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1.
Ieee Internet of Things Journal ; 8(21):15829-15838, 2021.
Article in English | Web of Science | ID: covidwho-1570228

ABSTRACT

The rapid development of the COVID-19 pandemic has threatened the lives of people around the world. Many people were caught in anxiety and panic, which also prevents people from fully concentrating on their normal lives. However, the current common neurofeedback therapies used to solve the problem of lack of attention cannot fully deal with the differences in each individual. In addition, direct contact between the patient and the doctor also increases the risk of virus transmission during treatment. This article combines neurofeedback and IoT to establish an adaptive attention adjustment method. IoT connects patients and doctors remotely, reducing the direct contact between them. In order to adapt to individual differences, the feedback indicators of each individual are individually calibrated. In addition, the proportional, integral, and derivative controller was used to adjust the difficulty of the feedback task to adapt to each individual's self-regulation ability and provide the individual with a higher level of regulation. We also designed adaptive attention adjustment experiments for different individuals. The results show that through adaptive feedback training, the individual's feedback indicator has dropped by 77.90%, and the individual can adjust his attention state to the individual's optimal baseline threshold, and the oscillation error gradually reduces to the expected threshold range. This method can cope with the differences between different individuals and provide each individual with the same level of feedback regulation. In the future, this study may provide a general adjuvant treatment for other mental illnesses.

2.
Zhonghua Yu Fang Yi Xue Za Zhi ; 55(8): 1016-1021, 2021 Aug 06.
Article in Chinese | MEDLINE | ID: covidwho-1377014

ABSTRACT

The continuously spreading of SARS-CoV-2 poses a threat not only to public health but also to all aspects of socio-economics. Current public health measures are costly and have potential health risks, thus, it is imminent that developing efficient and economical early warning surreillance tools from a public health perspective. In this review, we summarized the current COVID-19 epidemiological surveillance measures and the efficiency, economic, and cutting edge of wastewater-based epidemiology (WBE). The WBE-based surveillance is organized and reviewed from three aspects: early warning system for the timing of epidemic, routine epidemic surveillance, and parameters determination of predicting epidemiological models of COVID-19. It reveals the application value of WBE as an early warning and surveillance system of public health, and then, discussing its current weakness and strength, adding literature for a WBE-based surveillance system for COVID-19 epidemic in China.


Subject(s)
COVID-19 , Wastewater-Based Epidemiological Monitoring , Humans , Public Health , SARS-CoV-2 , Waste Water
3.
Journal of Clinical Oncology ; 39(15 SUPPL), 2021.
Article in English | EMBASE | ID: covidwho-1339174

ABSTRACT

Background: Documenting GOC is integral to patient care and quality performance but has been underutilized by oncologists due to many barriers. As oncologists play a key role in initiating GOC discussions, we implemented a clinical initiative to improve their GOC documentation and evaluated the impact of such documentation on patient care during the EOL (last 30 days of life). Methods: We launched the initiative among 270 medical oncologists in an academic cancer center in 4/2020. A newly formulated GOC note to ease documentation was embedded in oncology outpatient and inpatient notes. Oncologists completed components in the GOC note that applied to their communication about GOC with the patient: 1) cancer natural history, 2) patient goals, and 3) EOL discussion: patient resuscitation preferences and, when pertinent, receptivity to hospice referral. GOC notes were pulled to a centralized location in the electronic health record (EHR) that displays documents relevant to patients' values, goals and preferences. A dashboard allowed continual monitoring of documentation performance. We evaluated the association between GOC notes and outcomes of patient care at EOL. We further analyzed the impact of EOL discussion on EOL care. Results: The GOC note completion rate steadily rose after implementation. GOC notes were present in EHR for 46% of 10,006 patients who were either seen in outpatient clinic or discharged from hospital during the 1 week of January 2021. Among 1790 patients who died between 7/1/20 and 12/31/20 and had either at least an outpatient visit or hospitalization during EOL, the median days from first GOC note and first EOL discussion to the patient's death were 71 days and 24 days, respectively. Linear regression analysis demonstrated that patients who had GOC note 60 days before death spent less time as inpatient during EOL (0.4 day less/patient, from 8.1 to 7.7, P = 0.01). When EOL discussion was documented 30 days before death, patients also spent less time in the hospital (1.2 days less/patient, from 9.7 to 8.5, P < 0.001) and in the ICU (0.3 days less/patient, from 1.7 to 1.4 ICU days, P = 0.04), and were 4% less likely to receive chemotherapy (from 38% to 34%, P = 0.004) at EOL. During the same period, among 1,009 patients with hospital admission in the last 30 days of life, those with a prior documented EOL discussion had shorter inpatient stay (7.7 vs 13.1 days, P < 0.001) and were more likely to be discharged to hospice (34% vs 22%, P = 0.003). Conclusions: During the COVID-19 pandemic, we successfully implemented GOC documentation by medical oncologists that is easily visible by the full care team. Documentation of GOC including EOL discussion was associated with fewer days in the hospital and ICU, increased hospice referral, and lower likelihood of receiving chemotherapy during patients' last 30 days of life.

4.
International Journal of Hospitality Management ; 97, 2021.
Article in English | Scopus | ID: covidwho-1275357

ABSTRACT

Corporate social responsibility (CSR) contributions are essential for hospitality companies during the COVID-19 pandemic. However, little is known about how CSR contribution timing during the pandemic might affect consumers’ prepayment purchase intentions. This paper takes a hospitality company as an example, using two experiments to explore (a) the effect of CSR contribution timing on consumers’ prepayment purchase intentions and (b) the potential roles of psychological contracts and distance to the COVID-19 risk center. Study 1 demonstrated that CSR contributions during the COVID-19 outbreak (vs. after its peak) led consumers to have higher prepayment purchase intentions, revealing the impact of CSR contribution timing. This effect was also driven by psychological contracts between consumers and the hospitality company. Study 2 showed that, when participants were in the peripheral area of a COVID-19 outbreak, CSR contributions during the outbreak (vs. after its peak) increased prepayment purchase intentions whereas the opposite effect occurred when consumers were in the risk center. © 2021 Elsevier Ltd

5.
Pharmaceutics ; 13(4):14, 2021.
Article in English | MEDLINE | ID: covidwho-1208951

ABSTRACT

Since coronavirus disease 2019 (COVID-19) is a serious new worldwide public health crisis with significant morbidity and mortality, effective therapeutic treatments are urgently needed. Drug repurposing is an efficient and cost-effective strategy with minimum risk for identifying novel potential treatment options by repositioning therapies that were previously approved for other clinical outcomes. Here, we used an integrated network-based pharmacologic and transcriptomic approach to screen drug candidates novel for COVID-19 treatment. Network-based proximity scores were calculated to identify the drug-disease pharmacological effect between drug-target relationship modules and COVID-19 related genes. Gene set enrichment analysis (GSEA) was then performed to determine whether drug candidates influence the expression of COVID-19 related genes and examine the sensitivity of the repurposing drug treatment to peripheral immune cell types. Moreover, we used the complementary exposure model to recommend potential synergistic drug combinations. We identified 18 individual drug candidates including nicardipine, orantinib, tipifarnib and promethazine which have not previously been proposed as possible treatments for COVID-19. Additionally, 30 synergistic drug pairs were ultimately recommended including fostamatinib plus tretinoin and orantinib plus valproic acid. Differential expression genes of most repurposing drugs were enriched significantly in B cells. The findings may potentially accelerate the discovery and establishment of an effective therapeutic treatment plan for COVID-19 patients.

6.
Chinese Journal of Clinical Infectious Diseases ; 13(6):467-474, 2020.
Article in Chinese | Scopus | ID: covidwho-1143652

ABSTRACT

COVID-19 is a global pandemic, which is the third outbreak and epidemic of infectious disease caused by coronavirus in this century and constitutes a major threat to human health.In this paper, COCOVID-19, Severeacute respiratory syndrome (SARS) and Middle East Respiratory syndrome (MERS) were analyzed to distinguish their clinical features, diagnosis, prognosis and prevention, so as to better prevent and treat related diseases. © 2020 Chinese Medical Association

7.
Beijing Da Xue Xue Bao Yi Xue Ban ; 53(1):159-166, 2020.
Article in Chinese | PubMed | ID: covidwho-1064018

ABSTRACT

OBJECTIVE: To investigate the risk factors for acute myocardial injury in coronavirus disease 2019 (COVID-19) patients. METHODS: This is a retrospective analysis of a COVID-19 cohort, in which 149 confirmed COVID-19 patients enrolled were divided into the group of myocardial injury (19 cases) and the group of non-myocardial injury (130 cases). Myocardial injury was defined according to Fourth universal definition of myocardial infarction released by European Society of Cardiology (ESC) in 2018, that cardiac troponin (cTn) was above 99th percentile of the reference level. Clinical information and results of laboratory tests of the eligible patients were collected. Factors associated with myocardial injury in COVID-19 patients were evaluated. RESULTS: Compared with the group of non-injury, the patients in the group of injury were older and had a larger proportion of severe or critical cases (P < 0.05), higher respiratory rate and lower percutaneous oxygen saturation (SpO(2)) without oxygen therapy on admission (P < 0.05). All inflammatory indexes except for tumor necrosis factor α (TNF-α) showed significant elevation in the patients of the group of injury (P < 0.05). Analyzed by Spearman correlation test, we showed that the levels of circulatory cTnI were in positive correlation with the levels of high-sensitivity C-reactive protein (hs-CRP), ferritin, receptor of interleukin-2 (IL-2R), interleukin-6 (IL-6) and interleukin-8 (IL-8) (ρ > 0, P < 0.05). Lower SpO(2) without oxygen therapy on admission (OR: 0.860, 95%CI: 0.779-0.949, P=0.003) and higher plasma IL-6 levels (OR: 1.068, 95%CI: 1.019-1.120, P=0.006) were independent risk factors for acute myocardial injury in the patients with COVID-19 by multivariate Logistic regression analyses. CONCLUSION: Hypoxic state and inflammation may play a key role in the pathogenesis of acute myocardial injury in COVID-19 patients.

10.
Zhonghua Bing Li Xue Za Zhi ; 49(5): 411-417, 2020 May 08.
Article in Chinese | MEDLINE | ID: covidwho-8646

ABSTRACT

Objective: To investigate the pathological characteristics and the clinical significance of novel coronavirus (2019-nCoV)-infected pneumonia (termed by WHO as coronavirus disease 2019, COVID-19). Methods: Minimally invasive autopsies from lung, heart, kidney, spleen, bone marrow, liver, pancreas, stomach, intestine, thyroid and skin were performed on three patients died of novel coronavirus pneumonia in Chongqing, China. Hematoxylin and eosin staining (HE), transmission electron microcopy, and histochemical staining were performed to investigate the pathological changes of indicated organs or tissues. Immunohistochemical staining was conducted to evaluate the infiltration of immune cells as well as the expression of 2019-nCoV proteins. Real time PCR was carried out to detect the RNA of 2019-nCoV. Results: Various damages were observed in the alveolar structure, with minor serous exudation and fibrin exudation. Hyaline membrane formation was observed in some alveoli. The infiltrated immune cells in alveoli were majorly macrophages and monocytes. Moderate multinucleated giant cells, minimal lymphocytes, eosinophils and neutrophils were also observed. Most of infiltrated lymphocytes were CD4-positive T cells. Significant proliferation of type Ⅱ alveolar epithelia and focal desquamation of alveolar epithelia were also indicated. The blood vessels of alveolar septum were congested, edematous and widened, with modest infiltration of monocytes and lymphocytes. Hyaline thrombi were found in a minority of microvessels. Focal hemorrhage in lung tissue, organization of exudates in some alveolar cavities, and pulmonary interstitial fibrosis were observed. Part of the bronchial epithelia were exfoliated. Coronavirus particles in bronchial mucosal epithelia and type Ⅱ alveolar epithelia were observed under electron microscope. Immunohistochemical staining showed that part of the alveolar epithelia and macrophages were positive for 2019-nCoV antigen. Real time PCR analyses identified positive signals for 2019-nCoV nucleic acid. Decreased numbers of lymphocyte, cell degeneration and necrosis were observed in spleen. Furthermore, degeneration and necrosis of parenchymal cells, formation of hyaline thrombus in small vessels, and pathological changes of chronic diseases were observed in other organs and tissues, while no evidence of coronavirus infection was observed in these organs. Conclusions: The lungs from novel coronavirus pneumonia patients manifest significant pathological lesions, including the alveolar exudative inflammation and interstitial inflammation, alveolar epithelium proliferation and hyaline membrane formation. While the 2019-nCoV is mainly distributed in lung, the infection also involves in the damages of heart, vessels, liver, kidney and other organs. Further studies are warranted to investigate the mechanism underlying pathological changes of this disease.


Subject(s)
Coronavirus Infections , Lung/pathology , Pandemics , Pneumonia, Viral , Autopsy , Betacoronavirus/genetics , Betacoronavirus/isolation & purification , COVID-19 , China , Coronavirus Infections/pathology , Humans , Kidney/pathology , Liver/pathology , Myocardium/pathology , Pneumonia, Viral/pathology , Real-Time Polymerase Chain Reaction , SARS-CoV-2 , Skin/pathology , Thyroid Gland/pathology
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