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1.
Journal of Medical Virology ; 94(5):i-i, 2022.
Article in English | Wiley | ID: covidwho-1750403

ABSTRACT

Front Cover Caption: The cover image is based on the Research Article Aggregation of high-frequency RBD mutations of SARS-CoV-2 with three VOCs did not cause significant antigenic drift by Tao Li et al., https://doi.org/10.1002/jmv.27596.

2.
J Med Virol ; 94(5): 2108-2125, 2022 05.
Article in English | MEDLINE | ID: covidwho-1627779

ABSTRACT

Variants of SARS-CoV-2 continue to emerge, posing great challenges in outbreak prevention and control. It is important to understand in advance the impact of possible variants of concern (VOCs) on infectivity and antigenicity. Here, we constructed one or more of the 15 high-frequency naturally occurring amino acid changes in the receptor-binding domain (RBD) of Alpha, Beta, and Gamma variants. A single mutant of A520S, V367F, and S494P in the above three VOCs enhanced infectivity in ACE2-overexpressing 293T cells of different species, LLC-MK2 and Vero cells. Aggregation of multiple RBD mutations significantly reduces the infectivity of the possible three VOCs. Regarding neutralization, it is noteworthy that E484K, N501Y, K417N, and N439K predispose to monoclonal antibodies (mAbs) protection failure in the 15 high-frequency mutations. Most importantly, almost all possible VOCs (single RBD mutation or aggregation of multiple mutations) showed no more than a fourfold decrease in neutralizing activity with convalescent sera, vaccine sera, and immune sera of guinea pigs with different immunogens, and no significant antigenic drift was formed. In conclusion, our pseudovirus results could reduce the concern that the aggregation of multiple high-frequency mutations in the RBD of the spike protein of the three VOCs would lead to severe antigenic drift, and this would provide value for vaccine development strategies.


Subject(s)
COVID-19 , SARS-CoV-2 , Animals , Antibodies, Neutralizing , Antigenic Drift and Shift , COVID-19/therapy , Chlorocebus aethiops , Guinea Pigs , Humans , Immunization, Passive , Mutation , SARS-CoV-2/genetics , Spike Glycoprotein, Coronavirus , Vero Cells
3.
Fractals ; 29(7), 2021.
Article in English | ProQuest Central | ID: covidwho-1546575

ABSTRACT

To examine the overall properties of the China’s stock market affected by the COVID-19 pandemic, we provide a comprehensive study of the multifractal properties across stock market sectors applying multifractal detrended fluctuation analysis (MF-DFA). We focus on intra-day 5min transaction data of 10 sectors in the Shanghai Stock Exchange, and the time-depended MF-DFA was also used to explore the dynamical evolution of the multifractal characterize for the overall period. We found that all sectors exhibit stronger multifractality and the weak market efficiency during the period of COVID-19, MHII performed best with the lower multifractal properties and higher market efficiency, three worse performers were ITII, TBII, and EII. While ITII, TBII, MCII, and UII were the four fastest recovering sectors from the gloom of the epidemic, with the plummeted multifractal intensity and the significantly increased market efficiency for the post-phase of the pandemic. The results based on the time-varying MF-DFA confirmed that the Chinese stock market is not only affected by the COVID-19 epidemic domestic but the impact of the US stock market crash in March was also transmitted to it, causing those industries sensitive to the market to fluctuate subsequently.

4.
International Journal of Production Economics ; : 108076, 2021.
Article in English | ScienceDirect | ID: covidwho-1116866

ABSTRACT

In 2019 China accounted for 14 percent of world total outward foreign direct investment, with 188 countries recipients of this investment. However research suggests that 67 percent of this investment is considered unsuccessful. Furthermore, the current Covid-19 outbreak has severely hindered global economic and trade activities. This is partly due to an under-efficiency of Chinese expatriate executives resulting from the lack of cultural intelligence of these executives to maximize team efficiency in production. From a data set of 358 expatriate Chinese executives, this research utilizes structural equation modeling to examine the role of expatriate executives' cultural intelligence on team efficiency. The research shows that the relationship between an expatriate executive’s cultural intelligence and team efficiency is mediated by their ability to recognize international opportunity and moderated by openness to experience. Additional leadership development on cultural intelligence of expatriate executives will improve international efficiency and wider multinational efficiency.

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