Your browser doesn't support javascript.
Show: 20 | 50 | 100
Results 1 - 17 de 17
Filter
1.
2022 International Joint Conference on Neural Networks, IJCNN 2022 ; JOUR, 2022-July.
Article in English | Scopus | ID: covidwho-2097609

ABSTRACT

With the worldwide spreading of Coronavirus disease 2019 (Covid-19) pandemic, besides the traditional diagnosing approach, Artificial Intelligence provides additional support for the pre-diagnosis of Covid-19 by using data such as patients' images, and sounds, etc. Being able to recognize Covid-19 positive patients quickly and correctly is the key to preventing the expansion of the disease. However, the existing Covid-19 diagnosis models still face challenges due to the complex network structure and additional medical examination. It takes much time to return a diagnosis result. In this paper, a diagnostic model is proposed as an early work for Covid-19 diagnosis using sound samples. The features of sound signals are expressed by Mel Frequency Cepstral Coefficients, which are input into the Online Sequential Extreme Learning Machine for normal/abnormal detection. Data from an open-source database were used to train the proposed model, the experiments show that using vowel pronunciations the model can achieve an accuracy of 96.4% on average, with about 10 times faster for testing than the Support Vector Machine. © 2022 IEEE.

2.
Fundamental Research ; 2(3):476-486, 2022.
Article in English | Web of Science | ID: covidwho-2041756

ABSTRACT

Global pandemics such as COVID-19 have resulted in significant global social and economic disruption. Although polymerase chain reaction (PCR) is recommended as the standard test for identifying the SARS-CoV-2, conventional assays are time-consuming. In parallel, although artificial intelligence (AI) has been employed to contain the disease, the implementation of AI in PCR analytics, which may enhance the cognition of diagnostics, is quite rare. The information that the amplification curve reveals can reflect the dynamics of reactions. Here, we present a novel AI-aided on-chip approach by integrating deep learning with microfluidic paper-based analytical devices (mu PADs) to detect synthetic RNA templates of the SARS-CoV-2 ORFlab gene. The mu PADs feature a multilayer structure by which the devices are compatible with conventional PCR instruments. During analysis, real-time PCR data were synchronously fed to three unsupervised learning models with deep neural networks, including RNN, LSTM, and GRU. Of these, the GRU is found to be most effective and accurate. Based on the experimentally obtained datasets, qualitative forecasting can be made as early as 13 cycles, which significantly enhances the efficiency of the PCR tests by 67.5% (similar to 40 min). Also, an accurate prediction of the end-point value of PCR curves can be obtained by GRU around 20 cycles. To further improve PCR testing efficiency, we also propose AI-aided dynamic evaluation criteria for determining critical cycle numbers, which enables real-time quantitative analysis of PCR tests. The presented approach is the first to integrate AI for on-chip PCR data analysis. It is capable of forecasting the final output and the trend of qPCR in addition to the conventional end-point Cq calculation. It is also capable of fully exploring the dynamics and intrinsic features of each reaction. This work leverages methodologies from diverse disciplines to provide perspectives and insights beyond the scope of a single scientific field. It is universally applicable and can be extended to multiple areas of fundamental research.

3.
Natural Product Communications ; 17(8), 2022.
Article in English | Web of Science | ID: covidwho-2005549

ABSTRACT

Objective: To explore the potential active components of Chaiyin particles (CYPs) in the treatment of coronavirus disease 2019 (COVID-19) and their mechanism of action using network pharmacology and molecular docking technology. Methods: Based on the components of CYPs, we obtained potential targets of the interaction between CYPs and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The potential targets were analyzed by protein-protein interaction, gene ontology, and Kyoto Encyclopedia of Genes and Genomes pathway analyses. The key active components of CYPs were subjected to molecular docking with 3-chymotrypsin-like protease, angiotensin-converting enzyme II (ACE2), RNA-dependent RNA polymerase, and papain-like protease. The components that may bind to the key target proteins of SARS-CoV-2 were screened to obtain the potential active components, targets and pathways for CYP treatment of COVID-19. The above-described network analysis results were then verified experimentally. Results: CYPs may prevent and treat COVID-19 by inhibiting the release of inflammatory factors such as IL-6 and TNF-alpha;participating in the AGE-Rage signaling pathway, the HIF-1 signaling pathway, and other anti-inflammatory, antiviral, and immune regulatory signaling pathways;and blocking ACE2 via fortunellin and baicalin. Conclusion: This work illustrated that CYPs mainly play an anti-inflammatory and immunomodulatory role in COVID-19 prevention and treatment. The potential active components and molecular mechanism of CYPs can provide theoretical support and a pharmacological basis for further development and utilization of CYPs in the prevention and treatment of COVID-19. These results provide important insights into future studies of Traditional Chinese medicines (TCMs) modernization and prevention.

4.
Chinese Journal of Anesthesiology ; 42(1):1-2, 2022.
Article in Chinese | Scopus | ID: covidwho-1924331
5.
Chinese Journal of Applied Clinical Pediatrics ; 36(18):1368-1372, 2021.
Article in Chinese | Scopus | ID: covidwho-1481061

ABSTRACT

Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)infection is still worldwide.As a vulnerable group, severe and dead pediatric cases are also reported.Under this severe epidemic situation, children should be well protected.With the widespread vaccination of SARS-CoV-2 vaccine in adults, the infection rate have decreased.Therefore, SARS-CoV-2 vaccine inoculation for children groups step by step is of great significance to the protection of children and the prevention and control of corona virus disease 2019(COVID-19) as a whole.But the safety of children vaccinated with SARS-CoV-2 vaccine is a main concern of parents.Therefore, in order to ensure the safety of vaccination and the implementation of vaccination work, National Clinical Research Center for Respiratory Diseases, National Center for Children's Health and the Society of Pediatrics, Chinese Medical Association organized experts to interpret the main issue of parents about SARS-CoV-2 vaccine for children, in order to answer the doubts of parents. Copyright © 2021 by the Chinese Medical Association.

6.
Chinese Journal of Applied Clinical Pediatrics ; 36(18):1361-1367, 2021.
Article in Chinese | Scopus | ID: covidwho-1481060

ABSTRACT

At present, severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)infection is still rampant worldwide.As of September 10, 2021, there were about 222 million confirmed cases of corona virus disease 2019(COVID-19)and more than 4.6 million deaths worldwide.With the development of COVID-19 vaccines and the gradual vaccination worldwide, the increasing number of cases in children and unvaccinated young people has drawn attention.According to World Health Organization surveillance data, the proportion of COVID-19 infection cases in children gradually increased, and the proportion of cases in the age groups of under 5 years and 5-14 years increased from 1.0% and 2.5% in January 2020 to 2.0% and 8.7% in July 2021, respectively.At present, billions of adults have been vaccinated with various COVID-19 vaccines worldwide, and their protective effects including reducing infection and transmission, reducing severe disease and hospitalization, and reducing death, as well as high safety have been confirmed.Canada, the United States, Europe and other countries have approved the emergency COVID-19 vaccination in children and adolescents aged 12 to 17 years, and China has also approved the phased vaccination of COVID-19 vaccination in children and adolescents aged 3 to 17 years. For smooth advancement and implementation of COVID-19 vaccination in children, academic institutions, including National Clinical Research Center for Respiratory Diseases, National Center for Children's Health, and The Society of Pediatrics, Chinese Medical Association organized relevant experts to reach this consensus on COVID-19 vaccination in children. Copyright © 2021 by the Chinese Medical Association.

7.
37th IEEE International Conference on Data Engineering, ICDE 2021 ; 2021-April:2729-2732, 2021.
Article in English | Scopus | ID: covidwho-1369295

ABSTRACT

Contact tracing is an essential public health tool for controlling epidemic disease outbreaks such as the COVID-19 pandemic. Digital contact tracing using real-time locations or proximity of individuals can be used to significantly speed up and scale up contact tracing. In this demonstration, we present our system, REACT, for REAl-time Contact Tracing and risk monitoring via privacy-enhanced tracking of users' locations. With privacy enhancement that allows users to control and refine the precision with which their information will be collected and used, REACT will enable: 1) contact tracing of individuals who are exposed to infected cases and identification of hot-spot locations, 2) individual risk monitoring based on the locations they visit and their contact with others. In this paper, we demonstrate the procedure of contact tracing using our application and the utility of contact tracing given the protected locations. © 2021 IEEE.

8.
Chinese Journal of Applied Clinical Pediatrics ; 36(10):721-732, 2021.
Article in Chinese | Scopus | ID: covidwho-1278526

ABSTRACT

2019 novel coronavirus(2019-nCoV) outbreak is one of the public health emergency of international concern.Since the 2019-nCoV outbreak, China has been adopting strict prevention and control measures, and has achieved remarkable results in the initial stage of prevention and control.However, some imported cases and sporadic regional cases have been found, and even short-term regional epidemics have occurred, indicating that the preventing and control against the epidemic remains grim.With the change of the incidence proportion and the number of cases in children under 18 years old, some new special symptoms and complications have appeared in children patients.In addition, with the occurrence of virus mutation, it has not only attracted attention from all parties, but also proposed a new topic for the prevention and treatment of 2019-nCoV infection in children of China.Based on the second edition, the present consensus further summarizes the clinical characteristics and experience of children's cases, and puts forward recommendations on the diagnostic criteria, laboratory examination, treatment, prevention and control of children's cases for providing reference for further guidance of treatment of 2019-nCoV infection in children. © 2021 Chinese Medical Association

10.
IEEE Int. Conf. E-Health Netw., Appl. Serv., HEALTHCOM ; 2021.
Article in English | Scopus | ID: covidwho-1214729

ABSTRACT

Epidemics especially those caused by major contagious diseases have entailed huge losses in human history. The fights have thus never stopped to prevent pandemics. Due to its acute outbreak, is generally susceptible to the population regardless of ages, so strict quarantine of the infections becomes the most effective means for the epidemic control, which has been proved in the prevention of other contagious diseases such as SARS and H1N1. The key strategy widely used to find infected and suspected patients is still the epidemiological tracking of confirmed cases. However, this may fail to identify infections especially when patients do not show any symptoms. Therefore, the approach to rapid, effective, and simple infection identification is essential to prevent the spread of a contagious disease. This paper proposes to leverage a social apps and Geospatial artificial intelligence (GeoAI) with Blockchain to effectively identify infections with privacy concern. Since people widely use social apps, a large scale of social data with geospatial information could be easily collected and kept on Blockchain with privacy preservation, which thus provides a framework of decentralized, tamper-proof, and privacy-preserved information sharing. With the support of GeoAI, which analyzes the spatial distribution of diseases from the shared data, we could study the influence factors based on spatial propagation of contagious diseases for infection identification. Since WeChat is widely used in China, we take COVID-19 as an example to use the experiments on real-life datasets demonstrate the effectiveness of our method, and provide insight into epidemic control in terms of geo-social data sharing. © 2021 IEEE.

11.
Eur Rev Med Pharmacol Sci ; 25(2): 1070-1079, 2021 01.
Article in English | MEDLINE | ID: covidwho-1084631

ABSTRACT

OBJECTIVE: Coronavirus disease 2019 (COVID-19) has elevated mortality in severe and critical patients globally. This study examined the effect of glucocorticoids (GCS) on the time of virus clearance and absorption of lung lesions in severe and critical COVID-19 patients. PATIENTS AND METHODS: Severe and critical COVID-19 cases diagnosed in Wuhan Pulmonary Hospital from January 7 to February 10, 2020 were analyzed. The generalized linear model was utilized to assess the effects of GCS therapy on the times of nucleic acid test turning negative and improved pulmonary imaging, respectively. RESULTS: Of 66 patients, 51 (77.3%) and 15 (22.7%) were severe and critical cases, respectively, and aged 62 ± 11 years. A total of 58 patients (87.9%) tested negative, and 56 (84.8%) showed improved lung imaging. Age, thrombocytopenia, CD8 + T cell count, course of GCS therapy, and total dose were correlated with the time of nucleic acid test turning negative (p < 0.05), and sex was correlated with the time of initial pulmonary imaging improvement (p < 0.05). The time of nucleic acid test turning negative in individuals with GCS therapy course ≤ 10 days was shorter than that of the GCS therapy course > 10 days group (p=0.001). No statistical difference was found in the dose, course of GCS, and initial time of improved lung imaging. CONCLUSIONS: Increasing the dose of GCS and prolonging the course of treatment do not shorten the time of nucleic acid test turning negative or improved absorption of pulmonary lesions. Thus, the rational use of GCS is particularly important.


Subject(s)
COVID-19/diagnostic imaging , COVID-19/drug therapy , Critical Illness/therapy , Glucocorticoids/administration & dosage , Severity of Illness Index , Aged , Cohort Studies , Female , Humans , Male , Middle Aged , Prognosis , Retrospective Studies , Treatment Outcome
12.
Chinese Journal of Anesthesiology ; 40(2):129-130, 2020.
Article in Chinese | Scopus | ID: covidwho-1061620

ABSTRACT

In the medical treatment activities to fight against the coronavirus disease 2019 epidemic, many anesthesia practioners in the country, especially the intensive care unit (ICU) medical staff, are on the front line and perform the therapeutic procedures with high risk of infection such as tracheal intubation, sputum suction, bronchoscopy and so on in ICU with most high risk of infection. What should the anesthesia practioners pay attention to? In the fight against the SARS epidemic in 2003, the author served as ICU director of SARS designated hospital, the Beijing Xiaotangshan hospital, for nearly 2 months and had some experience. Combining the situation of this epidemic, the author puts forward some personal suggestions: 1. Improving the success rate of critically ill patients is an important basis to avoid social panic. 2. For confirmed and suspected patients, non-emergency surgery should not be performed if possible;3. For confirmed and suspected patients who must undergo surgery, the highest level of protection must be taken;4. Before the outbreak is resolved, unconventional treatment must be taken even if anesthesia is performed for routine surgery. 5. Ensuring self-protection is the greatest contribution to the control of the epidemic. © 2020 Chinese Medical Association

13.
Chinese Journal of Anesthesiology ; 40(3):299-301, 2020.
Article in Chinese | Scopus | ID: covidwho-1061572

ABSTRACT

The identification and diagnosis of coronavirus disease 2019 (COVID-19) is of great significance in the treatment of COVID-19. Based on Diagnosis and Treatment Protocol for COVID-19 (Trial Version 5) issued on February 8, 2020 by the National Health Commission, there is no fungal pneumonia among the disease listed in the identification and diagnosis item. Thus, we reported a case of patient with AIDS associated with pneumocystis carinii severe pneumonia admitted to Shanghai Fourth People′s Hospital affiliated to Tongji University School of Medicine in January, 2020, which was helpful in improving the identification and diagnosis of COVID-19. © 2020 Chinese Medical Association

14.
Chinese Journal of Anesthesiology ; 40(3):271-274, 2020.
Article in Chinese | Scopus | ID: covidwho-1055138

ABSTRACT

During the epidemic of coronavirus disease 2019 (COVID-19), the infection of the elderly population will bring great challenges to clinical diagnosis and treatment, outcome and management.Combined with the characteristics of anesthesia and the pathophysiological characteristics of COVID-19 on lung function impairment in elderly patients, Chinese Society of Anesthesiology formulated the " Recommendations for anesthesia management and infection control in elderly patients with COVID-19″. This recommendation expounds preoperative visit and infection control, anesthesia management protocol, anesthesia monitoring, anesthesia induction/endotracheal intubation, anesthesia maintenance and infection control, intraoperative lung protection strategy, anti-stress and anti-inflammatory management, hemodynamic optimization, infection control during emergence from anesthesia, and postoperative analgesia in elderly patients with COVID-19, and provides the reference for the safe and effective implementation of anesthesia management in elderly patients during the prevention and control of COVID-19 epidemic. © 2020 Chinese Medical Association

15.
International Journal of Contemporary Hospitality Management ; 2020.
Article in English | Scopus | ID: covidwho-936579

ABSTRACT

Purpose: The purpose of this paper is to present initial findings from a vulnerability assessment based on the perceptions of practitioners working in four tourism and hospitality sectors in Wuhan and Hubei Province, namely, cruise lines, hotels, travel agencies and touristic attractions. Design/methodology/approach: The research note focuses on the coronavirus (COVID-19) outbreak from January to March 2020. Using the destination sustainability framework and an “interpretation” mixed methods research design, the authors analyze phone interviews (n = 151) and subsequent online surveys (n = 370) to assess sector-specific perceptions of exposure, sensitivity and system adaptiveness. Findings: Overall, findings paint a grim picture of each sector in the short-term. All respondents reported an immediate economic loss due to COVID-19, as well as recovery concerns and uncertainties. Immediate actions for addressing these issues centered on internal cost control and governmental subsidies, while anticipated next steps focused on product adjustment, a transformation of business structures and seeking governmental guidance and policies in restoring market confidence. Findings also allude to future strategies/directions. Research limitations/implications: This study is limited in its focus on practitioner views in the immediate COVID-19 outbreak. Implications highlight a crucial strategic dependence of each sector on effective government/managerial communication and support, with smaller, local businesses needing particular attention in crisis situations. Originality/value: To the authors’ knowledge, this research note is the first comprehensive study presenting vital information pertaining to the impact of COVID-19 on tourism and hospitality businesses from a large group of business leaders in the site of the initial outbreak (i.e. Wuhan and Hubei Province). With the highly infectious COVID-19 representing an ongoing threat for populations worldwide, this paper hopes this research note provides valuable insights for practitioners in other vulnerable regions, as well as for researchers examining strategies for resilience against this and future disasters. © 2020, Emerald Publishing Limited.

17.
Acta Virol ; 64(2): 245-250, 2020.
Article in English | MEDLINE | ID: covidwho-608475

ABSTRACT

An outbreak of new severe acute respiratory syndrome coronavirus disease, coronavirus disease 2019 (COVID-19), has emerged during December 2019. The ongoing outbreak in Wuhan City spread rapidly throughout China, where the fatality rate ranged from 2.1 to 4.9%. Due to its high transmissibility, the World Health Organization (WHO) declared a public health emergency of international concern on 30 January 2020. The current outbreak has the potential to become the first pandemic of the new millennium. Most patients who were first diagnosed with COVID-19 worked at or lived in the vicinity of the local Huanan Seafood Wholesale  Market, where live animals were also on sale. The concerted efforts of Chinese scientists led to the independent isolation from patients and identification of a novel coronavirus, SARS coronavirus 2 (SARS-CoV-2), on 6 January 2020; this has been an important step in the development of treatment. The purpose of this article is to overview the history, epidemiology, clinical characteristics, diagnosis, and treatment of COVID 2019 reported in recently published studies. Based on the results of virus genome sequencing and a model of the interaction between host cells and the virus, we propose several possible targets for antiviral drugs, which may provide new ideas for epidemic control and vaccine development. Keywords: 2019 novel coronavirus; pneumonia; SARS-CoV-2; Coronaviridae; COVID-19.


Subject(s)
Betacoronavirus/isolation & purification , Coronavirus Infections , Pandemics , Pneumonia, Viral , Animals , COVID-19 , China , Coronavirus Infections/diagnosis , Coronavirus Infections/epidemiology , Coronavirus Infections/therapy , Humans , Pneumonia, Viral/diagnosis , Pneumonia, Viral/epidemiology , Pneumonia, Viral/therapy , SARS-CoV-2
SELECTION OF CITATIONS
SEARCH DETAIL