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1.
Adv Exp Med Biol ; 1321: 173-180, 2021.
Article in English | MEDLINE | ID: covidwho-1114246

ABSTRACT

The COVID-19 pandemic, caused by the SARS-C0V-2 virus, was initially considered and managed in a similar manner to the previous SARS epidemic as they are both caused by coronaviruses. What has now become apparent is that a major cause of morbidity and mortality in COVID-19 is abnormal thrombosis. This thrombosis occurs on a macro- and microvascular level and is unique to this disease. The virus has been demonstrated in the endothelium of the pulmonary alveoli and as such is thought to contribute to the devastating respiratory complications encountered. D-dimer concentrations are frequently raised in COVID to levels not frequently seen previously. The optimal anticoagulation treatment in COVID remains to be determined, and the myriad of pathophysiologic effects caused by this virus in the human host have also yet to be fully elucidated.


Subject(s)
COVID-19 , Coronavirus , Hemostatics , Humans , Pandemics , SARS-CoV-2
2.
Adv Exp Med Biol ; 1321: 163-172, 2021.
Article in English | MEDLINE | ID: covidwho-1114245

ABSTRACT

From its early origins, COVID-19 has spread extensively and was declared a global pandemic by the World Health Organization in March of 2020. Although initially thought to be predominantly a respiratory infection, more recent evidence points to a multisystem systemic disease which is associated with numerous haematological and immunological disturbances in addition to its other effects. Here we review the current knowledge on the haematological effects of COVID-19.


Subject(s)
COVID-19 , Respiratory Tract Infections , Humans , Pandemics , SARS-CoV-2
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