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Applied Clinical Trials ; 31(6):22-25, 2022.
Article in English | ProQuest Central | ID: covidwho-20244830


In the arena of clinical research, gender equity accelerates research excellence: we need multiple perspectives and all the brain power we can muster to maximize research productivity and quality. [...]women physician investigators enhance enrollment of women as participants in clinical trials, which is crucial to our ability to generalize from the data and to maintain the health of women. Women are underrepresented among academic grand rounds speakers,14 speakers at medical conferences15, and award recipients from medical specialty societies.16 Time pressure is especially intense on young women faculty. Besides spending more time on domestic chores, they spend more time at work on teaching, service, and mentoring. Female primary care physicians spend more time with patients.22 Elderly hospitalized patients treated by female internists experience lower mortality and readmission rates.23 Patients undergoing coronary artery bypass grafting had shorter hospital length of stay when treated by an all-female physician team as compared with an all-male team.24 Female patients treated by male physicians following acute myocardial infarction have higher mortality than those treated by female physicians.25 Sex discordance between patient and surgeon is associated with increased likelihood of adverse postoperative outcomes-and that observation that is driven by worse outcomes for female patients treated by male physicians.26 Clinical trials play a fundamental role in bringing new medications and interventions to our patients, yet women have often been excluded from participation. Among 60 randomized controlled trials (RCTs) of lipidlowering therapies reported between 1990 and 2018, there was a modest increase in enrollment of women over time, but women remain underrepresented compared with the relative burden of disease.30 In another study of 317 RCTs of heart failure with reduced ejection fraction published in highimpact journals over the past 20 years, only 25% of participants overall were female, and females were under-enrolled in 72% of these trials.

Applied Clinical Trials ; 31(6):22-25, 2022.
Article in English | Academic Search Complete | ID: covidwho-1905458


The article reports that he COVID-19 pandemic has wreaked global havoc, with millions of lives lost. The effects of the pandemic on healthcare workers have been especially severe in terms of mortality, burnout, and diversion from non-pandemic critical work. This impact has also been felt in clinical research, just as the importance of clinical research has become obvious to the general public from the wide reporting of trials of drug.

Ann Intern Med ; 174(9): 1327-1328, 2021 09.
Article in English | MEDLINE | ID: covidwho-1464000