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1.
EuropePMC; 2021.
Preprint in English | EuropePMC | ID: ppcovidwho-311596

ABSTRACT

Introduction: Angiotensin-converting enzyme 2 (ACE2) is the receptor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The effects of SARS-CoV-2 on normal pituitary glands function or pituitary neuroendocrine tumors (PitNETs) have not yet been elucidated. Thus, the present study aimed to investigate the potential risks of SARS-CoV-2 infection on the impairment of pituitary glands and the development of PitNETs. Methods: : PitNETs tissues were obtained from 114 patients, and normal pituitary gland tissues were obtained from the autopsy. The mRNA levels of ACE2 and angiotensin II receptor type 1 (AGTR1) were examined by quantitative real-time PCR. Immunohistochemical staining was performed for ACE2 in 69 PitNETs and 3 normal pituitary glands. The primary tumor cells and pituitary cell lines (MMQ, GH3 and AtT-20/D16v-F2) were treated with diminazene aceturate (DIZE), an ACE2 agonist, with various dose regimens. The pituitary hormones between 43 patients with SARS-CoV-2 infection were compared with 45 healthy controls. Results: : Pituitary glands and the majority of PitNET tissues showed low/negative ACE2 expression at both the mRNA and protein levels, while AGTR1 showed high expression in normal pituitary and corticotroph adenomas. ACE2 agonist increased the secretion of ACTH in AtT-20/D16v-F2 cells through downregulating AGTR1. The level of serum adrenocorticotropic hormone (ACTH) was significantly increased in COVID-19 patients as compared to normal controls (p<0.001), but was dramatically decreased in critical cases as compared to non-critical patients (p=0.003). Conclusion: This study revealed a potential impact of SARS-CoV-2 infection on corticotroph cells and adenomas.

2.
Asian Agricultural Research ; 12(5):1-6, 2020.
Article in English | CAB Abstracts | ID: covidwho-1175840

ABSTRACT

Radix Glycyrrhizae is the dominant native medicinal material variety in the north and northwestern medicinal materials producing areas. It is a main Chinese medicine of effective TCM drugs and formulas for the treatment of new coronavirus disease(COVID-19). This paper introduces the medicinal value of Radix Glycyrrhizae, involving the labeling, cultural heritage, and creative intellectual property rights of the Chinese medicinal materials, analyzes the poverty-stricken areas that are ecologically suitable for Radix Glycyrrhizae cultivation, and the superior counties and production bases of the Chinese medicinal materials. Besides, mainly from the aspects of perfect intellectual property rights, the establishment of authentic medicinal material production bases, and the construction of quality control systems, etc., it discusses the rural revitalization strategy and the development strategy of traditional Chinese medicine(TCM), agricultural intellectual property protection and high-quality development strategy of Radix Glycyrrhizae.

3.
Endocrine ; 72(2): 340-348, 2021 05.
Article in English | MEDLINE | ID: covidwho-1159631

ABSTRACT

INTRODUCTION: Angiotensin-converting enzyme 2 (ACE2) is the receptor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The effects of SARS-CoV-2 on normal pituitary glands function or pituitary neuroendocrine tumors (PitNETs) have not yet been elucidated. Thus, the present study aimed to investigate the potential risks of SARS-CoV-2 infection on the impairment of pituitary glands and the development of PitNETs. METHODS: PitNETs tissues were obtained from 114 patients, and normal pituitary gland tissues were obtained from the autopsy. The mRNA levels of ACE2 and angiotensin II receptor type 1 (AGTR1) were examined by quantitative real-time PCR. Immunohistochemical staining was performed for ACE2 in 69 PitNETs and 3 normal pituitary glands. The primary tumor cells and pituitary cell lines (MMQ, GH3 and AtT-20/D16v-F2) were treated with diminazene aceturate (DIZE), an ACE2 agonist, with various dose regimens. The pituitary hormones between 43 patients with SARS-CoV-2 infection were compared with 45 healthy controls. RESULTS: Pituitary glands and the majority of PitNET tissues showed low/negative ACE2 expression at both the mRNA and protein levels, while AGTR1 showed high expression in normal pituitary and corticotroph adenomas. ACE2 agonist increased the secretion of ACTH in AtT-20/D16v-F2 cells through downregulating AGTR1. The level of serum adrenocorticotropic hormone (ACTH) was significantly increased in COVID-19 patients compared to normal controls (p < 0.001), but was dramatically decreased in critical cases compared to non-critical patients (p = 0.003). CONCLUSIONS: This study revealed a potential impact of SARS-CoV-2 infection on corticotroph cells and adenomas.


Subject(s)
COVID-19 , Neuroendocrine Tumors , Humans , Peptidyl-Dipeptidase A/genetics , Pituitary Gland/metabolism , SARS-CoV-2
4.
Medicinal Plant ; 11(4):3-9, 2020.
Article in English | CAB Abstracts | ID: covidwho-1140853

ABSTRACT

The discovery of highly effective medicine " Qingfei Paidu Decoction" for COVID-19 is a new era gift of traditional Chinese medicine to the world. The traditional Chinese medicine Scutellaria baicalensis Georgi, as a medicinal plant in the family of Labiatae, is the dominant variety of genuine medicinal material in North China. It is the leading traditional Chinese medicine in the advantageous area of agricultural products with Chinese characteristics in Shangdang of Changzhi City, and it is one of the 21 herbal medicines in the new national prescription " Qingfei Paidu Decoction" for the rapid and effective treatment of COVID-19. This paper introduces S. baicalensis Georgi and its traditional Chinese medicine GAP base, ecologically suitable planting county and medicinal value in poor areas, and studies the intellectual property resources related to S. baicalensis Georgi, such as traditional knowledge, biological genetic resources, patents, new plant varieties, geographical indications, and trademarks. This paper mainly discusses the inheritance essence, innovation and high-quality development strategy of S. baicalensis Georgi under the rural revitalization strategy and traditional Chinese medicine development strategy from the aspects of intellectual property rights, important agricultural cultural heritage, advantageous areas of characteristic agricultural products and so on.

5.
Medicine (Baltimore) ; 100(6): e24141, 2021 Feb 12.
Article in English | MEDLINE | ID: covidwho-1101918

ABSTRACT

BACKGROUND: The global neo-coronary pneumonia epidemic has increased the workload of healthcare institutions in various countries and directly affected the physical and psychological recovery of the vast majority of patients requiring hospitalization in China. We anticipate that post-total knee arthroplasty kinesiophobia may have an impact on patients' postoperative pain scores, knee function, and ability to care for themselves in daily life. The purpose of this study is to conduct a micro-video intervention via WeChat to verify the impact of this method on the rapid recovery of patients with kinesiophobia after total knee arthroplasty during neo-coronary pneumonia. METHODS: Using convenience sampling method, 78 patients with kinesiophobia after artificial total knee arthroplasty who met the exclusion criteria were selected and randomly grouped, with the control group receiving routine off-line instruction and the intervention group receiving micro-video intervention, and the changes in the relevant indexes of the two groups of patients at different time points on postoperative day 1, 3 and 7 were recorded and analyzed. RESULTS: There were no statistical differences in the scores of kinesiophobia, pain, knee flexion mobility (ROM) and ability to take care of daily life between the two groups on the first postoperative day (P > .05). On postoperative day 3 and 7, there were statistical differences in Tampa Scale for kinesiophobia, pain, activities of daily living scale score and ROM between the two groups (P < .01), and the first time of getting out of bed between the two groups (P < .05), and by repeated-measures ANOVA, there were statistically significant time points, groups and interaction effects of the outcome indicators between the 2 groups (P < .01), indicating that the intervention group reconstructed the patients' postoperative kinesiophobiaand hyperactivity. The level of pain awareness facilitates the patient's acquisition of the correct functional exercises to make them change their misbehavior. CONCLUSIONS: WeChat micro-video can reduce the fear of movement score and pain score in patients with kinesiophobia after unilateral total knee arthroplasty, shorten the first time out of bed, and improve their joint mobility and daily living ability. ETHICS: This study has passed the ethical review of the hospital where it was conducted and has been filed, Ethics Approval Number: 20181203-01.


Subject(s)
Arthroplasty, Replacement, Knee/psychology , COVID-19/psychology , Phobic Disorders/psychology , Pneumonia/epidemiology , Activities of Daily Living , Aged , Arthroplasty, Replacement, Knee/adverse effects , COVID-19/complications , COVID-19/diagnosis , COVID-19/virology , Case-Control Studies , China/epidemiology , Female , Humans , Knee Joint/physiopathology , Knee Joint/surgery , Male , Middle Aged , Pain, Postoperative/diagnosis , Pain, Postoperative/psychology , Pneumonia/virology , Postoperative Period , Prospective Studies , Range of Motion, Articular , Recovery of Function , Rehabilitation/methods , Rehabilitation/psychology , SARS-CoV-2/genetics , Videoconferencing/instrumentation , Videoconferencing/statistics & numerical data
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