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1.
Bull Cancer ; 2022 Jul 02.
Article in French | MEDLINE | ID: covidwho-1920735

ABSTRACT

The COVID-19 pandemic disorganized the allogeneic stem cell transplantation activities all over the world, with the necessity to cryopreserve allografts to secure the procedure for both the recipient and the donor. Cryopreservation, usually anecdotal, has been used by all the French speaking centers; data collected from 24 centers were assessed in order to determine the impact of cryopreservation on the quality of allografts. Our analysis clearly demonstrates that increasing transit time (more than 48hours) is deleterious for CD34+ recovery, legitimates the slight increase of the requested CD34+ cell dose with respect to the average recovery rate as well as the importance of the quality control on the infused product.

3.
Bone Marrow Transplant ; 57(5): 742-752, 2022 05.
Article in English | MEDLINE | ID: covidwho-1702554

ABSTRACT

In 2020, 45,364 HCT in 41,016 patients, 18,796 (41%) allogeneic and 26,568 (59%) autologous in 690 centers were reported. Changes observed were as follows: total number of HCT -6.5%, allogeneic HCT -5.1%, autologous HCT -7.5%, and were more pronounced in non-malignant disorders for allogeneic HCT and in autoimmune disease for autologous HCT. Main indications were myeloid malignancies 10,441 (25%), lymphoid malignancies 26,120 (64%) and non-malignant disorders 2532 (6%). A continued growth in CAR-T cellular therapies to 1874 (+65%) patients in 2020 was observed. In allogeneic HCT, the use of haploidentical donors increased while use of unrelated and sibling donors decreased. Cord blood HCT increased by 11.7% for the first time since 2012. There was a significant increase in the use of non-myeloablative but a drop in myeloablative conditioning and in use of marrow as stem cell source. We interpreted these changes as being due to the SARS-CoV-2 pandemic starting early in 2020 in Europe and provided additional data reflecting the varying impact of the pandemic across selected countries and larger cities. The transplant community confronted with the pandemic challenge, continued in providing patients access to treatment. This annual report of the EBMT reflects current activities useful for health care planning.


Subject(s)
COVID-19 , Hematopoietic Stem Cell Transplantation , Neoplasms , Europe/epidemiology , Hematopoietic Stem Cell Transplantation/adverse effects , Humans , Neoplasms/etiology , Pandemics , SARS-CoV-2 , Transplantation, Homologous
4.
Bull Cancer ; 108(12S): S90-S97, 2021 Dec.
Article in French | MEDLINE | ID: covidwho-1559003

ABSTRACT

Infections occurring after CAR T-cells are a common complication. At the acute phase of treatment following CAR T-cell infusion, the exact incidence of infections is unknown given the overlapping symptoms with cytokine release syndrome. The risk factors for infection include the malignant underlying disease and its multiple treatments, and an immunosuppressive state induced by CAR-T cells themselves and the treatment of their complications. During the twelfth edition of practice harmonization workshops of the Francophone society of bone marrow transplantation and cellular therapy (SFGM-TC), a working group focused its work on the management of post-CAR infectious complications. In this review we discuss anti-infection prophylaxis and vaccination of patients undergoing CAR T-cell therapy as well as a special chapter for the specific case of COVID-19. These recommendations apply to commercial CAR-T cells, in order to guide strategies for the management and prevention of infectious complications associated with this new therapeutic approach.


Subject(s)
Bacterial Infections/prevention & control , Immunotherapy, Adoptive , Mycoses/prevention & control , Receptors, Chimeric Antigen/therapeutic use , Virus Diseases/prevention & control , Bone Marrow Transplantation , COVID-19/prevention & control , Cell Transplantation , Cytokine Release Syndrome , Humans , Immunization , Immunocompromised Host , Immunoglobulins/therapeutic use , Immunotherapy, Adoptive/adverse effects , Neoplasms/complications , Neoplasms/therapy , Pneumocystis , Risk Factors
5.
Bull Cancer ; 108(12S): S20-S25, 2021 Dec.
Article in French | MEDLINE | ID: covidwho-1293624

ABSTRACT

The SARS-CoV-2 (COVID-19) pandemic has rapidly impacted cell therapy activities across the globe. Not only was this, unexpected event, a threat to patients who had previously received hematopoietic cell transplantation or other cell therapy such as CAR-T cells, but also, it was responsible for a disruption of cell therapy activities due to the danger of the virus and to the lack of solid scientific data on the management of patients and donors. The Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC) devoted a workshop to issue useful recommendations in such an unexpected event in order to harmonize the actions of all the actors involved in cellular therapy programs so that we can collectively face, in the future, the challenges that could threaten our patients. This work is not specifically dedicated to the SARS-CoV-2 outbreak, but the latter has been used as a concrete example of an unexpected event to build up our recommendations.


Subject(s)
Bone Marrow Transplantation/standards , COVID-19/epidemiology , Cell Transplantation/standards , Pandemics , Cryopreservation , Health Services Accessibility , Hematopoietic Stem Cell Transplantation/standards , Humans , Immunotherapy, Adoptive/standards , Receptors, Chimeric Antigen/therapeutic use , Societies, Medical , Tissue Donors
7.
Bone Marrow Transplant ; 55(11): 2071-2076, 2020 11.
Article in English | MEDLINE | ID: covidwho-260560

ABSTRACT

The new coronavirus SARS-CoV-2 has rapidly spread over the world causing the disease by WHO called COVID-19. This pandemic poses unprecedented stress on the health care system including programs performing allogeneic and autologous hematopoietic cell transplantation (HCT) and cellular therapy such as with CAR T cells. Risk factors for severe disease include age and predisposing conditions such as cancer. The true impact on stem cell transplant and CAR T-cell recipients in unknown. The European Society for Blood and Marrow Transplantation (EBMT) has therefore developed recommendations for transplant programs and physicians caring for these patients. These guidelines were developed by experts from the Infectious Diseases Working Party and have been endorsed by EBMT's scientific council and board. This work intends to provide guidelines for transplant centers, management of transplant candidates and recipients, and donor issues until the COVID-19 pandemic has passed.


Subject(s)
Betacoronavirus , Coronavirus Infections , Delivery of Health Care/standards , Hematopoietic Stem Cell Transplantation , Immunotherapy, Adoptive , Infection Control/standards , Pandemics , Pneumonia, Viral , Accreditation/organization & administration , Allografts , COVID-19 , COVID-19 Testing , Clinical Laboratory Techniques , Continuity of Patient Care , Coronavirus Infections/diagnosis , Coronavirus Infections/epidemiology , Coronavirus Infections/prevention & control , Cross Infection/prevention & control , Europe , Health Personnel , Hematopoietic Stem Cell Transplantation/methods , Hematopoietic Stem Cell Transplantation/statistics & numerical data , Humans , Immunocompromised Host , Infectious Disease Transmission, Patient-to-Professional/prevention & control , Infectious Disease Transmission, Professional-to-Patient/prevention & control , Office Visits , Pandemics/prevention & control , Pneumonia, Viral/diagnosis , Pneumonia, Viral/epidemiology , Pneumonia, Viral/prevention & control , Procedures and Techniques Utilization , SARS-CoV-2 , Telemedicine , Tissue Donors , Transplant Recipients , Transplantation, Autologous , Visitors to Patients
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