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Frontiers in medicine ; 7:373-373, 2020.
Article | WHO COVID | ID: covidwho-689146


Background: With the adoption of powerful preventive and therapeutic measures, a large number of patients with COVID-19 have recovered and been discharged from hospitals in Wuhan, China Prevention of epidemic rebound is a top priority of current works However, information regarding post-discharge quarantine and surveillance of recovered patients with COVID-19 is scarce Methods: This study followed up 337 patients with COVID-19 in a Wuhan East-West Lake Fangcang shelter hospital during the post-discharge quarantine Demographic, clinical characteristics, comorbidities, and chest computed tomography (CT) image, mental state, medication status, and nucleic acid test data were summarized and analyzed Results: 21/337 (6 2%) patients were SARS-CoV-2 nucleic acid re-positive, and 4 /337(1 2%) patients were suspected positive The median day interval between the discharge to nucleic acid re-positivity was 7 5 days (IQR, 6-13), ranging from 6 to 13 days Cough/expectoration are the most common symptoms, followed by chest congestion/dyspnea during the 2 weeks post-discharge quarantine Risk factors of nucleic acid re-positivity including the number of lobes infiltration (odds ratio[OR], 1 14;95% CI, 1 09-1 19), distribution (OR, 0 16;95% CI, 0 13-0 19), CT imaging feature of patchy shadowing accompanying with consolidation (OR, 9 36;95% CI, 7 84-11 17), respiratory symptoms of cough accompanying with expectoration (OR, 1 39;95% CI, 1 28-1 52), and chest congestion accompanying by dyspnea (OR, 1 42;95% CI, 1 28-1 57) Conclusion: The 2 weeks post-discharge quarantine may be an effective measure to prevent the outbreak from rebounding from the recovered patients The second week is a critical period during post-discharge quarantine Special attention should be paid to cough, expectoration, chest congestion, and dyspnea in recovered COVID-19 patients A few recovered patients may prolong the quarantine based on clinical symptoms and signs and nucleic acid results in the 2 weeks of medical observation