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1.
Chinese Public Administration Review ; 2023.
Article in English | PubMed Central | ID: covidwho-2195308

ABSTRACT

Since early 2020, COVID-19 has been a major public security crisis that has had an enormous impact on the world. With the spread of the epidemic, rumors occur, some of which have even caused public panic. They have greatly affected the government's efforts of epidemic prevention and thus urgently need to be evaluated. This study aimed to examine how to make flexible use of different policy tools to govern rumors based on their different characteristics. From the perspective of behavioral public policy, this study observes the effectiveness of various behavioral policy tools in rumor governance, hoping to explore the optimal solution of rumor governance from the perspective of micro public psychology. The survey experiment shows that individual behavior-related rumors (hereafter referred to as IBRs) are easier to be governed than epidemic progress-related rumors (hereafter referred to as EPRs) are, and that quick response is more effective than non-quick response. Through interaction analysis, it is known that in the governance of IBRs, nudge is more effective in rapid response, while in the context of non-quick response, boost outperforms nudge in rumor governance. A similar phenomenon can be seen in the scenario of EPR governance, despite a tinier difference in effectiveness compared with that of IBRs. The study enlightens us that rumor refutation requires not only people's disbelief in and restraint on rumors, but also the implementation of science-based targeted policies. Based on the conclusion, this study puts forward suggestions on implementing targeted policies of rumor governance.

2.
Open Forum Infectious Diseases ; 9(Supplement 2):S65-S66, 2022.
Article in English | EMBASE | ID: covidwho-2189528

ABSTRACT

Background. Respiratory virus infections (RVIs) in adult hematopoietic cell transplant (HCT) candidates have been shown to impact posttransplant outcomes;however, there are few studies in pediatric patients. We sought to evaluate the role of specific viruses and the location of viral infection on post HCT outcomes. Methods. We evaluated allogeneic pediatric HCT recipients receiving myeloablative conditioning from 3/2010-3/2018. All patients had a multiplex PCR for RVIs prior to HCT, regardless of symptoms. Delaying HCT was recommended when feasible for RSV, parainfluenza, metapneumovirus, adenovirus, and influenza, but not routinely for human rhinovirus (HRV) and endemic coronaviruses. We utilized Cox proportional hazards models to evaluate progression to lower respiratory disease (LRD) post HCT and linear regression models to evaluated days alive and out of hospital (DAOH) by 100 days post HCT. Results. Of 310 allogeneic HCT recipients receiving myeloablative conditioning, 133 (43%) were positive for a RVI before HCT. Baseline characteristics were notable for differences for age, recipient CMV serostatus, and delayed HCT (Table 1). The most common RVI was HRV (97, 73%) and 81 (61%) patients were symptomatic at the time of detection. Most patients had a URI (92%) and 11 patients had LRD (3 proven, 8 possible). In univariate analysis, HRV as virus type was associated with fewer DAOH and preHCT URI as location of viral infection (with and without symptoms) trended towards fewer DAOH (Figure 1a). When adjusted for age, preHCT lymphocyte count, cell source, and conditioning regimen, both HRV and preHCT URI showed a trend towards fewer DAOH, but no significant association was found (Figure 1b,c). Twenty patients progressed to LRD after HCT with the same preHCT RVI;no factors, including delay of transplant, were associated with reduced progression to LRD. Conclusion. In this single center study, HRV as virus type and URI as location of viral infection before myeloablative allogeneic HCT were associated with increased hospitalization after HCT, but not inmultivariatemodels. Larger multicenter studies are needed to provide timely evaluation and adequate statistical power to definitivelydetermine role of URI versus LRD and the impact of transplant delay and treatment strategies. (Table Presented).

3.
Chin J Nat Med ; 21(1):65-80, 2023.
Article in English | PubMed | ID: covidwho-2184754

ABSTRACT

Acute respiratory infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) had caused a global pandemic since 2019, and posed a serious threat to global health security. Traditional Chinese medicine (TCM) has played an indispensable role in the battle against the epidemic. Many components originated from TCMs were found to inhibit the production of SARS-CoV-2 3C-like protease (3CLpro) and papain-like protease (PLpro), which are two promising therapeutic targets to inhibit SARS-CoV-2. This study describes a systematic investigation of the roots and rhizomes of Sophora tonkinensis, which results in the characterization of 12 new flavonoids, including seven prenylated flavanones (1-7), one prenylated flavonol (8), two prenylated chalcones (9-10), one isoflavanone (11), and one isoflavan dimer (12), together with 43 known compounds (13-55). Their structures including the absolute configurations were elucidated by comprehensive analysis of MS, 1D and 2D NMR data, and time-dependent density functional theory electronic circular dichroism (TDDFT ECD) calculations. Compounds 12 and 51 exhibited inhibitory effects against SARS-CoV-2 3CLpro with IC(50) values of 34.89 and 19.88 μmol·L(-1), repectively while compounds 9, 43 and 47 exhibited inhibitory effects against PLpro with IC(50) values of 32.67, 79.38, and 16.74 μmol·L(-1), respectively.

4.
Int J Biol Macromol ; 2022.
Article in English | PubMed | ID: covidwho-2158943

ABSTRACT

Targeting the interaction between the spike protein receptor binding domain (S-RBD) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and angiotensin-converting enzyme 2 (ACE2) is a potential therapeutic strategy for treating coronavirus disease 2019 (COVID-19). However, we still lack small-molecule drug candidates for this target due to the missing knowledge in the hot spots for the protein-protein interaction. Here, we used NanoBiT technology to identify three Ginkgolic acids from an in-house traditional Chinese medicine (TCM) library, and they interfere with the S-RBD/ACE2 interplay. Our pseudovirus assay showed that one of the compounds, Ginkgolic acid C17:1 (GA171), significantly inhibits the entry of original SARS-CoV-2 and its variants into the ACE2-overexpressed HEK293T cells. We investigated and proposed the binding sites of GA171 on S-RBD by combining molecular docking and molecular dynamics simulations. Site-directed mutagenesis and surface plasmon resonance revealed that GA171 specifically binds to the pocket near R403 and Y505, critical residues of S-RBD for S-RBD interacting with ACE2. Thus, we provide structural insights into developing new small-molecule inhibitors and vaccines against the proposed S-RBD binding site.

5.
Chinese Journal of School Health ; 43(3):341-344, 2022.
Article in Chinese | Scopus | ID: covidwho-2155899

ABSTRACT

Objective To understand the online learning-related screen use duration and screen types in school-aged children in Shanghai during the COVID-19 epidemic. Methods Random clustering sampling was used to select 5 591 parents of students from 8 primary and junior schools that are in the sampling pool of the national myopia survey in districts of Jiading, Pudong and Baoshan in Shanghai in April 2020. Electronic questionnaire was administered to parents regarding their child's online learning-related screen use. Results On average, the median weekly duration of online learning-related screen use was 13.33 hours, the curricular and extracurricular parts of which were 10(8.75, 16.67) and 0(0, 3.33) hours, respectively. About 29.44% of investigated school-aged children only used small-size screen for online learning. Children in higher grades, being myopic and parents neither being myopic were associated with reporting higher weekly duration(P<0.05);children in higher grades of primary school and parents neither being myopic were associated with a higher likelihood of using small-size screen for online learning(P<0.05). Conclusion At the early stage of the COVID-19 epidemic, the burden associated with online-learning-related screen use was high in school-aged children in Shanghai. Health education regarding online learning-related screen use should be addressed in parents to guide their children to use screen appropriately. © 2022 Chin J Sch Health. All rights reserved.

6.
PLoS ONE [Electronic Resource] ; 17(12):e0278294, 2022.
Article in English | MEDLINE | ID: covidwho-2154290

ABSTRACT

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causative agent of the Coronavirus disease 2019 (Covid-19) pandemic, continues to evolve and circulate globally. Current prophylactic and therapeutic countermeasures against Covid-19 infection include vaccines, small molecule drugs, and neutralizing monoclonal antibodies. SARS-CoV-2 infection is mainly mediated by the viral spike glycoprotein binding to angiotensin converting enzyme 2 (ACE2) on host cells for viral entry. As emerging mutations in the spike protein evade efficacy of spike-targeted countermeasures, a potential strategy to counter SARS-CoV-2 infection is to competitively block the spike protein from binding to the host ACE2 using a soluble recombinant fusion protein that contains a human ACE2 and an IgG1-Fc domain (ACE2-Fc). Here, we have established Chinese Hamster Ovary (CHO) cell lines that stably express ACE2-Fc proteins in which the ACE2 domain either has or has no catalytic activity. The fusion proteins were produced and purified to partially characterize physicochemical properties and spike protein binding. Our results demonstrate the ACE2-Fc fusion proteins are heavily N-glycosylated, sensitive to thermal stress, and actively bind to five spike protein variants (parental, alpha, beta, delta, and omicron) with different affinity. Our data demonstrates a proof-of-concept production strategy for ACE2-Fc fusion glycoproteins that can bind to different spike protein variants to support the manufacture of potential alternative countermeasures for emerging SARS-CoV-2 variants.

7.
Can J Psychiatry ; : 7067437221140375, 2022.
Article in English | PubMed | ID: covidwho-2153362

ABSTRACT

OBJECTIVE: Examine time trends in suicidal ideation in post-secondary students over the first three waves of the COVID-19 pandemic in Canada and identify subpopulations of students with increased risk. METHOD: We analysed 14 months of data collected through repeated cross-sectional deployment of the World Health Organization (WHO) World Mental Health-International College Student (WMH-ICS) survey at the University of British Columbia. Estimated log odds weekly trends of 30-day suicidal ideation (yes/no) were plotted against time with adjustments for demographics using binary logistic generalized additive model (GAM). Risk factors for 30-day suicidal ideation frequency (four categories) were examined using the ordered logistic GAM, with a cubic smoothing spline for modelling time trend in obervation weeks and accounting for demographics. RESULTS: Nearly one-fifth (18.9%) of students experienced suicidal ideation in the previous 30 days. While the estimated log odds suggested that binary suicidal ideation was relatively stable across the course of the pandemic, an initial drop followed by an increasing trend was observed. Risk factors for suicidal ideation frequency during the pandemic included identifying as Chinese or as another non-Indigenous ethnic minority;experiencing current symptoms of depression or anxiety;having a history of suicidal planning or attempts;and feeling overwhelmed but unable to get help as a result of COVID-19. Older age was identified as a protective factor. CONCLUSIONS: The general university student population in our study was relatively resilient with respect to suicidal ideation during the first three waves of the pandemic, but trends indicate the possibility of delayed impact. Specific sub-populations were found to be at increased risk and should be considered for targeted support. Further analyses should be undertaken to continue monitoring suicidality trends throughout the remainder of the pandemic and beyond.

8.
European Review for Medical and Pharmacological Sciences ; 26(19):7305-7312, 2022.
Article in English | Web of Science | ID: covidwho-2124782

ABSTRACT

OBJECTIVE: Acne vulgaris is a common skin disease worldwide. Throughout the COVID-19 pandemic, many patients with ac-ne complained of worsening symptoms. This investigation was designed to survey the impact of COVID-19 regulations on acne and guide patients with acne on symptom management during the pandemic. MATERIALS AND METHODS: From April 7th to April 21st, 2020, an anonymous, self -completed, web-based questionnaire was distributed to patients previously diagnosed with acne (via the Chinese internet medical software). Information collected included patients' mask-wearing routines and behavioral factors including dietary habits, sleep habits, facial hygiene, and make-up use habits. RESULTS: 508 qualified questionnaire responses were collected. During the COVID-19 outbreak in China, there was an overall worsening of patients' acne symptoms (152, 29.9%). Behaviors including intake of sweets (34.9% vs. 16.0%, p < 0.01), dairy consumption (32.9% vs. 23.3%, p < 0.05), greasy (19.1% vs. 11.2%, p < 0.05) and spicy food intake (30.3% vs. 14.3%, p < 0.01) and mask-wearing frequency (> 28 hours per week) (25.0% vs. 15.3%, p < 0.05) presented a statistically significant difference between the acne aggravated and non-aggravated groups. Long-time mask-wearing (> 28 hours per week), rather than the mask type, was significantly associat-ed with acne symptom deterioration during the COVID-19 outbreak (odds ratio [OR]: 2.164;95% confidence interval [CI]: 1.232-3.801). CONCLUSIONS: Besides the well-known risk factors, such as sweets intake, dairy consump-tion, and greasy and spicy food intake, wearing masks appears to trigger or aggravate acne during the COVID-19 pandemic. Limiting overall mask-wearing time may help to manage acne.

9.
6th International Conference on Big Data and Internet of Things, BDIOT 2022 ; : 64-69, 2022.
Article in English | Scopus | ID: covidwho-2088939

ABSTRACT

In recent years, the use of the Internet of Things (IoT) has become more widespread, which has had a great impact on the animal health system. In the context of the COVID-19 pandemic, interactions between people and pets have been of great help in the regulation of mood and spirit. And in modern society, more and more people regard pets as their emotional sustenance, it can be said that pets are no longer just living in the family as animals, but also a kind of "loved ones", so the health and care of pets is particularly important. IoT devices come in the form of wearables for tracking human activity. Now wearables can also be used to monitor animal activity. Novel Pet Collaborative Care (NPCC) uses biosensors and corresponding software to monitor and maintain animal health records, as well as supports remote virtual interactions with pets or virtual pets. The main purpose of this article is to review the latest advances in the field of animal health, and to improve and strengthen them on this basis, with the aim of conducting research and development in the hope of bringing more benefits to pets. © 2022 ACM.

10.
Eur Rev Med Pharmacol Sci ; 26(19): 7305-7312, 2022 Oct.
Article in English | MEDLINE | ID: covidwho-2081435

ABSTRACT

OBJECTIVE: Acne vulgaris is a common skin disease worldwide. Throughout the COVID-19 pandemic, many patients with acne complained of worsening symptoms. This investigation was designed to survey the impact of COVID-19 regulations on acne and guide patients with acne on symptom management during the pandemic. MATERIALS AND METHODS: From April 7th to April 21st, 2020, an anonymous, self-completed, web-based questionnaire was distributed to patients previously diagnosed with acne (via the Chinese internet medical software). Information collected included patients' mask-wearing routines and behavioral factors including dietary habits, sleep habits, facial hygiene, and make-up use habits. RESULTS: 508 qualified questionnaire responses were collected. During the COVID-19 outbreak in China, there was an overall worsening of patients' acne symptoms (152, 29.9%). Behaviors including intake of sweets (34.9% vs. 16.0%, p<0.01), dairy consumption (32.9% vs. 23.3%, p<0.05), greasy (19.1% vs. 11.2%, p<0.05) and spicy food intake (30.3% vs. 14.3%, p<0.01) and mask-wearing frequency (>28 hours per week) (25.0% vs. 15.3%, p<0.05) presented a statistically significant difference between the acne aggravated and non-aggravated groups. Longtime mask-wearing (>28 hours per week), rather than the mask type, was significantly associated with acne symptom deterioration during the COVID-19 outbreak (odds ratio [OR]: 2.164; 95% confidence interval [CI]: 1.232-3.801). CONCLUSIONS: Besides the well-known risk factors, such as sweets intake, dairy consumption, and greasy and spicy food intake, wearing masks appears to trigger or aggravate acne during the COVID-19 pandemic. Limiting overall mask-wearing time may help to manage acne.


Subject(s)
Acne Vulgaris , COVID-19 , Humans , COVID-19/epidemiology , Pandemics , Cross-Sectional Studies , Acne Vulgaris/epidemiology , China/epidemiology , Internet , Masks
11.
Ieee Access ; 10:103176-103186, 2022.
Article in English | Web of Science | ID: covidwho-2070270

ABSTRACT

In large MOOC cohorts, the sheer variance and volume of discussion forum posts can make it difficult for instructors to distinguish nuanced emotion in students, such as engagement levels or stress, purely from textual data. Sentiment analysis has been used to build student behavioral models to understand emotion, however, more recent research suggests that separating sentiment and stress into different measures could improve approaches. Detecting stress in a MOOC corpus is challenging as students may use language that does not conform to standard definitions, but new techniques like TensiStrength provide more nuanced measures of stress by considering it as a spectrum. In this work, we introduce an ensemble method that extracts feature categories of engagement, semantics and sentiment from an AdelaideX student dataset. Stacked and voting methods are used to compare performance measures on how accurately these features can predict student grades. The stacked method performed best across all measures, with our Random Forest baseline further demonstrating that negative sentiment and stress had little impact on academic results. As a secondary analysis, we explored whether stress among student posts increased in 2020 compared to 2019 due to COVID-19, but found no significant change. Importantly, our model indicates that there may be a relationship between features, which warrants future research.

12.
Journal of Craniofacial Surgery ; 33(6):2059-2062, 2022.
Article in English | MEDLINE | ID: covidwho-2063120

ABSTRACT

: Use of facial mask coverings has been a strong Centers for Disease Control and Prevention recommendation as an essential mitigation measure in the spread of the SARS-CoV-2 novel coronavirus (COVID)-19 virus. Face mask utilization has been shown to induce changes in the skin microclimate, especially around the perioral and perinasal regions. This results in increased mask adjustments and development of friction between masks and the underlying skin. The authors report novel findings of 2 individuals with skin cancer who underwent facial reconstruction during the COVID-19 pandemic. They encountered untoward sequelae of facial flap pressure necrosis due to the use of face mask coverings. These individuals were ultimately successfully treated with local wound care. One individual experienced auricular implant extrusion and flap loss. It is critical that reconstructive surgeons be aware of potential complications and the need for potential revision surgeries due to the use of face masks, and educate their patients to properly position the protective face masks based on the type of reconstruction performed. Plastic surgeons might also reconsider reconstructive management options in light of these additional obstacles.

13.
2022 International Symposium on Educational Technology, ISET 2022 ; : 8-12, 2022.
Article in English | Scopus | ID: covidwho-2052031

ABSTRACT

The purpose of this study is to incorporate a collaborative flipped classroom technique using student-generated videos to increase classroom participation. Traditional flipped classroom methods depend on educators to spend resources to produce video content. However, there is uncertainty whether a scalable and sustainable method with student-generated content can be used. Student-generated videos may provide opportunities for increasing collaboration and online engagement. The lack of knowledge and evidence has motivated this pilot study for which students record short reflective videos prior or after class using a private social media application, Soqqle. This was performed across three classes of differing modules in Hong Kong and Thailand. Evaluation and analysis of the classes differ, between participation and learning improvements, although having a similar teaching method of using student-generated videos. Results were mixed. In some cases, the predictors of correlational analysis were contradicting. In one group, results show a 64.2% increase in participation compared to the COVID-19 period. In another group, a regression analysis was able to predict learning performance with 41.2% accuracy (p= <. 001), using the number of videos watched and average duration as predictors. A teaching and learning framework for using the collaborative flipped classroom model is proposed and can be adapted by future researchers. Suggestions to further enhance the model are discussed. © 2022 IEEE.

14.
Journal of Ecology and Rural Environment ; 38(5):578-586, 2022.
Article in Chinese | Scopus | ID: covidwho-2026019

ABSTRACT

Coordination is an important part of the new development philosophy. Promoting the coordinated development is the main goal of deepening the reform and development in state-owned forest region. Aiming to provide scientific basis and theoretical supports for promoting the continuous deepening of reform of state-owned forest region and realizing comprehensive and high-quality coordinated development, the key state-owned forest region in Daxing'anling, Heilongjiang Province was chosen as the research object. A compound system covering ecological conservation, industrial development, enterprise management, well-being of the people and support capability was constructed. The coupling coordination model was used to quantitatively evaluate the coupling coordination status of the compound system from 2000 to 2020. The Grey Markov model was used to predict the trend of coupling coordination development in this compound system from 2021 to 2022. Results show that, after 21-year of transformation and development, the development index of each subsystem of state-owned forest region in Daxing'anling, Heilongjiang Province has been changed, however, the process were different among subsystems. The growth rates of the subsystems of well-being of the people and resource conservation have been high, while the subsystems of enterprise management and the support capability have been lagged dramatically behind. The development stage of coupling coordination of the compound system has changed from misalignment to coordination, nevertheless, the coordinated development level was regressive in recent years due to certain factors such as policy, COVID-19, etc. It is predicted that by 2022, the development stage of coupling coordination of compound system will be recovered to the benign coordinated development type, however, there is still a big gap before it reaches the high-quality coordinated development type. It is suggested that the existing support policies and inputs should be kept stable, moreover, the enterprise management and support capability should be strengthened, in order to promote the stable and high-quality coupling coordinated development in the key state-owned forest regions in Daxing'anling, Heilongjiang Province. © 2022, China Environmental Science Press. All rights reserved.

15.
Advances in Artificial Intelligence and Applied Cognitive Computing ; : 263-276, 2021.
Article in English | Web of Science | ID: covidwho-2013836
16.
Annals of the Rheumatic Diseases ; 81:162-163, 2022.
Article in English | EMBASE | ID: covidwho-2008864

ABSTRACT

Background: Individuals with autoimmune rheumatic diseases (ARDs) may be at greater risk of severe COVID-19 outcomes than individuals in the general population. Objectives: This study assesses the risk of COVID-19-related hospitali-zation, intensive care unit (ICU) admission, and COVID-19-specific mortality in patients with ARDs compared to matched general population comparators. Methods: We conducted a population-based cohort study, using administrative datasets from British Columbia, Canada (February 2020-August 2021). Among all test-positive SARS-CoV-2 adults, we used ICD codes to identify all individuals with an ARD: rheumatoid arthritis (RA), psoriasis/psoriatic arthritis (PsO/PsA), ankylosing spondylitis (AS), and systemic autoimmune rheumatic diseases (SARDs), including systemic lupus erythematosus (SLE), Sjogren's syndrome, systemic sclerosis, myositis, and adult systemic vas-culitides. Individuals with an ARD were matched 1:5 to general population test-positive SARS-CoV-2 individuals on age (± 5 years), sex, month/year of initial positive SARS-CoV-2 test, and health authority. Conditional logistic regression models adjusting for socioeconomic status, Charlson comorbidity index, hypertension, rural address, and number of previous COVID-19 PCR tests were performed to assess risk of COVID-19-related hospitalizations, ICU admissions, and COVID-19-specifc mortality (mortality with primary ICD code for COVID-19). Results: The risk of COVID-19-related hospitalization was signifcantly increased for patients with ARDs overall (aOR: 1.30) (Table 1). Within ARDs, the patient group at greatest risk of hospitalization was adult systemic vasculitides (aOR: 2.18). The risk of ICU admission was signifcantly increased for patients with ARDs overall (aOR: 1.30). Within ARDs, the patient group at greatest risk of ICU admission was those with AS (aOR: 2.03). The risk of COVID-19-specifc mortality was signifcantly increased for patients with ARDs overall (aOR: 1.24). Within ARDs, the patient group at greatest risk of COVID-19-specifc mortality was those with AS (aOR: 2.15). Conclusion: The risk of severe COVID-19 outcomes is increased in some ARDs, although magnitude differs across individual diseases. Strategies to mitigate risk, such as booster vaccination, prompt diagnosis, and early intervention with available therapies (e.g., oral antivirals) should be prioritized in these groups according to risk.

17.
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi ; 57(6): 774-777, 2022 Jun 07.
Article in Chinese | MEDLINE | ID: covidwho-1903516
19.
Modern Pathology ; 35(SUPPL 2):385-386, 2022.
Article in English | EMBASE | ID: covidwho-1857880

ABSTRACT

Background: With COVID-19 restrictions remaining in place for the past year in Ontario, Canada, we have integrated weekly virtual gross rounds (VGR) as a part of regular post-graduate training since May 2020. We used Zoom (Zoom Video Communication, San Jose, CA USA) to livestream our rounds and maintained a steady attendance and interest. In addition to resident trainees, our VGR sessions are now attended by residents, staff, and pathologists' assistants (PA), PA students and medical laboratory technologists at community and academic institutions throughout Canada. We aimed to evaluate whether a virtual platform could maintain an engaging learning community in pathology. Specifically, we sought to identify the key elements and tools within a virtual format, as well as the attitudes of our learners, that were most conducive to virtual learning and building a pathology learning community for residents and PAs. Design: Surveys were sent to 237 registered participants of VGR at 12 months from the start of VGR. Residents and PA respondents were asked to rate their overall experience and rank the perceived effectiveness of VGR on pathology community building. In addition, survey participants ranked the least and most effective virtual engagement tools used during the sessions. Results: 78 participants completed the survey, a response rate of 33%. Both residents (n=21) and PAs (n=49) had an overall positive reception of VGR (average score 4.4/5) during this time. The tools which enhanced a sense of learning community were ranked from most to least useful (Table 1). Our participants identified the polls and chats as the most effective ways of engaging with each other. Most participants agreed or strongly agreed that VGR was effective at creating an online learning community as well as building interprofessional connections among residents and PAs (Figure 1 and 2). The availability of archived, edited, and interactive video recordings of the VGR sessions was identified as an important resource for learning. Conclusions: We report continued positive perception of virtual gross pathology learning among our residents and PA attendees. Specifically, we highlight the role of virtual learning in building a gross pathology learning community in Canada. We identified the ideal tools and techniques that are most helpful in engaging learners and sustaining an online community.

20.
International Journal of Electrochemical Science ; 17, 2022.
Article in English | Scopus | ID: covidwho-1847942

ABSTRACT

Detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV CoV-2) pathogen and protein biomarkers can improve the diagnosis accuracy for Coronavirus disease 2019 (COVID-19). Electrochemical biosensors have attracted extensive attention in the scientific community because of their simple design, fast response, good portability, high sensitivity and high selectivity. In this review, we summarized the progress in the electrochemical detection of COVID-19 pathogen and SARS-CoV-2 biomarkers, including SARS-CoV-2 spike protein and nucleocapsid protein and their antibodies. © 2022. The Authors. Published by ESG. All Rights Reserved.

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