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1.
Journal of Educational Computing Research ; : 07356331221106918, 2022.
Article in English | Sage | ID: covidwho-1883420

ABSTRACT

Higher-order thinking skills (HOTS) are reliable predictors of success in school and the workplace. A typical technique for encouraging higher-order thinking is to use instructional design interventions that engage learners in simple cognitive activities. Business simulation game (BSG) is one of the types of interactive learning environments that can increase HOTS. In addition, student engagement and attitude toward technology use are considered strong influences on HOTS. The study explored the effect of using a BSG on HOTS and student engagement. It examined the influence of attitude toward the use of a BSG on HOTS and student engagement. The results of the t-test analysis showed that learning activities using BSG had a positive effect on HOTS and student engagement. Additionally, PLS-SEM analysis results indicated that immersion, interaction, and intention to use the game influence student engagement. Furthermore, student engagement significantly influenced HOTS. The findings indicate that students must demonstrate that they are engaging actively in a course to improve HOTS and that a BSG can be a valuable and effective tool for promoting engagement. Moreover, the COVID-19 pandemic caused limitations in sampling and representativeness of respondents. Future research should involve a bigger sample size and students who have attended related courses.

2.
Front Public Health ; 10: 858157, 2022.
Article in English | MEDLINE | ID: covidwho-1847240

ABSTRACT

This study aimed to examine the current suicidal risk and whether the suicidal risk was associated with a wide range of trauma. The self-administered online questionnaire was adopted to collect suicide risk (SR) such as suicidal ideation, self-harm, suicide attempts, and different trauma information of the adolescents by cluster sampling in Chongqing, China. Multivariable linear regression was presented to assess the association between different risks of trauma and SR scores. Approximately 14.7% of adolescents enrolled reported suicide ideation and more than 10% of adolescents have experienced one kind of trauma during the Coronavirus disease 2019 (COVID-19) pandemic period. After adjusting for confounding variables, adolescents who suffered family hurt had a higher risk score of SR (beta coefficients (ß) = 0.289, 95% confidence interval (CI) = 0.115-0.463). A positive association was found among participants from junior and senior school (ß = 0.415, 95% CI = 0.152, 0.768), and the SR score was positively associated with sexism among participants from the university/college (ß = 0.238, 95% CI = 0.042, 0.434). The most potentially obvious trauma that contributed to SR in junior and senior school adolescents might be cyberbullying. Family neglect or abuse might be a detrimental factor in SR for adolescents whether those in junior school or those in university school in China. More interventions, like education related to cyberbullying and family abuse, should be prioritized to reduce the risk of suicide.


Subject(s)
COVID-19 , Adolescent , COVID-19/epidemiology , China/epidemiology , Cross-Sectional Studies , Humans , Pandemics , Students , Suicidal Ideation
3.
Environ Sci Pollut Res Int ; 2022 Apr 26.
Article in English | MEDLINE | ID: covidwho-1803047

ABSTRACT

Baoji is a typical heavy industrial city in northwest China. Its air quality is greatly impacted by the emission from the factories. Elements in fine particulate matter (PM2.5) that are greatly emitted from anthropogenic sources could pose diverse health impacts on humans. In this study, an online AMMS-100 atmospheric heavy metal analyzer was used to quantify 30 elements in PM2.5 under the weak and strong anthropogenic disturbance scenarios before the city lockdown period (from January 9th to 23rd) and the lockdown period (from January 26th to February 9th) due to the outbreak of COVID-19 in 2020. During the lockdown period, the average total concentration of total quantified elements was 3475.0 ng/m3, which was 28% and 33% lower than that of the week and strong anthropogenic disturbance scenarios during the pre-lockdown period. The greatest reductions were found for the elements of chromium (Cr), titanium (Ti), manganese (Mn), and Zinc (Zn), consistent with the industrial structure of Baoji. The mass concentrations of most elements showed obvious reductions when the government post-alerted the industries to reduce the operations and production. Dust, traffic sources, combustion, non-ferrous metal processing, and Ti-related industrial processing that are the contributors of the elements in the pre-lockdown period were apportioned by the positive matrix factorization (PMF) model. Substantial changes in the quantified elements' compositions and sources were found in the lockdown period. Health assessment was conducted and characterized by apportioned sources. The highest non-carcinogenic risk (HQ) was seen for Zn, demonstrating the high emissions from the related industrial activities. The concentration level of arsenic (As) exceeded the incremental lifetime carcinogenic risk (ILCR) in the lockdown period. This could be attributed to the traditional firework activities for the celebration of the Chinese New Year within the lockdown period.

4.
J Vis Commun Med ; 45(2): 39-47, 2022 Apr.
Article in English | MEDLINE | ID: covidwho-1764444

ABSTRACT

Navigating for accurate information, especially health- and science-related content, on social media has been challenging during the COVID-19 pandemic. Although infographics are a popular medium for simplifying text-based information into visual components, their usefulness during a global health crisis has not been explored. The study aims to explore the perceptions of infographics in conveying scientific information related to COVID-19 on social media. Following a social media campaign that published COVID-19 related infographics from May to August 2020, a cross-sectional survey was administered to social media users, primarily students from Western University. Several questions asked respondents to make comparisons with written articles when reporting their perceptions of infographics. Seventy-three percent of students from 361 responses belonged to health-related academic backgrounds. Seventy-two percent felt more likely to share infographics than written articles on social media due to the visual appeal. Nearly 90% felt it was easier to navigate through complicated science and that more scientists should use infographics on social media. Educational background did not influence the perceived usefulness of infographics in understanding scientific information. Infographics are perceived favourably in conveying scientific information about COVID-19 on social media. Findings from this study can inform communication strategies during a pandemic and, more broadly, global crises.


Subject(s)
COVID-19 , Social Media , COVID-19/epidemiology , Communication , Cross-Sectional Studies , Data Visualization , Humans , Pandemics , Surveys and Questionnaires
5.
EuropePMC; 2020.
Preprint in English | EuropePMC | ID: ppcovidwho-307719

ABSTRACT

During coronavirus disease 2019 (COVID-19) pandemic, medical resources in every country is in shortage. Efficacious indicators of discriminating severe illness and predicting outcome is in urgent need. We collected data and clinical records from 79 COVID-19 patients admitted between January 12, 2020 and February 21, 2020 at Wuhan Union hospital, China. Spearman’s correlation analysis, receiver operating characteristic (ROC) curve, logistic regression model, and Kaplan-Meier survival curves were employed in the analysis. Of 79 patients enrolled, 2 died in hospital, 8 were transferred to other hospitals, and 69 were discharged. Patients with elevated ferritin levels (> 200 ng/mL) had a higher incidence of severity illness when compared with those with normal ferritin levels (≤ 200 ng/mL) (50.0% vs 2.9%). In addition, severity illness manifested significantly higher level of ferritin as compared with non-severe ones (median 921.3 vs 130.7 ng/mL, p < 0.001). Furthermore, ferritin could effectively discriminate severity and non-severity, with an area under the ROC curve (AUC) reaching 0.873 (sensitivity 96%, specificity 70%), larger than that of age (0.697), C-reactive protein (0.730) and lymphocytes% (0.717). Combined model incorporating multivariate revealed a similar manner with ferritin alone (p = 0.981). Furthermore, elevated ferritin group showed longer viral clearance time (median 16 vs 6 days, p < 0.001) and in-hospital length (median 18 vs 10 days, p < 0.001). Our results suggest that ferritin could act as a simple and efficacious complementary tool to identify severe COVID-19 patients at early stage and predict their outcome. This indicator would provide guidance for subsequent clinical practice, alleviate the medical stress and reduce the mortality.

6.
J Thromb Thrombolysis ; 2022 Jan 29.
Article in English | MEDLINE | ID: covidwho-1653674

ABSTRACT

This study aimed to explore the effectiveness, and safety of internet-based warfarin management during the pandemic. In this single-center retrospective cohort study, we compared the safety and efficacy of online warfarin management using a smartphone app (the Alfalfa app) versus conventional outpatient clinic management from January 1, 2020 to March 31, 2020. Patients in the online management group used the Alfalfa app to communicate coagulation test results and other relevant information to a doctor or clinical pharmacist, who then responded with the dose adjustment plan and the date of the next blood test. The outcomes examined were the time in therapeutic range (TTR), incidence of clinical events (i.e., bleeding events, thrombotic events, warfarin-related emergency department visits, and warfarin-related hospital admissions), and the distribution of international normalized ratio (INR) values. Data from 117 patients were analyzed in this study. TTR was significantly higher in the online group than in the offline group (61.0% vs. 39.6%, P < 0.01). Incidence of major bleeding events, thrombotic events, and warfarin-related hospital admissions were comparable between the online and offline groups. However, minor bleeds (5.3% vs. 28.3%, P < 0.01) and warfarin-related emergency department visits (1.8% vs. 23.3%, P = 0.02) were significantly fewer in the online group than in the offline group. The proportion of INR values in the therapeutic range (53.8% vs. 40.1%, P < 0.01) was significantly higher in the online group. Warfarin management using the Alfalfa app appears to be a safe and effective method for warfarin management when patients cannot physically visit hospitals for follow-up.

7.
J Med Virol ; 93(12): 6496-6505, 2021 Dec.
Article in English | MEDLINE | ID: covidwho-1544293

ABSTRACT

The COVID-19 epidemic is not only a medical issue but also a sophisticated social problem. We propose a network dynamics model of epidemic transmission introducing a heterogeneous control factor. The proposed model applied the classical susceptible- exposed-infectious-recovered model to the network based on effective distance and was modified by introducing a heterogeneous control factor with temporal and spatial characteristics. International aviation data were approximately used to estimate the flux fraction matrix, and the effective distance was calculated. Through parameter estimation and simulation, the theoretical values of the modified model fit well with practical values. By adjusting the parameters and observing the change of the results, we found that the modified model is more in line with the actual needs and has higher credibility in the comprehensive analysis. The assessment shows that the number of confirmed cases worldwide will reach about 20 million optimistically. In severe cases, the peak value will exceed 80 million, and the late stage of the epidemic shows a long tail shape, lasting more than one and a half years. The effective way to control the global epidemic is to strengthen international cooperation and to impose international travel restrictions and other measures.


Subject(s)
COVID-19/prevention & control , COVID-19/transmission , Communicable Disease Control/methods , Primary Prevention/methods , Computer Simulation , Humans , Physical Distancing , Quarantine , SARS-CoV-2
8.
Emerg Microbes Infect ; 10(1): 2090-2097, 2021 Dec.
Article in English | MEDLINE | ID: covidwho-1479918

ABSTRACT

Since December 2019, coronavirus disease 2019 (COVID-19) caused by SARS coronavirus 2 (SARS-CoV-2) has spread and threatens public health worldwide. The recurrence of SARS-CoV-2 RNA detection in patients after discharge from hospital signals a risk of transmission from such patients to the community and challenges the current discharge criteria of COVID-19 patients. A wide range of clinical specimens has been used to detect SARS-CoV-2. However, to date, a consensus has not been reached regarding the most appropriate specimens to use for viral RNA detection in assessing COVID-19 patients for discharge. An anal swab sample was proposed as the standard because of prolonged viral detection. In this retrospective longitudinal study of viral RNA detection in 60 confirmed COVID-19 patients, we used saliva, oropharyngeal/nasopharyngeal swab (O/N swab) and anal swab procedures from admission to discharge. The conversion times of saliva and anal swab were longer than that of O/N swab. The conversion time of hyper sensitive-CRP was the shortest and correlated with that of CT scanning and viral detection. Some patients were found to be RNA-positive in saliva while RNA-negative in anal swab while the reverse was true in some other patients, which indicated that false negatives were inevitable if only the anal swab is used for evaluating suitability for discharge. These results indicated that double-checking for viral RNA using multiple and diverse specimens was essential, and saliva could be a candidate to supplement anal swabs to reduce false-negative results and facilitate pandemic control.


Subject(s)
COVID-19 Nucleic Acid Testing/methods , COVID-19/diagnosis , SARS-CoV-2/isolation & purification , Saliva/virology , Adult , Anal Canal/virology , False Negative Reactions , Female , Humans , Male , Middle Aged , Nasopharynx/virology , Oropharynx/virology , Patient Discharge , RNA, Viral/analysis , Retrospective Studies , Young Adult
9.
Int J Environ Res Public Health ; 18(20)2021 10 16.
Article in English | MEDLINE | ID: covidwho-1470862

ABSTRACT

Although the health and economic risks of COVID-19 may differ for higher- and lower-socioeconomic-status (SES) populations, some studies found that people with lower SES do not necessarily experience more psychological panic. In this research, we examine how SES is related with psychological panic during the COVID-19 pandemic using a large nationwide Chinese sample. Participants were 933 adults (mean age = 30.04, SD = 8.19) who completed an online questionnaire between 11 and 12 February 2020. Lower SES individuals have higher trust in government and thus experience less psychological panic, and the indirect effect of this trust suppresses the direct negative association between SES and psychological panic. In addition to this difference in trust in government between lower- and higher-status individuals, the indirect effect of the trust only exists among people with low (not high) authoritarian personalities. This study provides evidence that political trust may serve as a buffer, suppressing the negative association between SES and psychological panic; thus, policies and actions enhancing political trust are vital to support the mental health of individuals with lower SES during the pandemic, especially for citizens with low authoritarian personalities.


Subject(s)
COVID-19 , Trust , Adult , China/epidemiology , Cross-Sectional Studies , Government , Humans , Pandemics , Personality , SARS-CoV-2 , Social Class
10.
Mol Med Rep ; 24(4)2021 10.
Article in English | MEDLINE | ID: covidwho-1395037

ABSTRACT

Parkinson's disease (PD) is the second most common neurodegenerative disease amongst the middle­aged and elderly populations. Several studies have confirmed that the microbiota­gut­brain axis (MGBA) serves a key role in the pathogenesis of PD. Changes to the gastrointestinal microbiome (GM) cause misfolding and abnormal aggregation of α­synuclein (α­syn) in the intestine. Abnormal α­syn is not eliminated via physiological mechanisms and is transported into the central nervous system (CNS) via the vagus nerve. The abnormal levels of α­syn aggregate in the substantia nigra pars compacta, not only leading to the formation of eosinophilic Lewis Bodies in the cytoplasm and mitochondrial dysfunction in dopaminergic (DA) neurons, but also leading to the stimulation of an inflammatory response in the microglia. These pathological changes result in an increase in oxidative stress (OS), which triggers nerve cell apoptosis, a characteristic of PD. This increase in OS further oxidizes and intensifies abnormal aggregation of α­syn, eventually forming a positive feedback loop. The present review discusses the abnormal accumulation of α­syn in the intestine caused by the GM changes and the increased levels of α­syn transport to the CNS via the MGBA, resulting in the loss of DA neurons and an increase in the inflammatory response of microglial cells in the brain of patients with PD. In addition, relevant clinical therapeutic strategies for improving the GM and reducing α­syn accumulation to relieve the symptoms and progression of PD are described.


Subject(s)
/physiology , Disease Progression , Gastrointestinal Microbiome/physiology , Parkinson Disease/microbiology , alpha-Synuclein/metabolism , Aged , Bacteria/classification , Brain/metabolism , Dopaminergic Neurons/metabolism , Dysbiosis , Humans , Microglia , Middle Aged , Neurodegenerative Diseases , Oxidative Stress , alpha-Synuclein/genetics
11.
J Med Virol ; 93(12): 6496-6505, 2021 Dec.
Article in English | MEDLINE | ID: covidwho-1182174

ABSTRACT

The COVID-19 epidemic is not only a medical issue but also a sophisticated social problem. We propose a network dynamics model of epidemic transmission introducing a heterogeneous control factor. The proposed model applied the classical susceptible- exposed-infectious-recovered model to the network based on effective distance and was modified by introducing a heterogeneous control factor with temporal and spatial characteristics. International aviation data were approximately used to estimate the flux fraction matrix, and the effective distance was calculated. Through parameter estimation and simulation, the theoretical values of the modified model fit well with practical values. By adjusting the parameters and observing the change of the results, we found that the modified model is more in line with the actual needs and has higher credibility in the comprehensive analysis. The assessment shows that the number of confirmed cases worldwide will reach about 20 million optimistically. In severe cases, the peak value will exceed 80 million, and the late stage of the epidemic shows a long tail shape, lasting more than one and a half years. The effective way to control the global epidemic is to strengthen international cooperation and to impose international travel restrictions and other measures.


Subject(s)
COVID-19/prevention & control , COVID-19/transmission , Communicable Disease Control/methods , Primary Prevention/methods , Computer Simulation , Humans , Physical Distancing , Quarantine , SARS-CoV-2
12.
Biomarkers ; 26(3): 207-212, 2021 May.
Article in English | MEDLINE | ID: covidwho-1174775

ABSTRACT

AIM: Ferritin is a hepatic protein that plays vital roles in diagnosing and predicting diseases, but its potential in coronavirus disease 2019 (COVID-19) remains unknown. METHOD: We collected clinical records from 79 COVID-19 patients at Wuhan Union hospital (China). Spearman's correlation analysis, receiver operating characteristic (ROC) curve and Kaplan-Meier survival curves were employed. RESULTS: Patients with elevated ferritin levels had a higher incidence of severity illness (50.0 vs 2.9%) and liver injury (52.3 vs 20.0%) when compared with patients with normal ferritin levels (p < 0.05). Ferritin could effectively identify the severity of illness (ROC area 0.873) and liver injury (ROC area 0.752). The elevated ferritin group showed longer viral clearance time (median 16 vs 6 days, p < 0.001) and in-hospital length (median 18 vs 10 days, p < 0.001). CONCLUSIONS: It suggests that ferritin could act as an easy-to-use tool to identify liver injury and severity illness and predict the prognosis of COVID-19 patients. Intensive surveillance is necessary for patients with abnormal ferritin levels.


Subject(s)
COVID-19/pathology , Liver/pathology , Adult , Biomarkers/blood , COVID-19/blood , COVID-19/epidemiology , COVID-19/virology , China/epidemiology , Female , Ferritins/blood , Humans , Liver/physiopathology , Liver Function Tests , Male , Middle Aged , SARS-CoV-2/isolation & purification , Severity of Illness Index
13.
Medicine (Baltimore) ; 100(6): e24141, 2021 Feb 12.
Article in English | MEDLINE | ID: covidwho-1101918

ABSTRACT

BACKGROUND: The global neo-coronary pneumonia epidemic has increased the workload of healthcare institutions in various countries and directly affected the physical and psychological recovery of the vast majority of patients requiring hospitalization in China. We anticipate that post-total knee arthroplasty kinesiophobia may have an impact on patients' postoperative pain scores, knee function, and ability to care for themselves in daily life. The purpose of this study is to conduct a micro-video intervention via WeChat to verify the impact of this method on the rapid recovery of patients with kinesiophobia after total knee arthroplasty during neo-coronary pneumonia. METHODS: Using convenience sampling method, 78 patients with kinesiophobia after artificial total knee arthroplasty who met the exclusion criteria were selected and randomly grouped, with the control group receiving routine off-line instruction and the intervention group receiving micro-video intervention, and the changes in the relevant indexes of the two groups of patients at different time points on postoperative day 1, 3 and 7 were recorded and analyzed. RESULTS: There were no statistical differences in the scores of kinesiophobia, pain, knee flexion mobility (ROM) and ability to take care of daily life between the two groups on the first postoperative day (P > .05). On postoperative day 3 and 7, there were statistical differences in Tampa Scale for kinesiophobia, pain, activities of daily living scale score and ROM between the two groups (P < .01), and the first time of getting out of bed between the two groups (P < .05), and by repeated-measures ANOVA, there were statistically significant time points, groups and interaction effects of the outcome indicators between the 2 groups (P < .01), indicating that the intervention group reconstructed the patients' postoperative kinesiophobiaand hyperactivity. The level of pain awareness facilitates the patient's acquisition of the correct functional exercises to make them change their misbehavior. CONCLUSIONS: WeChat micro-video can reduce the fear of movement score and pain score in patients with kinesiophobia after unilateral total knee arthroplasty, shorten the first time out of bed, and improve their joint mobility and daily living ability. ETHICS: This study has passed the ethical review of the hospital where it was conducted and has been filed, Ethics Approval Number: 20181203-01.


Subject(s)
Arthroplasty, Replacement, Knee/psychology , COVID-19/psychology , Phobic Disorders/psychology , Pneumonia/epidemiology , Activities of Daily Living , Aged , Arthroplasty, Replacement, Knee/adverse effects , COVID-19/complications , COVID-19/diagnosis , COVID-19/virology , Case-Control Studies , China/epidemiology , Female , Humans , Knee Joint/physiopathology , Knee Joint/surgery , Male , Middle Aged , Pain, Postoperative/diagnosis , Pain, Postoperative/psychology , Pneumonia/virology , Postoperative Period , Prospective Studies , Range of Motion, Articular , Recovery of Function , Rehabilitation/methods , Rehabilitation/psychology , SARS-CoV-2/genetics , Videoconferencing/instrumentation , Videoconferencing/statistics & numerical data
14.
Anal Chem ; 92(19): 13396-13404, 2020 10 06.
Article in English | MEDLINE | ID: covidwho-933642

ABSTRACT

Rapid, accurate, reliable, and risk-free tracking of pathogenic microorganisms at the single-cell level is critical to achieve efficient source control and prevent outbreaks of microbial infectious diseases. For the first time, we report a promising approach for integrating the concepts of a remarkably large Stokes shift and dual-recognition into a single matrix to develop a pathogenic microorganism stimuli-responsive ratiometric fluorescent nanoprobe with speed, cost efficiency, stability, ultrahigh specificity, and sensitivity. As a proof-of-concept, we selected the Gram-positive bacterium Staphylococcus aureus (S. aureus) as the target analyte model, which easily bound to its recognition aptamer and the broad-spectrum glycopeptide antibiotic vancomycin (Van). To improve the specificity and short sample-to-answer time, we employed classic noncovalent π-π stacking interactions as a driving force to trigger the binding of Van and aptamer dual-functionalized near-infrared (NIR) fluorescent Apt-Van-QDs to the surface of an unreported blue fluorescent π-rich electronic carbon nanoparticles (CNPs), achieving S. aureus stimuli-responsive ratiometric nanoprobe Apt-Van-QDs@CNPs. In the assembly of Apt-Van-QDs@CNPs, the blue CNPs (energy donor) and NIR Apt-Van-QDs (energy acceptor) became close to allow the fluorescence resonance energy transfer (FRET) process, leading to a remarkable blue fluorescence quenching for the CNPs at ∼465 nm and a clear NIR fluorescence enhancement for Apt-Van-QDs at ∼725 nm. In the presence of S. aureus, the FRET process from CNPs to Apt-Van-QDs was disrupted, causing the nanoprobe Apt-Van-QDs@CNPs to display a ratiometric fluorescent response to S. aureus, which exhibited a large Stokes shift of ∼260 nm and rapid sample-to-answer detection time (∼30.0 min). As expected, the nanoprobe Apt-Van-QDs@CNPs showed an ultrahigh specificity for ratiometric fluorescence detection of S. aureus with a good detection limit of 1.0 CFU/mL, allowing the assay at single-cell level. Moreover, we also carried out the precise analysis of S. aureus in actual samples with acceptable results. We believe that this work offers new insight into the rational design of efficient ratiometric nanoprobes for rapid on-site accurate screening of pathogenic microorganisms at the single-cell level in the early stages, especially during the worldwide spread of COVID-19 today.


Subject(s)
Bacteria/chemistry , Bacterial Infections/diagnosis , Bacterial Infections/microbiology , Biosensing Techniques/methods , Fluorescent Dyes/chemical synthesis , Nanotechnology/methods , Anti-Bacterial Agents/pharmacology , Aptamers, Nucleotide , COVID-19 , Coronavirus Infections/complications , Coronavirus Infections/microbiology , Fluorescence , Fluorescence Resonance Energy Transfer , Food Microbiology/methods , Humans , Nanoparticles , Pandemics , Pneumonia, Viral/complications , Pneumonia, Viral/microbiology , Sensitivity and Specificity , Spectroscopy, Near-Infrared , Staphylococcal Infections/diagnosis , Staphylococcal Infections/microbiology , Staphylococcus aureus/chemistry , Vancomycin/pharmacology
15.
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi ; 34(3): 193-195, 2020 Mar.
Article in Chinese | MEDLINE | ID: covidwho-721655

ABSTRACT

It is a critical period of fighting against new coronavirus(SARS-CoV-2) disease now,since its outbreak on December 2019 in Wuhan.Even though the front line staffs are thought heroes,the ENT doctors and nurses are also indispensable power in defending the disease.The number of outpatients of ENT is huge.The early stage of SARS-CoV-2 pneumonia(COVID-19) may present pharyngalgia or cough without fever.Thus,the ENT doctors have high risks of being consulted by early stage COVID-19 patients.This paper means to talk about the contributions of ENT doctors and nurses in defending against SARS-CoV-2 virus,as well as the mental status of them.


Subject(s)
Coronavirus Infections/diagnosis , Health Personnel , Otolaryngologists , Pneumonia, Viral/diagnosis , Betacoronavirus , COVID-19 , China , Humans , Mental Health , Pandemics , SARS-CoV-2
16.
Carbohydr Polym ; 240: 116346, 2020 Jul 15.
Article in English | MEDLINE | ID: covidwho-102080

ABSTRACT

The new coronavirus pneumonia, named COVID-19 by the World Health Organization, has become a pandemic. It is highly pathogenic and reproduces quickly. There are currently no specific drugs to prevent the reproduction and spread of COVID-19. Some traditional Chinese medicines, especially the Lung Cleansing and Detoxifying Decoction (Qing Fei Pai Du Tang), have shown therapeutic effects on mild and ordinary COVID-19 patients. Polysaccharides are important ingredients in this decoction. This review summarizes the potential pharmacological activities of polysaccharides isolated by hot water extraction from Lung Cleansing and Detoxifying Decoction, which is consistent with its production method, to provide the theoretical basis for ongoing research on its application.


Subject(s)
Coronavirus Infections/therapy , Drugs, Chinese Herbal/therapeutic use , Lung/drug effects , Phytochemicals/therapeutic use , Pneumonia, Viral/therapy , Polysaccharides/therapeutic use , Adjuvants, Immunologic/chemistry , Animals , Anti-Inflammatory Agents/therapeutic use , Betacoronavirus , COVID-19 , COVID-19 Vaccines , Coronavirus Infections/drug therapy , Coronavirus Infections/prevention & control , Humans , Medicine, Chinese Traditional , Mice , Mice, Inbred C57BL , Pandemics , SARS-CoV-2 , Viral Vaccines
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