangxi, propose that its strengths are transportation network, speed, safety and stability and cost effectiveness, weaknesses are informatization and operation process, opportunities are national and local policies, threats are competition in the industry and COVID-19. After that, make an attempt of making four strategic combinations, and make a strategic decision of strengths-opportunities combination through comparison. Finally propose many measures to ensure the implementation of the strategy: seizing the external opportunities by following up the polities and giving full play to the strengths by increasing investment in capital and technology, adjusting the management mode, determining annual production target reasonably and cooperating with other express enterprises. © 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.

4.
Jisuanji Jicheng Zhizao Xitong/Computer Integrated Manufacturing Systems, CIMS ; 28(1):242-257, 2022.
Article in Chinese | Scopus | ID: covidwho-1698657

ABSTRACT

COVID-19 has an impact on the global supply chain, which is mainly manifested in the simultaneous interruption of production capacity and demand. To explore the impact of government subsidy strategies on recovery in the context of supply chain interruption, the low-demand products during the epidemic were used as the research object, and the government's choice of subsidies for production capacity and demand interruption as a recovery strategy. The cumulative profit of supply chain members was taken as the recovery index, and system dynamics was used to construct the "manufacturer-distribution center" secondary supply chain. The changes in cumulative profits for different subsidy options were simulate under partial and complete interruption scenarios. The simulation results showed that the choice of government subsidy strategies under different interruption scenarios had different effects on the supply chain recovery effect. In the scenario of partial demand interruption, government subsidies for manufacturers with interrupted production capacity would make the supply chain recovery better. In the scenario of complete demand interruption, government subsidies for distribution centers with interrupted demand would make the supply chain recovery better. © 2022, Editorial Department of CIMS. All right reserved.

5.
Applied Catalysis B: Environmental ; 298, 2021.
Article in English | Scopus | ID: covidwho-1330633

ABSTRACT

With the worldwide pandemic of COVID-19, a tremendous amount of face masks have been consumed and discarded, resulting in serious environment pollution and infectious hazards. Herein a green and high-yield route has been developed to recycle waste masks (WMs) into CNTs/Ni hybrids via catalytic carbonization. Our results exhibited that the yield of carbon was as high as 64.4 g/100 g WMs. Furthermore, the as-fabricated CNTs/Ni hybrids were applied for microwave absorption, which displayed superior performances, including a strong reflection loss of -56.3 dB and an absorption bandwidth of 4.3 GHz with absorber thickness of only 2.0 mm. The mechanism was mainly ascribed to the favorable synergistic effects of CNTs and Ni on conduction and magnetic losses, dipolar polarization, interfacial polarization and impedance matching. Thus, this work provides an environmentally friendly, scalable and cost-effective strategy for recycling waste masks into high-valuable carbon nanomaterials, and exploits their potential application for microwave absorption. © 2021 Elsevier B.V.

6.
International Journal of Production Research ; : 17, 2021.
Article in English | Web of Science | ID: covidwho-1309498

ABSTRACT

Coronavirus (COVID-19) is a highly infectious respiratory disease which spread can be effectively curbed by wearing facial masks, especially N95 and surgical masks. In this paper, we develop a stylised game-theoretical model to evaluate the impacts of producing and selling masks on supply chain profits, safety index and consumer and social welfare. Firstly, we find that as the infection probability without protection (IPWP) increases, both the retail price and demand for these masks will increase. When the IPWP is sufficiently low, those consumers who want to purchase masks are more likely to purchase N95 masks, but when the IPWP increases, surgical masks are more popular amongst consumers. Secondly, we develop a safety index that indicates the effectiveness of using masks in preventing respiratory disease infection. This index is especially crucial in cases where the IPWP is moderate;in other words, recommending to wear masks is particularly important when the IPWP is moderate. We also examine the impacts of government involvement in handling the outbreak of respiratory diseases. Providing consumer subsidies and promoting the social mask enterprise can effectively combat respiratory diseases under different conditions. Our results can be used for combating COVID-19 and preparing for future health crisess.

7.
Journal of Applied Polymer Science ; 2021.
Article in English | Scopus | ID: covidwho-1192096

ABSTRACT

Developing 3D printing high-performance biodegradable materials is important to protect the environment and deal with emergencies such as COVID-19. Fused deposition modeling (FDM), one of the 3D printing methods, has many advantages, such as low cost and wide range of materials. However, the weak interlayer adhesion is an important factor restricting the development of FDM. In addition to the influence of material properties, the optimization of 3D printing parameters is also an important means to give full play to the inherent properties of materials. The optimal 3D printing parameters are conducive to the diffusion and entanglement of molecular chains between adjacent layers. PLA/PBAT/PLA-g-GMA (70/30/10 wt%, PLA-g-GMA was a compatibilizer synthesized in our lab) was used as the research object. This work aims to analyze the mechanical properties response of biodegradable polymers products manufactured through FDM. Herein, the effect of 3D printing parameters including layer thickness, nozzle temperature, printing speed and platform temperature have been systematically investigated by orthogonal experimental design. The result showed that the excellent performance of 3D printing specimen was obtained when the layer thickness was 0.15 mm, the printing speed was 50 mm·s−1, the nozzle temperature was 200°C and the platform temperature was 50°C. The SEM images showed that the optimal 3D printing products had the best interlayer adhesion and the lowest porosity. Undergoing optimization of 3D printing processing, the yield strength and elongation at break of specimen increased by 115% and 229%, respectively. In this paper, the interlayer adhesion and mechanical properties of 3D printing products can be significantly improved by simply optimizing the 3D printing parameters without complex material modification. This work provided a new method for improving the interlayer adhesion of FDM and the mechanical properties of FDM products. © 2021 Wiley Periodicals LLC.

8.
Psychosomatics ; 61(6):616-624, 2020.
Article in English | Web of Science | ID: covidwho-1001421

ABSTRACT

Background: Coronovirus disease 2019 (COVID-19) first broke out in Wuhan, Hubei Province, China, in 2019, and now it spreads in more than 100 countries around the world. On January 30th, the World Health Organization (WHO) declared COVID-19 a public health emergency of international concern. It was classified as a pandemic by the WHO on March 11, 2020. With the increase in the number of cases reported by various countries every day, the COVID-19 pandemic has attracted more and more attention around the world. At the same time, this public health emergency has caused a variety of psychological problems, such as panic disorder, anxiety, and depression. In addition, the Wuhan Mental Health Center's analysis of 2144 calls from the psychological hotline from February 4 to February 20, 2020, showed that the general public accounted for 70%, medical workers accounted for 2.2%, patients with mental disorders accounted for 19.5%, and other personnel accounted for 8.3% (https://mp.weixin.qq.com/s/kmff1vnaLsT2d9xQkK5pwg). Conclusion: Therefore, while controlling the pandemic, the government should also pay attention to the mental health of the general public, medical workers, and patients with mental disorders. Community mental health service systems, online mental health services, telemedicine, and other measures for patients with mental disorders may play a vital role during the pandemic.

9.
Chinese Journal of Perinatal Medicine ; 23(7):447-455, 2020.
Article in Chinese | Scopus | ID: covidwho-823308

ABSTRACT

Objective: To fully understand the maternal and neonatal outcomes in pregnant women with COVID-19 and explore the evidence of intrauterine vertical transmission of 2019-nCoV by analyzing clinical and laboratory information in peer-reviewed publications on COVID-19 in pregnant women. Methods: PubMed, Embase, China National Knowledge Infrastructure, China Academic Journals, and Wanfang Databases were searched to retrieve articles on COVID-19 in pregnancy published from December 1, 2019, to April 9, 2020. In addition, the World Health Organization COVID-19 Database and the reference lists in each included article were also searched. All included cases were positive for 2019-nCoV nucleic acid with maternal and neonatal outcomes regardless of delivery or not. Clinical manifestations, perinatal and neonatal outcomes were analyzed systematically. Results: This study reviewed 29 publications involving 146 pregnant women who tested positive for 2019-nCoV nucleic acid and their 116 newborns (including two twins). Five cases of severe COVID-19 and three cases of unidentified type that were admitted to ICU for treatment were severe symptoms, accounting for 5.5% (8/146) of all cases. Totally, 69.9% (102/146) of the women underwent cesarean section and 8.2% (12/146) gave birth vaginally. Thirty (20.5%) women continued their pregnancies. One case (0.7%, 1/146) terminated the pregnancy at 26 weeks of gestation due to bidirectional affective disorder and one (0.7%, 1/146) received artificial abortion at 6 weeks of gestation. Fever (58.2%, 85/146) and cough (32.9%, 48/146) were the most common symptoms. However, 15.8% (23/146) of the pregnant women were asymptomatic on admission and symptoms appeared or became worse after delivery in 20.5% (30/146). Lymphocytopenia (49.6%, 56/113) and elevated C-reactive protein (58.4%, 66/113) were the main laboratory findings. The most common computed tomography (CT) finding was bilateral multiple patchy ground-glass opacity in lungs (79.7%, 94/118). The outcomes of 92.2% (107/116) of the newborns were good, and the rest 7.8% (9/116) showed different abnormalities of varying degrees. Among the nine newborns, six showed different degrees of dyspnea, cyanosis and vomiting including one died of multiple organ failure and disseminated intravascular coagulation;one tested positive for viral nucleic acid 36 hours after birth;one was stillbirth due to unknown reason, but intrauterine vertical transmission was excluded;one neonatal death in a critically ill mother undergoing cesarean delivery. Conclusions: Pregnant women are less likely to progress to severe COVID-19 and mostly have a good outcome. Despite reports of adverse neonatal outcomes, evidence of intrauterine vertical transmission of 2019-nCoV remains insufficient. Copyright © 2020 by the Chinese Medical Association.

10.
11.
Zhonghua Gan Zang Bing Za Zhi ; 28(2): 100-106, 2020 Feb 20.
Article in Chinese | MEDLINE | ID: covidwho-686167

ABSTRACT

Objective: To explore and analyze the possible mechanism of liver injury in patients with coronavirus disease 2019 (novel coronavirus pneumonia, NCP). Methods: The correlation between ALT, AST and other liver enzyme changes condition and NCP patients' disease status reported in the literature was comprehensively analyzed. ACE2 expression in liver tissue for novel coronavirus was analyzed based on single cell sequencing (GSE115469) data. RNA-Seq method was used to analyze Ace2 expression and transcription factors related to its expression in liver tissues at various time-points after hepatectomy in mouse model of acute liver injury with partial hepatectomy. t-test or Spearman rank correlation analysis was used for statistical analysis. Results: ALT and AST were abnormally elevated in some patients with novel coronavirus infection, and the rate and extent of ALT and AST elevation in severe NCP patients were higher than those in non-severe patients. Liver tissue results of single cell sequencing and immunohistochemistry showed that ACE2 was only expressed in bile duct epithelial cells of normal liver tissues, and very low in hepatocytes. In a mouse model of acute liver injury with partial hepatectomy, Ace2 expression was down-regulated on the first day, but it was elevated up to twice of the normal level on the third day, and returned to normal level on seventh day when the liver recovered and hepatocyte proliferation stopped. Whether this phenomenon suggests that the bile duct epithelial cells with positive expression of Ace2 participate in the process of liver regeneration after partial hepatectomy deserves further study. In RNA-Seq data, 77 transcription factors were positively correlated with the expression of Ace2 (r > 0.2, FDR < 0.05), which were mainly enriched in the development, differentiation, morphogenesis and cell proliferation of glandular epithelial cells. Conclusion: We assumed that in addition to the over activated inflammatory response in patients with NCP, the up-regulation of ACE2 expression in liver tissue caused by compensatory proliferation of hepatocytes derived from bile duct epithelial cells may also be the possible mechanism of liver tissue injury caused by 2019 novel coronavirus infection.


Subject(s)
Betacoronavirus , Coronavirus Infections , Pandemics , Pneumonia, Viral , Animals , COVID-19 , Humans , Liver , Mice , Peptidyl-Dipeptidase A , SARS-CoV-2
12.
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences ; 49(1):0, 2020.
Article | WHO COVID | ID: covidwho-14273

ABSTRACT

Since the corona virus disease 2019 (COVID-19) affects the cardio-pulmonary function of pregnant women, the anesthetic management in the cesarean section for the patients, as well as the protection for medical staff is significantly different from that in ordinary surgical operation. This paper reports a pregnant woman with COVID-19, for whom a cesarean section was successfully performed in our hospital on February 8, 2020. Anesthetic management, protection of medical staff and psychological intervention for the patients during the operation are discussed. Importance should be attached to the preoperative evaluation of pregnant women with COVID-19 and the implementation of anesthesia plan. For ordinary COVID-19 patients intraspinal anesthesia is preferred in cesarean section, and the influence on respiration and circulation in both maternal and infant should be reduced;while for severe or critically ill patients general anesthesia with endotracheal intubation should be adopted. The safety of medical environment should be ensured, and level- standard protection should be taken for anesthetists. Special attention and support should be given to maternal psychology. It is important to give full explanation before operation to reduce anxiety;to relieve the discomfort during operation to reduce tension;to avoid the bad mood of patients due to pain after operation.

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