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1.
National Journal of Community Medicine ; 13(9):642-650, 2022.
Article in English | Scopus | ID: covidwho-2091797

ABSTRACT

Purpose: The present study analyzed the existing literature related to COVID 19 and Mental Health by using the technique of bibliometric analysis which may serve as guide-map for future researchers and policy makers. Method: Bibliometric analysis is conducted in the present study by using various techniques like citation analysis, co-citation analysis, co-occurrence of keywords, thematic mapping by using visualization of similarities (VOS) viewer open-source software and R-based bibliometrix. Results: The study highlighted the most significant journals, authors, co-cited authors, institutions, keywords co-occurrence, and most cited articles in the area of COVID-19 and Mental Health on the basis of bibliometric analysis of 149 studies taken from the database of Scopus for the past three years (2020– first quarter of 2022). Also, authors identified few relevant themes such as Economic Effects of COVID-19, COVID-19 and its Impact on Healthcare workers, COVID-19 and its Impact on Patients and General Population as important emerging key areas for further research. Conclusion: We have highlighted significant citations, co-citations and keywords co-occurrence to summarize the literature. The present bibliometric study convincingly confirms the effect of COVID 19 pandemic on mental health and provides enough evidence to advocate formulation of strategies to tackle mental health issues. © 2022, MedSci Publications. All rights reserved.

2.
NeuroQuantology ; 20(10):7320-7335, 2022.
Article in English | EMBASE | ID: covidwho-2067315

ABSTRACT

As the threat of a coronavirus disease 2019 (COVID-19) pandemic subsides, governments throughout the world are dealing with epidemic concerns due to the occurrence of monkeypox cases in various areas. Previously limited to African countries, the majority of monkeypox cases associated with the 2022 epidemic have been recorded in countries throughout Europe and the Western Hemisphere. While multiple organisations are doing contact-tracing operations, it is still unclear how this outbreak began. Monkeypox virus is one of several zoonotic viruses in the Orthopoxvirus genus of the Poxviridae family. Following the universal abolition of smallpox in the 1970s, monkeypox outbreaks drew international attention.The smallpox immunisation provided immunity against the monkeypox virus. Monkeypox cases rose when smallpox vaccine was halted. It wasn't until the 2003 US pandemic that monkeypox became well known. The virus did not originate in monkeys, despite the name "monkeypox." Although other rodents and small animals have been recognised as the virus's origins, the precise origin of monkeypox is uncertain. The viral infection was originally observed in macaque monkeys, thus the term monkeypox. Although human-to-human transmission of monkeypox is exceedingly rare, it is usually associated with respiratory droplets or direct contact with infected people's mucocutaneous sores. There is presently no treatment available for infected people;however, supportive therapies can be utilised to relieve symptoms;drugs such as tecovirimat may be used in severe cases. Many therapy are subjective since there are no unambiguous guidelines for symptom relief.

3.
Medical Journal of Dr. D.Y. Patil Vidyapeeth ; 15(7):S77-S83, 2022.
Article in English | Scopus | ID: covidwho-2024840

ABSTRACT

Aim: The aim of the study was to correlate environmental changes with coronavirus disease 2019 (COVID-19) cases in four metropolitan cities. Methodology: Data on monthly cumulative new cases, monthly average temperatures, humidity, precipitation, and average monthly air quality index (AQI) levels for the four Indian cities - Chennai, New Delhi, Mumbai, and Kolkata, and biomedical waste (BMW) quantity at national level were ed for the period from March 2020 to December 2020. Results: An inverse correlation was observed between temperature and transmission of the disease in New Delhi and Kolkata which was of fair degree for New Delhi (r = 0.299, P = 0.402) and poor for Kolkata (r = 0.200, P value = 0.579). Positive correlation of fair and poor degrees was observed between temperature and transmission of the disease in Mumbai (r = 0.272, P = 0.448) and Chennai (r = 0.196, P = 0.588), respectively. A positive correlation was observed between the transmission of the disease and humidity in New Delhi, Mumbai, and Kolkata, which was of moderate-to-good degree for Mumbai (r = 0.729, P = 0.017) and poor for New Delhi (r = 0.242, P = 0.501) and Kolkata (r = 0.123, P = 0.735). A significant positive correlation was observed between the rise in COVID-19 cases and the quantity of BMW generated (r = 0.88, P = 0.009). Furthermore, significant improvement in air quality AQI in four metros and water quality biological oxygen demand/chemical oxygen demand of Yamuna river was observed. Conclusions: Understanding of the interplay of environmental meteorological factors on COVID-19 disease transmission and vice versa is necessary for better informed policy framing and future research. © Medical Journal of Dr. D.Y. Patil Vidyapeeth 2022.

4.
Medical Journal of Dr. D.Y. Patil Vidyapeeth ; 15(7):S84-S88, 2022.
Article in English | Scopus | ID: covidwho-2024837

ABSTRACT

Introduction: The present study was conducted for vaccine effectiveness in the prevention of mortality among moderate to severe COVID-19 cases. Methods: The study was conducted in a dedicated COVID-19 hospital in Northern India from April 2021 to June 2021. Only moderate and severe COVID-19 cases were admitted to the hospital. All patients with the outcome (recovery or mortality) till 30 June 2021 constitute the study population for the study. The study is designed as a case-control study. The outcome was mortality due to COVID-19. The control group was cases who have recovered. The exposure was vaccination status. The data about the age, sex, and vaccination status including the type of vaccine was collected from the case sheets. Results: A total of 735 participants were recruited, out of which 409 patients survived and 326 patients died due to COVID-19 in the hospital. The mean age was 52.80 years (SD = 14.1 years) in the cases group and 60.92 years (SD = 14.97 years) in control group (P = 0.001). 137 (33.50%) were female and 272 (66.50%) were male in the control group while in cases 134 (41.10%) were female and 192 (58.90%) were male (P = 0.03). A total of 473 (64.35%) patients were unvaccinated, 199 (27.07%) were partially vaccinated, and 63 (8.57%) were fully vaccinated. Among the patients who survived, 101 (24.69%) were partially vaccinated and 28 (6.85%) were fully vaccinated;in the cases group, 98 (30.06%) people were partially vaccinated and 35 (10.74%) were fully vaccinated. On multiple regression analysis, there was no association between vaccination status and mortality among moderate and severe cases. Conclusion: The present study brought out that there is no association between vaccination and mortality among moderate to severe COVID-19 cases admitted to the makeshift hospital in Delhi. © Medical Journal of Dr. D.Y. Patil Vidyapeeth 2022.

5.
Journal of Marine Medical Society ; 24(3):25-29, 2022.
Article in English | Web of Science | ID: covidwho-1997942

ABSTRACT

Introduction: The world is enveloped with the coronavirus disease 2019 (COVID-19) Pandemic with modern medicine and public health facing their most significant challenges ever posed. As the number of COVID-19 cases increased worldwide, an important issue of concern was the continuation of routine immunization services for children. This study has been conceptualized to assess the effect of the COVID-19 pandemic on infant Immunization. Materials and Methods: This study was a descriptive study conducted in an urban community amongst healthy children < 1-year-old from January 2018 to September 2021. Immunization records of infants were obtained from data generated during each immunization session and strength, weakness, opportunity, and threat analysis was done using a questionnaire. Results: During the study, a total of 3518 vaccinations were done, a total of 3010 vaccinations (85.5%) were done on time, and the total delayed vaccinations were 508 (14.5%). The difference among the years was statistically significant, with the highest delay in the year 2020 (P < 0.001). However, in the year 2021, the number of vaccinations carried out from April to September was 568, with delayed vaccination of only 10.9%. Conclusion: The Armed Forces childhood immunization program could be sustained during the COVID-19 pandemic due to a multitude of contributing factors such as adherence to national guidelines that prioritized vaccination, infrastructure, and availability of trained workforce and most importantly commitment to strict COVID appropriate behavior.

6.
Journal of Marine Medical Society ; 24(3):5-10, 2022.
Article in English | Web of Science | ID: covidwho-1997936

ABSTRACT

Background: The coronavirus disease-2019 (COVID-19) pandemic has introduced new ethical challenges in the care of patients and people who may have been exposed to severe acute respiratory syndrome coronavirus-2 or have mild to moderate COVID-19. Refusal to get tested for COVID-19 and having poor adherence to infection prevention protocols are the areas of concern for the ongoing pandemic. Such situations increase the risk of infection to other patients and staff. The factors affecting testing refusal were studied with the help of the Google questionnaire. Methodology: The cross-sectional survey tool was developed and distributed after pilot testing. The study population was selected using mix sampling method, snowball, and random sampling using the mobile number of the participants. All the participants were informed about the purpose of the study and included after taking consent. Results: Of the 176 study participants, the majority were male (112, 63.6%), with a mean age of 37.2 years (standard deviation 10.4). Forty-one (23.3%) were health-care workers and 74 (42.1%) were private company employees. Seventy-one (40.3%) refused to get tested for COVID-19 when asked whether they will get tested in the presence of any COVID-19 symptoms and 81 (46.8%) refused to get tested in the absence of any symptoms. Conclusion: Health policy-makers should utilize the study results to formulate the policy regarding any future pandemic to reduce the level of stigma associated with an unknown disease. These clarifications and excuses asked to the study participants are meant to provide a deeper understanding to address the pandemic better.

7.
International Journal of Clinical Dentistry ; 15(2):347-356, 2022.
Article in English | Scopus | ID: covidwho-1958501

ABSTRACT

Objectives: The study aimed at evaluating orthodontics and dental emergencies during the COVID-19 pandemic. Materials and methods: An online-questionnaire survey was developed using google form and sent to orthodontists and dental surgeons in Nepal, practicing during the pandemic. Responses were collected and statistical analysis was done using SPSS version 16.0. Result: It was seen that the most frequently encountered orthodontic emergencies were due to, loose brackets (60%) and poking wires (47.6%) followed by loose bands (31.4%) and debonded loose buccal tubes (30.5%). Most frequently reported dental emergencies were broken or loose removable prosthesis and broken or loose crowns and/or bridges (13.3%) followed by bleeding while brushing (41.9%), swelling due to periodontal origin (33.1%), and severe pain due to tooth decay (44.8%). Conclusion: Loosening of brackets and poking wires were the most frequently reported orthodontic emergencies while, broken or loose prosthesis were reported commonly during the pandemic. © 2022 Nova Science Publishers, Inc.

8.
Journal of Humanitarian Logistics and Supply Chain Management ; 2022.
Article in English | Scopus | ID: covidwho-1874115

ABSTRACT

Purpose: Each individual needs to be vaccinated to control the spread of the COVID-19 pandemic in the shortest possible time. However, the vaccine distribution with an already strained supply chain in low- and middle-income countries (LMICs) will not be effective enough to vaccinate all the population in stipulated time. The purpose of this paper is to show that there is a need to revolutionize the vaccine supply chain (VSC) by overcoming the challenges of sustainable vaccine distribution. Design/methodology/approach: An integrated lean, agile and green (LAG) framework is proposed to overcome the challenges of the sustainable vaccine supply chain (SVSC). A hybrid best worst method (BWM)–Measurement of Alternatives and Ranking According to COmpromise Solution (MARCOS) methodology is designed to analyze the challenges and solutions. Findings: The analysis shows that vaccine wastage is the most critical challenge for SVSC, and the coordination among stakeholders is the most significant solution followed by effective management support. Social implications: The result of the analysis can help the health care organizations (HCOs) to manage the VSC. The effective vaccination in stipulated time will help control the further spread of the virus, which will result in the normalcy of business and availability of livelihood for millions of people. Originality/value: To the best of the author's knowledge, this is the first study to explore sustainability in VSC by considering the environmental and social impact of vaccination. The LAG-based framework is also a new approach in VSC to find the solution for existing challenges. © 2022, Emerald Publishing Limited.

9.
International Journal of Productivity and Performance Management ; 2022.
Article in English | Scopus | ID: covidwho-1741097

ABSTRACT

Purpose: The already-strained vaccine supply chain (VSC) of the expanded program for immunization (EPI) require a more robust and structured distribution network for pandemic/outbreak vaccination due to huge volume demand and time constraint. In this paper, a lean-agile-green (LAG) practices approach is proposed to improve the operational, economic and environmental efficiency of the VSC. Design/methodology/approach: A fuzzy decision framework of importance performance analysis (IPA)–analytical hierarchy process (AHP)–technique for order for preference by similarity in ideal solution (TOPSIS) has been presented in this paper to prioritize the LAG practices on the basis of the influence on performance indicators. Sensitivity analysis is carried out to check the robustness of the presented model. Findings: The derived result indicates that sustainable packaging, coordination among supply chain stakeholders and cold chain technology improvement are among the top practices affecting most of the performance parameters of VSC. The sensitivity analysis reveals that the priority of practices is highly dependent on the weightage of performance indicators. Practical implications: This study's finding will help policymakers reframe strategies for sustainable VSC (SVSC) by including new management practices that can handle regular immunization programs as well as emergency mass vaccination. Originality/value: To the best of the authors' knowledge, this is the first study that proposes the LAG framework for SVSC. The IPA–Fuzzy AHP (FAHP)–Fuzyy TOPSIS (FTOPSIS) is also a novel combination in decision-making. © 2022, Emerald Publishing Limited.

10.
Kidney International Reports ; 7(2):S109, 2022.
Article in English | EMBASE | ID: covidwho-1705178

ABSTRACT

Introduction: Studies have linked lower vitamin D levels with cardiovascular disease (CVD) and mortality in general population and chronic kidney disease (CKD). The preliminary evidence of vitamin D supplementation is encouraging but there is a huge void with respect to good quality long term data supporting the use of this promising intervention for translation into better outcomes for CVD in CKD. This study is exploring the effect of cholecalciferol supplementation on cardiovascular disease, markers of inflammation and bone metabolism in CKD. We present the baseline characteristics of feasibility phase of the trial. Methods: The study is a multicentric, prospective, randomized, placebo controlled, double blind trial in two parallel groups and feasibility phase is being done at Postgraduate Institute of Medical Education and Research, Chandigarh, India. The trial is registered at Clinical Trials Registry of India (CTRI/2019/05/019211). After a run-in period of 2 weeks, the enrolled subjects are randomized in 1:1 to receive either 60,000 IU/2 weeks of cholecalciferol or matching placebo. The subjects will be then followed up every three month till 3 years. The primary outcome of the study is a composite of major adverse cardiac events (MACE). Secondary outcome measures include all-cause mortality, need of RRT, change in hsCRP, IL-6, iPTH, FGF-23, bone specific alkaline phosphatase, and CTX-1. Results: A total of 720 subjects have been screened till date. Out of 119 enrolled, 86 subjects have been randomized over 24 months period. 76% subjects have completed annual follow up at 12 months, 66% subjects - 15thmonths follow up, 40%- 18 months follow up, 26% subjects - 21 months follow up, 6% subjects – 24 months follow up. Baseline characteristics and serum biomarkers levels has been analysed in 80 subjects. Mean age of the subjects were 51.3 ± 12.2 years and 58.8 % were males. Serum haemoglobin levels were 11.6 ±1.7 g/dl. Mean eGFR was 26.3 (17.4, 35.1) ml/min/1.73m2. Outcome events were;MACE: 1 (due to CVD), death other than due to MACE: 1 (due to COVID 19), subjects with composite of all-cause death and non-fatal MACE: 2, subject with need of RRT:1 and subjects with composite of 50% decline in GFR or need of RRT: 3. 2 serious adverse events unrelated to study drug were reported during the course of study. Table: Baseline levels of various serum biomarkers [Formula presented] Conclusions: Despite COVID 19 related restrictions being in place for most of the last 18 months, the study has been able to screen and enrol participants. The follow ups have been ensured either through physical or remote (mobile/telephonic) means. Once in the multi-centric phase, the study will be able to test a relatively inexpensive intervention in the form of vitamin D supplementation for CVD in CKD. No conflict of interest

11.
Journal of Marine Medical Society ; 23(2):145-148, 2021.
Article in English | Web of Science | ID: covidwho-1704996

ABSTRACT

Background: The ongoing coronavirus disease 2019 (COVID-19) pandemic has placed an unprecedented strain on Indian healthcare systems, with rapidly increasing demand for life-saving equipment and intensive care unit beds. The present study presents an analysis of average length of stay (LOS) as per different demographic and clinical factors in a dedicated COVID hospital. As the pandemic escalates, average LOS in COVID hospital will form the basis of determining the optimum requirement for healthcare resources (beds, staff, and equipment), which is a key priority for bolstering a strong public health response against COVID-19. Materials and Methods: Using the medical records at a dedicated COVID-19 hospital, the demographic details and select clinical characteristics of 342 admitted patients (from July 13, 2020, to August 30, 2020) were ed. Hospital LOS, calculated from the actual admission and discharge dates, was compared within the categories of demographic and clinical characteristics using Student's test and analysis of variance. SPSS version 20 was used for descriptive as well as inferential statistics. Results: The mean LOS was 9.93 +/- 4.45 days with a range of 3-37 days. LOS increased with increasing age, with maximum being for >61 years (12.69 +/- 7.14) and minimum for the younger age category of <40 years (8.88 +/- 1.95) (P = 0.001). As COVID-19 severity increased, LOS increased, with longest being for severe patients (25.59 +/- 7.30) and shortest being for Mild patients (8.74 +/- 1.80) (P = 0.001). LOS was also longer for patients having multiple comorbidities (13.00 +/- 7.96) and shortest for those with no comorbidities (9.33 +/- 2.96) (P = 0.001). Conclusion: LOS is significantly affected by age, severity, and comorbidities. The actual duration and factors influencing LOS are crucial for health administrators and policymakers to better allocate the already scarce health resources.

12.
Journal of Biomolecular Structure & Dynamics ; 40(1):86-100, 2022.
Article in English | MEDLINE | ID: covidwho-1597994

ABSTRACT

Novel Coronavirus or SARS-CoV-2 outbreak has developed a pandemic condition all over the world. The virus is highly infectious and spreads by human to human local transmission mode. Till date, there is no vaccination or drugs been approved for the treatment by the World Health Organisation. Henceforth, the discovery of the potential drugs is an urgent and utmost requirement for the medical fraternity. Since, the side effects of plant-derived compounds will be lower compared to synthetic/chemical drugs. The Main protease (3CLpro or NSP5) and endoribonuclease (NSP15) proteins are necessity for viral replication and its survival in the host cell. In the present study, in-silico approach of drug development was used to search for potential antiviral plant-derived compounds as inhibitors against SARS-CoV-2 replication proteins. Eight plant-derived compounds of which the antiviral activity was known and available, and two reported drugs against SARS-CoV-2 selected for the molecular docking analysis. The docking results suggested that bisdemethoxycurcumin, demethoxycurcumin, scutellarin, quercetin and myricetin showed least binding energy, i.e., greater than -6.5 Kcal/mol against 3CLpro and endoribonuclease of SARS-CoV-2. Further studies of ADME-Tox and bioavailability of drugs were also performed that exhibited efficient parameters of drug likeness. Molecular dynamics simulation calculations were performed for the most negative binding affinity of the compound to evaluate the dynamic behavior,and stability of protein-ligand complex. Our findings suggest that these compounds could be potential inhibitors of SARS-CoV-2 main protease and endoribonuclease. However, further in-vitro and pre-clinical experiments would validate the potential inhibitors of SARS-CoV-2 proteins.

13.
Sci Rep ; 11(1): 22013, 2021 11 10.
Article in English | MEDLINE | ID: covidwho-1510606

ABSTRACT

To meet the unprecedented requirement of diagnostic testing for SARS-CoV-2, a large number of diagnostic kits were authorized by concerned authorities for diagnostic use within a short period of time during the initial phases of the ongoing pandemic. We undertook this study to evaluate the inter-test agreement and other key operational features of 5 such commercial kits that have been extensively used in India for routine diagnostic testing for COVID-19. The five commercial kits were evaluated, using a panel of positive and negative respiratory samples, considering the kit provided by National Institute of Virology, Indian Council of Medical Research (2019-nCoV Kit) as the reference. The positive panel comprised of individuals who fulfilled the 3 criteria of being clinically symptomatic, having history of contact with diagnosed cases and testing positive in the reference kit. The negative panel included both healthy and disease controls, the latter being drawn from individuals diagnosed with other respiratory viral infections. The same protocol of sample collection, same RNA extraction kit and same RT-PCR instrument were used for all the kits. Clinical samples were collected from a panel of 92 cases and 60 control patients, who fulfilled our inclusion criteria. The control group included equal number of healthy individuals and patients infected with other respiratory viruses (n = 30, in each group). We observed varying sensitivity and specificity among the evaluated kits, with LabGun COVID-19 RT-PCR kit showing the highest sensitivity and specificity (94% and 100% respectively), followed by TaqPath COVID-19 Combo and Allplex 2019-nCoV assays. The extent of inter-test agreement was not associated with viral loads of the samples. Poor correlation was observed between Ct values of the same genes amplified using different kits. Our findings reveal the presence of wide heterogeneity and sub-optimal inter-test agreement in the diagnostic performance of the evaluated kits and hint at the need of adopting stringent standards for fulfilling the quality assurance requirements of the COVID-19 diagnostic process.


Subject(s)
COVID-19 Testing , COVID-19 , Humans , Pandemics , Reverse Transcriptase Polymerase Chain Reaction , Sensitivity and Specificity
14.
Medical Journal of Dr. D.Y. Patil Vidyapeeth ; 14(5):481-485, 2021.
Article in English | Scopus | ID: covidwho-1403953

ABSTRACT

Introduction: Risk communication is a vital component of the management of health-care crisis including the present pandemic. The health-care professionals play an important role in risk communication;however, health-care professionals have been found wanting when it comes to risk communication during any health-care crisis. The doctors/health-care professionals, being the technical personnel, are required to provide the technical information in a nontechnical or laymen language to the relevant authorities, which in turn are expected to share this knowledge to the people at risk. This study attempts to unravel the perceptions of health-care professionals on this important topic concerning public health. Methodology: A cross-sectional descriptive study was designed for the study question. An online survey was conducted based on Google Forms using snowball sampling technique. The data, collected using a pilot-tested questionnaire, were compiled in MS Excel and analyzed using SPSS software version 23. Requisite permission was taken from the institutional ethic committee. All participants were informed of the voluntary nature of the study, and the data collection was done in an anonymous manner. Results: A majority of participants (61.5%) answered in affirmative when asked if they know what risk communication is and 13 (7.7%) were not aware of it. A majority of the participants (60.9%) perceived risk communication as an exchange of information between health experts and general public, whereas 23 (13.6%) participants felt that risk communication is exchange of information between health experts and other health-care workers. Rumor management was not considered an essential part of risk communication by about half (48.5%) of the participants. Conclusion: We found significant gaps in the knowledge and perception of risk communication in the health-care professionals, which can be attributed to lack of training. Risk communication needs to be incorporated as a part of formal medical education to plug this gap. © 2021 Medical Journal of Dr. D.Y. Patil Vidyapeeth.

15.
Med J Armed Forces India ; 77: S271-S277, 2021 Jul.
Article in English | MEDLINE | ID: covidwho-1333668

ABSTRACT

BACKGROUND: The first dose of the ChAdOx1 nCoV- 19 Corona Virus Vaccine (Covishield) was administered to the eligible beneficiaries of tertiary care institute of Western Maharashtra on 16 Jan 21 and in the past three months almost 97% of the staff has been vaccinated. The present study analyses the incidence of COVID cases in the unvaccinated and vaccinated population of the institute. METHODS: All Covid 19 infections (RT-PCR positive) from 01 February 21 to 25 April 21 were included in the study and analyzed as per their vaccination status. To assess the COVID 19 transmission in contacts, Secondary Attack Rates (SAR) of the pre-vaccination period (Jun-Oct 20) was compared with the present SAR. RESULTS: A total of 113 cases occurred in the study period (01 Feb to 25 Apr 21). Lower number of infections were observed among the fully vaccinated as compared to partially vaccinated and non-vaccinated. The overall vaccine effectiveness was found to be 88.6% (81.55-92.37) and 44.1% (4.55-67.3) in completely and partially vaccinated individuals respectively. Hazard Ratios for getting infected dropped significantly after 28 days of the second dose. The SAR in high risk contacts (HRCs) was found to be 4.25%, which was lower than SAR (20.6%) of pre-vaccination period. CONCLUSION: This is one of the earliest studies in India to report the impact of COVID-19 vaccination. The results indicate that the vaccine provides effective protection against COVID-19 infection. However, given the complex dynamics of vaccination, the role of NPIs and implementation of COVID appropriate behavior cannot be undermined.

16.
Medical Journal of Dr. D.Y. Patil Vidyapeeth ; 14(4):380-384, 2021.
Article in English | Scopus | ID: covidwho-1296050

ABSTRACT

Introduction: Numerous vaccine candidates are in the race of successful clinical trials in response to the ongoing coronavirus disease-2019 (COVID-19) pandemic. This study was conducted to assess the perception and hesitancy among the physicians of major cities of India toward the upcoming COVID-19 vaccine. Methodology: A cross-sectional online survey was conducted between November 25, and December 25, 2020, among the frontline physicians, and they were asked if they would get vaccinated as soon as the vaccine is available in the market. Associations between sociodemographic characteristics and acceptance and hesitancy of an upcoming COVID-19 vaccine were analyzed. Results: Among 139 respondents who gave consent, the majority was male (121, 83.4%). Seventy-six (54.7%) respondents would like to get vaccinated as soon as the vaccine is available. Fifty-six (40.28%) participants had shown fear against the new vaccines, and self-perceived knowledge about the vaccine was found low (79, 56.83%). The majority of the physicians agreed to get vaccinated once reverse transcription-polymerase chain reaction positive or recovered in the past. Self-perceived protection of the new COVID-19 vaccine was high (102, 73.4%), and most physicians thought it safe for humans (89, 64%). Conclusion: The acceptance among the physicians positively influences the approval of a COVID-19 vaccine in the general population. Failure to address physicians' hesitancy leaves immunization programs at significant risk of any country. © 2021 Wolters Kluwer Medknow Publications. All rights reserved.

17.
International Journal of Safety and Security Engineering ; 11(2):193-199, 2021.
Article in English | Scopus | ID: covidwho-1257285

ABSTRACT

Cloud computing has emerged as a potential substitute over traditional computing systems during the time of the COVID-19 pandemic. Almost all organizations shift their working from conventional ways to the online form of working. Most of the organizations are planning to permanently change some % of their work to online WFH (Work from Home) mode. There are numerous benefits of using cloud services in terms of cost, portability, platform independence, accessibility, elasticity, etc. But security is the biggest barrier when one wants to move towards cloud computing services, especially the cloud storage service. To overcome the problem of security in cloud storage systems, we have presented an approach for data security in cloud storage. The proposed approach uses the cryptographic methods and provides security and monitoring features to the user data stored in cloud storage systems. The proposed approach continuously monitors user’s data for any kind of modification by attackers. Thus, approach not only provides data security but also improves user’s trust on cloud based storage services. © 2021 WITPress. All rights reserved.

18.
Journal of Biomolecular Structure & Dynamics ; : 1-15, 2020.
Article in English | MEDLINE | ID: covidwho-1214128

ABSTRACT

Novel Coronavirus or SARS-CoV-2 outbreak has developed a pandemic condition all over the world. The virus is highly infectious and spreads by human to human local transmission mode. Till date, there is no vaccination or drugs been approved for the treatment by the World Health Organisation. Henceforth, the discovery of the potential drugs is an urgent and utmost requirement for the medical fraternity. Since, the side effects of plant-derived compounds will be lower compared to synthetic/chemical drugs. The Main protease (3CL<sup>pro</sup> or NSP5) and endoribonuclease (NSP15) proteins are necessity for viral replication and its survival in the host cell. In the present study, in-silico approach of drug development was used to search for potential antiviral plant-derived compounds as inhibitors against SARS-CoV-2 replication proteins. Eight plant-derived compounds of which the antiviral activity was known and available, and two reported drugs against SARS-CoV-2 selected for the molecular docking analysis. The docking results suggested that bisdemethoxycurcumin, demethoxycurcumin, scutellarin, quercetin and myricetin showed least binding energy, i.e., greater than -6.5 Kcal/mol against 3CL<sup>pro</sup> and endoribonuclease of SARS-CoV-2. Further studies of ADME-Tox and bioavailability of drugs were also performed that exhibited efficient parameters of drug likeness. Molecular dynamics simulation calculations were performed for the most negative binding affinity of the compound to evaluate the dynamic behavior,and stability of protein-ligand complex. Our findings suggest that these compounds could be potential inhibitors of SARS-CoV-2 main protease and endoribonuclease. However, further in-vitro and pre-clinical experiments would validate the potential inhibitors of SARS-CoV-2 proteins.

19.
Mater Today Chem ; 20: 100443, 2021 Jun.
Article in English | MEDLINE | ID: covidwho-1131652

ABSTRACT

The World Health Organization (WHO) has declared the COVID-19 an international health emergency due to the severity of infection progression, which became more severe due to its continuous spread globally and the unavailability of appropriate therapy and diagnostics systems. Thus, there is a need for efficient devices to detect SARS-CoV-2 infection at an early stage. Nowadays, the reverse transcription polymerase chain reaction (RT-PCR) technique is being applied for detecting this virus around the globe; however, factors such as stringent expertise, long diagnostic times, invasive and painful screening, and high costs have restricted the use of RT-PCR methods for rapid diagnostics. Therefore, the development of cost-effective, portable, sensitive, prompt and selective sensing systems to detect SARS-CoV-2 in biofluids at fM/pM/nM concentrations would be a breakthrough in diagnostics. Immunosensors that show increased specificity and sensitivity are considerably fast and do not imply costly reagents or instruments, reducing the cost for COVID-19 detection. The current developments in immunosensors perhaps signify the most significant opportunity for a rapid assay to detect COVID-19, without the need of highly skilled professionals and specialized tools to interpret results. Artificial intelligence (AI) and the Internet of Medical Things (IoMT) can also be equipped with this immunosensing approach to investigate useful networking through database management, sharing, and analytics to prevent and manage COVID-19. Herein, we represent the collective concepts of biomarker-based immunosensors along with AI and IoMT as smart sensing strategies with bioinformatics approach to monitor non-invasive early stage SARS-CoV-2 development, with fast point-of-care (POC) diagnostics as the crucial goal. This approach should be implemented quickly and verified practicality for clinical samples before being set in the present times for mass-diagnostic research.

20.
Journal of Marine Medical Society ; 22(2):110-112, 2020.
Article in English | Web of Science | ID: covidwho-1119600
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