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Chinese Journal of Nosocomiology ; 30(19):2913-2917, 2020.
Article in Chinese | GIM | ID: covidwho-923247


OBJECTIVE: To analyze the key points and difficulties of diagnosis and management of the patients by reporting the case of positive nucleic re-examination in patient after treatment of a light novel coronavirus pneumonia. METHODS: A case of light novel coronavirus pneumonia diagnosed and treated in January 2020, the possible factors of rejuvenation and the process of isolation management during the period were retrospectively analyzed. RESULTS: The patient had only dry cough symptoms and no history of clear contact. After two times of pharynx swabs tested negative for nucleic acid, the patient was tested positive again, who was less likely re-infected and may have long detoxification time with the risk of spreading the virus. It maybe related to the limitations of nucleic acid reagent testing and sampling method. CONCLUSION: It is of great significance to accurately identify and control light and "Fuyang" patients and take strictly quarantine measures to reduce risk of transmission.

EMBO Mol Med ; 12(7): e12421, 2020 07 07.
Article in English | MEDLINE | ID: covidwho-306055


Progression to severe disease is a difficult problem in treating coronavirus disease 2019 (COVID-19). The purpose of this study is to explore changes in markers of severe disease in COVID-19 patients. Sixty-nine severe COVID-19 patients were included. Patients with severe disease showed significant lymphocytopenia. Elevated level of lactate dehydrogenase (LDH), C-reactive protein (CRP), ferritin, and D-dimer was found in most severe cases. Baseline interleukin-6 (IL-6) was found to be associated with COVID-19 severity. Indeed, the significant increase of baseline IL-6 was positively correlated with the maximal body temperature during hospitalization and with the increased baseline of CRP, LDH, ferritin, and D-dimer. High baseline IL-6 was also associated with more progressed chest computed tomography (CT) findings. Significant decrease in IL-6 and improved CT assessment was found in patients during recovery, while IL-6 was further increased in exacerbated patients. Collectively, our results suggest that the dynamic change in IL-6 can be used as a marker for disease monitoring in patients with severe COVID-19.

Coronavirus Infections/pathology , Interleukin-6/analysis , Pneumonia, Viral/pathology , Adult , Aged , Aged, 80 and over , Antiviral Agents/therapeutic use , Betacoronavirus/isolation & purification , Biomarkers/analysis , C-Reactive Protein/analysis , COVID-19 , Coronavirus Infections/drug therapy , Coronavirus Infections/virology , Female , Humans , Lymphopenia/etiology , Male , Middle Aged , Pandemics , Pneumonia, Viral/drug therapy , Pneumonia, Viral/virology , SARS-CoV-2 , Severity of Illness Index , Tomography, X-Ray Computed