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1.
IEEE J Biomed Health Inform ; PP2021 Dec 31.
Article in English | MEDLINE | ID: covidwho-1599120

ABSTRACT

This paper presents a novel Lasso Logistic Regression model based on feature-based time series data to determine disease severity and when to administer drugs or escalate intervention procedures in patients with coronavirus disease 2019 (COVID-19). Advanced features were extracted from highly enriched and time series vital sign data of hospitalized COVID-19 patients, including oxygen saturation readings, and with a combination of patient demographic and comorbidity information, as inputs into the dynamic feature-based classification model. Such dynamic combinations brought deep insights to guide clinical decision-making of complex COVID-19 cases, including prognosis prediction, timing of drug administration, admission to intensive care units, and application of intervention procedures like ventilation and intubation. The COVID-19 patient classification model was developed utilizing 900 hospitalized COVID-19 patients in a leading multi-hospital system in Texas, United States. By providing mortality prediction based on time-series physiologic data, demographics, and clinical records of individual COVID-19 patients, the dynamic feature-based classification model can be used to improve efficacy of the COVID-19 patient treatment, prioritize medical resources, and reduce casualties. The uniqueness of our model is that it is based on just the first 24 hours of vital sign data such that clinical interventions can be decided early and applied effectively. Such a strategy could be extended to prioritize resource allocations and drug treatment for future pandemic events.

2.
J Am Med Inform Assoc ; 27(11): 1721-1726, 2020 11 01.
Article in English | MEDLINE | ID: covidwho-1024117

ABSTRACT

Global pandemics call for large and diverse healthcare data to study various risk factors, treatment options, and disease progression patterns. Despite the enormous efforts of many large data consortium initiatives, scientific community still lacks a secure and privacy-preserving infrastructure to support auditable data sharing and facilitate automated and legally compliant federated analysis on an international scale. Existing health informatics systems do not incorporate the latest progress in modern security and federated machine learning algorithms, which are poised to offer solutions. An international group of passionate researchers came together with a joint mission to solve the problem with our finest models and tools. The SCOR Consortium has developed a ready-to-deploy secure infrastructure using world-class privacy and security technologies to reconcile the privacy/utility conflicts. We hope our effort will make a change and accelerate research in future pandemics with broad and diverse samples on an international scale.


Subject(s)
Biomedical Research , Computer Security , Coronavirus Infections , Information Dissemination , Pandemics , Pneumonia, Viral , Privacy , COVID-19 , Humans , Information Dissemination/ethics , Internationality , Machine Learning
3.
Ieee Computational Intelligence Magazine ; 15(4):10-22, 2020.
Article in English | Web of Science | ID: covidwho-900841

ABSTRACT

Computational intelligence has been used in many applications in the fields of health sciences and epidemiology. In particular, owing to the sudden and massive spread of COVID-19, many researchers around the globe have devoted intensive efforts into the development of computational intelligence methods and systems for combating the pandemic. Although there have been more than 200,000 scholarly articles on COVID-19, SARS-CoV-2, and other related coronaviruses, these articles did not specifically address in-depth the key issues for applying computational intelligence to combat COVID-19. Hence, it would be exhausting to filter and summarize those studies conducted in the field of computational intelligence from such a large number of articles. Such inconvenience has hindered the development of effective computational intelligence technologies for fighting COVID-19. To fill this gap, this survey focuses on categorizing and reviewing the current progress of computational intelligence for fighting this serious disease. In this survey, we aim to assemble and summarize the latest developments and insights in transforming computational intelligence approaches, such as machine learning, evolutionary computation, soft computing, and big data analytics, into practical applications for fighting COVID-19. We also explore some potential research issues on computational intelligence for defeating the pandemic.

4.
Ieee Computational Intelligence Magazine ; 15(4):8-9, 2020.
Article in English | Web of Science | ID: covidwho-900840

ABSTRACT

This Fast-Track Special Issue is in line with the COVID-19 Initiative of IEEE CIS, aiming to present the latest developments and insights in applying computational intelligence approaches into practical applications for combating COVID-19.

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