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1.
Wuli Xuebao/Acta Physica Sinica ; 72(9), 2023.
Article in Chinese | Scopus | ID: covidwho-20245263

ABSTRACT

Owing to the continuous variant of the COVID-19 virus, the present epidemic may persist for a long time, and each breakout displays strongly region/time-dependent characteristics. Predicting each specific burst is the basic task for the corresponding strategies. However, the refinement of prevention and control measures usually means the limitation of the existing records of the evolution of the spread, which leads to a special difficulty in making predictions. Taking into account the interdependence of people' s travel behaviors and the epidemic spreading, we propose a modified logistic model to mimic the COVID-19 epidemic spreading, in order to predict the evolutionary behaviors for a specific bursting in a megacity with limited epidemic related records. It continuously reproduced the COVID-19 infected records in Shanghai, China in the period from March 1 to June 28, 2022. From December 7, 2022 when Mainland China adopted new detailed prevention and control measures, the COVID-19 epidemic broke out nationwide, and the infected people themselves took "ibuprofen” widely to relieve the symptoms of fever. A reasonable assumption is that the total number of searches for the word "ibuprofen” is a good representation of the number of infected people. By using the number of searching for the word "ibuprofen” provided on Baidu, a famous searching platform in Mainland China, we estimate the parameters in the modified logistic model and predict subsequently the epidemic spreading behavior in Shanghai, China starting from December 1, 2022. This situation lasted for 72 days. The number of the infected people increased exponentially in the period from the beginning to the 24th day, reached a summit on the 31st day, and decreased exponentially in the period from the 38th day to the end. Within the two weeks centered at the summit, the increasing and decreasing speeds are both significantly small, but the increased number of infected people each day was significantly large. The characteristic for this prediction matches very well with that for the number of metro passengers in Shanghai. It is suggested that the relevant departments should establish a monitoring system composed of some communities, hospitals, etc. according to the sampling principle in statistics to provide reliable prediction records for researchers. © 2023 Chinese Physical Society.

2.
Signa Vitae ; 19(2):12-19, 2023.
Article in English | EMBASE | ID: covidwho-2297088

ABSTRACT

This study aimed to investigate the usefulness of cerebral regional oxygen saturation (rSO2) during the initial 5 and 10 minutes of cardiopulmonary resuscitation (CPR) compared with an initial rSO2 and mean rSO2 during entire CPR to predict the futility of resuscitation for patients without of-hospital-cardiac arrest (OHCA). This was a prospective study involving 52 adult patients presenting in OHCA and whose cerebral rSO2 values were measured until either CPR was terminated or sustained return of spontaneous circulation (ROSC) was achieved. Receiver operating characteristics analyses were used to evaluate which time and type of measurement is better to predict non-ROSC. The area under the curve (AUC) of each rSO2 value according to measurement time (overall, initial 5 minutes and 10 minutes) were the highest value of 0.743, 0.724, and 0.739, mean values of 0.724, 0.677 and 0.701 and rSO2 (Changes in values of regional cerebral oxygen) value of 0.722, 0.734 and 0.724, respectively, while all of the initial values had a poor AUC (<0.7) and also were not statistically significant. The optimal cut-off value of each rSO2 values during overall, initial 5 minutes and 10 minutes were the highest value of 26% (sensitivity, 53.9% specificity, 92.3%), 24% (sensitivity, 56.4% specificity, 92.3%), and 30% (sensitivity, 61.5% specificity, 84.6%), mean value of 15.2%, 15.3% and 16%, respectively. None of the patients with a persistent rSO2 <=18% during the overall period achieved ROSC. Initial 5 minutes and 10 minutes cerebral rSO2 values an out-of-hospital-cardiac arrest (OHCA) are a better predictor in deciding the futility of CPR, compared to initial and overall measurements.Copyright © 2023 The Author(s). Published by MRE Press.

3.
Chinese Pharmacological Bulletin ; 38(3):460-469, 2022.
Article in Chinese | EMBASE | ID: covidwho-2115512

ABSTRACT

Aim To determine the antiviral and anti-inflammatory effects of the recommended prescription for COVID-2019-lung-spleen qi deficiency(4-1)against in vitro infection of SARS-CoV-2 and common coronaviruses.Methods The main chemical substances of 4-1 were analyzed by LC-MS.The toxicity and antiviral effects of of 4-1 were detected by MTT and by CPE assay, respectively.The viral loads in cell supernatant and the expression of inflammatory factors induced by viral infection were determined by qRT-PCR.Results The recommended prescription 4-1 contained 94 chemical compounds, including flavonoids, steroids, sesquiterpenoids, and so on.The range of selection indexes for SARS-CoV-2 and common coronaviruses was 8.44+/-0.49~52.26+/-2.3.This prescription could inhibit the proliferation of SARS-CoV-2, the expression of ACE2 and S mRNA, and down regulate IL-1alpha and CCL-5/RANTES at 10, 5, and 2.5 g*L-1 doses.Further, at doses of 20, 10 and 5 g*L-1, it could inhibit the proliferation of three common coronaviruses and suppress the overexpression of IL-6, CXCL-8/IL-8, CXCL-10/IP-10, TNF-alpha, IFN-alpha, CCL-2/MCP-1, MIG and CCL-5/RANTES induced by OC43/229E infection.The inhibitory effects were dose-dependent.Conclusions The prescription 4-1 has antiviral and anti-inflammation effects against multiple coronaviruses.This study provides the research basis for the treatment of common respiratory viral infections and emerging infectious diseases such as COVID-19 by using traditional Chinese medicine. Copyright © 2022 Publication Centre of Anhui Medical University. All rights reserved.

4.
Chinese Journal of New Drugs ; 31(21):2082-2089, 2022.
Article in Chinese | EMBASE | ID: covidwho-2111997

ABSTRACT

The research, development and application of corona virus disease 2019 (COVID-19) vaccine play an important role against the global pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. There are 11 candidate vaccines that have been issued for emergency use list (EUL) by WHO, which have been shown effective protection with safety against infection, severe diseases and death in clinical trials and real world. They have become powerful weapons for human beings to prevent infection and transmission of SARS-CoV-2. In this paper, the efficacy and safety of COVID-19 vaccines were briefly reviewed. Copyright © 2022, Chinese Journal of New Drugs Co. Ltd. All right reserved.

5.
Journal of the Architectural Institute of Korea ; 38(8):3-14, 2022.
Article in Korean | Scopus | ID: covidwho-2056134

ABSTRACT

Working from home is increasing worldwide due to the spread of COVID-19, and the sudden telecommuting environment in existing residential spaces has caused a lot of inconvenience. This study deals with the variable system and space developed to support working from home in existing residences. The purpose of this study is to find a way to secure a flexible independent working from home space at any time, and to design a housing model using smart wall system. To achieve this, 1) Problem analyzed and requirements were derived of residential spaces for working from home, 2) A smart wall system was built for the realization of a flexible teleworking space at any time, and a plan was sought for its utilization. 3) A variable space was designed using a smart wall that varies in various ways. The smart wall presented in this study is a system that secures variable performance, IoT communication easiness, and information display performance while including furniture and devices so that a telecommuting space can be newly constructed. By using this, it was designed on a basic floor plan of an apartment of 84㎡, the size of a national house, and 5 ways to use it were derived, designed and simulated based on the scenarios for each space. In addition, in order to realize various variable spaces, it has implications that the variable space of a columnar structure should be a base structure. © 2022 Architectural Institute of Korea.

6.
Allergy Asthma & Respiratory Disease ; 10(1):9-14, 2022.
Article in Korean | Web of Science | ID: covidwho-1675020

ABSTRACT

The incidence of coronavirus diseases 2019 (COVID-19), including severe cases, has been increasing in both children and adolescents with the spread of the delta variant. COVID-19 vaccines have been identified to be effective in the prevention of COVID-19 transmission in children and adolescents and keeping schools open. However, adverse reactions associated with COVID-19 vaccination in children and adolescents contribute to parents' hesitation to proceed with vaccination, especially due to serious, albeit rare, reactions. The results from COVID-19 vaccine clinical trials on the safety and efficacy of COVID-19 vaccines in children and adolescents are promising in terms of their effects on COVID-19 infection prevention. In the present study, we summarize the adverse reactions of COVID-19 vaccines in children and adolescents, based on the clinical trials, mainly including Pfizer-BioNTech and Moderna COVID-19 vaccines. In the Pfizer-BioNTech COVID-19 clinical trials, the most common local adverse reaction was pain at the injection site in 74.1%-86%, depending on age, and the most common systemic adverse reaction was fatigue, followed by headache, myalgia, diarrhea, and fever with differences in the distribution according to age. There was no severe adverse reaction related to any COVID-19 vaccine in children and adolescents during the study period. In the mass vaccination program of COVID-19 in children and adolescent, myocarditis has rarely been diagnosed after COVID-19 vaccination, which most commonly occurred in boys after the second dose. Currently, Pfizer-BioNTech COVID-19 vaccines can be safely recommended in children and adolescents for the prevention of COVID-19 infection and the reduction in COVID-19 severity.

7.
Atmosphere ; 12(9):14, 2021.
Article in English | Web of Science | ID: covidwho-1444087

ABSTRACT

This study aims to evaluate the accuracy and effectiveness of real-time personal monitoring of exposure to PM concentrations using low-cost sensors, in comparison to conventional data collection method based on fixed stations. PM2.5 data were measured every 5 min using a low-cost sensor attached to a bag carried by 47 asthmatic children living in the Seoul Metropolitan area between November 2019 and March 2020, along with the real-time GPS location, temperature, and humidity. The mobile sensor data were then matched with station-based hourly PM2.5 data using the time and location. Despite some uncertainty and inaccuracy of the sensor data, similar temporal patterns were found between the two sources of PM2.5 data on an aggregate level. However, average PM2.5 concentrations via personal monitoring tended to be lower than those from the fixed stations, particularly when the subjects were indoors, during nighttime, and located farther from the fixed station. On an individual level, a substantial discrepancy is observed between the two PM2.5 data sources while staying indoors. This study provides guidance to policymakers and researchers on improving the feasibility of personal monitoring via low-cost mobile sensors as an alternative or supplement to the conventional station-based monitoring.

8.
Journal of Travel & Tourism Marketing ; 38(2):155-166, 2021.
Article in English | Web of Science | ID: covidwho-1114778

ABSTRACT

This study aims to explore the psychological needs and satisfaction of Chinese, Japanese, and Korean tourists across three phases (i.e. before, during and perceived aftermath) of the COVID-19 pandemic. It fulfilled the theoretical extension of the Existence, Relatedness and Growth (ERG) theory to identify the basic psychological needs of the tourists in a pandemic situation. In-depth interviews, findings confirmed ERG processes of Satisfaction-Progression, Frustration-Regression, and Simple-Frustration. Nevertheless, the predominant psychological needs of tourists were different in each phase. The study contributes to a better understanding of post-pandemic needs of the tourists and is useful in redesigning travel experiences.

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